SSRP1 (structure specific recognition protein 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6749
• Gene name: Structure specific recognition protein 1
• Gene symbol: SSRP1
• Synonyms (NCBI Gene): FACT, FACT80, T160
• Chromosome: 11
• Chromosome location: 11q12.1
• Summary: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongatio

miRNA Show/Hide all (341)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050489	hsa-miR-20a-5p	CLASH	23622248
MIRT050408	hsa-miR-23a-3p	CLASH	23622248
MIRT050286	hsa-miR-25-3p	CLASH	23622248
MIRT046282	hsa-miR-23b-3p	CLASH	23622248
MIRT041569	hsa-miR-193b-3p	CLASH	23622248
MIRT040724	hsa-miR-92b-3p	CLASH	23622248
MIRT036046	hsa-miR-1301-3p	CLASH	23622248
MIRT052826	hsa-miR-3200-3p	CLASH	23622248
MIRT054451	hsa-miR-211-5p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	24039954
MIRT467002	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT467001	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT467000	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT466999	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT466998	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT466997	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT466996	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT466993	hsa-miR-922	PAR-CLIP	20371350
MIRT466992	hsa-miR-212-5p	PAR-CLIP	20371350
MIRT466991	hsa-miR-3189-3p	PAR-CLIP	20371350
MIRT466990	hsa-miR-4424	PAR-CLIP	20371350
MIRT466989	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT466988	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT466987	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT466986	hsa-miR-208a-3p	PAR-CLIP	20371350
MIRT466985	hsa-miR-208b-3p	PAR-CLIP	20371350
MIRT466984	hsa-miR-499a-5p	PAR-CLIP	20371350
MIRT466983	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT467002	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT467001	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT467000	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT466999	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT466998	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT466997	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT466996	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT466995	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT466994	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT466993	hsa-miR-922	PAR-CLIP	23592263
MIRT466992	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT466991	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT466990	hsa-miR-4424	PAR-CLIP	23592263
MIRT466989	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT466988	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT466987	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT466986	hsa-miR-208a-3p	PAR-CLIP	23592263
MIRT466985	hsa-miR-208b-3p	PAR-CLIP	23592263
MIRT466984	hsa-miR-499a-5p	PAR-CLIP	23592263
MIRT466983	hsa-miR-450a-1-3p	PAR-CLIP	23592263
