Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 72

13 diseases · 44 shared-gene connections
13 Diseases
44 Unique genes
0.388 Avg. similarity score
Hemoglobin m disease Most-connected disease (10 links)
Log in to save this analysis

Save This Analysis

Disease Searched: methemoglobinemia, alpha type Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Hemoglobin m disease 10 10 3
erythrocytosis, familial, 7 10 10 2
methemoglobinemia, alpha type 10 10 2
Alpha thalassemia 7 7 3
Hemoglobin barts fetalis syndrome 7 7 3
Hemoglobin h disease 7 7 3
Thalassemia 7 7 5
Unstable hemoglobin disease 7 7 3
Methemoglobinemia 6 6 6
HBA1-related alpha thalassemia spectrum 5 5 1
HBA2-related alpha thalassemia spectrum 5 5 1
Chloracne 4 4 33
Polycythemia vera 3 3 9

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
HBA1 12 / 13 Alpha thalassemia, Chloracne, erythrocytosis, familial, 7, HBA1-related alpha thalassemia spectrum and 8 more
HBA2 11 / 13 Alpha thalassemia, Chloracne, erythrocytosis, familial, 7, HBA2-related alpha thalassemia spectrum and 7 more
HBB 6 / 13 Chloracne, Hemoglobin m disease, Methemoglobinemia, Polycythemia vera and 2 more
ATRX 3 / 13 Alpha thalassemia, Hemoglobin barts fetalis syndrome, Hemoglobin h disease
GSTM1 2 / 13 Chloracne, Thalassemia
HBD 2 / 13 Chloracne, Thalassemia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Erythrocytes take up oxygen and release carbon dioxide
HBA1, HBA2, HBB
 Reactome 3 / 9 91.0× 3.80e-6 1.63e-4 ✓ sig.
Scavenging of heme from plasma
HBA1, HBA2, HBB
 Reactome 3 / 13 63.0× 1.28e-5 4.35e-4 ✓ sig.
Erythrocytes take up carbon dioxide and release oxygen
HBA1, HBA2, HBB
 Reactome 3 / 13 63.0× 1.28e-5 4.35e-4 ✓ sig.
Pathways in cancer
CDK6, CDKN1B, CYCS, EGFR, GADD45A, GSTM1, GSTM3, PTGER4, IFNA2, JAK2
 KEGG 10 / 533 5.1× 1.73e-5 5.58e-4 ✓ sig.
Factors involved in megakaryocyte development and platelet production
HBB, HBD, HBG1, IFNA2, JAK2
 Reactome 5 / 99 13.8× 2.89e-5 8.55e-4 ✓ sig.
Malaria
HBA1, HBA2, HBB, ITGB2
 KEGG 4 / 50 21.8× 3.19e-5 9.25e-4 ✓ sig.
Measles
CD28, CDK6, CDKN1B, CYCS, IFNA2
 KEGG 5 / 139 9.8× 1.46e-4 3.12e-3 ✓ sig.
African trypanosomiasis
HBA1, HBA2, HBB
 KEGG 3 / 37 22.1× 3.27e-4 5.92e-3 ✓ sig.
Small cell lung cancer
CDK6, CDKN1B, CYCS, GADD45A
 KEGG 4 / 93 11.7× 3.61e-4 6.42e-3 ✓ sig.
Vitamin C (ascorbate) metabolism
CYB5A, CYB5R3
 Reactome 2 / 8 68.2× 3.62e-4 6.43e-3 ✓ sig.
Hepatocellular carcinoma
CDK6, EGFR, GADD45A, GSTM1, GSTM3
 KEGG 5 / 170 8.0× 3.72e-4 6.57e-3 ✓ sig.
Influenza A
CDK6, CYCS, RAB11A, IFNA2, JAK2
 KEGG 5 / 173 7.9× 4.03e-4 7.00e-3 ✓ sig.
Cyclin D associated events in G1
CDK6, CDKN1B, JAK2
 Reactome 3 / 44 18.6× 5.47e-4 8.86e-3 ✓ sig.
Epstein-Barr virus infection
CDK6, CDKN1B, CYCS, GADD45A, IFNA2
 KEGG 5 / 204 6.7× 8.53e-4 1.24e-2 ✓ sig.
