Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 140

10 diseases · 22 shared-gene connections
10 Diseases
15 Unique genes
0.252 Avg. similarity score
Cardiac rhythm disease Most-connected disease (7 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Cardiac rhythm disease 7 7 2
SCN5A-related cardiac rhythm disorder 7 7 1
dilated cardiomyopathy 1E 7 7 1
Atrial standstill 5 5 3
Ectopic rhythm 5 5 2
Paroxysmal tachycardia 4 4 7
Paroxysmal ventricular fibrillation 4 4 2
Torsades de pointes 3 3 3
Hypercapnia 1 1 2
primary ciliary dyskinesia 5 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
SCN5A 8 / 10 Atrial standstill, Cardiac rhythm disease, dilated cardiomyopathy 1E, Ectopic rhythm and 4 more
HYDIN 2 / 10 Paroxysmal tachycardia, primary ciliary dyskinesia 5
NPPA 2 / 10 Atrial standstill, Hypercapnia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Voltage gated Potassium channels
KCND3, KCNH2
 Reactome 2 / 43 37.2× 1.28e-3 1.63e-2 ✓ sig.
Opioid Signalling
PDYN
 Reactome 1 / 3 267× 3.74e-3 3.59e-2 ✓ sig.
CREB3 factors activate genes
CREBRF
 Reactome 1 / 5 160× 6.23e-3 5.06e-2
NOSTRIN mediated eNOS trafficking
CAV1
 Reactome 1 / 5 160× 6.23e-3 5.06e-2
Biosynthesis of maresin-like SPMs
CYP3A4
 Reactome 1 / 6 133× 7.47e-3 5.69e-2
Phase 1 - inactivation of fast Na+ channels
KCND3
 Reactome 1 / 7 114× 8.71e-3 6.31e-2
Phase 3 - rapid repolarisation
KCNH2
 Reactome 1 / 8 100× 9.95e-3 6.82e-2
Spinocerebellar ataxia
KCND3, PDYN
 KEGG 2 / 144 11.1× 1.35e-2 8.18e-2
FOXO-mediated transcription of cell cycle genes
CAV1
 Reactome 1 / 11 72.8× 1.37e-2 8.23e-2
Physiological factors
NPPA
 Reactome 1 / 12 66.7× 1.49e-2 8.66e-2
Phagosome
MRC2, CTSS
 KEGG 2 / 155 10.3× 1.56e-2 8.90e-2
eNOS activation
CAV1
 Reactome 1 / 13 61.6× 1.61e-2 9.11e-2
Trafficking and processing of endosomal TLR
CTSS
 Reactome 1 / 13 61.6× 1.61e-2 9.11e-2
YAP1- and WWTR1 (TAZ)-stimulated gene expression
NPPA
 Reactome 1 / 14 57.2× 1.74e-2 9.50e-2
Tuberculosis
MRC2, CTSS
 KEGG 2 / 181 8.8× 2.09e-2 1.05e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
regulation of heart rate by cardiac conduction
GJA5, SCN5A, KCND3, CAV1, KCNH2
 GO:0086091 5 / 43 145× 1.50e-10 4.13e-8 ✓ sig.
cardiac conduction system development
GJA5, NPPA, SCN5A
 GO:0003161 3 / 16 234× 2.33e-7 2.46e-5 ✓ sig.
ventricular cardiac muscle cell action potential
GJA5, SCN5A, KCNH2
 GO:0086005 3 / 17 220× 2.83e-7 2.90e-5 ✓ sig.
regulation of ventricular cardiac muscle cell membrane repolarization
GJA5, SCN5A, KCNH2
 GO:0060307 3 / 21 178× 5.52e-7 5.08e-5 ✓ sig.
AV node cell to bundle of His cell communication
GJA5, SCN5A
 GO:0086067 2 / 3 831× 1.80e-6 1.33e-4 ✓ sig.
regulation of atrial cardiac muscle cell membrane repolarization
NPPA, SCN5A
 GO:0060372 2 / 6 415× 9.00e-6 4.81e-4 ✓ sig.
