Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 279
6
Diseases
43
Unique genes
0.099
Avg. similarity score
Hoarding disorder
Most-connected disease (4 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Hoarding disorder
Pericardium disorder
Pericarditis
ciliary dyskinesia, primary, 44
acute myeloid leukemia
hearing loss, autosomal recessive
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Hoarding disorder | 4 | 4 | 20 |
| Pericardium disorder | 4 | 4 | 3 |
| Pericarditis | 3 | 3 | 19 |
| ciliary dyskinesia, primary, 44 | 3 | 3 | 1 |
| acute myeloid leukemia | 1 | 1 | 1 |
| hearing loss, autosomal recessive | 1 | 1 | 7 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| NEK10 | 4 / 6 | ciliary dyskinesia, primary, 44, Hoarding disorder, Pericarditis, Pericardium disorder |
| LRRC3B | 3 / 6 | Hoarding disorder, Pericarditis, Pericardium disorder |
| PTPRQ | 3 / 6 | hearing loss, autosomal recessive, Pericarditis, Pericardium disorder |
| CEBPA | 2 / 6 | acute myeloid leukemia, Hoarding disorder |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| sensory perception of sound | GO:0007605 | 4 / 162 | 10.7× | 5.16e-4 | 9.76e-3 ✓ sig. |
| detection of mechanical stimulus involved in sensory perception of sound | GO:0050910 | 2 / 18 | 48.3× | 7.73e-4 | 1.28e-2 ✓ sig. |
| auditory receptor cell stereocilium organization | GO:0060088 | 2 / 19 | 45.7× | 8.63e-4 | 1.37e-2 ✓ sig. |
| protein quality control for misfolded or incompletely synthesized proteins | GO:0006515 | 2 / 22 | 39.5× | 1.16e-3 | 1.66e-2 ✓ sig. |
| retinoic acid receptor signaling pathway | GO:0048384 | 2 / 24 | 36.2× | 1.38e-3 | 1.84e-2 ✓ sig. |
| integrated stress response signaling | GO:0140467 | 2 / 25 | 34.8× | 1.50e-3 | 1.91e-2 ✓ sig. |
| lung development | GO:0030324 | 3 / 108 | 12.1× | 1.96e-3 | 2.23e-2 ✓ sig. |
| determination of bilateral symmetry | GO:0009855 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration | GO:0021813 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| glucagon processing | GO:0120116 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| caudate nucleus development | GO:0021757 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| putamen development | GO:0021758 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| intermediate-density lipoprotein particle remodeling | GO:0034373 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| meiotic mismatch repair | GO:0000710 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
| D-alanine transmembrane transport | GO:0042941 | 1 / 1 | 435× | 2.30e-3 | 2.45e-2 ✓ sig. |
Pairs within this cluster, by significance
| Disease A ⇵ | Disease B ⇵ | Similarity score ⇵ | Shared genes ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Pericarditis | Pericardium disorder | 0.150 | 3 | 1.59e-9 | 1.50e-8 ✓ sig. |
| Hoarding disorder | Pericardium disorder | 0.091 | 2 | 4.80e-6 | 2.64e-5 ✓ sig. |
| ciliary dyskinesia, primary, 44 | Pericardium disorder | 0.250 | 1 | 1.95e-4 | 5.28e-4 ✓ sig. |
| Hoarding disorder | Pericarditis | 0.053 | 2 | 2.70e-4 | 6.67e-4 ✓ sig. |
| ciliary dyskinesia, primary, 44 | Pericarditis | 0.050 | 1 | 1.23e-3 | 1.97e-3 ✓ sig. |
| acute myeloid leukemia | Hoarding disorder | 0.048 | 1 | 1.30e-3 | 2.04e-3 ✓ sig. |
| ciliary dyskinesia, primary, 44 | Hoarding disorder | 0.048 | 1 | 1.30e-3 | 2.04e-3 ✓ sig. |
| hearing loss, autosomal recessive | Pericardium disorder | 0.100 | 1 | 1.36e-3 | 2.13e-3 ✓ sig. |