Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	25759
Gene name	SHC adaptor protein 2
Gene symbol	SHC2
Synonyms (NCBI Gene)	SCKSHCBSLI
Chromosome	19
Chromosome location	19p13.3

78 Show/Hide all (78)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050116	hsa-miR-26a-5p	CLASH	23622248
MIRT044976	hsa-miR-186-5p	CLASH	23622248
MIRT1346499	hsa-miR-125a-3p	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346501	hsa-miR-3125	CLIP-seq
MIRT1346502	hsa-miR-3619-3p	CLIP-seq
MIRT1346503	hsa-miR-3916	CLIP-seq
MIRT1346504	hsa-miR-3934	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346508	hsa-miR-4747-5p	CLIP-seq
MIRT1346509	hsa-miR-591	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346511	hsa-miR-671-5p	CLIP-seq
MIRT1346512	hsa-miR-764	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346502	hsa-miR-3619-3p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346509	hsa-miR-591	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT2102561	hsa-miR-1915	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT2102562	hsa-miR-3192	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT2327018	hsa-miR-4722-5p	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT2102561	hsa-miR-1915	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT2394449	hsa-miR-331-3p	CLIP-seq
MIRT2394450	hsa-miR-3667-3p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT2394451	hsa-miR-4726-3p	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq
MIRT1346500	hsa-miR-2467-5p	CLIP-seq
MIRT1346505	hsa-miR-4428	CLIP-seq
MIRT1346506	hsa-miR-4476	CLIP-seq
MIRT1346507	hsa-miR-4533	CLIP-seq
MIRT1346510	hsa-miR-658	CLIP-seq

6 Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16273093, 24728074
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0030971	Function	Receptor tyrosine kinase binding	IBA
GO:0035556	Process	Intracellular signal transduction	IEA

MIM	HGNC	e!Ensembl
605217	29869	ENSG00000129946

P98077

Protein name

SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)

Protein function

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	487 → 558	SH2 domain	Domain
PF00640	PID	153 → 308	Phosphotyrosine interaction domain (PTB/PID)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus. {ECO:0000269|PubMed:9507002}.

Sequence

MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA
DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA
AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR
EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ
VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL
RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT
QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL
DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE
QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV
VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP

Sequence length

582

Interactions

View interactions

KEGG Pathway	Reactome Pathway
EGFR tyrosine kinase inhibitor resistance	Signalling to RAS
Endocrine resistance	VEGFA-VEGFR2 Pathway
ErbB signaling pathway	RAF/MAP kinase cascade
Ras signaling pathway
Chemokine signaling pathway
Phospholipase D signaling pathway
VEGF signaling pathway
Focal adhesion
Natural killer cell mediated cytotoxicity
Neurotrophin signaling pathway
Insulin signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Relaxin signaling pathway
Growth hormone synthesis, secretion and action
Alcoholism
Bacterial invasion of epithelial cells
Glioma
Chronic myeloid leukemia
Breast cancer
Hepatocellular carcinoma
Gastric cancer

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
SHC3	[]	23	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
SHC4	[]	21	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
SHC1	[]	23	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
SOS2	[]	20	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway","Prolactin signaling pathway"]	[]
RAF1	[]	21	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","Phospholipase D signaling pathway","VEGF signaling pathway","Focal adhesion","Natural killer cell mediated cytotoxicity","Neurotrophin signaling pathway","Insulin signaling pathway","Estrogen signaling pathway"]	[]

SHC2 (SHC adaptor protein 2)

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