Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	7419
Gene name	Voltage dependent anion channel 3
Gene symbol	VDAC3
Synonyms (NCBI Gene)	HD-VDAC3VDAC-3
Chromosome	8
Chromosome location	8p11.21
Summary	This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are kno

130 Show/Hide all (130)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048181	hsa-miR-196a-5p	CLASH	23622248
MIRT038613	hsa-miR-186-3p	CLASH	23622248
MIRT1483660	hsa-miR-3650	CLIP-seq
MIRT1483661	hsa-miR-3974	CLIP-seq
MIRT1483662	hsa-miR-4645-5p	CLIP-seq
MIRT1483663	hsa-miR-4648	CLIP-seq
MIRT1483664	hsa-miR-4654	CLIP-seq
MIRT1483665	hsa-miR-4673	CLIP-seq
MIRT1483666	hsa-miR-4769-5p	CLIP-seq
MIRT1483667	hsa-miR-4786-5p	CLIP-seq
MIRT1483668	hsa-miR-522	CLIP-seq
MIRT1483669	hsa-miR-549	CLIP-seq
MIRT1483670	hsa-miR-624	CLIP-seq
MIRT1483671	hsa-miR-656	CLIP-seq
MIRT1483672	hsa-miR-1286	CLIP-seq
MIRT1483673	hsa-miR-1302	CLIP-seq
MIRT1483660	hsa-miR-3650	CLIP-seq
MIRT1483674	hsa-miR-4298	CLIP-seq
MIRT1483663	hsa-miR-4648	CLIP-seq
MIRT1483664	hsa-miR-4654	CLIP-seq
MIRT1483675	hsa-miR-4722-5p	CLIP-seq
MIRT1483666	hsa-miR-4769-5p	CLIP-seq
MIRT1483668	hsa-miR-522	CLIP-seq
MIRT2145602	hsa-miR-1322	CLIP-seq
MIRT2366042	hsa-miR-203	CLIP-seq
MIRT2366043	hsa-miR-3664-3p	CLIP-seq
MIRT2366044	hsa-miR-4276	CLIP-seq
MIRT2366045	hsa-miR-4287	CLIP-seq
MIRT2366046	hsa-miR-4297	CLIP-seq
MIRT2366047	hsa-miR-4302	CLIP-seq
MIRT2366048	hsa-miR-4433	CLIP-seq
MIRT2366049	hsa-miR-4459	CLIP-seq
MIRT2366050	hsa-miR-4469	CLIP-seq
MIRT2366051	hsa-miR-4685-3p	CLIP-seq
MIRT2366052	hsa-miR-4768-3p	CLIP-seq
MIRT2366053	hsa-miR-4779	CLIP-seq
MIRT2366054	hsa-miR-498	CLIP-seq
MIRT2366055	hsa-miR-513a-3p	CLIP-seq
MIRT2366056	hsa-miR-532-5p	CLIP-seq
MIRT1483671	hsa-miR-656	CLIP-seq
MIRT1483672	hsa-miR-1286	CLIP-seq
MIRT1483673	hsa-miR-1302	CLIP-seq
MIRT2366042	hsa-miR-203	CLIP-seq
MIRT2659562	hsa-miR-27a	CLIP-seq
MIRT2659563	hsa-miR-27b	CLIP-seq
MIRT2659564	hsa-miR-3150a-3p	CLIP-seq
MIRT2659565	hsa-miR-3151	CLIP-seq
MIRT2659566	hsa-miR-3159	CLIP-seq
MIRT2659567	hsa-miR-3175	CLIP-seq
MIRT1483660	hsa-miR-3650	CLIP-seq
MIRT2366043	hsa-miR-3664-3p	CLIP-seq
MIRT2659568	hsa-miR-377	CLIP-seq
MIRT1483661	hsa-miR-3974	CLIP-seq
MIRT2366044	hsa-miR-4276	CLIP-seq
MIRT2366045	hsa-miR-4287	CLIP-seq
MIRT2366046	hsa-miR-4297	CLIP-seq
MIRT1483674	hsa-miR-4298	CLIP-seq
MIRT2366047	hsa-miR-4302	CLIP-seq
MIRT2366048	hsa-miR-4433	CLIP-seq
MIRT2659569	hsa-miR-4447	CLIP-seq
