ZNF438 (zinc finger protein 438)

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Gene Gene information from NCBI Gene database.
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Entrez ID 220929
Gene name Zinc finger protein 438
Gene symbol ZNF438
Synonyms (NCBI Gene)
bA330O11.1
Chromosome 10
Chromosome location 10p11.23
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT2670431 hsa-miR-3671 CLIP-seq
MIRT2670432 hsa-miR-607 CLIP-seq
MIRT2670431 hsa-miR-3671 CLIP-seq
MIRT2670432 hsa-miR-607 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
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GO ID Ontology Definition Evidence Reference
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0003700 Function DNA-binding transcription factor activity IDA 17669267
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
620749 21029 ENSG00000183621
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z4V0
Protein name Zinc finger protein 438
Protein function Isoform 1 acts as a transcriptional repressor.
Family and domains
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:17669267}.
Sequence 
MQNSVSVPPKDEGESNIPSGTIQSRKGLQNKSQFRTIAPKIVPKVLTSRMLPCHSPSRSD
QVNLGPSINSKLLGMSTQNYALMQVAGQEGTFSLVALPHVASAQPIQKPRMSLPENLKLP
IPRYQPPRNSKASRKKPILIFPKSGCSKAPAQTQMCPQMSPSPPHHPELLYKPSPFEEVP
SLEQAPASISTAALTNGSDHGDLRPPVTNTHGSLNPPATPASSTPEEPAKQDLTALSGKA
HFVSKITSSKPSAVASEKFKEQVDLAKTMTNLSPTILGNAVQLISSVPKGKLPIPPYSRM
KTMEVYKIKSDANIAGFSLPGPKADCDKIPSTTEGFNAATKVASRLPVPQVSQQSACESA
FCPPTKLDLNHKTKLNSGAAKRKGRKRKVPDEILAFQGKRRKYIINKCRDGKERVKNDPQ
EFRDQKLGTLKKYRSIMPKPIMVIPTLASLASPTTLQSQMLGGLGQDVLLNNSLTPKYLG
CKQDNSSSPKPSSVFRNGFSGIKKPWHRCHVCNHHFQFKQHLRDHMNTHTNRRPYSCRIC
RKSYVRPGSLSTHMKLHHGENRLKKLMCCEFCAKVFGHIRVYFGHLKEVHRVVISTEPAP
SELQPGDIPKNRDMSVRGMEGSLERENKSNLEEDFLLNQADEVKLQIKCGRCQITAQSFA
EIKFHLLDVHGEEIEGRLQEGTFPGSKGTQEELVQHASPDWKRHPERGKPEKVHSSSEES
HACPRLKRQLHLHQNGVEMLMENEGPQSGTNKPRETCQGPECPGLHTFLLWSHSGFNCLL
CAEMLGRKEDLLHHWKHQHNCEDPSKLWAILNTVSNQGVIELSSEAEK
Sequence length 828
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (14)
Phenotype Name Clinical Significance Source Reference Evidence Score
ATOPIC ECZEMA — GWAS catalog 39245941
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CANCER — GWAS catalog 38538606
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA — GWAS catalog 38538606
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARPAL TUNNEL SYNDROME — GWAS catalog 35332129
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLEAR CELL RENAL CARCINOMA — GWAS catalog 38671320
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 39953635 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer UNIPROT_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
melanoma Melanoma CTD_human_DG 22535842
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Stroke Stroke Pubtator 39953635 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
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PKD1L2 2 shared diseasesCongenital left-sided heart lesions, Otosclerosis 1 shared evidence sourceGWAS catalog (Congenital left-sided heart lesions) Related via 2 shared diseases including Congenital left-sided heart lesions, Otosclerosis — evidence mostly GWAS catalog. PREX1 2 shared diseasesOtosclerosis, Preeclampsia 2 shared evidence sourcesGWAS catalog (Otosclerosis), GWAS catalog (Preeclampsia) Related via 2 shared diseases including Otosclerosis, Preeclampsia — evidence mostly GWAS catalog. CLDN23 1 shared diseaseOtosclerosis 2 shared evidence sourcesGWAS catalog (Endometriosis), GWAS catalog (Otosclerosis) Related via 1 shared disease including Otosclerosis — evidence mostly GWAS catalog. KIF18B 2 shared evidence sourcesGWAS catalog (Endometriosis), CTD (Melanoma) Related via 2 shared evidence sources. ZNF831 1 shared diseasePreeclampsia 2 shared evidence sourcesCTD (Melanoma), GWAS catalog (Preeclampsia) Related via 1 shared disease including Preeclampsia — evidence mostly CTD.
Coronary artery disease Linked via 3 of 5 related genesPREX1, CLDN23, ZNF831 Major depressive disorder Linked via 3 of 5 related genesPREX1, CLDN23, ZNF831 Prostate cancer Linked via 3 of 5 related genesPREX1, CLDN23, KIF18B Attention deficit hyperactivity disorder Linked via 2 of 5 related genesPKD1L2, PREX1 Cardiovascular disease Linked via 2 of 5 related genesPREX1, ZNF831