Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	64901
Gene name	RAN binding protein 17
Gene symbol	RANBP17
Synonyms (NCBI Gene)	-
Chromosome	5
Chromosome location	5q35.1
Summary	The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044077	hsa-miR-361-5p	CLASH	23622248
MIRT1289482	hsa-miR-1207-5p	CLIP-seq
MIRT1289483	hsa-miR-1301	CLIP-seq
MIRT1289484	hsa-miR-1321	CLIP-seq
MIRT1289485	hsa-miR-1827	CLIP-seq
MIRT1289486	hsa-miR-1914	CLIP-seq
MIRT1289487	hsa-miR-299-5p	CLIP-seq
MIRT1289488	hsa-miR-3193	CLIP-seq
MIRT1289489	hsa-miR-374a	CLIP-seq
MIRT1289490	hsa-miR-374b	CLIP-seq
MIRT1289491	hsa-miR-3942-3p	CLIP-seq
MIRT1289492	hsa-miR-4266	CLIP-seq
MIRT1289493	hsa-miR-4270	CLIP-seq
MIRT1289494	hsa-miR-4441	CLIP-seq
MIRT1289495	hsa-miR-4499	CLIP-seq
MIRT1289496	hsa-miR-4520a-5p	CLIP-seq
MIRT1289497	hsa-miR-4520b-5p	CLIP-seq
MIRT1289498	hsa-miR-4648	CLIP-seq
MIRT1289499	hsa-miR-4649-3p	CLIP-seq
MIRT1289500	hsa-miR-4654	CLIP-seq
MIRT1289501	hsa-miR-4660	CLIP-seq
MIRT1289502	hsa-miR-4739	CLIP-seq
MIRT1289503	hsa-miR-4756-5p	CLIP-seq
MIRT1289504	hsa-miR-4763-3p	CLIP-seq
MIRT1289505	hsa-miR-4769-5p	CLIP-seq
MIRT1289506	hsa-miR-490-3p	CLIP-seq
MIRT1289507	hsa-miR-501-5p	CLIP-seq
MIRT1289508	hsa-miR-5047	CLIP-seq
MIRT1289509	hsa-miR-548u	CLIP-seq
MIRT1289510	hsa-miR-556-3p	CLIP-seq
MIRT1289511	hsa-miR-570	CLIP-seq
MIRT1289512	hsa-miR-659	CLIP-seq
MIRT1289513	hsa-miR-9	CLIP-seq
MIRT1289514	hsa-miR-940	CLIP-seq
MIRT2086011	hsa-miR-1208	CLIP-seq
MIRT2086012	hsa-miR-1912	CLIP-seq
MIRT2086013	hsa-miR-4662a-5p	CLIP-seq
MIRT2086014	hsa-miR-4729	CLIP-seq
MIRT2086015	hsa-miR-4789-3p	CLIP-seq
MIRT2086016	hsa-miR-495	CLIP-seq
MIRT2086017	hsa-miR-499-3p	CLIP-seq
MIRT2086018	hsa-miR-499a-3p	CLIP-seq
MIRT2086019	hsa-miR-606	CLIP-seq
MIRT2086020	hsa-miR-642b	CLIP-seq
MIRT2393460	hsa-miR-1200	CLIP-seq
MIRT2086011	hsa-miR-1208	CLIP-seq
MIRT2393461	hsa-miR-4324	CLIP-seq
MIRT2393462	hsa-miR-4329	CLIP-seq
MIRT2086013	hsa-miR-4662a-5p	CLIP-seq
MIRT2393463	hsa-miR-4786-5p	CLIP-seq
MIRT2086015	hsa-miR-4789-3p	CLIP-seq
MIRT2086017	hsa-miR-499-3p	CLIP-seq
MIRT2086018	hsa-miR-499a-3p	CLIP-seq
MIRT2393464	hsa-miR-544b	CLIP-seq
MIRT2086020	hsa-miR-642b	CLIP-seq
MIRT2393465	hsa-miR-769-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005049	Function	Nuclear export signal receptor activity	IBA
GO:0005049	Function	Nuclear export signal receptor activity	IEA
GO:0005525	Function	GTP binding	NAS	11024021
GO:0005634	Component	Nucleus	IEA
GO:0005643	Component	Nuclear pore	IBA
GO:0005643	Component	Nuclear pore	IEA
GO:0005643	Component	Nuclear pore	NAS	11024021
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006606	Process	Protein import into nucleus	NAS	11024021
GO:0006611	Process	Protein export from nucleus	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0051028	Process	MRNA transport	IEA
GO:0051169	Process	Nuclear transport	IEA