MIRT467002	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT467001	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT467000	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT466999	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT466997	hsa-miR-497-5p	Luciferase reporter assay, qRT-PCR, Western blot	26755331
MIRT466997	hsa-miR-497-5p	Luciferase reporter assay, qRT-PCR, Western blot	26755331
MIRT466997	hsa-miR-497-5p	Luciferase reporter assay, qRT-PCR, Western blot	26755331
MIRT466997	hsa-miR-497-5p	Luciferase reporter assay, qRT-PCR, Western blot	26755331
MIRT467002	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT467001	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT467000	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT466999	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT466998	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT466997	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT466996	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT466993	hsa-miR-922	PAR-CLIP	20371350
MIRT466992	hsa-miR-212-5p	PAR-CLIP	20371350
MIRT466991	hsa-miR-3189-3p	PAR-CLIP	20371350
MIRT466990	hsa-miR-4424	PAR-CLIP	20371350
MIRT466989	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT466988	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT466987	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT466986	hsa-miR-208a-3p	PAR-CLIP	20371350
MIRT466985	hsa-miR-208b-3p	PAR-CLIP	20371350
MIRT466984	hsa-miR-499a-5p	PAR-CLIP	20371350
MIRT466983	hsa-miR-450a-1-3p	PAR-CLIP	20371350
MIRT467002	hsa-miR-15a-5p	PAR-CLIP	23592263
MIRT467001	hsa-miR-15b-5p	PAR-CLIP	23592263
MIRT467000	hsa-miR-16-5p	PAR-CLIP	23592263
MIRT466999	hsa-miR-195-5p	PAR-CLIP	23592263
MIRT466998	hsa-miR-424-5p	PAR-CLIP	23592263
MIRT466997	hsa-miR-497-5p	PAR-CLIP	23592263
MIRT466996	hsa-miR-6838-5p	PAR-CLIP	23592263
MIRT466995	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT466994	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT466993	hsa-miR-922	PAR-CLIP	23592263
MIRT466992	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT466991	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT466990	hsa-miR-4424	PAR-CLIP	23592263
MIRT466989	hsa-miR-6828-5p	PAR-CLIP	23592263
MIRT466988	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT466987	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT466986	hsa-miR-208a-3p	PAR-CLIP	23592263
MIRT466985	hsa-miR-208b-3p	PAR-CLIP	23592263
MIRT466984	hsa-miR-499a-5p	PAR-CLIP	23592263
MIRT466983	hsa-miR-450a-1-3p	PAR-CLIP	23592263
MIRT755875	hsa-miR-204-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35474446
MIRT054451	hsa-miR-211-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35474446
MIRT756044	hsa-miR-708-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35866896
MIRT1392776	hsa-miR-15a	CLIP-seq
MIRT1392777	hsa-miR-15b	CLIP-seq
MIRT1392778	hsa-miR-16	CLIP-seq
MIRT1392779	hsa-miR-195	CLIP-seq
MIRT1392780	hsa-miR-208a	CLIP-seq
MIRT1392781	hsa-miR-208b	CLIP-seq
MIRT1392782	hsa-miR-28-5p	CLIP-seq
MIRT1392783	hsa-miR-3139	CLIP-seq
