Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	7188
Gene name	TNF receptor associated factor 5
Gene symbol	TRAF5
Synonyms (NCBI Gene)	MGC:39780RNF84
Chromosome	1
Chromosome location	1q32.3
Summary	The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF protei

SNP ID	Visualize variation	Clinical significance	Consequence
rs756183569	AGAG>-	Likely-pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant

380 Show/Hide all (380)

miRTarBase ID	miRNA	Experiments	Reference
MIRT553425	hsa-miR-8485	PAR-CLIP	21572407
MIRT553424	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT553423	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT553422	hsa-miR-603	PAR-CLIP	21572407
MIRT553421	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT553420	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT553419	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT553418	hsa-miR-567	PAR-CLIP	21572407
MIRT553417	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT553416	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT553415	hsa-miR-3941	PAR-CLIP	21572407
MIRT553414	hsa-miR-3924	PAR-CLIP	21572407
MIRT553413	hsa-miR-297	PAR-CLIP	21572407
MIRT553412	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT553411	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT465320	hsa-miR-383-5p	PAR-CLIP	23592263
MIRT465319	hsa-miR-3614-5p	PAR-CLIP	23592263
MIRT465318	hsa-miR-6500-3p	PAR-CLIP	23592263
MIRT465317	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT465315	hsa-miR-4459	PAR-CLIP	23592263
MIRT465316	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT731422	hsa-miR-26b-5p	Luciferase reporter assay	26872428
MIRT731422	hsa-miR-26b-5p	Luciferase reporter assay	26872428
MIRT737074	hsa-miR-23a-3p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	34249436
MIRT553425	hsa-miR-8485	PAR-CLIP	21572407
MIRT553424	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT553423	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT553422	hsa-miR-603	PAR-CLIP	21572407
MIRT553421	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT553420	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT553419	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT553418	hsa-miR-567	PAR-CLIP	21572407
MIRT553417	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT553416	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT553415	hsa-miR-3941	PAR-CLIP	21572407
MIRT553414	hsa-miR-3924	PAR-CLIP	21572407
