Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BREAST CANCER	MONDO_0007254	GPC5	Unknown	29059683	GWAS catalog	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPR161	Unknown	29059683 37340002	GWAS catalog	Hedgehog signaling pathway Hedgehog 'off' state Hedgehog 'on' state
		GPX6	Unknown	29059683	GWAS catalog	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +4 more
		GREB1	Unknown	29059683	GWAS catalog	Estrogen signaling pathway Estrogen-dependent gene expression
		GRHL1	Unknown	29059683 32139696	GWAS catalog	PPARA activates gene expression
		GRIK1	Unknown	17903305	GWAS catalog	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
		GRK5	Unknown	37340002	GWAS catalog	Chemokine signaling pathway Endocytosis Morphine addiction +1 more
		GRM3	Unknown	29059683	GWAS catalog	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSTM2	Unknown	29059683 32424353	GWAS catalog	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GTF2H3	Unknown	38538606	GWAS catalog	Basal transcription factors Nucleotide excision repair Viral carcinogenesis +20 more
		GTF2I	Unknown	29059683	GWAS catalog	Basal transcription factors cGMP-PKG signaling pathway
		GTF2IRD2	Unknown	29059683	GWAS catalog	—
		GXYLT1	Unknown	38538606	GWAS catalog	Other types of O-glycan biosynthesis
		H2AC1	Unknown	29059683	GWAS catalog	ATP-dependent chromatin remodeling Necroptosis Neutrophil extracellular trap formation +10 more
		H2BC18	Unknown	29059683	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +6 more
		H2BC6	Unknown	29059683	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H4C13	Unknown	29059683	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HABP2	Unknown	29059683	GWAS catalog	—
		HCN1	Unknown	17529967 20872241 29059683 32808324 32887889 34290314 37340002 38538606	GWAS catalog	GnRH secretion HCN channels
		HELZ	Unknown	37380357	GWAS catalog	—
		HIPK1	Unknown	38538606	GWAS catalog	Cellular senescence YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors +1 more
		HIVEP3	Unknown	29059683	GWAS catalog	—
		HLA-DOB	Unknown	38538606	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLX	Unknown	38538606	GWAS catalog	—
		HMCN1	Unknown	37296840	GWAS catalog	—
		HMCN2	Unknown	38538606	GWAS catalog	—
		HNF4G	Unknown	23535729 25751625 29059683 32139696 32887889 36819030 37380357	GWAS catalog	Maturity onset diabetes of the young Nuclear Receptor transcription pathway
		HOOK2	Unknown	29059683	GWAS catalog	—
		HORMAD2	Unknown	29059683 38538606	GWAS catalog	—
		HS6ST3	Unknown	38501904	GWAS catalog	Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS-GAG biosynthesis
		HSD17B2	Unknown	29059683	GWAS catalog	Steroid hormone biosynthesis Metabolic pathways Ovarian steroidogenesis +1 more
		HSD17B6	Unknown	37380357	GWAS catalog	Steroid hormone biosynthesis Retinol metabolism Metabolic pathways +2 more
		HSF2	Unknown	29059683 37340002	GWAS catalog	—
		HSF2BP	Unknown	37340002	GWAS catalog	—
		HSPA4	Unknown	29059683 32139696 36819030	GWAS catalog	Tight junction Antigen processing and presentation Lipid and atherosclerosis +1 more
		HTR1B	Unknown	38538606	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTRA1	Unknown	37851288	GWAS catalog	Degradation of the extracellular matrix
		HYCC2	Unknown	27117709 29059683	GWAS catalog	—
		IGSF21	Unknown	29059683 32139696	GWAS catalog	—
		IGSF5	Unknown	37851288	GWAS catalog	Tight junction Epithelial cell signaling in Helicobacter pylori infection
		INCENP	Unknown	29059683	GWAS catalog	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion +4 more
		INHBB	Unknown	27117709 34594039 38538606 38741014	GWAS catalog	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		INHBE	Unknown	37380357	GWAS catalog	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		INSC	Unknown	29059683	GWAS catalog	—
		INTS10	Unknown	29059683	GWAS catalog	RNA polymerase II transcribes snRNA genes
		IPO8	Unknown	40229280	GWAS catalog	Nucleocytoplasmic transport Transcriptional regulation by small RNAs
		IRF1	Unknown	29059683 34234117	GWAS catalog	C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway +5 more
		IST1	Unknown	29059683	GWAS catalog	Virion - Hepatitis viruses Endocytosis Neutrophil degranulation +1 more
		ITGA6	Unknown	40229280	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +17 more
