ZFYVE9 (zinc finger FYVE-type containing 9)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 9372 |
| Gene name | Zinc finger FYVE-type containing 9 |
| Gene symbol | ZFYVE9 |
| Synonyms (NCBI Gene) |
MADHIPNSPPPP1R173SARASMADIP
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| Chromosome | 1 |
| Chromosome location | 1p32.3 |
| Summary | This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O95405 | ||||||||||||||||||||
| Protein name | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | ||||||||||||||||||||
| Protein function | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating th | ||||||||||||||||||||
| PDB | 1DEV , 1MK2 , 4BKW , 5MJY | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes. | ||||||||||||||||||||
| Sequence |
MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESA |
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| Sequence length | 1425 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with ZFYVE9 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ZFYVE9 (see Related Genes above), that are NOT already directly curated for ZFYVE9 itself -- a lead worth checking, not a confirmed association.
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