MIRT553413	hsa-miR-297	PAR-CLIP	21572407
MIRT553412	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT553411	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT465320	hsa-miR-383-5p	PAR-CLIP	23592263
MIRT465319	hsa-miR-3614-5p	PAR-CLIP	23592263
MIRT465318	hsa-miR-6500-3p	PAR-CLIP	23592263
MIRT465317	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT465315	hsa-miR-4459	PAR-CLIP	23592263
MIRT465316	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT1451006	hsa-miR-1262	CLIP-seq
MIRT1451007	hsa-miR-153	CLIP-seq
MIRT1451008	hsa-miR-15a	CLIP-seq
MIRT1451009	hsa-miR-15b	CLIP-seq
MIRT1451010	hsa-miR-16	CLIP-seq
MIRT1451011	hsa-miR-181a	CLIP-seq
MIRT1451012	hsa-miR-181b	CLIP-seq
MIRT1451013	hsa-miR-181c	CLIP-seq
MIRT1451014	hsa-miR-181d	CLIP-seq
MIRT1451015	hsa-miR-195	CLIP-seq
MIRT1451016	hsa-miR-3145-5p	CLIP-seq
MIRT1451017	hsa-miR-3149	CLIP-seq
MIRT1451018	hsa-miR-329	CLIP-seq
MIRT1451019	hsa-miR-365	CLIP-seq
MIRT1451020	hsa-miR-410	CLIP-seq
MIRT1451021	hsa-miR-424	CLIP-seq
MIRT1451022	hsa-miR-4252	CLIP-seq
MIRT1451023	hsa-miR-4262	CLIP-seq
MIRT1451024	hsa-miR-4457	CLIP-seq
MIRT1451025	hsa-miR-448	CLIP-seq
MIRT1451026	hsa-miR-4504	CLIP-seq
MIRT1451027	hsa-miR-452	CLIP-seq
MIRT1451028	hsa-miR-4524	CLIP-seq
MIRT1451029	hsa-miR-4641	CLIP-seq
MIRT1451030	hsa-miR-4676-3p	CLIP-seq
MIRT1451031	hsa-miR-4701-3p	CLIP-seq
MIRT1451032	hsa-miR-4789-5p	CLIP-seq
MIRT1451033	hsa-miR-4795-5p	CLIP-seq
MIRT1451034	hsa-miR-494	CLIP-seq
MIRT1451035	hsa-miR-497	CLIP-seq
MIRT1451036	hsa-miR-499-3p	CLIP-seq
MIRT1451037	hsa-miR-499a-3p	CLIP-seq
MIRT1451038	hsa-miR-503	CLIP-seq
MIRT1451039	hsa-miR-508-5p	CLIP-seq
MIRT1451040	hsa-miR-513b	CLIP-seq
MIRT1451041	hsa-miR-520d-5p	CLIP-seq
MIRT1451042	hsa-miR-524-5p	CLIP-seq
MIRT1451043	hsa-miR-568	CLIP-seq
MIRT1451044	hsa-miR-646	CLIP-seq
MIRT1451045	hsa-miR-661	CLIP-seq
MIRT1451046	hsa-miR-766	CLIP-seq
MIRT1451047	hsa-miR-1827	CLIP-seq
MIRT1451048	hsa-miR-3120-5p	CLIP-seq
MIRT1451049	hsa-miR-34b	CLIP-seq
MIRT1451050	hsa-miR-3613-3p	CLIP-seq
MIRT1451051	hsa-miR-3664-3p	CLIP-seq
MIRT1451052	hsa-miR-3664-5p	CLIP-seq
MIRT1451053	hsa-miR-371-5p	CLIP-seq
MIRT1451054	hsa-miR-371b-5p	CLIP-seq
MIRT1451055	hsa-miR-3929	CLIP-seq
MIRT1451056	hsa-miR-4419b	CLIP-seq
MIRT1451057	hsa-miR-4433	CLIP-seq
MIRT1451058	hsa-miR-4452	CLIP-seq
MIRT1451059	hsa-miR-4478	CLIP-seq
MIRT1451026	hsa-miR-4504	CLIP-seq
MIRT1451060	hsa-miR-4649-3p	CLIP-seq
MIRT1451061	hsa-miR-4695-5p	CLIP-seq