SA node cell action potential
GJA5, SCN5A
 GO:0086015 2 / 6 415× 9.00e-6 4.81e-4 ✓ sig.
regulation of ventricular cardiac muscle cell membrane depolarization
GJA5, SCN5A
 GO:0060373 2 / 7 356× 1.26e-5 6.25e-4 ✓ sig.
regulation of atrial cardiac muscle cell membrane depolarization
GJA5, SCN5A
 GO:0060371 2 / 10 249× 2.70e-5 1.13e-3 ✓ sig.
membrane repolarization during cardiac muscle cell action potential
KCND3, KCNH2
 GO:0086013 2 / 10 249× 2.70e-5 1.13e-3 ✓ sig.
membrane depolarization during action potential
SCN5A, KCNH2
 GO:0086010 2 / 10 249× 2.70e-5 1.13e-3 ✓ sig.
negative regulation of potassium ion transmembrane transport
CAV1, KCNH2
 GO:1901380 2 / 13 192× 4.67e-5 1.71e-3 ✓ sig.
membrane repolarization during ventricular cardiac muscle cell action potential
KCND3, KCNH2
 GO:0098915 2 / 13 192× 4.67e-5 1.71e-3 ✓ sig.
membrane repolarization
KCND3, KCNH2
 GO:0086009 2 / 14 178× 5.44e-5 1.92e-3 ✓ sig.
potassium ion export across plasma membrane
KCND3, KCNH2
 GO:0097623 2 / 15 166× 6.28e-5 2.13e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
dilated cardiomyopathy 1E SCN5A-related cardiac rhythm disorder 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Paroxysmal ventricular fibrillation SCN5A-related cardiac rhythm disorder 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Ectopic rhythm SCN5A-related cardiac rhythm disorder 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Cardiac rhythm disease dilated cardiomyopathy 1E 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Cardiac rhythm disease SCN5A-related cardiac rhythm disorder 0.333 1 1.30e-4 3.90e-4 ✓ sig.
dilated cardiomyopathy 1E Paroxysmal ventricular fibrillation 0.333 1 1.30e-4 3.90e-4 ✓ sig.
dilated cardiomyopathy 1E Ectopic rhythm 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Atrial standstill SCN5A-related cardiac rhythm disorder 0.250 1 1.95e-4 5.28e-4 ✓ sig.
SCN5A-related cardiac rhythm disorder Torsades de pointes 0.250 1 1.95e-4 5.28e-4 ✓ sig.
dilated cardiomyopathy 1E Torsades de pointes 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Atrial standstill dilated cardiomyopathy 1E 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Cardiac rhythm disease Paroxysmal ventricular fibrillation 0.250 1 2.60e-4 6.40e-4 ✓ sig.
Cardiac rhythm disease Ectopic rhythm 0.250 1 2.60e-4 6.40e-4 ✓ sig.
Ectopic rhythm Paroxysmal ventricular fibrillation 0.250 1 2.60e-4 6.40e-4 ✓ sig.
Atrial standstill Ectopic rhythm 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Atrial standstill Cardiac rhythm disease 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Atrial standstill Hypercapnia 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Cardiac rhythm disease Torsades de pointes 0.200 1 3.90e-4 8.52e-4 ✓ sig.
Paroxysmal tachycardia primary ciliary dyskinesia 5 0.125 1 4.55e-4 9.55e-4 ✓ sig.
dilated cardiomyopathy 1E Paroxysmal tachycardia 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Paroxysmal tachycardia SCN5A-related cardiac rhythm disorder 0.125 1 4.55e-4 9.55e-4 ✓ sig.
Cardiac rhythm disease Paroxysmal tachycardia 0.111 1 9.09e-4 1.56e-3 ✓ sig.