RALB (RAS like proto-oncogene B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 5899 |
| Gene name | RAS like proto-oncogene B |
| Gene symbol | RALB |
| Synonyms (NCBI Gene) |
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| Chromosome | 2 |
| Chromosome location | 2q14.2 |
| Summary | This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Ju |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P11234 | ||||||||||
| Protein name | Ras-related protein Ral-B (EC 3.6.5.2) | ||||||||||
| Protein function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269). Accomplishes | ||||||||||
| PDB | 2KE5 , 2KWI , 6ZQT , 6ZRN | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 206 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with RALB across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to RALB (see Related Genes above), that are NOT already directly curated for RALB itself -- a lead worth checking, not a confirmed association.
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