MIRT1451062	hsa-miR-4722-5p	CLIP-seq
MIRT1451063	hsa-miR-4738-3p	CLIP-seq
MIRT1451033	hsa-miR-4795-5p	CLIP-seq
MIRT1451064	hsa-miR-485-5p	CLIP-seq
MIRT1451065	hsa-miR-501-3p	CLIP-seq
MIRT1451066	hsa-miR-502-3p	CLIP-seq
MIRT1451067	hsa-miR-510	CLIP-seq
MIRT1451068	hsa-miR-512-5p	CLIP-seq
MIRT1451069	hsa-miR-563	CLIP-seq
MIRT1451070	hsa-miR-659	CLIP-seq
MIRT1451071	hsa-miR-940	CLIP-seq
MIRT1451007	hsa-miR-153	CLIP-seq
MIRT1451008	hsa-miR-15a	CLIP-seq
MIRT1451009	hsa-miR-15b	CLIP-seq
MIRT1451010	hsa-miR-16	CLIP-seq
MIRT1451047	hsa-miR-1827	CLIP-seq
MIRT1451015	hsa-miR-195	CLIP-seq
MIRT1451072	hsa-miR-29a	CLIP-seq
MIRT1451073	hsa-miR-29b	CLIP-seq
MIRT1451074	hsa-miR-29c	CLIP-seq
MIRT1451075	hsa-miR-3119	CLIP-seq
MIRT1451076	hsa-miR-3122	CLIP-seq
MIRT1451077	hsa-miR-3140-3p	CLIP-seq
MIRT1451078	hsa-miR-3160-3p	CLIP-seq
MIRT1451079	hsa-miR-3166	CLIP-seq
MIRT1451080	hsa-miR-3678-3p	CLIP-seq
MIRT1451081	hsa-miR-3689a-3p	CLIP-seq
MIRT1451082	hsa-miR-3689c	CLIP-seq
MIRT1451083	hsa-miR-3913-5p	CLIP-seq
MIRT1451021	hsa-miR-424	CLIP-seq
MIRT1451084	hsa-miR-4311	CLIP-seq
MIRT1451057	hsa-miR-4433	CLIP-seq
MIRT1451025	hsa-miR-448	CLIP-seq
MIRT1451085	hsa-miR-4487	CLIP-seq
MIRT1451086	hsa-miR-450b-5p	CLIP-seq
MIRT1451028	hsa-miR-4524	CLIP-seq
MIRT1451087	hsa-miR-4728-5p	CLIP-seq
MIRT1451088	hsa-miR-4753-5p	CLIP-seq
MIRT1451089	hsa-miR-4771	CLIP-seq
MIRT1451033	hsa-miR-4795-5p	CLIP-seq
MIRT1451035	hsa-miR-497	CLIP-seq
MIRT1451090	hsa-miR-499a-5p	CLIP-seq
MIRT1451038	hsa-miR-503	CLIP-seq
MIRT1451091	hsa-miR-507	CLIP-seq
MIRT1451041	hsa-miR-520d-5p	CLIP-seq
MIRT1451042	hsa-miR-524-5p	CLIP-seq
MIRT1451092	hsa-miR-557	CLIP-seq
MIRT1451093	hsa-miR-558	CLIP-seq
MIRT1451094	hsa-miR-601	CLIP-seq
MIRT1451044	hsa-miR-646	CLIP-seq
MIRT1555184	hsa-miR-4797-5p	CLIP-seq
MIRT2134812	hsa-miR-1226	CLIP-seq
MIRT1451011	hsa-miR-181a	CLIP-seq
MIRT1451012	hsa-miR-181b	CLIP-seq
MIRT1451013	hsa-miR-181c	CLIP-seq
MIRT1451014	hsa-miR-181d	CLIP-seq
MIRT2134813	hsa-miR-216a	CLIP-seq
MIRT2134814	hsa-miR-216b	CLIP-seq
MIRT2134815	hsa-miR-218	CLIP-seq
MIRT2134816	hsa-miR-3148	CLIP-seq
MIRT2134817	hsa-miR-3660	CLIP-seq
MIRT2134818	hsa-miR-3682-5p	CLIP-seq
MIRT2134819	hsa-miR-382	CLIP-seq
MIRT2134820	hsa-miR-4256	CLIP-seq
MIRT1451023	hsa-miR-4262	CLIP-seq
MIRT2134821	hsa-miR-4279	CLIP-seq
MIRT2134822	hsa-miR-4328	CLIP-seq
MIRT2134823	hsa-miR-4477b	CLIP-seq
MIRT2134824	hsa-miR-4496	CLIP-seq
MIRT2134825	hsa-miR-4517	CLIP-seq