		ITPR1	Unknown	23535729 25751625 29059683 32139696 38741014	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Phosphatidylinositol signaling system +53 more
BREAST CARCINOMA	EFO_0000305	GPC5	Unknown	29059683	GWAS catalog	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPR161	Unknown	29059683 37340002	GWAS catalog	Hedgehog signaling pathway Hedgehog 'off' state Hedgehog 'on' state
		GPX6	Unknown	29059683	GWAS catalog	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +4 more
		GREB1	Unknown	29059683 35803233	GWAS catalog	Estrogen signaling pathway Estrogen-dependent gene expression
		GRHL1	Unknown	29059683 32139696	GWAS catalog	PPARA activates gene expression
		GRIK1	Unknown	17903305	GWAS catalog	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
		GRK5	Unknown	37340002	GWAS catalog	Chemokine signaling pathway Endocytosis Morphine addiction +1 more
		GRM3	Unknown	29059683	GWAS catalog	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GSTM2	Unknown	29059683 32424353 35803233	GWAS catalog	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GTF2H3	Unknown	38538606	GWAS catalog	Basal transcription factors Nucleotide excision repair Viral carcinogenesis +20 more
		GTF2I	Unknown	29059683	GWAS catalog	Basal transcription factors cGMP-PKG signaling pathway
		GTF2IRD2	Unknown	29059683	GWAS catalog	—
		GXYLT1	Unknown	38538606	GWAS catalog	Other types of O-glycan biosynthesis
		H2AC1	Unknown	29059683	GWAS catalog	ATP-dependent chromatin remodeling Necroptosis Neutrophil extracellular trap formation +10 more
		H2BC18	Unknown	29059683	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +6 more
		H2BC6	Unknown	29059683	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		H4C13	Unknown	29059683	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HABP2	Unknown	29059683	GWAS catalog	—
		HCN1	Unknown	17529967 20872241 29059683 32424353 32808324 32887889 34290314 34737426 37340002 37467357 38538606	GWAS catalog	GnRH secretion HCN channels
		HIPK1	Unknown	38538606	GWAS catalog	Cellular senescence YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors +1 more
		HIVEP3	Unknown	29059683	GWAS catalog	—
		HLA-DOB	Unknown	38538606	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLX	Unknown	38538606	GWAS catalog	—
		HMCN2	Unknown	38538606	GWAS catalog	—
		HNF4G	Unknown	23535729 25751625 29058716 29059683 32139696 32887889	GWAS catalog	Maturity onset diabetes of the young Nuclear Receptor transcription pathway
		HOOK2	Unknown	29059683	GWAS catalog	—
		HORMAD2	Unknown	29059683 32424353 38538606	GWAS catalog	—
		HSD17B2	Unknown	29059683	GWAS catalog	Steroid hormone biosynthesis Metabolic pathways Ovarian steroidogenesis +1 more
		HSF2	Unknown	29059683 37340002	GWAS catalog	—
		HSF2BP	Unknown	37340002	GWAS catalog	—
		HSPA4	Unknown	29059683 32139696 35803233	GWAS catalog	Tight junction Antigen processing and presentation Lipid and atherosclerosis +1 more
		HTR1B	Unknown	38538606	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTRA1	Unknown	37851288	GWAS catalog	Degradation of the extracellular matrix
		HYCC2	Unknown	27117709 29059683	GWAS catalog	—
		IGSF21	Unknown	29059683 32139696	GWAS catalog	—
		IGSF5	Unknown	37851288	GWAS catalog	Tight junction Epithelial cell signaling in Helicobacter pylori infection
		INCENP	Unknown	27432226 29059683	GWAS catalog	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion +4 more
		INHBB	Unknown	27117709 34594039 38538606 38741014	GWAS catalog	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		INHBE	Unknown	37467357	GWAS catalog	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		INSC	Unknown	29059683	GWAS catalog	—
		INTS10	Unknown	29059683	GWAS catalog	RNA polymerase II transcribes snRNA genes
		IPO8	Unknown	40229280	GWAS catalog	Nucleocytoplasmic transport Transcriptional regulation by small RNAs
		IRF1	Unknown	29059683 34234117	GWAS catalog	C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway +5 more
		IST1	Unknown	29059683	GWAS catalog	Virion - Hepatitis viruses Endocytosis Neutrophil degranulation +1 more
		ITGA6	Unknown	40229280	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +17 more
		ITPR1	Unknown	23535729 25751625 29059683 32139696 38741014	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Phosphatidylinositol signaling system +53 more

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Breast cancer

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