MIRT1392784	hsa-miR-3176	CLIP-seq
MIRT1392785	hsa-miR-3646	CLIP-seq
MIRT1392786	hsa-miR-3662	CLIP-seq
MIRT1392787	hsa-miR-3922-3p	CLIP-seq
MIRT1392788	hsa-miR-424	CLIP-seq
MIRT1392789	hsa-miR-4438	CLIP-seq
MIRT1392790	hsa-miR-4633-3p	CLIP-seq
MIRT1392791	hsa-miR-4650-5p	CLIP-seq
MIRT1392792	hsa-miR-4698	CLIP-seq
MIRT1392793	hsa-miR-4726-3p	CLIP-seq
MIRT1392794	hsa-miR-4747-3p	CLIP-seq
MIRT1392795	hsa-miR-4757-5p	CLIP-seq
MIRT1392796	hsa-miR-497	CLIP-seq
MIRT1392797	hsa-miR-499-5p	CLIP-seq
MIRT1392798	hsa-miR-500b	CLIP-seq
MIRT1392799	hsa-miR-5095	CLIP-seq
MIRT1392800	hsa-miR-548v	CLIP-seq
MIRT1392801	hsa-miR-708	CLIP-seq
MIRT2117871	hsa-miR-1288	CLIP-seq
MIRT1392776	hsa-miR-15a	CLIP-seq
MIRT1392777	hsa-miR-15b	CLIP-seq
MIRT1392778	hsa-miR-16	CLIP-seq
MIRT1392779	hsa-miR-195	CLIP-seq
MIRT2117872	hsa-miR-217	CLIP-seq
MIRT2117873	hsa-miR-221	CLIP-seq
MIRT2117874	hsa-miR-222	CLIP-seq
MIRT2117875	hsa-miR-223	CLIP-seq
MIRT2117876	hsa-miR-3150b-3p	CLIP-seq
MIRT2117877	hsa-miR-3157-3p	CLIP-seq
MIRT2117878	hsa-miR-3199	CLIP-seq
MIRT2117879	hsa-miR-3974	CLIP-seq
MIRT1392788	hsa-miR-424	CLIP-seq
MIRT2117880	hsa-miR-4277	CLIP-seq
MIRT2117881	hsa-miR-433	CLIP-seq
MIRT2117882	hsa-miR-4436a	CLIP-seq
MIRT2117883	hsa-miR-4685-5p	CLIP-seq
MIRT2117884	hsa-miR-4689	CLIP-seq
MIRT2117885	hsa-miR-4700-3p	CLIP-seq
MIRT2117886	hsa-miR-4784	CLIP-seq
MIRT1392796	hsa-miR-497	CLIP-seq
MIRT2117887	hsa-miR-646	CLIP-seq
MIRT2339804	hsa-miR-1224-3p	CLIP-seq
MIRT2339805	hsa-miR-1245b-3p	CLIP-seq
MIRT2339806	hsa-miR-1253	CLIP-seq
MIRT2339807	hsa-miR-1260	CLIP-seq
MIRT2339808	hsa-miR-1260b	CLIP-seq
MIRT2339809	hsa-miR-1280	CLIP-seq
MIRT2339810	hsa-miR-1293	CLIP-seq
MIRT2339811	hsa-miR-146b-3p	CLIP-seq
MIRT1392776	hsa-miR-15a	CLIP-seq
MIRT1392777	hsa-miR-15b	CLIP-seq
MIRT1392778	hsa-miR-16	CLIP-seq
MIRT2339812	hsa-miR-183	CLIP-seq
MIRT1392779	hsa-miR-195	CLIP-seq
MIRT2339813	hsa-miR-204	CLIP-seq
MIRT1392780	hsa-miR-208a	CLIP-seq
MIRT1392781	hsa-miR-208b	CLIP-seq
MIRT2339814	hsa-miR-211	CLIP-seq
MIRT2117875	hsa-miR-223	CLIP-seq
MIRT2339815	hsa-miR-3115	CLIP-seq
MIRT2339816	hsa-miR-3150a-3p	CLIP-seq
MIRT2117877	hsa-miR-3157-3p	CLIP-seq
MIRT2339817	hsa-miR-3173-5p	CLIP-seq
MIRT2339818	hsa-miR-3175	CLIP-seq
MIRT2339819	hsa-miR-329	CLIP-seq
MIRT2339820	hsa-miR-33a	CLIP-seq
MIRT2339821	hsa-miR-33b	CLIP-seq
MIRT2339822	hsa-miR-362-3p	CLIP-seq
MIRT2339823	hsa-miR-3675-3p	CLIP-seq
MIRT2339824	hsa-miR-3941	CLIP-seq
MIRT2339825	hsa-miR-3942-3p	CLIP-seq
MIRT1392788	hsa-miR-424	CLIP-seq
MIRT2117880	hsa-miR-4277	CLIP-seq
MIRT2339826	hsa-miR-4317	CLIP-seq
MIRT2339827	hsa-miR-4477a	CLIP-seq
MIRT2339828	hsa-miR-4483	CLIP-seq
MIRT2339829	hsa-miR-4755-5p	CLIP-seq
MIRT2339830	hsa-miR-4768-3p	CLIP-seq
MIRT2339831	hsa-miR-4785	CLIP-seq
MIRT2339832	hsa-miR-4787-5p	CLIP-seq
MIRT2339833	hsa-miR-491-5p	CLIP-seq
MIRT1392796	hsa-miR-497	CLIP-seq
MIRT1392797	hsa-miR-499-5p	CLIP-seq
MIRT1392798	hsa-miR-500b	CLIP-seq
MIRT2339834	hsa-miR-532-3p	CLIP-seq
MIRT2339835	hsa-miR-603	CLIP-seq
