Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BREAST CANCER	MONDO_0007254 114480	JMJD1C	Unknown	29059683	GWAS catalog	Transcriptional misregulation in cancer Factors involved in megakaryocyte development and platelet production
		KANSL1	Unknown	29059683	GWAS catalog	HATs acetylate histones
		KCNJ6	Unknown	34981446	GWAS catalog	Circadian entrainment Retrograde endocannabinoid signaling Cholinergic synapse +9 more
		KCNMB3	Unknown	37340002	GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +1 more
		KCNN4	Unknown	23535729 25751625 29059683 32139696	GWAS catalog	Insulin secretion GnRH secretion Salivary secretion +2 more
		KCNS3	Unknown	29059683	GWAS catalog	Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
		KCNU1	Unknown	25751625 27117709 29059683 32139696 32887889 34290314 34594039 37340002	GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +1 more
		KCTD1	Unknown	29059683	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
		KDM4C	Unknown	29059683	GWAS catalog	HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
		KHDC4	Unknown	29059683	GWAS catalog	—
		KIF1B	Unknown	32887889	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KIF4B	Unknown	29059683	GWAS catalog	Motor proteins MHC class II antigen presentation Recycling pathway of L1 +2 more
		KIF5C	Unknown	38501904	GWAS catalog	Endocytosis Dopaminergic synapse Motor proteins +8 more
		KIF9	Unknown	29059683	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KLC1	Unknown	29059683	GWAS catalog	Motor proteins Alzheimer disease Parkinson disease +9 more
		KLF4	Unknown	29059683	GWAS catalog	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLHDC4	Unknown	40229280	GWAS catalog	—
		KLHDC7A	Unknown	29059683 32139696	GWAS catalog	—
		KLHL14	Unknown	29059683	GWAS catalog	—
		KLHL18	Unknown	29059683	GWAS catalog	—
		KLHL25	Unknown	40229280	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		KLHL38	Unknown	29059683 32139696	GWAS catalog	—
		KLHL5	Unknown	38501904	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		KRAS	Unknown	—	HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KREMEN1	Unknown	29059683	GWAS catalog	Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
		KRIT1	Unknown	29059683	GWAS catalog	Rap1 signaling pathway Adherens junction
		KRTAP4-7	Unknown	29059683	GWAS catalog	—
		KRTAP4-8	Unknown	29059683	GWAS catalog	Keratinization
		L3MBTL2	Unknown	29059683	GWAS catalog	Polycomb repressive complex SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
		L3MBTL3	Unknown	29058716 29059683 32139696	GWAS catalog	Polycomb repressive complex
		LAMB2	Unknown	29059683	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +9 more
		LAX1	Unknown	32887889	GWAS catalog	—
		LDB1	Unknown	29059683	GWAS catalog	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in differentiation of HSCs
		LDLRAD4	Unknown	37340002	GWAS catalog	—
		LEKR1	Unknown	29059683 32424353	GWAS catalog	—
		LGR6	Unknown	23535733 27117709	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination
		LINC02210-CRHR1	Unknown	36819030 37636041	GWAS catalog	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
		LLGL1	Unknown	38501904	GWAS catalog	Hippo signaling pathway Tight junction Human papillomavirus infection
		LMO4	Unknown	27354352	GWAS catalog	—
		LMTK2	Unknown	29059683	GWAS catalog	—
		LMX1B	Unknown	29059683 31757997 32139696	GWAS catalog	—
		LPCAT1	Unknown	29059683	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Metabolic pathways +5 more
		LRBA	Unknown	37340002	GWAS catalog	—
		LRPPRC	Unknown	37380357	GWAS catalog	TP53 Regulates Metabolic Genes Respiratory electron transport
		LRRC3B	Unknown	38538606	GWAS catalog	—
		LRRD1	Unknown	29059683	GWAS catalog	—
		LSM8	Unknown	38538606	GWAS catalog	RNA degradation Spliceosome mRNA Splicing - Major Pathway
		LSP1	Unknown	17529967 23535729 25751625 27117709 29059683 32139696 32887889 34290314 34594039 37340002	GWAS catalog	C-type lectin receptor signaling pathway Tuberculosis
		LYPD5	Unknown	23535729 25751625 29059683 32139696	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		LYST	Unknown	38501904	GWAS catalog	—