MIRT2134826	hsa-miR-4526	CLIP-seq
MIRT2134827	hsa-miR-4693-3p	CLIP-seq
MIRT2134828	hsa-miR-4693-5p	CLIP-seq
MIRT2134829	hsa-miR-4733-3p	CLIP-seq
MIRT2134830	hsa-miR-4799-5p	CLIP-seq
MIRT2134831	hsa-miR-491-3p	CLIP-seq
MIRT1451041	hsa-miR-520d-5p	CLIP-seq
MIRT1451042	hsa-miR-524-5p	CLIP-seq
MIRT2134832	hsa-miR-548an	CLIP-seq
MIRT2134833	hsa-miR-548g	CLIP-seq
MIRT2134834	hsa-miR-548m	CLIP-seq
MIRT2134835	hsa-miR-556-3p	CLIP-seq
MIRT2134836	hsa-miR-605	CLIP-seq
MIRT2134837	hsa-miR-636	CLIP-seq
MIRT2134838	hsa-miR-639	CLIP-seq
MIRT1451044	hsa-miR-646	CLIP-seq
MIRT2134839	hsa-miR-924	CLIP-seq
MIRT2356081	hsa-miR-1323	CLIP-seq
MIRT1451047	hsa-miR-1827	CLIP-seq
MIRT2134813	hsa-miR-216a	CLIP-seq
MIRT2134814	hsa-miR-216b	CLIP-seq
MIRT2356082	hsa-miR-3065-3p	CLIP-seq
MIRT1451076	hsa-miR-3122	CLIP-seq
MIRT2356083	hsa-miR-3187-3p	CLIP-seq
MIRT1451049	hsa-miR-34b	CLIP-seq
MIRT2356084	hsa-miR-3612	CLIP-seq
MIRT1451051	hsa-miR-3664-3p	CLIP-seq
MIRT1451081	hsa-miR-3689a-3p	CLIP-seq
MIRT1451082	hsa-miR-3689c	CLIP-seq
MIRT2134819	hsa-miR-382	CLIP-seq
MIRT1451083	hsa-miR-3913-5p	CLIP-seq
MIRT2356085	hsa-miR-3926	CLIP-seq
MIRT1451055	hsa-miR-3929	CLIP-seq
MIRT2134821	hsa-miR-4279	CLIP-seq
MIRT1451056	hsa-miR-4419b	CLIP-seq
MIRT1451057	hsa-miR-4433	CLIP-seq
MIRT2356086	hsa-miR-4435	CLIP-seq
MIRT1451058	hsa-miR-4452	CLIP-seq
MIRT2356087	hsa-miR-4455	CLIP-seq
MIRT2356088	hsa-miR-4470	CLIP-seq
MIRT1451059	hsa-miR-4478	CLIP-seq
MIRT2134824	hsa-miR-4496	CLIP-seq
MIRT1451060	hsa-miR-4649-3p	CLIP-seq
MIRT2356089	hsa-miR-4684-5p	CLIP-seq
MIRT1451061	hsa-miR-4695-5p	CLIP-seq
MIRT2356090	hsa-miR-4701-5p	CLIP-seq
MIRT1451062	hsa-miR-4722-5p	CLIP-seq
MIRT1451087	hsa-miR-4728-5p	CLIP-seq
MIRT1451064	hsa-miR-485-5p	CLIP-seq
MIRT1451067	hsa-miR-510	CLIP-seq
MIRT1451068	hsa-miR-512-5p	CLIP-seq
MIRT2356091	hsa-miR-548c-3p	CLIP-seq
MIRT2134834	hsa-miR-548m	CLIP-seq
MIRT2356092	hsa-miR-548o	CLIP-seq
MIRT2356093	hsa-miR-548s	CLIP-seq
MIRT2356094	hsa-miR-566	CLIP-seq
MIRT2356095	hsa-miR-588	CLIP-seq
MIRT2356096	hsa-miR-650	CLIP-seq
MIRT1451071	hsa-miR-940	CLIP-seq
MIRT1451076	hsa-miR-3122	CLIP-seq
MIRT1451081	hsa-miR-3689a-3p	CLIP-seq
MIRT1451082	hsa-miR-3689c	CLIP-seq
MIRT1451083	hsa-miR-3913-5p	CLIP-seq
MIRT2134821	hsa-miR-4279	CLIP-seq
MIRT1451057	hsa-miR-4433	CLIP-seq
MIRT1451025	hsa-miR-448	CLIP-seq
MIRT2134824	hsa-miR-4496	CLIP-seq
MIRT1451087	hsa-miR-4728-5p	CLIP-seq
MIRT2134834	hsa-miR-548m	CLIP-seq