MIRT2339836	hsa-miR-623	CLIP-seq
MIRT2339837	hsa-miR-874	CLIP-seq
MIRT2339838	hsa-miR-939	CLIP-seq
MIRT2633739	hsa-miR-1185	CLIP-seq
MIRT2339805	hsa-miR-1245b-3p	CLIP-seq
MIRT2339806	hsa-miR-1253	CLIP-seq
MIRT2633740	hsa-miR-1263	CLIP-seq
MIRT2117871	hsa-miR-1288	CLIP-seq
MIRT2339810	hsa-miR-1293	CLIP-seq
MIRT2633741	hsa-miR-1468	CLIP-seq
MIRT2339811	hsa-miR-146b-3p	CLIP-seq
MIRT1392776	hsa-miR-15a	CLIP-seq
MIRT1392777	hsa-miR-15b	CLIP-seq
MIRT1392778	hsa-miR-16	CLIP-seq
MIRT2339812	hsa-miR-183	CLIP-seq
MIRT1392779	hsa-miR-195	CLIP-seq
MIRT2117872	hsa-miR-217	CLIP-seq
MIRT2117873	hsa-miR-221	CLIP-seq
MIRT2117874	hsa-miR-222	CLIP-seq
MIRT2339815	hsa-miR-3115	CLIP-seq
MIRT2339816	hsa-miR-3150a-3p	CLIP-seq
MIRT2117876	hsa-miR-3150b-3p	CLIP-seq
MIRT2633742	hsa-miR-3153	CLIP-seq
MIRT2117877	hsa-miR-3157-3p	CLIP-seq
MIRT2339817	hsa-miR-3173-5p	CLIP-seq
MIRT2339818	hsa-miR-3175	CLIP-seq
MIRT2117878	hsa-miR-3199	CLIP-seq
MIRT2339819	hsa-miR-329	CLIP-seq
MIRT2633743	hsa-miR-338-3p	CLIP-seq
MIRT2339820	hsa-miR-33a	CLIP-seq
MIRT2339821	hsa-miR-33b	CLIP-seq
MIRT2633744	hsa-miR-3605-5p	CLIP-seq
MIRT2339822	hsa-miR-362-3p	CLIP-seq
MIRT2633745	hsa-miR-3667-3p	CLIP-seq
MIRT2633746	hsa-miR-3679-5p	CLIP-seq
MIRT2633747	hsa-miR-3925-5p	CLIP-seq
MIRT2339824	hsa-miR-3941	CLIP-seq
MIRT2339825	hsa-miR-3942-3p	CLIP-seq
MIRT2117879	hsa-miR-3974	CLIP-seq
MIRT1392788	hsa-miR-424	CLIP-seq
MIRT2633748	hsa-miR-4311	CLIP-seq
MIRT2339826	hsa-miR-4317	CLIP-seq
MIRT2117881	hsa-miR-433	CLIP-seq
MIRT2633749	hsa-miR-4426	CLIP-seq
MIRT2117882	hsa-miR-4436a	CLIP-seq
MIRT2633750	hsa-miR-4455	CLIP-seq
MIRT2339828	hsa-miR-4483	CLIP-seq
MIRT2633751	hsa-miR-4530	CLIP-seq
MIRT2633752	hsa-miR-4647	CLIP-seq
MIRT2633753	hsa-miR-4662b	CLIP-seq
MIRT2117883	hsa-miR-4685-5p	CLIP-seq
MIRT2117884	hsa-miR-4689	CLIP-seq
MIRT2633754	hsa-miR-4691-5p	CLIP-seq
MIRT2117885	hsa-miR-4700-3p	CLIP-seq
MIRT2633755	hsa-miR-4738-3p	CLIP-seq
MIRT2339830	hsa-miR-4768-3p	CLIP-seq
MIRT2117886	hsa-miR-4784	CLIP-seq
MIRT2339831	hsa-miR-4785	CLIP-seq
MIRT2339832	hsa-miR-4787-5p	CLIP-seq
MIRT2339833	hsa-miR-491-5p	CLIP-seq
MIRT1392796	hsa-miR-497	CLIP-seq
MIRT2633756	hsa-miR-548a-5p	CLIP-seq
MIRT2633757	hsa-miR-548ab	CLIP-seq
MIRT2633758	hsa-miR-548ak	CLIP-seq
MIRT2633759	hsa-miR-548b-5p	CLIP-seq
MIRT2633760	hsa-miR-548c-5p	CLIP-seq
MIRT2633761	hsa-miR-548d-5p	CLIP-seq
MIRT2633762	hsa-miR-548h	CLIP-seq
MIRT2633763	hsa-miR-548i	CLIP-seq
MIRT2633764	hsa-miR-548j	CLIP-seq
MIRT2633765	hsa-miR-548w	CLIP-seq
MIRT2633766	hsa-miR-548y	CLIP-seq
MIRT2633767	hsa-miR-559	CLIP-seq
MIRT2633768	hsa-miR-582-3p	CLIP-seq
MIRT2633769	hsa-miR-589	CLIP-seq
MIRT2339835	hsa-miR-603	CLIP-seq
MIRT2117887	hsa-miR-646	CLIP-seq
MIRT2633770	hsa-miR-766	CLIP-seq
MIRT2339837	hsa-miR-874	CLIP-seq
MIRT2633771	hsa-miR-891b	CLIP-seq
MIRT2339838	hsa-miR-939	CLIP-seq
MIRT2633739	hsa-miR-1185	CLIP-seq
MIRT2339805	hsa-miR-1245b-3p	CLIP-seq
MIRT2339806	hsa-miR-1253	CLIP-seq
MIRT2633740	hsa-miR-1263	CLIP-seq
MIRT2117871	hsa-miR-1288	CLIP-seq
MIRT2339810	hsa-miR-1293	CLIP-seq