MIM	HGNC	e!Ensembl
606141	14428	ENSG00000204764

Q9H2T7

Protein name

Ran-binding protein 17

Protein function

May function as a nuclear transport receptor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03810	IBN_N	30 → 95	Importin-beta N-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied. {ECO:0000269|PubMed:11071879}.

Sequence

MALHFQSLAELEVLCTHLYIGTDLTQRIEAEKALLELIDSPECLSKCQLLLEQGTTSYAQ
LLAATCLSKLVSRVSPLPVEQRMDIRNYILNYVASQPKLAPFVIQALIQVIAKITKLGWF
EVQKDQFVFREIIADVKKFLQGTVEHCIIGVIILSELTQEMNLVDYSRPSAKHRKIATSF
RDTSLKDVLVLACSLLKEVFAKPLNLQDQCQQNLVMQVLKLVLNCLNFDFIGSSADESAD
DLCTVQIPTTWRTIFLEPETLDLFFNLYHSLPPLLSQLALSCLVQFASTRRSLFNSPERA
KYLGNLIKGVKRILENPQGLSDPGNYHEFCRFLARLKTNYQLGELVMVKEYPEVIRLIAN
FTITSLQHWEFAPNSVHYLLTLWQRMVASVPFVKSTEPHLLDTYAPEITKAFITSRLDSV
AIVVRDHLDDPLDDTATVFQQLEQLCTVSRCEYEKTCALLVQLFDQNAQNYQKLLHPYSG
VTVDITIQEGRLAWLVYLVGTVVGGRLTYTSTDEHDAMDGELSCRVFQLISLMDTGLPRC
CNEKIELAILWFLDQFRKTYVGDQLQRTSKVYARMSEVLGITDDNHVLETFMTKIVTNLK
YWGRYEPVISRTLQFLNDLSVGYILLKKLVKIDAVKFMLKNHTSEHFPFLGISDNHSLSD
FRCRTTFYTALTRLLMVDLGEDEDEFENFMLPLTVAFETVLQIFNNNFKQEDVKRMLIGL
ARDLRGIAFALNTKTSYTMLFDWMYPTYLPLLQNAVERWYGEPTCTTPILKLMAELMQNR
SQRLNFDVSSPNGILLFREASKMVCTYGNQILSLGSLSKDQIYPMKLKGISICYSALKSA
LCGNYVSFGVFKLYGDNHFDNVLQAFVKMLLSVSHSDLLQYRKLSQSYYPLLECLTQDHM
SFIINLEPPVLMYVLTSISEGLTTLDTVVSSSCCTSLDYIVTYLFKHIAKEGKKPLRCRE
ATQAGQRLLHFMQQNPDVLQQMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELR
ASLINSQPLPKQEVLAQCFRNLMEGVEQNLSVKNRDRFTQNLSVFRRDVAEALRSDGNTE
PCSLDMMS

Sequence length

1088

Interactions

View interactions

KEGG Pathway
Nucleocytoplasmic transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (14)
Acute myeloid leukemia	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	34446935	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL HYDROCEPHALUS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	34982113	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	36292730	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	38469033	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RANBP17-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	33239738, 38839884	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	38317187	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	34446935	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	32541925, 36292730, 39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	12399963		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	35850701	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RANBP17 (RAN binding protein 17)

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