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Gene Gene information from NCBI Gene database.
Entrez ID 51465
Gene name Ubiquitin conjugating enzyme E2 J1
Gene symbol UBE2J1
Synonyms (NCBI Gene)
CGI-76HSPC153HSPC205HSU93243NCUBE-1NCUBE1UBC6UBC6EUbc6p
Chromosome 6
Chromosome location 6q15
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju
miRNA miRNA information provided by mirtarbase database.
478 Show/Hide all (478)
miRTarBase ID miRNA Experiments Reference
MIRT001488 hsa-miR-155-5p pSILAC 18668040
MIRT001488 hsa-miR-155-5p Proteomics 18668040
MIRT024199 hsa-miR-221-3p Sequencing 20371350
MIRT028135 hsa-miR-93-5p Sequencing 20371350
MIRT651976 hsa-miR-211-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27 Show/Hide all (27)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000209 Process Protein polyubiquitination IBA
GO:0000836 Component Hrd1p ubiquitin ligase complex IDA 28827405
GO:0005515 Function Protein binding IDA 33472082
GO:0005515 Function Protein binding IPI 19690564, 22119785, 28514442, 28827405, 32296183, 32814053, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616175 17598 ENSG00000198833
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y385
Protein name Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
Protein function Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00179 UQ_con 14 → 129 Ubiquitin-conjugating enzyme Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in testes. {ECO:0000269|PubMed:35831855}.
Sequence
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHG
RIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMP
TKGEGAIGS
LDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDSSQADQEAKELA
RQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGLQNSSAASFHQP
TQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQPRDNHTDHGGSAVLIVILTLALAA
LIFRRIYLANEYIFDFEL
Sequence length 318
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation
Protein processing in endoplasmic reticulum  
Parkinson disease  
Pathways of neurodegeneration - multiple diseases