Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	399694
Gene name	SHC adaptor protein 4
Gene symbol	SHC4
Synonyms (NCBI Gene)	RaLPSHCD
Chromosome	15
Chromosome location	15q21.1

159 Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017379	hsa-miR-335-5p	Microarray	18185580
MIRT504427	hsa-miR-543	PAR-CLIP	20371350
MIRT504425	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT504426	hsa-miR-3143	PAR-CLIP	20371350
MIRT504424	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT504423	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT504422	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT504421	hsa-miR-552-5p	PAR-CLIP	20371350
MIRT504427	hsa-miR-543	PAR-CLIP	21572407
MIRT504425	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT504426	hsa-miR-3143	PAR-CLIP	21572407
MIRT504424	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT504423	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT504422	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT504421	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT504427	hsa-miR-543	PAR-CLIP	23446348
MIRT504425	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT504426	hsa-miR-3143	PAR-CLIP	23446348
MIRT504424	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT504423	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT504422	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT504421	hsa-miR-552-5p	PAR-CLIP	23446348
MIRT734551	hsa-miR-26a-5p	Luciferase reporter assayMicroarray	32494663
MIRT504427	hsa-miR-543	PAR-CLIP	20371350
MIRT504425	hsa-miR-6499-3p	PAR-CLIP	20371350
MIRT504426	hsa-miR-3143	PAR-CLIP	20371350
MIRT504424	hsa-miR-455-3p	PAR-CLIP	20371350
MIRT504423	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT504422	hsa-miR-6516-5p	PAR-CLIP	20371350
MIRT504421	hsa-miR-552-5p	PAR-CLIP	20371350
MIRT504427	hsa-miR-543	PAR-CLIP	21572407
MIRT504425	hsa-miR-6499-3p	PAR-CLIP	21572407
MIRT504426	hsa-miR-3143	PAR-CLIP	21572407
MIRT504424	hsa-miR-455-3p	PAR-CLIP	21572407
MIRT504423	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT504422	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT504421	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT504427	hsa-miR-543	PAR-CLIP	23446348
MIRT504425	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT504426	hsa-miR-3143	PAR-CLIP	23446348
MIRT504424	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT504423	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT504422	hsa-miR-6516-5p	PAR-CLIP	23446348
MIRT504421	hsa-miR-552-5p	PAR-CLIP	23446348
MIRT755930	hsa-miR-142-5p	Western blottingqRT-PCRin vitro cullelar assays	35194440
MIRT1346638	hsa-miR-1283	CLIP-seq
MIRT1346639	hsa-miR-1284	CLIP-seq
MIRT1346640	hsa-miR-1303	CLIP-seq
MIRT1346641	hsa-miR-1973	CLIP-seq
MIRT1346642	hsa-miR-218	CLIP-seq
MIRT1346643	hsa-miR-3119	CLIP-seq
MIRT1346644	hsa-miR-3140-3p	CLIP-seq
MIRT1346645	hsa-miR-3170	CLIP-seq
MIRT1346646	hsa-miR-3609	CLIP-seq
MIRT1346647	hsa-miR-3657	CLIP-seq
MIRT1346648	hsa-miR-3677-5p	CLIP-seq
MIRT1346649	hsa-miR-374c	CLIP-seq
MIRT1346650	hsa-miR-3913-3p	CLIP-seq
MIRT1346651	hsa-miR-3920	CLIP-seq
MIRT1346652	hsa-miR-4453	CLIP-seq
MIRT1346653	hsa-miR-4460	CLIP-seq
MIRT1346654	hsa-miR-4538	CLIP-seq
MIRT1346655	hsa-miR-4669	CLIP-seq
MIRT1346656	hsa-miR-4698	CLIP-seq
MIRT1346657	hsa-miR-4716-5p	CLIP-seq