MIRT1392776	hsa-miR-15a	CLIP-seq
MIRT1392777	hsa-miR-15b	CLIP-seq
MIRT1392778	hsa-miR-16	CLIP-seq
MIRT2339812	hsa-miR-183	CLIP-seq
MIRT1392779	hsa-miR-195	CLIP-seq
MIRT2117872	hsa-miR-217	CLIP-seq
MIRT2117873	hsa-miR-221	CLIP-seq
MIRT2117874	hsa-miR-222	CLIP-seq
MIRT2339815	hsa-miR-3115	CLIP-seq
MIRT2339816	hsa-miR-3150a-3p	CLIP-seq
MIRT2117876	hsa-miR-3150b-3p	CLIP-seq
MIRT2633742	hsa-miR-3153	CLIP-seq
MIRT2117877	hsa-miR-3157-3p	CLIP-seq
MIRT2339818	hsa-miR-3175	CLIP-seq
MIRT2117878	hsa-miR-3199	CLIP-seq
MIRT2339819	hsa-miR-329	CLIP-seq
MIRT2633743	hsa-miR-338-3p	CLIP-seq
MIRT2339820	hsa-miR-33a	CLIP-seq
MIRT2339821	hsa-miR-33b	CLIP-seq
MIRT2633744	hsa-miR-3605-5p	CLIP-seq
MIRT2339822	hsa-miR-362-3p	CLIP-seq
MIRT2633746	hsa-miR-3679-5p	CLIP-seq
MIRT2339824	hsa-miR-3941	CLIP-seq
MIRT2339825	hsa-miR-3942-3p	CLIP-seq
MIRT2117879	hsa-miR-3974	CLIP-seq
MIRT1392788	hsa-miR-424	CLIP-seq
MIRT2339826	hsa-miR-4317	CLIP-seq
MIRT2117881	hsa-miR-433	CLIP-seq
MIRT2633749	hsa-miR-4426	CLIP-seq
MIRT2117882	hsa-miR-4436a	CLIP-seq
MIRT2633750	hsa-miR-4455	CLIP-seq
MIRT2339828	hsa-miR-4483	CLIP-seq
MIRT2633751	hsa-miR-4530	CLIP-seq
MIRT2633752	hsa-miR-4647	CLIP-seq
MIRT2633753	hsa-miR-4662b	CLIP-seq
MIRT2117883	hsa-miR-4685-5p	CLIP-seq
MIRT2117884	hsa-miR-4689	CLIP-seq
MIRT2117885	hsa-miR-4700-3p	CLIP-seq
MIRT2633755	hsa-miR-4738-3p	CLIP-seq
MIRT2339830	hsa-miR-4768-3p	CLIP-seq
MIRT2117886	hsa-miR-4784	CLIP-seq
MIRT2339831	hsa-miR-4785	CLIP-seq
MIRT2339832	hsa-miR-4787-5p	CLIP-seq
MIRT2339833	hsa-miR-491-5p	CLIP-seq
MIRT1392796	hsa-miR-497	CLIP-seq
MIRT2633756	hsa-miR-548a-5p	CLIP-seq
MIRT2633757	hsa-miR-548ab	CLIP-seq
MIRT2633758	hsa-miR-548ak	CLIP-seq
MIRT2633759	hsa-miR-548b-5p	CLIP-seq
MIRT2633760	hsa-miR-548c-5p	CLIP-seq
MIRT2633761	hsa-miR-548d-5p	CLIP-seq
MIRT2633762	hsa-miR-548h	CLIP-seq
MIRT2633763	hsa-miR-548i	CLIP-seq
MIRT2633764	hsa-miR-548j	CLIP-seq
MIRT2633765	hsa-miR-548w	CLIP-seq
MIRT2633766	hsa-miR-548y	CLIP-seq
MIRT2633767	hsa-miR-559	CLIP-seq
MIRT2633768	hsa-miR-582-3p	CLIP-seq
MIRT2339835	hsa-miR-603	CLIP-seq
MIRT2117887	hsa-miR-646	CLIP-seq
MIRT2633770	hsa-miR-766	CLIP-seq
MIRT2339837	hsa-miR-874	CLIP-seq
MIRT2633771	hsa-miR-891b	CLIP-seq
MIRT2339838	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	1372440
GO:0003682	Function	Chromatin binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16902406, 19214185, 19836239, 22113938, 24981860, 25852190, 28514442, 30021884, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	9489704
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006334	Process	Nucleosome assembly	NAS	21362547
GO:0006337	Process	Nucleosome disassembly	IDA	16902406
GO:0006974	Process	DNA damage response	IEA
GO:0031491	Function	Nucleosome binding	IBA
GO:0035101	Component	FACT complex	IBA
GO:0035101	Component	FACT complex	IPI	16902406
GO:0042393	Function	Histone binding	IBA
GO:1902275	Process	Regulation of chromatin organization	IBA
GO:1902275	Process	Regulation of chromatin organization	IDA	27467129