Chemical carcinogenesis - receptor activation
EGFR, GSTM1, GSTM3, CYP1A2, JAK2
 KEGG 5 / 215 6.3× 1.08e-3 1.49e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
carbon dioxide transport
HBA1, HBA2, HBB, HBD, HBG1
 GO:0015670 5 / 13 163× 7.26e-11 2.19e-8 ✓ sig.
oxygen transport
HBA1, HBA2, HBB, HBD, HBG1
 GO:0015671 5 / 17 125× 3.47e-10 8.79e-8 ✓ sig.
erythrocyte development
HBA1, HBA2, HBB, HBD, HBG1
 GO:0048821 5 / 32 66.4× 1.10e-8 1.84e-6 ✓ sig.
nitric oxide transport
HBA1, HBA2, HBB
 GO:0030185 3 / 5 255× 1.21e-7 1.45e-5 ✓ sig.
hydrogen peroxide catabolic process
HBA1, HBA2, HBB
 GO:0042744 3 / 21 60.7× 1.57e-5 7.70e-4 ✓ sig.
nitrobenzene metabolic process
GSTM1, GSTM3
 GO:0018916 2 / 4 212× 3.24e-5 1.34e-3 ✓ sig.
xenobiotic catabolic process
GSTM1, GSTM3, CYP1A2
 GO:0042178 3 / 28 45.5× 3.83e-5 1.52e-3 ✓ sig.
cellular detoxification of nitrogen compound
GSTM1, GSTM3
 GO:0070458 2 / 5 170× 5.39e-5 1.97e-3 ✓ sig.
regulation of peptidyl-tyrosine phosphorylation
EGFR, ITGB2
 GO:0050730 2 / 6 142× 8.08e-5 2.68e-3 ✓ sig.
inflammatory response
HBA1, HBA2, CX3CR1, HBB, ITGB2, PTGER4, IFNA2
 GO:0006954 7 / 467 6.4× 1.00e-4 3.14e-3 ✓ sig.
response to hydrogen peroxide
HBA1, HBA2, HBB
 GO:0042542 3 / 39 32.7× 1.05e-4 3.24e-3 ✓ sig.
positive regulation of nitric oxide biosynthetic process
HBB, ITGB2, JAK2
 GO:0045429 3 / 42 30.3× 1.31e-4 3.82e-3 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
CD28, CX3CR1, EGFR, OSM, JAK2
 GO:0051897 5 / 217 9.8× 1.51e-4 4.26e-3 ✓ sig.
regulation of nitric oxide biosynthetic process
CX3CR1, JAK2
 GO:0045428 2 / 10 84.9× 2.41e-4 5.95e-3 ✓ sig.
immune response
CD28, CX3CR1, OSM, PTGER4, SERPINB9, DPP8, JAK2
 GO:0006955 7 / 543 5.5× 2.54e-4 6.16e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Chloracne Thalassemia 0.147 5 3.29e-14 4.42e-13 ✓ sig.
Alpha thalassemia Hemoglobin h disease 0.750 3 1.64e-12 1.92e-11 ✓ sig.
Hemoglobin barts fetalis syndrome Hemoglobin h disease 0.750 3 1.64e-12 1.92e-11 ✓ sig.
Hemoglobin m disease Unstable hemoglobin disease 0.750 3 1.64e-12 1.92e-11 ✓ sig.
Alpha thalassemia Hemoglobin barts fetalis syndrome 0.750 3 1.64e-12 1.92e-11 ✓ sig.
Thalassemia Unstable hemoglobin disease 0.500 3 1.64e-11 1.77e-10 ✓ sig.
Hemoglobin m disease Thalassemia 0.500 3 1.64e-11 1.77e-10 ✓ sig.
Methemoglobinemia Unstable hemoglobin disease 0.429 3 3.29e-11 3.41e-10 ✓ sig.
Hemoglobin m disease Methemoglobinemia 0.429 3 3.29e-11 3.41e-10 ✓ sig.
Methemoglobinemia Thalassemia 0.333 3 3.29e-10 3.12e-9 ✓ sig.
erythrocytosis, familial, 7 methemoglobinemia, alpha type 0.667 2 8.44e-9 6.82e-8 ✓ sig.