MIRT1346658	hsa-miR-4724-3p	CLIP-seq
MIRT1346659	hsa-miR-4727-3p	CLIP-seq
MIRT1346660	hsa-miR-4762-3p	CLIP-seq
MIRT1346661	hsa-miR-4766-3p	CLIP-seq
MIRT1346662	hsa-miR-4775	CLIP-seq
MIRT1346663	hsa-miR-489	CLIP-seq
MIRT1346664	hsa-miR-517b	CLIP-seq
MIRT1346665	hsa-miR-548a-3p	CLIP-seq
MIRT1346666	hsa-miR-548ah	CLIP-seq
MIRT1346667	hsa-miR-548e	CLIP-seq
MIRT1346668	hsa-miR-548f	CLIP-seq
MIRT1346669	hsa-miR-548p	CLIP-seq
MIRT1346670	hsa-miR-548t	CLIP-seq
MIRT1346671	hsa-miR-561	CLIP-seq
MIRT1346672	hsa-miR-578	CLIP-seq
MIRT1346673	hsa-miR-579	CLIP-seq
MIRT1346674	hsa-miR-590-3p	CLIP-seq
MIRT1346675	hsa-miR-592	CLIP-seq
MIRT1346676	hsa-miR-599	CLIP-seq
MIRT1346677	hsa-miR-636	CLIP-seq
MIRT1346678	hsa-miR-655	CLIP-seq
MIRT1346679	hsa-miR-676	CLIP-seq
MIRT2102582	hsa-miR-200b	CLIP-seq
MIRT2102583	hsa-miR-200c	CLIP-seq
MIRT1346649	hsa-miR-374c	CLIP-seq
MIRT2102584	hsa-miR-429	CLIP-seq
MIRT2102585	hsa-miR-4436b-5p	CLIP-seq
MIRT2102586	hsa-miR-4536	CLIP-seq
MIRT2102587	hsa-miR-4711-3p	CLIP-seq
MIRT1346678	hsa-miR-655	CLIP-seq
MIRT2102588	hsa-miR-892a	CLIP-seq
MIRT2102582	hsa-miR-200b	CLIP-seq
MIRT2102583	hsa-miR-200c	CLIP-seq
MIRT2327052	hsa-miR-329	CLIP-seq
MIRT2327053	hsa-miR-362-3p	CLIP-seq
MIRT2327054	hsa-miR-3664-5p	CLIP-seq
MIRT1346649	hsa-miR-374c	CLIP-seq
MIRT2327055	hsa-miR-3941	CLIP-seq
MIRT2102584	hsa-miR-429	CLIP-seq
MIRT2102585	hsa-miR-4436b-5p	CLIP-seq
MIRT2327056	hsa-miR-4714-5p	CLIP-seq
MIRT2327057	hsa-miR-603	CLIP-seq
MIRT1346678	hsa-miR-655	CLIP-seq
MIRT2327058	hsa-miR-767-3p	CLIP-seq
MIRT2622399	hsa-miR-1297	CLIP-seq
MIRT2622400	hsa-miR-1298	CLIP-seq
MIRT755930	hsa-miR-142-5p	CLIP-seq
MIRT2622401	hsa-miR-2054	CLIP-seq
MIRT2622402	hsa-miR-26a	CLIP-seq
MIRT2622403	hsa-miR-26b	CLIP-seq
MIRT2622404	hsa-miR-3149	CLIP-seq
MIRT2622405	hsa-miR-3189-5p	CLIP-seq
MIRT2622406	hsa-miR-380	CLIP-seq
MIRT2622407	hsa-miR-382	CLIP-seq
MIRT2622408	hsa-miR-4317	CLIP-seq
MIRT2622409	hsa-miR-4465	CLIP-seq
MIRT2622410	hsa-miR-4530	CLIP-seq
MIRT2622411	hsa-miR-4680-5p	CLIP-seq
MIRT2622412	hsa-miR-4758-3p	CLIP-seq
MIRT2622413	hsa-miR-582-5p	CLIP-seq
MIRT2622414	hsa-miR-616	CLIP-seq
MIRT2622415	hsa-miR-873	CLIP-seq
MIRT2690708	hsa-miR-1279	CLIP-seq
MIRT2690709	hsa-miR-140-3p	CLIP-seq
MIRT2102582	hsa-miR-200b	CLIP-seq
MIRT2102583	hsa-miR-200c	CLIP-seq
MIRT2622401	hsa-miR-2054	CLIP-seq
MIRT2690710	hsa-miR-3120-5p	CLIP-seq
MIRT2622404	hsa-miR-3149	CLIP-seq
MIRT2690711	hsa-miR-3173-5p	CLIP-seq
MIRT2690712	hsa-miR-3194-3p	CLIP-seq
MIRT2327052	hsa-miR-329	CLIP-seq
MIRT2327053	hsa-miR-362-3p	CLIP-seq
MIRT2327054	hsa-miR-3664-5p	CLIP-seq
MIRT1346649	hsa-miR-374c	CLIP-seq
MIRT2622406	hsa-miR-380	CLIP-seq
MIRT2690713	hsa-miR-3921	CLIP-seq
MIRT2327055	hsa-miR-3941	CLIP-seq
MIRT2102584	hsa-miR-429	CLIP-seq
MIRT2622408	hsa-miR-4317	CLIP-seq
MIRT2690714	hsa-miR-4653-5p	CLIP-seq
MIRT2622411	hsa-miR-4680-5p	CLIP-seq
MIRT2327056	hsa-miR-4714-5p	CLIP-seq
MIRT2690715	hsa-miR-4786-5p	CLIP-seq
MIRT2690716	hsa-miR-548n	CLIP-seq
MIRT1346670	hsa-miR-548t	CLIP-seq
MIRT2622413	hsa-miR-582-5p	CLIP-seq
MIRT2690717	hsa-miR-593	CLIP-seq
MIRT2327057	hsa-miR-603	CLIP-seq
MIRT2622414	hsa-miR-616	CLIP-seq
MIRT1346678	hsa-miR-655	CLIP-seq
MIRT2327058	hsa-miR-767-3p	CLIP-seq
MIRT2690718	hsa-miR-769-5p	CLIP-seq
MIRT2622415	hsa-miR-873	CLIP-seq

