Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 192
9
Diseases
35
Unique genes
0.154
Avg. similarity score
Ectodermal dysplasia
Most-connected disease (8 links)
Disease
Searched: Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type
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Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type
Ectodermal dysplasia
Hypohidrotic ectodermal dysplasia
Ectodermal dysplasia WNT10A related
Odonto-onycho-dermal dysplasia
Schopf-schulz-passarge syndrome
Ectodermal dysplasia 13, hair/tooth type
Ectodermal dysplasia 15, hypohidrotic/hair type
Ectodermal dysplasia 4, hair/nail type
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Ectodermal dysplasia | 8 | 8 | 33 |
| Hypohidrotic ectodermal dysplasia | 5 | 5 | 8 |
| Ectodermal dysplasia WNT10A related | 4 | 4 | 1 |
| Odonto-onycho-dermal dysplasia | 4 | 4 | 1 |
| Schopf-schulz-passarge syndrome | 4 | 4 | 1 |
| Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type | 2 | 2 | 1 |
| Ectodermal dysplasia 13, hair/tooth type | 1 | 1 | 1 |
| Ectodermal dysplasia 15, hypohidrotic/hair type | 1 | 1 | 1 |
| Ectodermal dysplasia 4, hair/nail type | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| WNT10A | 5 / 9 | Ectodermal dysplasia, Ectodermal dysplasia WNT10A related, Hypohidrotic ectodermal dysplasia, Odonto-onycho-dermal dysplasia and 1 more |
| KDF1 | 3 / 9 | Ectodermal dysplasia, Ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type, Hypohidrotic ectodermal dysplasia |
| CST6 | 2 / 9 | Ectodermal dysplasia, Ectodermal dysplasia 15, hypohidrotic/hair type |
| CSTB | 2 / 9 | Ectodermal dysplasia, Hypohidrotic ectodermal dysplasia |
| EDAR | 2 / 9 | Ectodermal dysplasia, Hypohidrotic ectodermal dysplasia |
| EDARADD | 2 / 9 | Ectodermal dysplasia, Hypohidrotic ectodermal dysplasia |
| IKBKG | 2 / 9 | Ectodermal dysplasia, Hypohidrotic ectodermal dysplasia |
| KREMEN1 | 2 / 9 | Ectodermal dysplasia, Ectodermal dysplasia 13, hair/tooth type |
| KRT85 | 2 / 9 | Ectodermal dysplasia, Ectodermal dysplasia 4, hair/nail type |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| NF-kappa B signaling pathway | KEGG | 6 / 105 | 19.6× | 5.11e-7 | 2.19e-5 ✓ sig. |
| Formation of the cornified envelope | Reactome | 6 / 130 | 15.8× | 1.80e-6 | 6.44e-5 ✓ sig. |
| Keratinization | Reactome | 6 / 152 | 13.5× | 4.46e-6 | 1.39e-4 ✓ sig. |
| TRAF6 mediated NF-kB activation | Reactome | 3 / 24 | 42.9× | 4.40e-5 | 9.16e-4 ✓ sig. |
| TNFs bind their physiological receptors | Reactome | 3 / 29 | 35.5× | 7.87e-5 | 1.45e-3 ✓ sig. |
| Adherens junctions interactions | Reactome | 3 / 32 | 32.2× | 1.06e-4 | 1.85e-3 ✓ sig. |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | Reactome | 3 / 33 | 31.2× | 1.17e-4 | 1.99e-3 ✓ sig. |
| Adherens junction | KEGG | 4 / 93 | 14.8× | 1.47e-4 | 2.40e-3 ✓ sig. |
| IkBA variant leads to EDA-ID | Reactome | 2 / 7 | 98.0× | 1.72e-4 | 2.71e-3 ✓ sig. |
| Nectin/Necl trans heterodimerization | Reactome | 2 / 7 | 98.0× | 1.72e-4 | 2.71e-3 ✓ sig. |
| Ovarian tumor domain proteases | Reactome | 3 / 38 | 27.1× | 1.78e-4 | 2.79e-3 ✓ sig. |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | Reactome | 2 / 8 | 85.8× | 2.28e-4 | 3.40e-3 ✓ sig. |
| Apoptotic cleavage of cell adhesion proteins | Reactome | 2 / 11 | 62.4× | 4.46e-4 | 5.77e-3 ✓ sig. |
| SUMOylation of immune response proteins | Reactome | 2 / 11 | 62.4× | 4.46e-4 | 5.77e-3 ✓ sig. |
| NF-kB is activated and signals survival | Reactome | 2 / 13 | 52.8× | 6.31e-4 | 7.55e-3 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| hair follicle development | GO:0001942 | 5 / 48 | 55.6× | 2.76e-8 | 4.24e-6 ✓ sig. |
| skin development | GO:0043588 | 5 / 55 | 48.5× | 5.56e-8 | 7.69e-6 ✓ sig. |
| odontogenesis of dentin-containing tooth | GO:0042475 | 5 / 56 | 47.7× | 6.10e-8 | 8.30e-6 ✓ sig. |
| epidermis development | GO:0008544 | 6 / 114 | 28.1× | 6.34e-8 | 8.59e-6 ✓ sig. |
| intermediate filament organization | GO:0045109 | 5 / 70 | 38.1× | 1.90e-7 | 2.14e-5 ✓ sig. |
| keratinization | GO:0031424 | 5 / 73 | 36.6× | 2.35e-7 | 2.55e-5 ✓ sig. |
| cellular response to cytokine stimulus | GO:0071345 | 4 / 53 | 40.3× | 2.83e-6 | 1.96e-4 ✓ sig. |
| cell-cell adhesion | GO:0098609 | 6 / 218 | 14.7× | 2.88e-6 | 1.99e-4 ✓ sig. |
| trachea gland development | GO:0061153 | 2 / 2 | 534× | 3.41e-6 | 2.28e-4 ✓ sig. |
| keratinocyte differentiation | GO:0030216 | 4 / 69 | 31.0× | 8.17e-6 | 4.56e-4 ✓ sig. |
| regulation of epidermal cell division | GO:0010482 | 2 / 3 | 356× | 1.02e-5 | 5.39e-4 ✓ sig. |
| intermediate filament cytoskeleton organization | GO:0045104 | 3 / 23 | 69.6× | 1.04e-5 | 5.46e-4 ✓ sig. |
| salivary gland cavitation | GO:0060662 | 2 / 5 | 214× | 3.40e-5 | 1.35e-3 ✓ sig. |
| hair follicle morphogenesis | GO:0031069 | 3 / 34 | 47.1× | 3.46e-5 | 1.37e-3 ✓ sig. |
| positive regulation of gene expression | GO:0010628 | 7 / 504 | 7.4× | 3.48e-5 | 1.37e-3 ✓ sig. |