MIRT2134813	hsa-miR-216a	CLIP-seq
MIRT2134814	hsa-miR-216b	CLIP-seq
MIRT2356082	hsa-miR-3065-3p	CLIP-seq
MIRT1451048	hsa-miR-3120-5p	CLIP-seq
MIRT1451076	hsa-miR-3122	CLIP-seq
MIRT1451050	hsa-miR-3613-3p	CLIP-seq
MIRT1451052	hsa-miR-3664-5p	CLIP-seq
MIRT1451081	hsa-miR-3689a-3p	CLIP-seq
MIRT1451082	hsa-miR-3689c	CLIP-seq
MIRT1451053	hsa-miR-371-5p	CLIP-seq
MIRT1451054	hsa-miR-371b-5p	CLIP-seq
MIRT1451083	hsa-miR-3913-5p	CLIP-seq
MIRT2356089	hsa-miR-4684-5p	CLIP-seq
MIRT1451087	hsa-miR-4728-5p	CLIP-seq
MIRT1451063	hsa-miR-4738-3p	CLIP-seq
MIRT2356091	hsa-miR-548c-3p	CLIP-seq
MIRT2462275	hsa-miR-619	CLIP-seq
MIRT2649595	hsa-miR-1256	CLIP-seq
MIRT2356081	hsa-miR-1323	CLIP-seq
MIRT1451007	hsa-miR-153	CLIP-seq
MIRT1451008	hsa-miR-15a	CLIP-seq
MIRT1451009	hsa-miR-15b	CLIP-seq
MIRT1451010	hsa-miR-16	CLIP-seq
MIRT1451047	hsa-miR-1827	CLIP-seq
MIRT1451015	hsa-miR-195	CLIP-seq
MIRT2649596	hsa-miR-2053	CLIP-seq
MIRT2134813	hsa-miR-216a	CLIP-seq
MIRT2134814	hsa-miR-216b	CLIP-seq
MIRT2134815	hsa-miR-218	CLIP-seq
MIRT2649597	hsa-miR-24	CLIP-seq
MIRT2649598	hsa-miR-298	CLIP-seq
MIRT2356082	hsa-miR-3065-3p	CLIP-seq
MIRT1451048	hsa-miR-3120-5p	CLIP-seq
MIRT1451076	hsa-miR-3122	CLIP-seq
MIRT2134816	hsa-miR-3148	CLIP-seq
MIRT2649599	hsa-miR-3154	CLIP-seq
MIRT2356083	hsa-miR-3187-3p	CLIP-seq
MIRT1451050	hsa-miR-3613-3p	CLIP-seq
MIRT1451019	hsa-miR-365	CLIP-seq
MIRT1451051	hsa-miR-3664-3p	CLIP-seq
MIRT1451052	hsa-miR-3664-5p	CLIP-seq
MIRT1451081	hsa-miR-3689a-3p	CLIP-seq
MIRT1451082	hsa-miR-3689c	CLIP-seq
MIRT1451053	hsa-miR-371-5p	CLIP-seq
MIRT1451054	hsa-miR-371b-5p	CLIP-seq
MIRT1451083	hsa-miR-3913-5p	CLIP-seq
MIRT2356085	hsa-miR-3926	CLIP-seq
MIRT1451055	hsa-miR-3929	CLIP-seq
MIRT1451020	hsa-miR-410	CLIP-seq
MIRT1451021	hsa-miR-424	CLIP-seq
MIRT1451056	hsa-miR-4419b	CLIP-seq
MIRT1451057	hsa-miR-4433	CLIP-seq
MIRT2356086	hsa-miR-4435	CLIP-seq
MIRT2649600	hsa-miR-4436a	CLIP-seq
MIRT2649601	hsa-miR-4437	CLIP-seq
MIRT2649602	hsa-miR-4453	CLIP-seq
MIRT1451024	hsa-miR-4457	CLIP-seq
MIRT2356088	hsa-miR-4470	CLIP-seq
MIRT2134823	hsa-miR-4477b	CLIP-seq
MIRT1451059	hsa-miR-4478	CLIP-seq
MIRT1451025	hsa-miR-448	CLIP-seq
MIRT2134825	hsa-miR-4517	CLIP-seq
MIRT1451028	hsa-miR-4524	CLIP-seq
MIRT2649603	hsa-miR-4538	CLIP-seq
MIRT1451029	hsa-miR-4641	CLIP-seq
MIRT2649604	hsa-miR-4642	CLIP-seq
MIRT1451060	hsa-miR-4649-3p	CLIP-seq
MIRT2356089	hsa-miR-4684-5p	CLIP-seq
MIRT1451061	hsa-miR-4695-5p	CLIP-seq
