RASA4 (RAS p21 protein activator 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10156
• Gene name: RAS p21 protein activator 4
• Gene symbol: RASA4
• Synonyms (NCBI Gene): CAPRI, GAPL
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this prote

miRNA Show/Hide all (189)

miRTarBase ID	miRNA	Experiments	Reference
MIRT649639	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649640	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT649639	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649638	hsa-miR-5193	HITS-CLIP	23824327
MIRT649637	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT649636	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT649635	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT649634	hsa-miR-8089	HITS-CLIP	23824327
MIRT649633	hsa-miR-637	HITS-CLIP	23824327
MIRT649632	hsa-miR-7155-5p	HITS-CLIP	23824327
MIRT649631	hsa-miR-4314	HITS-CLIP	23824327
MIRT439815	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439815	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT649639	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649640	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT649639	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649638	hsa-miR-5193	HITS-CLIP	23824327
MIRT649637	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT649636	hsa-miR-4667-5p	HITS-CLIP	23824327
MIRT649635	hsa-miR-4700-5p	HITS-CLIP	23824327
MIRT649634	hsa-miR-8089	HITS-CLIP	23824327
MIRT649633	hsa-miR-637	HITS-CLIP	23824327
MIRT649632	hsa-miR-7155-5p	HITS-CLIP	23824327
MIRT649631	hsa-miR-4314	HITS-CLIP	23824327
MIRT1291894	hsa-miR-1200	CLIP-seq
MIRT1291895	hsa-miR-1236	CLIP-seq
MIRT1291896	hsa-miR-1285	CLIP-seq
MIRT1291897	hsa-miR-146b-3p	CLIP-seq
MIRT1291898	hsa-miR-182	CLIP-seq
MIRT1291899	hsa-miR-204	CLIP-seq
MIRT1291900	hsa-miR-211	CLIP-seq
MIRT1291901	hsa-miR-2964a-3p	CLIP-seq
MIRT1291902	hsa-miR-300	CLIP-seq
MIRT1291903	hsa-miR-31	CLIP-seq
MIRT1291904	hsa-miR-3124-3p	CLIP-seq
MIRT1291905	hsa-miR-3187-5p	CLIP-seq
MIRT1291906	hsa-miR-3192	CLIP-seq
MIRT1291907	hsa-miR-337-3p	CLIP-seq
MIRT1291908	hsa-miR-3622b-5p	CLIP-seq
MIRT1291909	hsa-miR-3663-5p	CLIP-seq
MIRT1291910	hsa-miR-3670	CLIP-seq
MIRT1291911	hsa-miR-3671	CLIP-seq
MIRT1291912	hsa-miR-381	CLIP-seq
MIRT1291913	hsa-miR-383	CLIP-seq
MIRT1291914	hsa-miR-3945	CLIP-seq
MIRT1291915	hsa-miR-4253	CLIP-seq
MIRT1291916	hsa-miR-4255	CLIP-seq
MIRT1291917	hsa-miR-4302	CLIP-seq
MIRT1291918	hsa-miR-4324	CLIP-seq
MIRT1291919	hsa-miR-4684-5p	CLIP-seq
MIRT1291920	hsa-miR-4695-3p	CLIP-seq
MIRT1291921	hsa-miR-4755-5p	CLIP-seq
MIRT1291922	hsa-miR-4772-5p	CLIP-seq
MIRT1291923	hsa-miR-4778-3p	CLIP-seq
MIRT1291924	hsa-miR-4793-5p	CLIP-seq
MIRT1291925	hsa-miR-544b	CLIP-seq
MIRT1291926	hsa-miR-548c-3p	CLIP-seq
