SUCNR1 (succinate receptor 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56670
• Gene name: Succinate receptor 1
• Gene symbol: SUCNR1
• Synonyms (NCBI Gene): GPR91
• Chromosome: 3
• Chromosome location: 3q25.1
• Summary: This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which h

miRNA Show/Hide all (115)

miRTarBase ID	miRNA	Experiments	Reference
MIRT520869	hsa-miR-624-3p	HITS-CLIP	21572407
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509263	hsa-miR-4501	HITS-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520869	hsa-miR-624-3p	HITS-CLIP	21572407
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509263	hsa-miR-4501	HITS-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520869	hsa-miR-624-3p	HITS-CLIP	23313552
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT509263	hsa-miR-4501	HITS-CLIP	23313552
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT520869	hsa-miR-624-3p	HITS-CLIP	23313552
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT509263	hsa-miR-4501	HITS-CLIP	23824327
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT509263	hsa-miR-4501	HITS-CLIP	23824327
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509263	hsa-miR-4501	PAR-CLIP	20371350
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509263	hsa-miR-4501	PAR-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509263	hsa-miR-4501	PAR-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT520869	hsa-miR-624-3p	PAR-CLIP	23446348
MIRT520868	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509263	hsa-miR-4501	PAR-CLIP	23446348
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509263	hsa-miR-4501	PAR-CLIP	23446348
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT520869	hsa-miR-624-3p	HITS-CLIP	21572407
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509263	hsa-miR-4501	HITS-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520869	hsa-miR-624-3p	HITS-CLIP	21572407
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509263	hsa-miR-4501	HITS-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520869	hsa-miR-624-3p	HITS-CLIP	23313552
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT509263	hsa-miR-4501	HITS-CLIP	23313552
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT520869	hsa-miR-624-3p	HITS-CLIP	23313552
MIRT520868	hsa-miR-5580-3p	HITS-CLIP	23313552
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT509263	hsa-miR-4501	HITS-CLIP	23824327
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT509261	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT509264	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT509263	hsa-miR-4501	HITS-CLIP	23824327
MIRT509262	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509263	hsa-miR-4501	PAR-CLIP	20371350
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509263	hsa-miR-4501	PAR-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509263	hsa-miR-4501	PAR-CLIP	21572407
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT520869	hsa-miR-624-3p	PAR-CLIP	23446348
MIRT520868	hsa-miR-5580-3p	PAR-CLIP	23446348
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509263	hsa-miR-4501	PAR-CLIP	23446348
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509264	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509263	hsa-miR-4501	PAR-CLIP	23446348
MIRT509262	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509261	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT756463	hsa-miR-369-3p	Luciferase reporter assay	38703377
MIRT1402277	hsa-miR-3198	CLIP-seq
MIRT1402278	hsa-miR-4309	CLIP-seq
MIRT1402279	hsa-miR-4653-3p	CLIP-seq
MIRT1402280	hsa-miR-4666-5p	CLIP-seq
MIRT2342677	hsa-miR-124	CLIP-seq
MIRT2342678	hsa-miR-3714	CLIP-seq
MIRT2342679	hsa-miR-3910	CLIP-seq
MIRT2342680	hsa-miR-506	CLIP-seq

Gene ontology (GO) Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002001	Process	Renin secretion into blood stream	IEA
GO:0002281	Process	Macrophage activation involved in immune response	IEA
GO:0004930	Function	G protein-coupled receptor activity	IDA	18820681, 23770096, 34133934
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	15141213
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	18820681, 23770096, 34133934
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0050921	Process	Positive regulation of chemotaxis	IEA
GO:0051592	Process	Response to calcium ion	IEA
GO:0060177	Process	Regulation of angiotensin metabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097009	Process	Energy homeostasis	IEA
GO:0097009	Process	Energy homeostasis	ISS
GO:0097009	Process	Energy homeostasis	ISS

Other IDs

• MIM: 606381
• HGNC: 4542
• e!Ensembl: ENSG00000198829

Protein

• UniProt ID: Q9BXA5
• Protein name: Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)
• Protein function: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, PubMed:23770096, PubMed:34133934). Succinate
• PDB: 8JPN , 8JPP , 8WOG , 8WP1 , 8YKV , 8YKW , 8YKX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	40 → 295	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in kidney (PubMed:11273702). Highly expressed in immature dendritic cells, expression rapidly downregulates after maturation. Also expressed in macrophages (PubMed:18820681). {ECO:0000269|PubMed:11273702, ECO:000
• Sequence:

  MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNI
  YLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDR
  YLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGD
  PNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVI
  FSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGD
  HFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK

• Sequence length: 334

Pathways

KEGG Pathway	Reactome Pathway
cAMP signaling pathway	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events

Related Genes

Sort by: Blended Diseases Pathways Evidence source

HCAR2 3 shared pathwayscAMP signaling pathway, G alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors) Related via 3 shared pathways including cAMP signaling pathway, G alpha (i) signalling events. CNR2 2 shared pathwaysG alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors) Related via 2 shared pathways including G alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors). GPR183 2 shared pathwaysG alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors) Related via 2 shared pathways including G alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors). OXGR1 2 shared pathwaysG alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors) Related via 2 shared pathways including G alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors). GPR18 2 shared pathwaysG alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors) Related via 2 shared pathways including G alpha (i) signalling events, Class A/1 (Rhodopsin-like receptors).

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
HCAR2	0	[]	3	["cAMP signaling pathway","G alpha (i) signalling events","Class A\/1 (Rhodopsin-like receptors)"]	0	[]
CNR2	0	[]	2	["G alpha (i) signalling events","Class A\/1 (Rhodopsin-like receptors)"]	0	[]
GPR183	0	[]	2	["G alpha (i) signalling events","Class A\/1 (Rhodopsin-like receptors)"]	0	[]
OXGR1	0	[]	2	["G alpha (i) signalling events","Class A\/1 (Rhodopsin-like receptors)"]	0	[]
GPR18	0	[]	2	["G alpha (i) signalling events","Class A\/1 (Rhodopsin-like receptors)"]	0	[]

Diseases Linked via Similar Genes

Inflammatory bowel disease Linked via 3 of 5 related genesCNR2, GPR183, GPR18 Psoriasis Linked via 2 of 5 related genesHCAR2, GPR183 Schizophrenia Linked via 2 of 5 related genesHCAR2, CNR2 Crohn disease Linked via 2 of 5 related genesGPR183, GPR18 Ulcerative colitis Linked via 2 of 5 related genesGPR183, GPR18

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Inflammatory bowel disease	3	["CNR2","GPR183","GPR18"]
Psoriasis	2	["HCAR2","GPR183"]
Schizophrenia	2	["HCAR2","CNR2"]
Crohn disease	2	["GPR183","GPR18"]
Ulcerative colitis	2	["GPR183","GPR18"]