MIRT2356090	hsa-miR-4701-5p	CLIP-seq
MIRT1451062	hsa-miR-4722-5p	CLIP-seq
MIRT1451087	hsa-miR-4728-5p	CLIP-seq
MIRT1451063	hsa-miR-4738-3p	CLIP-seq
MIRT2134830	hsa-miR-4799-5p	CLIP-seq
MIRT1451064	hsa-miR-485-5p	CLIP-seq
MIRT1451034	hsa-miR-494	CLIP-seq
MIRT1451035	hsa-miR-497	CLIP-seq
MIRT1451036	hsa-miR-499-3p	CLIP-seq
MIRT1451037	hsa-miR-499a-3p	CLIP-seq
MIRT1451038	hsa-miR-503	CLIP-seq
MIRT1451067	hsa-miR-510	CLIP-seq
MIRT1451068	hsa-miR-512-5p	CLIP-seq
MIRT1451040	hsa-miR-513b	CLIP-seq
MIRT1451041	hsa-miR-520d-5p	CLIP-seq
MIRT1451042	hsa-miR-524-5p	CLIP-seq
MIRT2134832	hsa-miR-548an	CLIP-seq
MIRT2356091	hsa-miR-548c-3p	CLIP-seq
MIRT2356092	hsa-miR-548o	CLIP-seq
MIRT2356093	hsa-miR-548s	CLIP-seq
MIRT2649605	hsa-miR-549	CLIP-seq
MIRT2356094	hsa-miR-566	CLIP-seq
MIRT2356095	hsa-miR-588	CLIP-seq
MIRT2134836	hsa-miR-605	CLIP-seq
MIRT2649606	hsa-miR-617	CLIP-seq
MIRT2462275	hsa-miR-619	CLIP-seq
MIRT2649607	hsa-miR-627	CLIP-seq
MIRT2134837	hsa-miR-636	CLIP-seq
MIRT1451044	hsa-miR-646	CLIP-seq
MIRT2134839	hsa-miR-924	CLIP-seq
MIRT1451071	hsa-miR-940	CLIP-seq
MIRT2356081	hsa-miR-1323	CLIP-seq
MIRT2356092	hsa-miR-548o	CLIP-seq
MIRT2356081	hsa-miR-1323	CLIP-seq
MIRT1451047	hsa-miR-1827	CLIP-seq
MIRT2134813	hsa-miR-216a	CLIP-seq
MIRT2134814	hsa-miR-216b	CLIP-seq
MIRT2356082	hsa-miR-3065-3p	CLIP-seq
MIRT1451076	hsa-miR-3122	CLIP-seq
MIRT2356083	hsa-miR-3187-3p	CLIP-seq
MIRT1451049	hsa-miR-34b	CLIP-seq
MIRT1451051	hsa-miR-3664-3p	CLIP-seq
MIRT1451081	hsa-miR-3689a-3p	CLIP-seq
MIRT1451082	hsa-miR-3689c	CLIP-seq
MIRT1451083	hsa-miR-3913-5p	CLIP-seq
MIRT2356085	hsa-miR-3926	CLIP-seq
MIRT1451055	hsa-miR-3929	CLIP-seq
MIRT1451056	hsa-miR-4419b	CLIP-seq
MIRT1451057	hsa-miR-4433	CLIP-seq
MIRT2356086	hsa-miR-4435	CLIP-seq
MIRT2649602	hsa-miR-4453	CLIP-seq
MIRT2356088	hsa-miR-4470	CLIP-seq
MIRT1451059	hsa-miR-4478	CLIP-seq
MIRT2649603	hsa-miR-4538	CLIP-seq
MIRT1451060	hsa-miR-4649-3p	CLIP-seq
MIRT2356089	hsa-miR-4684-5p	CLIP-seq
MIRT1451061	hsa-miR-4695-5p	CLIP-seq
MIRT2356090	hsa-miR-4701-5p	CLIP-seq
MIRT1451062	hsa-miR-4722-5p	CLIP-seq
MIRT1451087	hsa-miR-4728-5p	CLIP-seq
MIRT1451064	hsa-miR-485-5p	CLIP-seq
MIRT1451067	hsa-miR-510	CLIP-seq
MIRT1451068	hsa-miR-512-5p	CLIP-seq
MIRT2356091	hsa-miR-548c-3p	CLIP-seq
MIRT2356092	hsa-miR-548o	CLIP-seq
MIRT2356093	hsa-miR-548s	CLIP-seq
MIRT2356094	hsa-miR-566	CLIP-seq
MIRT2356095	hsa-miR-588	CLIP-seq
MIRT2462275	hsa-miR-619	CLIP-seq
MIRT1451071	hsa-miR-940	CLIP-seq