MIRT1291927	hsa-miR-607	CLIP-seq
MIRT1291928	hsa-miR-612	CLIP-seq
MIRT1291929	hsa-miR-623	CLIP-seq
MIRT1291930	hsa-miR-103a	CLIP-seq
MIRT1291931	hsa-miR-105	CLIP-seq
MIRT1291932	hsa-miR-107	CLIP-seq
MIRT1291933	hsa-miR-1180	CLIP-seq
MIRT1291894	hsa-miR-1200	CLIP-seq
MIRT1291934	hsa-miR-1224-3p	CLIP-seq
MIRT1291935	hsa-miR-1224-5p	CLIP-seq
MIRT1291936	hsa-miR-1260	CLIP-seq
MIRT1291937	hsa-miR-1260b	CLIP-seq
MIRT1291938	hsa-miR-1280	CLIP-seq
MIRT1291939	hsa-miR-1301	CLIP-seq
MIRT1291940	hsa-miR-1304	CLIP-seq
MIRT1291941	hsa-miR-1321	CLIP-seq
MIRT1291942	hsa-miR-150	CLIP-seq
MIRT1291943	hsa-miR-185	CLIP-seq
MIRT1291944	hsa-miR-2114	CLIP-seq
MIRT1291901	hsa-miR-2964a-3p	CLIP-seq
MIRT1291945	hsa-miR-3074-3p	CLIP-seq
MIRT1291903	hsa-miR-31	CLIP-seq
MIRT1291946	hsa-miR-3136-3p	CLIP-seq
MIRT1291947	hsa-miR-3144-5p	CLIP-seq
MIRT1291948	hsa-miR-3150b-3p	CLIP-seq
MIRT1291949	hsa-miR-3153	CLIP-seq
MIRT1291950	hsa-miR-3191	CLIP-seq
MIRT1291906	hsa-miR-3192	CLIP-seq
MIRT1291951	hsa-miR-3194-5p	CLIP-seq
MIRT1291952	hsa-miR-3622a-3p	CLIP-seq
MIRT1291953	hsa-miR-3622b-3p	CLIP-seq
MIRT1291910	hsa-miR-3670	CLIP-seq
MIRT1291954	hsa-miR-370	CLIP-seq
MIRT1291955	hsa-miR-3914	CLIP-seq
MIRT1291956	hsa-miR-3915	CLIP-seq
MIRT1291957	hsa-miR-3925-5p	CLIP-seq
MIRT1291958	hsa-miR-4300	CLIP-seq
MIRT1291959	hsa-miR-4306	CLIP-seq
MIRT1291918	hsa-miR-4324	CLIP-seq
MIRT1291960	hsa-miR-4421	CLIP-seq
MIRT1291961	hsa-miR-4487	CLIP-seq
MIRT1291962	hsa-miR-450b-5p	CLIP-seq
MIRT1291963	hsa-miR-4540	CLIP-seq
MIRT1291964	hsa-miR-4644	CLIP-seq
MIRT1291965	hsa-miR-4652-5p	CLIP-seq
MIRT1291966	hsa-miR-4689	CLIP-seq
MIRT1291967	hsa-miR-4713-5p	CLIP-seq
MIRT1291968	hsa-miR-4715-3p	CLIP-seq
MIRT1291969	hsa-miR-4727-5p	CLIP-seq
MIRT1291970	hsa-miR-4731-5p	CLIP-seq
MIRT1291971	hsa-miR-4733-5p	CLIP-seq
MIRT1291972	hsa-miR-4739	CLIP-seq
MIRT1291973	hsa-miR-4753-3p	CLIP-seq
MIRT1291974	hsa-miR-4756-5p	CLIP-seq
MIRT1291975	hsa-miR-4769-3p	CLIP-seq
MIRT1291976	hsa-miR-4773	CLIP-seq
MIRT1291977	hsa-miR-4784	CLIP-seq
MIRT1291978	hsa-miR-5047	CLIP-seq
MIRT1291979	hsa-miR-507	CLIP-seq
MIRT1291980	hsa-miR-532-3p	CLIP-seq
MIRT1291925	hsa-miR-544b	CLIP-seq
MIRT1291981	hsa-miR-545	CLIP-seq
MIRT1291982	hsa-miR-557	CLIP-seq
MIRT1291983	hsa-miR-605	CLIP-seq
MIRT1291984	hsa-miR-920	CLIP-seq
MIRT1291985	hsa-miR-942	CLIP-seq
MIRT1920853	hsa-miR-4776-3p	CLIP-seq
MIRT1920853	hsa-miR-4776-3p	CLIP-seq
MIRT2086835	hsa-miR-140-5p	CLIP-seq
MIRT1291944	hsa-miR-2114	CLIP-seq
MIRT1291896	hsa-miR-1285	CLIP-seq
MIRT1291905	hsa-miR-3187-5p	CLIP-seq
MIRT1291928	hsa-miR-612	CLIP-seq
MIRT2311710	hsa-miR-128	CLIP-seq
MIRT2311711	hsa-miR-1343	CLIP-seq
MIRT2311712	hsa-miR-216a	CLIP-seq
MIRT2311713	hsa-miR-216b	CLIP-seq
MIRT1291901	hsa-miR-2964a-3p	CLIP-seq
MIRT1291903	hsa-miR-31	CLIP-seq
