Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BREAST CANCER	MONDO_0007254 MONDO:0007254	LYZL6	Unknown	34981446	GWAS catalog	—
		LZTR1	Unknown	37592023	Disgenet	—
		MAD1L1	Unknown	37380357	GWAS catalog	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +8 more
		MADD	Unknown	29059683	GWAS catalog	Regulation of TNFR1 signaling RAB GEFs exchange GTP for GDP on RABs
		MAGI3	Unknown	29059683	GWAS catalog	Rap1 signaling pathway
		MAP3K1	Unknown	17529967 19330030 20453838 23535729 24493630 25751625 29059683 31757997 32139696 32514122 32808324 32887889 34290314 34594039 36819030 37340002 37592023 38538606 39789286	Disgenet, GWAS catalog	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K7	Unknown	40229280	GWAS catalog	MAPK signaling pathway NF-kappa B signaling pathway Autophagy - animal +42 more
		MAP4	Unknown	29059683	GWAS catalog	—
		MAP4K4	Unknown	37340002	GWAS catalog	MAPK signaling pathway Oxidative Stress Induced Senescence
		MAPK10	Unknown	29059683	GWAS catalog	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +74 more
		MAPT	Unknown	29059683 37380357 37636041	GWAS catalog	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MARCHF5	Unknown	29059683	GWAS catalog	Mitophagy - animal
		MAST1	Unknown	29059683	GWAS catalog	—
		MAST2	Unknown	29059683	GWAS catalog	—
		MAST4	Unknown	38538606	GWAS catalog	—
		MBNL2	Unknown	40229280	GWAS catalog	—
		MC4R	Unknown	29059683	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MCHR2	Unknown	29059683	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MCM8	Unknown	29059683	GWAS catalog	Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex +3 more
		MCUR1	Unknown	23535729 25751625 29059683 32139696 36819030	GWAS catalog	—
		MDFIC	Unknown	37380357	GWAS catalog	Viral life cycle - HIV-1
		MDM4	Unknown	23535733 27117709	GWAS catalog	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MED13L	Unknown	40229280	GWAS catalog	Thyroid hormone signaling pathway PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		MED30	Unknown	29059683	GWAS catalog	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MED9	Unknown	37380357	GWAS catalog	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		MEGF6	Unknown	39753771	GWAS catalog	—
		MEI4	Unknown	39024449	GWAS catalog	—
		MEIS2	Unknown	29059683	GWAS catalog	—
		METRNL	Unknown	38538606	GWAS catalog	—
		MGAT5	Unknown	38254997	GWAS catalog	N-Glycan biosynthesis Metabolic pathways N-Glycan antennae elongation
		MGST1	Unknown	38538606	GWAS catalog	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +12 more
		MIER3	Unknown	24493630 29059683 31757997 32887889 34290314 38538606	GWAS catalog	—
		MLLT10	Unknown	23535729 25751625 29059683 32139696 32887889 34290314 36819030 37340002	GWAS catalog	—
		MN1	Unknown	29059683	GWAS catalog	—
		MOXD1	Unknown	37380357	GWAS catalog	—
		MPHOSPH6	Unknown	34594039	GWAS catalog	RNA degradation Major pathway of rRNA processing in the nucleolus and cytosol
		MPP4	Unknown	29059683	GWAS catalog	Tight junction
		MRPL22	Unknown	29059683	GWAS catalog	Ribosome Mitochondrial translation elongation Mitochondrial translation termination
		MRPS30	Unknown	20872241 29059683 32808324 34290314 37340002 38538606	GWAS catalog	Mitochondrial translation elongation Mitochondrial translation termination
		MRTFA	Unknown	23535729 23535733 25751625 27117709 29059683 32139696 32887889 34290314 34594039 37340002 37380357 38538606	GWAS catalog	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSH5	Unknown	36819030	GWAS catalog	—
		MSH6	Unknown	—	GenCC	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MSTO1	Unknown	29059683	GWAS catalog	—
		MTCL1	Unknown	25824743	GWAS catalog	—
		MTF2	Unknown	38501904	GWAS catalog	Polycomb repressive complex PRC2 methylates histones and DNA
		MTMR11	Unknown	29059683 32887889	GWAS catalog	—
		MTMR3	Unknown	34018994	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		MTUS2	Unknown	37851288	GWAS catalog	—
		MXD1	Unknown	29059683 31757997	GWAS catalog	—