Other IDs

• MIM: 604328
• HGNC: 11327
• e!Ensembl: ENSG00000149136

Protein

• UniProt ID: Q08945
• Protein name: FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recomb
• Protein function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During tran
• PDB: 4IFS , 5UMR , 5UMS , 5VWE , 6L1E , 6L1R , 6L34 , 6UPK , 6UPL , 9EH2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00505	HMG_box	547 → 615	HMG (high mobility group) box	Domain
  PF03531	SSrecog	106 → 170	Structure-specific recognition protein (SSRP1)	Domain
  PF08512	Rtt106	339 → 427	Histone chaperone Rttp106-like	Domain
  PF17292	POB3_N	5 → 99	POB3-like N-terminal PH domain	Domain

• Sequence:

  MAETLEFNDVYQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELTEGIWRRVALGH
  GLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGQLLS
  FDIGDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSLMEVRFYVPPTQEDGVDPVEA
  FAQNVLSKADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVL
  RLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLNMNEEEVEKRFEG
  RLTKNMSGSLYEMVSRVMKALVNRKITVPGNFQGHSGAQCITCSYKASSGLLYPLERGFI
  YVHKPPVHIRFDEISFVNFARGTTTTRSFDFEIETKQGTQYTFSSIEREEYGKLFDFVNA
  KKLNIKNRGLKEGMNPSYDEYADSDEDQHDAYLERMKEEGKIREENANDSSDDSGEETDE
  SFNPGEEEEDVAEEFDSNASASSSSNEGDSDRDEKKRKQLKKAKMAKDRKSRKKPVEVKK
  GKDPNAPKRPMSAYMLWLNASREKIKSDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKA
  EDARRDYEKAMKEYEGGRGESSKRDKSKKKKKVKVKMEKKSTPSRGSSSKSSSRQLSESF
  KSKEFVSSDESSSGENKSKKKRRRSEDSEEEELASTPPSSEDSASGSDE

• Sequence length: 709

Pathways

Reactome Pathway

Formation of RNA Pol II elongation complex

RNA Polymerase II Pre-transcription Events

TP53 Regulates Transcription of DNA Repair Genes

Regulation of TP53 Activity through Phosphorylation

RNA Polymerase II Transcription Elongation

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SUPT16H 5 shared pathwaysFormation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation, Regulation of TP53 Activity through Phosphorylation Related via 5 shared pathways including Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events. ELOA3D 4 shared pathwaysFormation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation Related via 4 shared pathways including Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events. ELOA3 4 shared pathwaysFormation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation Related via 4 shared pathways including Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events. ELOA2 4 shared pathwaysFormation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation Related via 4 shared pathways including Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events. ELOA 4 shared pathwaysFormation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events, TP53 Regulates Transcription of DNA Repair Genes, RNA Polymerase II Transcription Elongation Related via 4 shared pathways including Formation of RNA Pol II elongation complex , RNA Polymerase II Pre-transcription Events.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SUPT16H	0	[]	5	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Regulation of TP53 Activity through Phosphorylation"]	0	[]
ELOA3D	0	[]	4	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation"]	0	[]
ELOA3	0	[]	4	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation"]	0	[]
ELOA2	0	[]	4	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation"]	0	[]
ELOA	0	[]	4	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation"]	0	[]

Diseases Linked via Similar Genes

14q11.2 microduplication syndrome Linked via 1 of 5 related genesSUPT16H Neurodevelopmental disorder Linked via 1 of 5 related genesSUPT16H Conotruncal cardiac defect Linked via 1 of 5 related genesSUPT16H Dextrocardia Linked via 1 of 5 related genesSUPT16H Non-specific syndromic intellectual disability Linked via 1 of 5 related genesSUPT16H

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
14q11.2 microduplication syndrome	1	["SUPT16H"]
Neurodevelopmental disorder	1	["SUPT16H"]
Conotruncal cardiac defect	1	["SUPT16H"]
Dextrocardia	1	["SUPT16H"]
Non-specific syndromic intellectual disability	1	["SUPT16H"]