MIRT2311714	hsa-miR-3120-5p	CLIP-seq
MIRT2311715	hsa-miR-3173-3p	CLIP-seq
MIRT2311716	hsa-miR-3176	CLIP-seq
MIRT1291906	hsa-miR-3192	CLIP-seq
MIRT1291952	hsa-miR-3622a-3p	CLIP-seq
MIRT1291953	hsa-miR-3622b-3p	CLIP-seq
MIRT2311717	hsa-miR-3664-5p	CLIP-seq
MIRT2311718	hsa-miR-3672	CLIP-seq
MIRT2311719	hsa-miR-3691-3p	CLIP-seq
MIRT2311720	hsa-miR-3909	CLIP-seq
MIRT2311721	hsa-miR-3922-3p	CLIP-seq
MIRT2311722	hsa-miR-3926	CLIP-seq
MIRT2311723	hsa-miR-4433	CLIP-seq
MIRT2311724	hsa-miR-4459	CLIP-seq
MIRT2311725	hsa-miR-4522	CLIP-seq
MIRT1291968	hsa-miR-4715-3p	CLIP-seq
MIRT2311726	hsa-miR-4766-5p	CLIP-seq
MIRT2311727	hsa-miR-4768-3p	CLIP-seq
MIRT2311728	hsa-miR-4786-5p	CLIP-seq
MIRT2311729	hsa-miR-4802-3p	CLIP-seq
MIRT2311730	hsa-miR-513a-3p	CLIP-seq
MIRT1291925	hsa-miR-544b	CLIP-seq
MIRT2311731	hsa-miR-548s	CLIP-seq
MIRT2311732	hsa-miR-616	CLIP-seq
MIRT2311733	hsa-miR-622	CLIP-seq
MIRT1291901	hsa-miR-2964a-3p	CLIP-seq
MIRT1291902	hsa-miR-300	CLIP-seq
MIRT1291903	hsa-miR-31	CLIP-seq
MIRT2608173	hsa-miR-3122	CLIP-seq
MIRT1291906	hsa-miR-3192	CLIP-seq
MIRT1291912	hsa-miR-381	CLIP-seq
MIRT2608174	hsa-miR-3913-5p	CLIP-seq
MIRT2608175	hsa-miR-450b-3p	CLIP-seq
MIRT1291919	hsa-miR-4684-5p	CLIP-seq
MIRT2608176	hsa-miR-4713-3p	CLIP-seq
MIRT1291926	hsa-miR-548c-3p	CLIP-seq
MIRT2608177	hsa-miR-615-5p	CLIP-seq
MIRT2608178	hsa-miR-638	CLIP-seq
MIRT2608179	hsa-miR-769-3p	CLIP-seq
MIRT1291901	hsa-miR-2964a-3p	CLIP-seq
MIRT1291902	hsa-miR-300	CLIP-seq
MIRT1291903	hsa-miR-31	CLIP-seq
MIRT2608173	hsa-miR-3122	CLIP-seq
MIRT1291906	hsa-miR-3192	CLIP-seq
MIRT1291912	hsa-miR-381	CLIP-seq
MIRT2608174	hsa-miR-3913-5p	CLIP-seq
MIRT2608175	hsa-miR-450b-3p	CLIP-seq
MIRT1291919	hsa-miR-4684-5p	CLIP-seq
MIRT2608176	hsa-miR-4713-3p	CLIP-seq
MIRT1291926	hsa-miR-548c-3p	CLIP-seq
MIRT2608177	hsa-miR-615-5p	CLIP-seq
MIRT2608178	hsa-miR-638	CLIP-seq
MIRT2608179	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	11448776, 16009725
GO:0005096	Function	GTPase activator activity	IEA
GO:0005543	Function	Phospholipid binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	16009725
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	16009725
GO:0005886	Component	Plasma membrane	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0034260	Process	Negative regulation of GTPase activity	IDA	12845332
GO:0034260	Process	Negative regulation of GTPase activity	IMP	11448776
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046580	Process	Negative regulation of Ras protein signal transduction	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0071277	Process	Cellular response to calcium ion	IEA
GO:0071277	Process	Cellular response to calcium ion	IMP	16009725
GO:1902531	Process	Regulation of intracellular signal transduction	IBA