Chloracne Hemoglobin m disease 0.088 3 8.97e-9 7.22e-8 ✓ sig.
Chloracne Unstable hemoglobin disease 0.088 3 8.97e-9 7.22e-8 ✓ sig.
methemoglobinemia, alpha type Unstable hemoglobin disease 0.500 2 2.53e-8 1.93e-7 ✓ sig.
Hemoglobin m disease methemoglobinemia, alpha type 0.500 2 2.53e-8 1.93e-7 ✓ sig.
Hemoglobin h disease methemoglobinemia, alpha type 0.500 2 2.53e-8 1.93e-7 ✓ sig.
Hemoglobin barts fetalis syndrome methemoglobinemia, alpha type 0.500 2 2.53e-8 1.93e-7 ✓ sig.
erythrocytosis, familial, 7 Unstable hemoglobin disease 0.500 2 2.53e-8 1.93e-7 ✓ sig.
erythrocytosis, familial, 7 Hemoglobin h disease 0.500 2 2.53e-8 1.93e-7 ✓ sig.
Alpha thalassemia methemoglobinemia, alpha type 0.500 2 2.53e-8 1.93e-7 ✓ sig.
Alpha thalassemia erythrocytosis, familial, 7 0.500 2 2.53e-8 1.93e-7 ✓ sig.
erythrocytosis, familial, 7 Hemoglobin barts fetalis syndrome 0.500 2 2.53e-8 1.93e-7 ✓ sig.
erythrocytosis, familial, 7 Hemoglobin m disease 0.500 2 2.53e-8 1.93e-7 ✓ sig.
Hemoglobin barts fetalis syndrome Hemoglobin m disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Hemoglobin h disease Hemoglobin m disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
Alpha thalassemia Hemoglobin m disease 0.400 2 7.59e-8 5.41e-7 ✓ sig.
erythrocytosis, familial, 7 Thalassemia 0.333 2 8.44e-8 5.94e-7 ✓ sig.
methemoglobinemia, alpha type Thalassemia 0.333 2 8.44e-8 5.94e-7 ✓ sig.
erythrocytosis, familial, 7 Methemoglobinemia 0.286 2 1.27e-7 8.71e-7 ✓ sig.
Methemoglobinemia methemoglobinemia, alpha type 0.286 2 1.27e-7 8.71e-7 ✓ sig.
Chloracne Methemoglobinemia 0.081 3 1.79e-7 1.19e-6 ✓ sig.
Polycythemia vera Unstable hemoglobin disease 0.182 2 9.11e-7 5.37e-6 ✓ sig.
Hemoglobin m disease Polycythemia vera 0.182 2 9.11e-7 5.37e-6 ✓ sig.
Polycythemia vera Thalassemia 0.154 2 3.03e-6 1.63e-5 ✓ sig.
erythrocytosis, familial, 7 HBA2-related alpha thalassemia spectrum 0.333 1 1.30e-4 3.93e-4 ✓ sig.
HBA2-related alpha thalassemia spectrum methemoglobinemia, alpha type 0.333 1 1.30e-4 3.93e-4 ✓ sig.
HBA1-related alpha thalassemia spectrum methemoglobinemia, alpha type 0.333 1 1.30e-4 3.93e-4 ✓ sig.
erythrocytosis, familial, 7 HBA1-related alpha thalassemia spectrum 0.333 1 1.30e-4 3.93e-4 ✓ sig.
HBA2-related alpha thalassemia spectrum Hemoglobin barts fetalis syndrome 0.250 1 1.95e-4 5.35e-4 ✓ sig.
HBA2-related alpha thalassemia spectrum Hemoglobin h disease 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Alpha thalassemia HBA1-related alpha thalassemia spectrum 0.250 1 1.95e-4 5.35e-4 ✓ sig.
HBA1-related alpha thalassemia spectrum Hemoglobin barts fetalis syndrome 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Alpha thalassemia HBA2-related alpha thalassemia spectrum 0.250 1 1.95e-4 5.35e-4 ✓ sig.
HBA1-related alpha thalassemia spectrum Hemoglobin h disease 0.250 1 1.95e-4 5.35e-4 ✓ sig.