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Gene Gene information from NCBI Gene database.
Entrez ID 9372
Gene name Zinc finger FYVE-type containing 9
Gene symbol ZFYVE9
Synonyms (NCBI Gene)
MADHIPNSPPPP1R173SARASMADIP
Chromosome 1
Chromosome location 1p32.3
Summary This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There
miRNA miRNA information provided by mirtarbase database.
422 Show/Hide all (422)
miRTarBase ID miRNA Experiments Reference
MIRT046751 hsa-miR-222-3p CLASH 23622248
MIRT039606 hsa-miR-615-3p CLASH 23622248
MIRT630143 hsa-miR-6768-3p HITS-CLIP 23824327
MIRT630142 hsa-miR-4753-5p HITS-CLIP 23824327
MIRT630141 hsa-miR-4755-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 9865696, 10615055, 12154125, 12809483, 15231748, 17693260, 18511908, 22321011, 24366813, 25416956, 25502805, 31515488, 33961781
GO:0005545 Function 1-phosphatidylinositol binding IDA 11877415
GO:0005545 Function 1-phosphatidylinositol binding IEA
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603755 6775 ENSG00000157077
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95405
Protein name Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
Protein function Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating th
PDB 1DEV , 1MK2 , 4BKW , 5MJY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01363 FYVE 694 → 759 FYVE zinc finger Domain
PF11409 SARA 773 → 811 Smad anchor for receptor activation (SARA) Family
PF11979 DUF3480 1048 → 1400 Domain of unknown function (DUF3480) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
Sequence
MENYFQAEAYNLDKVLDEFEQNEDETVSSTLLDTKWNKILDPPSHRLSFNPTLASVNESA
VSNESQPQLKVFSLAHSAPLTTEEEDHCANGQDCNLNPEIATMWIDENAVAEDQLIKRNY
SWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCDKRTLQNDLQDCNNYNSQSLMDA
FSCSLDNENRQTDQFSFSINESTEKDMNSEKQMDPLNRPKTEGRSVNHLCPTSSDSLASV
CSPSQLKDDGSIGRDPSMSAITSLTVDSVISSQGTDGCPAVKKQENYIPDEDLTGKISSP
RTDLGSPNSFSHMSEGILMKKEPAEESTTEESLRSGLPLLLKPDMPNGSGRNNDCERCSD
CLVPNEVRADENEGYEHEETLGTTEFLNMTEHFSESQDMTNWKLTKLNEMNDSQVNEEKE
KFLQISQPEDTNGDSGGQCVGLADAGLDLKGTCISESEECDFSTVIDTPAANYLSNGCDS
YGMQDPGVSFVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGD
LMKKNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQ
NDFPANSGNNTKNKNDILGKAKLGENSATNVCSPSLGNISNVDTNGEHLESYEAEISTRP
CLALAPDSPDNDLRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRHH
CRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMN
AQAWENMMSASSQSPNPNNPA
EYCSTIPPLQQAQASGALSSPPPTVMVPVGV
LKHPGAEVAQPREQRRVWFADGILPNGEV
ADAAKLTMNGTSSAGTLAVSHDPVKPVTTSPLPAETDICLFSGSITQVGSPVGSAMNLIP
EDGLPPILISTGVKGDYAVEEKPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNR
KCWCFTTKGMHAVGQSEIVILLQCLPDEKCLPKDIFNHFVQLYRDALAGNVVSNLGHSFF
SQSFLGSKEHGGFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGA
EYRLYPCPLFSVRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIP
SNRYNEMMKAMNKSNEHVLAGGACFNEKADSHLVCVQNDDGNYQTQAISIHNQPRKVTGA
SFFVFSGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEP
QEHIHIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGKVIRWTEVFFLEND
DQHNCLSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSN
GQPLPSQYMNDLDSALVPVI
HGGACQLSEGPVVMELIFYILENIV
Sequence length 1425
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Endocytosis TGF-beta receptor signaling activates SMADs
TGF-beta signaling pathway SMAD2/3 Phosphorylation Motif Mutants in Cancer
  TGFBR1 KD Mutants in Cancer