Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	NCKIPSD	Unknown	22810696 24755471 26416732 22895193 25344691	Open Targets	Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis
		NCOA1	Unknown	29967250 22810696 26071483 29937994 26416732 26336987 25957691 25344691 29844865 24755471 22895193	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOA2	Unknown	29967250 27612425 29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	22810696 27023146 30038269 26071483 29937994 27612425 26416732 26336987 23856246 25957691 29316426 26109429 25344691 38725616 24755471 22895193 28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NCOR2	Unknown	22810696 30038269 26071483 29937994 26416732 26336987 25957691 26109429 32375028 25344691 38725616 24755471 22895193	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NDRG1	Unknown	25957691 24755471 22895193 25344691	Open Targets	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		NF2	Unknown	26071483 29937994 26416732 29316426 23856246 25957691 26109429 25344691 24755471 22895193 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFATC2	Unknown	22810696 30038269 26071483 29937994 26416732 25957691 26109429 25344691 24755471 22895193	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	22810696 34680263 26764183 29937994 29316426 25344691 22895193 28481359	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFIB	Unknown	30038269 29937994 25957691 30239619 25344691 24755471 22895193	Open Targets	—
		NFKB2	Unknown	22810696 30038269 26416732 25957691 26109429 25344691 29844865 38725616 24755471 22895193	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NFKBIE	Unknown	22810696 25344691 25957691	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NIN	Unknown	22810696 26764183 29937994 21203531 26416732 26336987 25957691 30239619 25344691 29844865 38725616 24755471 22895193	Open Targets	—
		NKX2-1	Unknown	22810696 25957691 25344691 29844865 22895193 28481359	Open Targets	—
		NONO	Unknown	22810696 30038269 26071483 26416732 23856246 25957691 22895193	Open Targets	—
		NOTCH1	Unknown	26071483 29665843 26764183 29937994 26416732 26336987 27247954 25957691 27756406 28145097 29316426 26109429 25344691 29844865 24755471 22895193 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	22810696 27023146 29967250 26071483 29937994 26416732 26336987 23856246 25957691 29316426 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	34680263 26109429 27756406 25957691 28481359	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NR2F2	Unknown	22810696 24755471 23856246 25344691	Open Targets	—
		NR4A3	Unknown	22810696 26071483 29937994 26416732 23856246 25957691 25344691 24755471 22895193	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NRAS	Unknown	28243320 26416732 28120820 29316426 27155048 21726664 20736745 22810696 29967250 34680263 23274911 37434969 27245685 1453686 25695693 29844865 25623536 27929064 26071483 27302369 27756406 28951457 22392911 25344691 26968814 22895193 27023146 23400451 28546418 22586653 24841357 28978093 30239619 31450901 22427190 25617745 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	22810696 26071483 26764183 27612425 29937994 26416732 26336987 25957691 26109429 30239619 25344691 38725616 24755471 22895193	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	22810696 29937994 26416732 23856246 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD2	Unknown	22810696 29937994 26416732 26336987 23856246 25957691 25344691 29844865 38725616 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NSD3	Unknown	26071483 29937994 26336987 25957691 25344691 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NT5C2	Unknown	22810696 29937994 27612425 25957691 25344691 24755471 22895193	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTHL1	Unknown	22895193 25344691 25957691	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		NTRK1	Unknown	22810696 29967250 30038269 26071483 26764183 29937994 2869410 26416732 25957691 25344691 29844865 31336886 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	22810696 27612425 29937994 26336987 29316426 25957691 26109429 30239619 25344691 38725616 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	22810696 29967250 26071483 29665843 26764183 29937994 26416732 29316426 28465371 25957691 26109429 30239619 25344691 29844865 31336886 24755471 22895193 28481359 38725616	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	22810696 26071483 29937994 21203531 26336987 23856246 25957691 30239619 25344691 29844865 38725616 24755471 22895193	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	22810696 29967250 21203531 23856246 25957691 26109429 30239619 25344691 29844865 38725616 24755471 22895193	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		NUP98	Unknown	22810696 26071483 26764183 29937994 26416732 25957691 26109429 30239619 32375028 25344691 29844865 31336886 24755471 22895193 38725616	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		NUTM1	Unknown	22810696 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	—
		NUTM2D	Unknown	22810696 25344691 25957691	Open Targets	—
		OLIG2	Unknown	30239619 22895193 25344691 25957691 26416732	Open Targets	—
		OMD	Unknown	25344691 29937994	Open Targets	Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 +2 more
		P2RY8	Unknown	22810696 30239619 25344691 25957691	Open Targets	Neuroactive ligand-receptor interaction
		PABPC1	Unknown	22810696 22895193 25957691 26109429 30239619 25344691 24699064	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAFAH1B2	Unknown	22895193 25344691	Open Targets	Ether lipid metabolism Metabolic pathways Neutrophil degranulation +1 more
		PALB2	Unknown	22810696 30038269 26071483 29937994 26416732 29316426 25957691 25344691 29844865 22895193 28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PATZ1	Unknown	22810696 24755471 30239619 25344691 29937994	Open Targets	—
		PAX3	Unknown	22810696 26071483 27612425 29937994 26416732 25957691 30239619 25344691 29844865 31336886 22895193	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	26071483 26764183 29937994 26416732 29316426 26336987 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	29967250 29937994 23856246 25957691 26109429 30239619 25344691 29844865 22895193	Open Targets	Transcriptional misregulation in cancer
		PAX8	Unknown	27612425 25957691 32375028 25344691 29844865 24755471 22895193	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PBRM1	Unknown	22810696 29937994 26416732 29316426 23856246 25957691 30239619 32375028 25344691 38725616 24755471 27566247 22895193 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	22810696 29937994 26416732 25344691 29844865 22895193	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCBP1	Unknown	22810696 30038269 26071483 26416732 26336987 25957691 30239619 25344691 22895193	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PCM1	Unknown	22810696 26071483 29937994 25957691 26109429 32375028 25344691 31336886 24755471 22895193	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more

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Colon adenocarcinoma

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