MIRT2366049	hsa-miR-4459	CLIP-seq
MIRT2366050	hsa-miR-4469	CLIP-seq
MIRT2659570	hsa-miR-4472	CLIP-seq
MIRT1483662	hsa-miR-4645-5p	CLIP-seq
MIRT1483663	hsa-miR-4648	CLIP-seq
MIRT1483664	hsa-miR-4654	CLIP-seq
MIRT1483665	hsa-miR-4673	CLIP-seq
MIRT2366051	hsa-miR-4685-3p	CLIP-seq
MIRT1483675	hsa-miR-4722-5p	CLIP-seq
MIRT2366052	hsa-miR-4768-3p	CLIP-seq
MIRT1483666	hsa-miR-4769-5p	CLIP-seq
MIRT2366053	hsa-miR-4779	CLIP-seq
MIRT1483667	hsa-miR-4786-5p	CLIP-seq
MIRT2659571	hsa-miR-491-5p	CLIP-seq
MIRT2366054	hsa-miR-498	CLIP-seq
MIRT2366055	hsa-miR-513a-3p	CLIP-seq
MIRT2659572	hsa-miR-513a-5p	CLIP-seq
MIRT1483668	hsa-miR-522	CLIP-seq
MIRT2366056	hsa-miR-532-5p	CLIP-seq
MIRT1483669	hsa-miR-549	CLIP-seq
MIRT1483670	hsa-miR-624	CLIP-seq
MIRT1483671	hsa-miR-656	CLIP-seq
MIRT2659573	hsa-miR-7	CLIP-seq
MIRT2659574	hsa-miR-9	CLIP-seq
MIRT2659575	hsa-miR-939	CLIP-seq
MIRT1483672	hsa-miR-1286	CLIP-seq
MIRT1483673	hsa-miR-1302	CLIP-seq
MIRT2366042	hsa-miR-203	CLIP-seq
MIRT2659562	hsa-miR-27a	CLIP-seq
MIRT2659563	hsa-miR-27b	CLIP-seq
MIRT2659564	hsa-miR-3150a-3p	CLIP-seq
MIRT2659565	hsa-miR-3151	CLIP-seq
MIRT2659566	hsa-miR-3159	CLIP-seq
MIRT2659567	hsa-miR-3175	CLIP-seq
MIRT1483660	hsa-miR-3650	CLIP-seq
MIRT2366043	hsa-miR-3664-3p	CLIP-seq
MIRT2659568	hsa-miR-377	CLIP-seq
MIRT1483661	hsa-miR-3974	CLIP-seq
MIRT2366044	hsa-miR-4276	CLIP-seq
MIRT2366045	hsa-miR-4287	CLIP-seq
MIRT2366046	hsa-miR-4297	CLIP-seq
MIRT1483674	hsa-miR-4298	CLIP-seq
MIRT2366047	hsa-miR-4302	CLIP-seq
MIRT2366048	hsa-miR-4433	CLIP-seq
MIRT2659569	hsa-miR-4447	CLIP-seq
MIRT2366049	hsa-miR-4459	CLIP-seq
MIRT2366050	hsa-miR-4469	CLIP-seq
MIRT2659570	hsa-miR-4472	CLIP-seq
MIRT1483662	hsa-miR-4645-5p	CLIP-seq
MIRT1483663	hsa-miR-4648	CLIP-seq
MIRT1483664	hsa-miR-4654	CLIP-seq
MIRT1483665	hsa-miR-4673	CLIP-seq
MIRT2366051	hsa-miR-4685-3p	CLIP-seq
MIRT1483675	hsa-miR-4722-5p	CLIP-seq
MIRT2366052	hsa-miR-4768-3p	CLIP-seq
MIRT1483666	hsa-miR-4769-5p	CLIP-seq
MIRT2366053	hsa-miR-4779	CLIP-seq
MIRT1483667	hsa-miR-4786-5p	CLIP-seq
MIRT2659571	hsa-miR-491-5p	CLIP-seq
MIRT2366054	hsa-miR-498	CLIP-seq
MIRT2366055	hsa-miR-513a-3p	CLIP-seq
MIRT2659572	hsa-miR-513a-5p	CLIP-seq
MIRT1483668	hsa-miR-522	CLIP-seq
MIRT2366056	hsa-miR-532-5p	CLIP-seq
MIRT1483669	hsa-miR-549	CLIP-seq
MIRT1483670	hsa-miR-624	CLIP-seq
MIRT1483671	hsa-miR-656	CLIP-seq
MIRT2659573	hsa-miR-7	CLIP-seq
MIRT2659574	hsa-miR-9	CLIP-seq
MIRT2659575	hsa-miR-939	CLIP-seq

