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Cluster 548

5 diseases · 7 shared-gene connections

5 Diseases

10 Unique genes

0.266 Avg. similarity score

Headache Most-connected disease (4 links)

Significant edges only (q < 0.05) Spacing Colour by

Disease Pinned (dragged)

Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Headache Angiofollicular ganglionic hyperplasia Angiolymphoid hyperplasia Castleman disease Congenital microtia

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵	Connections in cluster ⇵	Significant partners ⇵	Curated genes ⇵
Headache	4	4	10
Angiofollicular ganglionic hyperplasia	3	3	1
Angiolymphoid hyperplasia	3	3	1
Castleman disease	3	3	1
Congenital microtia	1	1	1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵	Member diseases ⇵	Linked diseases
IL6	4 / 5	Angiofollicular ganglionic hyperplasia, Angiolymphoid hyperplasia, Castleman disease, Headache
PRKRA	2 / 5	Congenital microtia, Headache

What do these columns mean?

Connections in cluster: How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners: How many of those links are statistically significant (FDR q < 0.05).
Curated genes: Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes): How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y): x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count: Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment: Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value: Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster): Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster): Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵	Source ⇵	Overlap genes ⇵	Fold enrichment ⇵	P-value ⇵	FDR q-value ⇵
JAK-STAT signaling pathway IL6, CSF3, IFNA2	KEGG	3 / 168	21.4×	3.00e-4	4.51e-3 ✓ sig.
Interleukin-10 signaling IL6, CSF3	Reactome	2 / 47	51.1×	6.61e-4	8.28e-3 ✓ sig.
Malaria IL6, CSF3	KEGG	2 / 50	48.0×	7.48e-4	9.09e-3 ✓ sig.
Coronavirus disease - COVID-19 IL6, CSF3, IFNA2	KEGG	3 / 238	15.1×	8.32e-4	9.85e-3 ✓ sig.
Vitamin E TTPA	Reactome	1 / 1	1,201×	8.33e-4	9.85e-3 ✓ sig.
Cytokine-cytokine receptor interaction IL6, CSF3, IFNA2	KEGG	3 / 298	12.1×	1.59e-3	1.61e-2 ✓ sig.
Cytosolic DNA-sensing pathway IL6, IFNA2	KEGG	2 / 83	28.9×	2.05e-3	1.93e-2 ✓ sig.
IL-17 signaling pathway IL6, CSF3	KEGG	2 / 94	25.6×	2.62e-3	2.32e-2 ✓ sig.
PI3K-Akt signaling pathway IL6, CSF3, IFNA2	KEGG	3 / 361	10.0×	2.76e-3	2.40e-2 ✓ sig.
Hematopoietic cell lineage IL6, CSF3	KEGG	2 / 100	24.0×	2.96e-3	2.52e-2 ✓ sig.
Toll-like receptor signaling pathway IL6, IFNA2	KEGG	2 / 109	22.0×	3.50e-3	2.83e-2 ✓ sig.
Vasopressin-like receptors OXT	Reactome	1 / 6	200×	4.99e-3	3.64e-2 ✓ sig.
Measles IL6, IFNA2	KEGG	2 / 139	17.3×	5.63e-3	3.95e-2 ✓ sig.
Alcoholic liver disease IL6, IFNA2	KEGG	2 / 144	16.7×	6.03e-3	4.12e-2 ✓ sig.
CD163 mediating an anti-inflammatory response IL6	Reactome	1 / 9	133×	7.47e-3	4.73e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵	GO ID ⇵	Overlap genes ⇵	Fold enrichment ⇵	P-value ⇵	FDR q-value ⇵
response to prostaglandin E GNRH1, OXT	GO:0034695	2 / 11	340×	1.41e-5	7.12e-4 ✓ sig.
positive regulation of ossification OXT, NIPBL	GO:0045778	2 / 21	178×	5.38e-5	1.95e-3 ✓ sig.
cell surface receptor signaling pathway via STAT IL6, IFNA2	GO:0097696	2 / 28	133×	9.67e-5	3.01e-3 ✓ sig.
response to steroid hormone GNRH1, OXT	GO:0048545	2 / 30	125×	1.11e-4	3.34e-3 ✓ sig.
response to peptide hormone GNRH1, OXT	GO:0043434	2 / 50	74.7×	3.11e-4	6.97e-3 ✓ sig.
response to activity IL6, OXT	GO:0014823	2 / 52	71.9×	3.37e-4	7.28e-3 ✓ sig.
response to glucocorticoid IL6, OXT	GO:0051384	2 / 53	70.5×	3.50e-4	7.49e-3 ✓ sig.
humoral immune response IL6, IFNA2	GO:0006959	2 / 58	64.4×	4.19e-4	8.47e-3 ✓ sig.
regulation of astrocyte activation IL6	GO:0061888	1 / 1	1,869×	5.35e-4	9.88e-3 ✓ sig.
glucagon secretion IL6	GO:0070091	1 / 1	1,869×	5.35e-4	9.88e-3 ✓ sig.
positive regulation of hindgut contraction OXT	GO:0060450	1 / 1	1,869×	5.35e-4	9.88e-3 ✓ sig.
negative regulation of establishment of blood-brain barrier TTPA	GO:0090212	1 / 1	1,869×	5.35e-4	9.88e-3 ✓ sig.
negative regulation of immature T cell proliferation GNRH1	GO:0033087	1 / 1	1,869×	5.35e-4	9.88e-3 ✓ sig.
external genitalia morphogenesis NIPBL	GO:0035261	1 / 1	1,869×	5.35e-4	9.88e-3 ✓ sig.
female pregnancy GNRH1, OXT	GO:0007565	2 / 80	46.7×	7.97e-4	1.28e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵	Disease B ⇵	Similarity score ⇵	Shared genes ⇵	P-value ⇵	FDR q-value ⇵
Angiofollicular ganglionic hyperplasia	Angiolymphoid hyperplasia	0.500	1	6.46e-5	1.98e-4 ✓ sig.
Angiofollicular ganglionic hyperplasia	Castleman disease	0.500	1	6.46e-5	1.98e-4 ✓ sig.
Angiolymphoid hyperplasia	Castleman disease	0.500	1	6.46e-5	1.98e-4 ✓ sig.
Congenital microtia	Headache	0.091	1	6.46e-4	1.09e-3 ✓ sig.
Angiofollicular ganglionic hyperplasia	Headache	0.091	1	6.46e-4	1.09e-3 ✓ sig.
Angiolymphoid hyperplasia	Headache	0.091	1	6.46e-4	1.09e-3 ✓ sig.
Castleman disease	Headache	0.091	1	6.46e-4	1.09e-3 ✓ sig.

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