		MYBPC1	Unknown	34594039	GWAS catalog	Cytoskeleton in muscle cells Striated Muscle Contraction
BREAST CARCINOMA	EFO_0000305	LYZL6	Unknown	34981446	GWAS catalog	—
		MADD	Unknown	29059683	GWAS catalog	Regulation of TNFR1 signaling RAB GEFs exchange GTP for GDP on RABs
		MAGI3	Unknown	29059683	GWAS catalog	Rap1 signaling pathway
		MAP3K1	Unknown	17529967 19330030 20453838 23535729 24493630 25751625 27197191 29058716 29059683 31757997 32139696 32514122 32808324 32887889 34290314 34594039 37340002 38538606 39789286	GWAS catalog	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K7	Unknown	40229280	GWAS catalog	MAPK signaling pathway NF-kappa B signaling pathway Autophagy - animal +42 more
		MAP4	Unknown	29059683	GWAS catalog	—
		MAP4K4	Unknown	37340002	GWAS catalog	MAPK signaling pathway Oxidative Stress Induced Senescence
		MAPK10	Unknown	29059683	GWAS catalog	Endocrine resistance MAPK signaling pathway ErbB signaling pathway +74 more
		MAPT	Unknown	29059683 37467357	GWAS catalog	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MARCHF5	Unknown	29059683	GWAS catalog	Mitophagy - animal
		MAST1	Unknown	29059683	GWAS catalog	—
		MAST2	Unknown	29059683	GWAS catalog	—
		MAST4	Unknown	38538606	GWAS catalog	—
		MBNL2	Unknown	40229280	GWAS catalog	—
		MC4R	Unknown	29059683	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MCHR2	Unknown	29059683	GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MCM8	Unknown	29059683	GWAS catalog	Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex +3 more
		MCUR1	Unknown	23535729 25751625 29059683 32139696	GWAS catalog	—
		MDM4	Unknown	23535733 23544013 27117709 29058716	GWAS catalog	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MED13L	Unknown	40229280	GWAS catalog	Thyroid hormone signaling pathway PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		MED30	Unknown	29059683	GWAS catalog	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEGF6	Unknown	39753771	GWAS catalog	—
		MEI4	Unknown	39024449	GWAS catalog	—
		MEIS2	Unknown	29059683	GWAS catalog	—
		METRNL	Unknown	38538606	GWAS catalog	—
		MGAT5	Unknown	38254997	GWAS catalog	N-Glycan biosynthesis Metabolic pathways N-Glycan antennae elongation
		MGST1	Unknown	38538606	GWAS catalog	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +12 more
		MIER3	Unknown	24493630 29059683 31757997 32887889 34290314 38538606	GWAS catalog	—
		MLLT10	Unknown	23535729 25751625 29059683 32139696 32887889 34290314 35803233 37340002	GWAS catalog	—
		MN1	Unknown	29059683	GWAS catalog	—
		MPHOSPH6	Unknown	34594039	GWAS catalog	RNA degradation Major pathway of rRNA processing in the nucleolus and cytosol
		MPP4	Unknown	29059683	GWAS catalog	Tight junction
		MRPL22	Unknown	29059683	GWAS catalog	Ribosome Mitochondrial translation elongation Mitochondrial translation termination
		MRPS30	Unknown	20872241 29059683 32808324 34290314 34737426 37340002 37467357 38538606	GWAS catalog	Mitochondrial translation elongation Mitochondrial translation termination
		MRTFA	Unknown	23535729 23535733 25751625 27117709 29058716 29059683 32139696 32887889 34290314 34594039 37340002 38538606	GWAS catalog	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSTO1	Unknown	29059683	GWAS catalog	—
		MTCL1	Unknown	25824743	GWAS catalog	—
		MTMR11	Unknown	29059683 32887889 33037222 35414113	GWAS catalog	—
		MTMR3	Unknown	34018994	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		MTUS2	Unknown	37851288	GWAS catalog	—
		MXD1	Unknown	29059683 31757997	GWAS catalog	—
		MYBPC1	Unknown	34594039	GWAS catalog	Cytoskeleton in muscle cells Striated Muscle Contraction
LUMINAL A BREAST CARCINOMA	MONDO_0021116	MLLT10	Unknown	38832928	GWAS catalog	—
LUMINAL A BREAST CARCINOMA	MONDO_0021116	MTUS2	Unknown	37851288	GWAS catalog	—
LUMINAL B BREAST CARCINOMA	MONDO_0021115	MLLT10	Unknown	38832928	GWAS catalog	—

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Breast cancer

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