Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 256

7 diseases · 14 shared-gene connections
7 Diseases
26 Unique genes
0.544 Avg. similarity score
Gilbert syndrome Most-connected disease (6 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Gilbert syndrome 6 6 10
Bilirubin metabolism disease 5 5 12
Crigler-najjar syndrome 4 4 9
Lucey-driscoll syndrome 4 4 9
Perinatal disease 4 4 10
Rotor syndrome 3 3 3
Hyperbilirubinemia 2 2 13

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
UGT1A1 5 / 7 Crigler-najjar syndrome, Gilbert syndrome, Hyperbilirubinemia, Lucey-driscoll syndrome and 1 more
UGT1A10 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A3 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A4 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A5 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A6 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A7 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A8 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
UGT1A9 5 / 7 Bilirubin metabolism disease, Crigler-najjar syndrome, Gilbert syndrome, Lucey-driscoll syndrome and 1 more
SLCO1B1 4 / 7 Bilirubin metabolism disease, Gilbert syndrome, Hyperbilirubinemia, Rotor syndrome
SLCO1B3 2 / 7 Hyperbilirubinemia, Rotor syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Bile secretion
SLCO1B1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1, ABCC2, SLCO1B3
 KEGG 13 / 90 66.7× 9.16e-22 9.83e-19 ✓ sig.
Glucuronidation
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 Reactome 9 / 22 189× 1.07e-19 7.99e-17 ✓ sig.
Ascorbate and aldarate metabolism
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 30 139× 3.05e-18 1.84e-15 ✓ sig.
Pentose and glucuronate interconversions
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 36 115× 1.99e-17 1.02e-14 ✓ sig.
Porphyrin metabolism
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 46 90.4× 2.30e-16 9.92e-14 ✓ sig.
Drug metabolism - other enzymes
DPYS, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 10 / 81 57.0× 5.34e-16 2.18e-13 ✓ sig.
Steroid hormone biosynthesis
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 63 66.0× 4.83e-15 1.63e-12 ✓ sig.
Retinol metabolism
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 68 61.1× 1.00e-14 3.12e-12 ✓ sig.
Chemical carcinogenesis - DNA adducts
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 70 59.4× 1.32e-14 3.98e-12 ✓ sig.
Drug metabolism - cytochrome P450
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 73 56.9× 1.96e-14 5.72e-12 ✓ sig.
Metabolism of xenobiotics by cytochrome P450
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 79 52.6× 4.12e-14 1.12e-11 ✓ sig.
Biosynthesis of cofactors
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 154 27.0× 1.92e-11 3.25e-9 ✓ sig.
Chemical carcinogenesis - receptor activation
UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 KEGG 9 / 215 19.3× 3.83e-10 4.80e-8 ✓ sig.
Heme degradation
SLCO1B1, UGT1A4, ABCC2, SLCO1B3
 Reactome 4 / 14 132× 1.70e-8 1.39e-6 ✓ sig.
Folate transport and metabolism
SLCO1B1, ABCC2, SLCO1B3, SLCO1B3-SLCO1B7
 KEGG 4 / 31 59.6× 5.22e-7 2.78e-5 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
negative regulation of fatty acid metabolic process
UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1, NCOR1
 GO:0045922 9 / 11 588× 2.24e-25 7.41e-22 ✓ sig.
xenobiotic metabolic process
SLCO1B1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A1, ABCC2, SLCO1B3
 GO:0006805 11 / 120 65.9× 3.41e-18 4.19e-15 ✓ sig.
flavone metabolic process
UGT1A10, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 GO:0051552 5 / 5 719× 3.47e-15 2.49e-12 ✓ sig.
flavonoid metabolic process
UGT1A3, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 GO:0009812 5 / 12 299× 2.73e-12 1.14e-9 ✓ sig.
retinoic acid metabolic process
UGT1A3, UGT1A7, UGT1A8, UGT1A9, UGT1A1
 GO:0042573 5 / 25 144× 1.81e-10 4.90e-8 ✓ sig.
heme catabolic process
SLCO1B1, UGT1A4, ABCC2, SLCO1B3
 GO:0042167 4 / 11 261× 9.65e-10 2.17e-7 ✓ sig.
liver development
UGT1A10, UGT1A7, UGT1A8, UGT1A9, HGF, SOD2
 GO:0001889 6 / 87 49.6× 1.83e-9 3.82e-7 ✓ sig.
steroid metabolic process
UGT1A3, UGT1A4, UGT1A5, UGT1A8, UGT1A1
 GO:0008202 5 / 135 26.6× 1.06e-6 8.71e-5 ✓ sig.
bilirubin conjugation
UGT1A4, UGT1A1
 GO:0006789 2 / 2 719× 1.86e-6 1.36e-4 ✓ sig.
vitamin D3 metabolic process
UGT1A3, UGT1A4
 GO:0070640 2 / 3 479× 5.58e-6 3.27e-4 ✓ sig.
toxin catabolic process
UGT1A10, UGT1A7
 GO:0009407 2 / 3 479× 5.58e-6 3.27e-4 ✓ sig.
negative regulation of steroid metabolic process
UGT1A8, UGT1A1
 GO:0045939 2 / 3 479× 5.58e-6 3.27e-4 ✓ sig.
bile acid and bile salt transport
SLCO1B1, ABCC2, SLCO1B3
 GO:0015721 3 / 26 82.9× 6.09e-6 3.51e-4 ✓ sig.
estrogen metabolic process
UGT1A3, UGT1A7, UGT1A1
 GO:0008210 3 / 30 71.9× 9.47e-6 5.01e-4 ✓ sig.
response to isolation stress
SOD2, TNF
 GO:0035900 2 / 4 359× 1.11e-5 5.66e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Crigler-najjar syndrome Lucey-driscoll syndrome 0.900 9 7.47e-33 2.66e-31 ✓ sig.
Crigler-najjar syndrome Gilbert syndrome 0.818 9 7.47e-32 2.56e-30 ✓ sig.
Crigler-najjar syndrome Perinatal disease 0.818 9 7.47e-32 2.56e-30 ✓ sig.
Gilbert syndrome Lucey-driscoll syndrome 0.818 9 7.47e-32 2.56e-30 ✓ sig.
Lucey-driscoll syndrome Perinatal disease 0.818 9 7.47e-32 2.56e-30 ✓ sig.
Gilbert syndrome Perinatal disease 0.750 9 7.47e-31 2.46e-29 ✓ sig.
Bilirubin metabolism disease Gilbert syndrome 0.643 9 1.64e-29 5.19e-28 ✓ sig.
Bilirubin metabolism disease Crigler-najjar syndrome 0.571 8 5.69e-26 1.54e-24 ✓ sig.
Bilirubin metabolism disease Lucey-driscoll syndrome 0.571 8 5.69e-26 1.54e-24 ✓ sig.
Bilirubin metabolism disease Perinatal disease 0.533 8 2.85e-25 7.47e-24 ✓ sig.
Hyperbilirubinemia Rotor syndrome 0.133 2 1.97e-6 1.16e-5 ✓ sig.
Gilbert syndrome Hyperbilirubinemia 0.091 2 2.95e-5 1.45e-4 ✓ sig.
Gilbert syndrome Rotor syndrome 0.077 1 1.95e-3 2.81e-3 ✓ sig.
Bilirubin metabolism disease Rotor syndrome 0.067 1 2.34e-3 3.23e-3 ✓ sig.