BREAST CARCINOMA	EFO_0000305	JMJD1C	Unknown	29059683 32424353	GWAS catalog	Transcriptional misregulation in cancer Factors involved in megakaryocyte development and platelet production
		KANSL1	Unknown	29059683 32887889	GWAS catalog	HATs acetylate histones
		KCNJ6	Unknown	34981446	GWAS catalog	Circadian entrainment Retrograde endocannabinoid signaling Cholinergic synapse +9 more
		KCNMB3	Unknown	37340002	GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +1 more
		KCNN4	Unknown	23535729 25751625 29058716 29059683 32139696	GWAS catalog	Insulin secretion GnRH secretion Salivary secretion +2 more
		KCNS3	Unknown	29059683	GWAS catalog	Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
		KCNU1	Unknown	25342443 25751625 27117709 29058716 29059683 32139696 32887889 33037222 34290314 34594039 35414113 37340002	GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +1 more
		KCTD1	Unknown	29059683	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors
		KDM4C	Unknown	29059683	GWAS catalog	HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
		KHDC4	Unknown	29059683	GWAS catalog	—
		KIF1B	Unknown	32887889	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KIF4B	Unknown	29059683	GWAS catalog	Motor proteins MHC class II antigen presentation Recycling pathway of L1 +2 more
		KIF9	Unknown	29059683	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KLC1	Unknown	29059683	GWAS catalog	Motor proteins Alzheimer disease Parkinson disease +9 more
		KLF4	Unknown	29059683	GWAS catalog	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KLHDC4	Unknown	40229280	GWAS catalog	—
		KLHDC7A	Unknown	29059683 32139696	GWAS catalog	—
		KLHL14	Unknown	29059683	GWAS catalog	—
		KLHL18	Unknown	29059683	GWAS catalog	—
		KLHL25	Unknown	40229280	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		KLHL38	Unknown	29059683 32139696	GWAS catalog	—
		KREMEN1	Unknown	29059683	GWAS catalog	Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
		KRIT1	Unknown	29059683	GWAS catalog	Rap1 signaling pathway Adherens junction
		KRTAP4-7	Unknown	29059683	GWAS catalog	—
		KRTAP4-8	Unknown	29059683	GWAS catalog	Keratinization
		L3MBTL2	Unknown	29059683	GWAS catalog	Polycomb repressive complex SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
		L3MBTL3	Unknown	29058716 29059683 32139696	GWAS catalog	Polycomb repressive complex
		LAMB2	Unknown	29059683	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +9 more
		LAX1	Unknown	32887889	GWAS catalog	—
		LDB1	Unknown	29059683	GWAS catalog	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in differentiation of HSCs
		LDLRAD4	Unknown	34290314 37340002	GWAS catalog	—
		LEKR1	Unknown	29059683 32424353	GWAS catalog	—
		LGR6	Unknown	23535733 27117709 29058716	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination
		LINC02210-CRHR1	Unknown	32887889	GWAS catalog	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
		LMO4	Unknown	27354352	GWAS catalog	—
		LMTK2	Unknown	29059683 32887889	GWAS catalog	—
		LMX1B	Unknown	29059683 31757997 32139696	GWAS catalog	—
		LPCAT1	Unknown	29059683	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Metabolic pathways +5 more
		LRBA	Unknown	37340002	GWAS catalog	—
		LRRC3B	Unknown	38538606	GWAS catalog	—
		LRRD1	Unknown	29059683	GWAS catalog	—
		LSM8	Unknown	38538606	GWAS catalog	RNA degradation Spliceosome mRNA Splicing - Major Pathway
		LSP1	Unknown	17529967 23535729 25751625 27117709 29059683 32139696 32887889 34290314 34594039 35414113 37340002	GWAS catalog	C-type lectin receptor signaling pathway Tuberculosis
		LYPD5	Unknown	23535729 25751625 29058716 29059683 32139696	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
FAMILIAL CANCER OF BREAST		KRAS	Unknown	—	ClinVar	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
LUMINAL A BREAST CARCINOMA	MONDO_0021116	KIF1B	Unknown	38832928	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
LUMINAL A BREAST CARCINOMA	MONDO_0021116	LGR6	Unknown	38832928	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination
LUMINAL B BREAST CARCINOMA	MONDO_0021115	KIF1B	Unknown	38832928	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

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Breast cancer

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