Other IDs

• MIM: 607943
• HGNC: 23181
• e!Ensembl: ENSG00000105808

Protein

• UniProt ID: O43374
• Protein name: Ras GTPase-activating protein 4 (Calcium-promoted Ras inactivator) (Ras p21 protein activator 4) (RasGAP-activating-like protein 2)
• Protein function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:114
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	133 → 234	C2 domain	Domain
  PF00168	C2	5 → 107	C2 domain	Domain
  PF00169	PH	567 → 672	PH domain	Domain
  PF00616	RasGAP	323 → 512	GTPase-activator protein for Ras-like GTPase	Family
  PF00779	BTK	681 → 710	BTK motif	Motif

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11448776}.
• Sequence:

  MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH
  LPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEI
  HLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW
  NETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK
  SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTST
  ECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAG
  MQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHL
  GALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIM
  SPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLK
  DFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEA
  LSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNE
  LNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDP
  LDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLR
  EAHSSSPAGSPPSEPNCLLELQT

• Sequence length: 803

Pathways

KEGG Pathway:

Ras signaling pathway

Reactome Pathway:

Regulation of RAS by GAPs

Related Genes

Sort by: Blended Diseases Pathways Evidence source

RASA3 2 shared pathwaysRas signaling pathway, Regulation of RAS by GAPs Related via 2 shared pathways including Ras signaling pathway, Regulation of RAS by GAPs. RASAL3 2 shared pathwaysRas signaling pathway, Regulation of RAS by GAPs Related via 2 shared pathways including Ras signaling pathway, Regulation of RAS by GAPs. RASAL1 2 shared pathwaysRas signaling pathway, Regulation of RAS by GAPs Related via 2 shared pathways including Ras signaling pathway, Regulation of RAS by GAPs. SYNGAP1 2 shared pathwaysRas signaling pathway, Regulation of RAS by GAPs Related via 2 shared pathways including Ras signaling pathway, Regulation of RAS by GAPs. RASAL2 2 shared pathwaysRas signaling pathway, Regulation of RAS by GAPs Related via 2 shared pathways including Ras signaling pathway, Regulation of RAS by GAPs.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RASA3	0	[]	2	["Ras signaling pathway","Regulation of RAS by GAPs"]	0	[]
RASAL3	0	[]	2	["Ras signaling pathway","Regulation of RAS by GAPs"]	0	[]
RASAL1	0	[]	2	["Ras signaling pathway","Regulation of RAS by GAPs"]	0	[]
SYNGAP1	0	[]	2	["Ras signaling pathway","Regulation of RAS by GAPs"]	0	[]
RASAL2	0	[]	2	["Ras signaling pathway","Regulation of RAS by GAPs"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 2 of 5 related genesRASA3, SYNGAP1 Schizophrenia Linked via 2 of 5 related genesRASA3, SYNGAP1 Autism Linked via 2 of 5 related genesSYNGAP1, RASAL2 Melanoma Linked via 1 of 5 related genesRASA3 Major depressive disorder Linked via 1 of 5 related genesRASA3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	2	["RASA3","SYNGAP1"]
Schizophrenia	2	["RASA3","SYNGAP1"]
Autism	2	["SYNGAP1","RASAL2"]
Melanoma	1	["RASA3"]
Major depressive disorder	1	["RASA3"]