Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9902
Gene name	Mannose receptor C-type 2
Gene symbol	MRC2
Synonyms (NCBI Gene)	CD280CLEC13EENDO180UPARAP
Chromosome	17
Chromosome location	17q23.2
Summary	This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization a

123 Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001355	hsa-miR-1-3p	pSILAC	18668040
MIRT001355	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT051126	hsa-miR-16-5p	CLASH	23622248
MIRT047526	hsa-miR-10a-5p	CLASH	23622248
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT1157633	hsa-miR-3170	CLIP-seq
MIRT1157634	hsa-miR-342-5p	CLIP-seq
MIRT1157635	hsa-miR-3690	CLIP-seq
MIRT1157636	hsa-miR-4254	CLIP-seq
MIRT1157637	hsa-miR-4268	CLIP-seq
MIRT1157638	hsa-miR-4448	CLIP-seq
MIRT1157639	hsa-miR-4651	CLIP-seq
MIRT1157640	hsa-miR-4664-5p	CLIP-seq
MIRT1157641	hsa-miR-593	CLIP-seq
MIRT1157642	hsa-miR-608	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT1551383	hsa-miR-4755-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2045098	hsa-miR-548ac	CLIP-seq
MIRT2045099	hsa-miR-548ae	CLIP-seq
MIRT2045100	hsa-miR-548aj	CLIP-seq
MIRT2045101	hsa-miR-548am	CLIP-seq
MIRT2045102	hsa-miR-548d-3p	CLIP-seq
MIRT2045103	hsa-miR-548x	CLIP-seq
MIRT2045104	hsa-miR-548z	CLIP-seq
MIRT2438781	hsa-miR-2392	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2465650	hsa-miR-2467-5p	CLIP-seq
MIRT2465651	hsa-miR-3194-3p	CLIP-seq
MIRT2465652	hsa-miR-3944-3p	CLIP-seq
MIRT1157637	hsa-miR-4268	CLIP-seq
MIRT2465653	hsa-miR-760	CLIP-seq
MIRT2573109	hsa-miR-1207-3p	CLIP-seq
MIRT2573110	hsa-miR-1224-3p	CLIP-seq
MIRT2573111	hsa-miR-1260	CLIP-seq
MIRT2573112	hsa-miR-1260b	CLIP-seq
MIRT2573113	hsa-miR-1280	CLIP-seq
MIRT2573114	hsa-miR-1538	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT2573115	hsa-miR-193a-5p	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT2573116	hsa-miR-24	CLIP-seq
MIRT2573117	hsa-miR-3620	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT2573118	hsa-miR-3940-3p	CLIP-seq
MIRT2573119	hsa-miR-4267	CLIP-seq
MIRT2573120	hsa-miR-4292	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2573121	hsa-miR-4690-3p	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2573122	hsa-miR-4725-5p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2573123	hsa-miR-4745-3p	CLIP-seq
MIRT2573124	hsa-miR-4793-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2573125	hsa-miR-504	CLIP-seq
MIRT2573126	hsa-miR-512-5p	CLIP-seq
MIRT2573127	hsa-miR-532-3p	CLIP-seq
MIRT2573128	hsa-miR-548c-3p	CLIP-seq
MIRT2573129	hsa-miR-662	CLIP-seq
MIRT2573130	hsa-miR-873	CLIP-seq
MIRT2573109	hsa-miR-1207-3p	CLIP-seq
MIRT2573110	hsa-miR-1224-3p	CLIP-seq
MIRT2573111	hsa-miR-1260	CLIP-seq
MIRT2573112	hsa-miR-1260b	CLIP-seq
MIRT2573113	hsa-miR-1280	CLIP-seq
MIRT2573114	hsa-miR-1538	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT2573115	hsa-miR-193a-5p	CLIP-seq
MIRT2685295	hsa-miR-214	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT2438781	hsa-miR-2392	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT2685296	hsa-miR-3619-5p	CLIP-seq
MIRT2573117	hsa-miR-3620	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT2573118	hsa-miR-3940-3p	CLIP-seq
MIRT2573119	hsa-miR-4267	CLIP-seq
MIRT2685297	hsa-miR-4269	CLIP-seq
MIRT2573120	hsa-miR-4292	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT2685298	hsa-miR-4530	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2573121	hsa-miR-4690-3p	CLIP-seq
MIRT2685299	hsa-miR-4690-5p	CLIP-seq
MIRT2685300	hsa-miR-4691-3p	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2573122	hsa-miR-4725-5p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2573123	hsa-miR-4745-3p	CLIP-seq
MIRT2685301	hsa-miR-4758-3p	CLIP-seq
MIRT2573124	hsa-miR-4793-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2573125	hsa-miR-504	CLIP-seq
MIRT2573126	hsa-miR-512-5p	CLIP-seq
MIRT2573127	hsa-miR-532-3p	CLIP-seq
MIRT2573128	hsa-miR-548c-3p	CLIP-seq
MIRT2573129	hsa-miR-662	CLIP-seq
MIRT2685302	hsa-miR-761	CLIP-seq
MIRT2573130	hsa-miR-873	CLIP-seq