32 Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001662	Process	Behavioral fear response	IEA
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IDA	31935282
GO:0005515	Function	Protein binding	IPI	29128334, 30021884, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HDA	20833797
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IBA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS	9781040
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0007270	Process	Neuron-neuron synaptic transmission	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007612	Process	Learning	IEA
GO:0008308	Function	Voltage-gated monoatomic anion channel activity	IBA
GO:0008308	Function	Voltage-gated monoatomic anion channel activity	IEA
GO:0008308	Function	Voltage-gated monoatomic anion channel activity	TAS	9781040
GO:0015288	Function	Porin activity	IEA
GO:0015853	Process	Adenine transport	TAS	9781040
GO:0016020	Component	Membrane	IDA	27641616
GO:0016020	Component	Membrane	IEA
GO:0045202	Component	Synapse	IEA
GO:0046930	Component	Pore complex	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0098656	Process	Monoatomic anion transmembrane transport	IEA
GO:0120317	Process	Sperm mitochondrial sheath assembly	IEA
GO:0120317	Process	Sperm mitochondrial sheath assembly	ISS

MIM	HGNC	e!Ensembl
610029	12674	ENSG00000078668

Q9Y277

Protein name

Non-selective voltage-gated ion channel VDAC3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)

Protein function

Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:31935282). Forms a high-conducting channel with a stable open state and a voltage-indu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01459	Porin_3	3 → 276	Eukaryotic porin	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in erythrocytes (at protein level) (PubMed:27641616). Widely expressed. Highest in testis (PubMed:9781040). {ECO:0000269|PubMed:27641616, ECO:0000269|PubMed:9781040}.

Sequence

MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLET
KYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKR
DCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQL
HTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNA
SLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

Sequence length

283

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Calcium signaling pathway	Ub-specific processing proteases
cGMP-PKG signaling pathway
Ferroptosis
Necroptosis
Cellular senescence
Neutrophil extracellular trap formation
NOD-like receptor signaling pathway
Cholesterol metabolism
Alzheimer disease
Parkinson disease
Huntington disease
Spinocerebellar ataxia
Prion disease
Pathways of neurodegeneration - multiple diseases
Hepatitis B
Human T-cell leukemia virus 1 infection
Viral carcinogenesis
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
VDAC2	[]	15	["Calcium signaling pathway","cGMP-PKG signaling pathway","Ferroptosis","Necroptosis","Cellular senescence","Neutrophil extracellular trap formation","NOD-like receptor signaling pathway","Cholesterol metabolism","Parkinson disease","Spinocerebellar ataxia","Prion disease","Human T-cell leukemia virus 1 infection"]	[]
VDAC1	[]	14	["Calcium signaling pathway","cGMP-PKG signaling pathway","Necroptosis","Cellular senescence","Neutrophil extracellular trap formation","NOD-like receptor signaling pathway","Cholesterol metabolism","Parkinson disease","Spinocerebellar ataxia","Prion disease","Human T-cell leukemia virus 1 infection","Chemical carcinogenesis - reactive oxygen species"]	[]
SLC25A31	[]	11	["Calcium signaling pathway","cGMP-PKG signaling pathway","Necroptosis","Cellular senescence","Neutrophil extracellular trap formation","Parkinson disease","Spinocerebellar ataxia","Prion disease","Human T-cell leukemia virus 1 infection","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	[]
SLC25A5	[]	11	["Calcium signaling pathway","cGMP-PKG signaling pathway","Necroptosis","Cellular senescence","Neutrophil extracellular trap formation","Parkinson disease","Spinocerebellar ataxia","Prion disease","Human T-cell leukemia virus 1 infection","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	[]
SLC25A4	[]	11	["Calcium signaling pathway","cGMP-PKG signaling pathway","Necroptosis","Cellular senescence","Neutrophil extracellular trap formation","Parkinson disease","Spinocerebellar ataxia","Prion disease","Human T-cell leukemia virus 1 infection","Chemical carcinogenesis - reactive oxygen species","Diabetic cardiomyopathy"]	[]

VDAC3 (voltage dependent anion channel 3)

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