15 Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24658140, 24728074, 31980649
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016020	Component	Membrane	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	IBA
GO:0030971	Function	Receptor tyrosine kinase binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0048863	Process	Stem cell differentiation	IEA

MIM	HGNC	e!Ensembl
617372	16743	ENSG00000185634

Q6S5L8

Protein name

SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)

Protein function

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	526 → 597	SH2 domain	Domain
PF00640	PID	192 → 348	Phosphotyrosine interaction domain (PTB/PID)	Domain

Tissue specificity

TISSUE SPECIFICITY: Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory comp

Sequence

MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH
FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN
QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPALLHSNK

Sequence length

630

Interactions

View interactions

KEGG Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
Phospholipase D signaling pathway
Focal adhesion
Natural killer cell mediated cytotoxicity
Neurotrophin signaling pathway
Insulin signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Relaxin signaling pathway
Growth hormone synthesis, secretion and action
Alcoholism
Bacterial invasion of epithelial cells
MicroRNAs in cancer
Glioma
Chronic myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (7)
BIPOLAR DISORDER	—	GWAS catalog	34099189	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EATING DISORDER	—	GWAS catalog	22911880	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	21621269, 29187746, 34099189	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	22911880	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	GWAS catalog	37033223	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	26198764, 34099189	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	37033223	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (12)
Bipolar Disorder	Bipolar Disorder	BEFREE	30149091, 30503783		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	30503783	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive disorder	Mental Depression	BEFREE	30149091		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Defects Congenital	Congenital heart defect	Pubtator	31819021	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	17409413		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	30149091		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	26139392	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28009146		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	36714595	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33316777	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	36683494	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
SHC3	[]	21	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
SHC2	[]	21	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
SOS2	[]	20	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
SHC1	[]	21	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
BRAF	[]	14	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Chemokine signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Alcoholism","Glioma","Chronic myeloid leukemia","Breast cancer"]	[]

SHC4 (SHC adaptor protein 4)

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