10 Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0005515	Function	Protein binding	IPI	7904248, 26481812
GO:0005518	Function	Collagen binding	IDA	10636902, 12972549
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006897	Process	Endocytosis	IEA
GO:0016020	Component	Membrane	HDA	16210410
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030574	Process	Collagen catabolic process	IDA	12972549
GO:0038023	Function	Signaling receptor activity	IBA

MIM	HGNC	e!Ensembl
612264	16875	ENSG00000011028

Q9UBG0

Protein name

C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protei

Protein function

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involve

PDB

5AO5 , 5AO6 , 5E4K , 5E4L , 5EW6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00040	fn2	187 → 228	Fibronectin type II domain	Domain
PF00059	Lectin_C	399 → 506	Lectin C-type domain	Domain
PF00059	Lectin_C	255 → 361	Lectin C-type domain	Domain
PF00059	Lectin_C	842 → 952	Lectin C-type domain	Domain
PF00059	Lectin_C	993 → 1109	Lectin C-type domain	Domain
PF00059	Lectin_C	693 → 810	Lectin C-type domain	Domain
PF00059	Lectin_C	538 → 646	Lectin C-type domain	Domain
PF00059	Lectin_C	1142 → 1245	Lectin C-type domain	Domain
PF00059	Lectin_C	1285 → 1395	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150,

Sequence

MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGG
QVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLR
WHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQG
NSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWD
KDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGL
NDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCK
KKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSI
HSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLED
CVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQV
TYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDE
VMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPD
PTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEE
HFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDD
DIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFF
EHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRF
RWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQ
PPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQ
AFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAV
VLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLL
QKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVS
EEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGS
CPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQS
YEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWR
PGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQ
SIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE

Sequence length

1479

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Phagosome	Cross-presentation of soluble exogenous antigens (endosomes)
Tuberculosis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (10)
ANEURYSM	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AORTIC ANEURYSM	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	16316942	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC ARRHYTHMIA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC RHYTHM DISEASE	—	GenCC	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	37069358	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	38062574	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HOARDING DISORDER	—	GWAS catalog	36379924	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	35115687	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	38062574	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (25)
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	29061505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	16316942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	CTD_human_DG	16316942		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34768883	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	16316942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20339555, 28365151	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	20339555	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	20845060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	11920633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25162823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	20845060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17974964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	25408555		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25162823, 28574834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Marfan Syndrome	Marfan syndrome	Pubtator	33230159	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	34768883	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11920633, 17974964, 22072289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	11920633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	35312779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34336102, 39972314	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	22792318	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	25408555		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25381222, 26567111, 36613987	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	17189524		★★★★★ ★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	16316942		★★★★★ ★☆☆☆☆ Found in Text Mining only

MRC2 (mannose receptor C-type 2)

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