41 Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	9153189, 9162022, 15121867, 21516116, 21822258, 22493164, 25241761, 25416956, 27107012, 28514442, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15121867
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005829	Component	Cytosol	IDA	15121867
GO:0005829	Component	Cytosol	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	9511754
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IBA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	ISS
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IEA
GO:0023035	Process	CD40 signaling pathway	IDA	15708970
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	11279055
GO:0031996	Function	Thioesterase binding	IEA
GO:0031996	Function	Thioesterase binding	IPI	11279055
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IMP	12296995
GO:0035591	Function	Signaling adaptor activity	IBA
GO:0035631	Component	CD40 receptor complex	IEA
GO:0035631	Component	CD40 receptor complex	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	22493164, 25416956, 32296183
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0043122	Process	Regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	12296995
GO:0046872	Function	Metal ion binding	IEA
GO:0048255	Process	MRNA stabilization	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	15121867
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	26453305
GO:0097400	Process	Interleukin-17-mediated signaling pathway	IEA

MIM	HGNC	e!Ensembl
602356	12035	ENSG00000082512

O00463

Protein name

TNF receptor-associated factor 5 (RING finger protein 84)

Protein function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably

PDB

7L3L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00097	zf-C3HC4	45 → 83	Zinc finger, C3HC4 type (RING finger)	Domain
PF02176	zf-TRAF	183 → 241	TRAF-type zinc finger	Family
PF02176	zf-TRAF	128 → 183	TRAF-type zinc finger	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.

Sequence

MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGC
GHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKV
ILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINL
QNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQ
HEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFG
KNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLE
NNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREA
VDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQ
RVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD
DTLFLKVAVDLTDLEDL

Sequence length

557

Interactions

View interactions

KEGG Pathway
NF-kappa B signaling pathway
Necroptosis
NOD-like receptor signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Shigellosis
Human cytomegalovirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Viral carcinogenesis
Small cell lung cancer

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Multiple myeloma	Likely pathogenic	rs756183569	RCV000984094	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (50)
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	24020968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	17277003	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	23116200		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	37330462	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	24020968, 24416204	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	24020968, 24416204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	24416204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	24416204	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30021196, 37366426	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	34983361	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Central Nervous System Neoplasms	Central Nervous System Neoplasms	GWASDB_DG	19578366		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	23329887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	Pubtator	23329887	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	23329887	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31078266		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29328486	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	20651286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	20651286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	20651286		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	23329887	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	23329887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	BEFREE	31420465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis Herpetiformis	Dermatitis herpetiformis	Pubtator	22991566	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30233141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	GWASDB_DG	19578366		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	22593207	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	11144929		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	BEFREE	31437850		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	23329887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	23329887	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory dermatosis	Dermatitis	BEFREE	31420465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	10595933	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31656043		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	26453305	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29202848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30774383		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	31722554		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29202848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	29202848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	17277003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Sjogren syndrome	Pubtator	34349764	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spondylitis Ankylosing	Ankylosing spondylitis	Pubtator	24020968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30774383		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	23329887		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveitis	Uveitis	Pubtator	24020968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveitis	Uveitis	BEFREE	24020968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveitis Anterior	Anterior uveitis	Pubtator	24020968	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveomeningoencephalitic Syndrome	Uveomeningoencephalitic syndrome	Pubtator	24416204	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveomeningoencephalitic Syndrome	Uveomeningoencephalitic Syndrome	BEFREE	24416204		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
TNFAIP3	[]	6	["NF-kappa B signaling pathway","Necroptosis","NOD-like receptor signaling pathway","IL-17 signaling pathway","TNF signaling pathway","Epstein-Barr virus infection"]	[]
TRADD	[]	10	["NF-kappa B signaling pathway","Necroptosis","IL-17 signaling pathway","TNF signaling pathway","Shigellosis","Human cytomegalovirus infection","Herpes simplex virus 1 infection","Epstein-Barr virus infection","Human immunodeficiency virus 1 infection","Viral carcinogenesis"]	[]
TRAF2	[]	12	["NF-kappa B signaling pathway","Necroptosis","NOD-like receptor signaling pathway","IL-17 signaling pathway","TNF signaling pathway","Shigellosis","Human cytomegalovirus infection","Herpes simplex virus 1 infection","Epstein-Barr virus infection","Human immunodeficiency virus 1 infection","Viral carcinogenesis","Small cell lung cancer"]	[]
TRAF3	[]	8	["NF-kappa B signaling pathway","NOD-like receptor signaling pathway","IL-17 signaling pathway","TNF signaling pathway","Herpes simplex virus 1 infection","Epstein-Barr virus infection","Viral carcinogenesis","Small cell lung cancer"]	[]
CGAS	[]	4	["Shigellosis","Human cytomegalovirus infection","Herpes simplex virus 1 infection","Human immunodeficiency virus 1 infection"]	[]

TRAF5 (TNF receptor associated factor 5)

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