ANGPT4 (angiopoietin 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51378
• Gene name: Angiopoietin 4
• Gene symbol: ANGPT4
• Synonyms (NCBI Gene): ANG3, ANG4
• Chromosome: 20
• Chromosome location: 20p13
• Summary: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis

miRNA Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016991	hsa-miR-335-5p	Microarray	18185580
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT662519	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662518	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662517	hsa-miR-940	HITS-CLIP	23824327
MIRT662516	hsa-miR-3929	HITS-CLIP	23824327
MIRT662515	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662514	hsa-miR-4478	HITS-CLIP	23824327
MIRT662513	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT662512	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT662511	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662510	hsa-miR-1827	HITS-CLIP	23824327
MIRT662509	hsa-miR-5008-5p	HITS-CLIP	23824327
MIRT662508	hsa-miR-6089	HITS-CLIP	23824327
MIRT662507	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT662506	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT662505	hsa-miR-3665	HITS-CLIP	23824327
MIRT662504	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT662503	hsa-miR-4736	HITS-CLIP	23824327
MIRT662502	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT662501	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT662500	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT662499	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT662498	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT662497	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT662496	hsa-miR-3165	HITS-CLIP	23824327
MIRT662495	hsa-miR-7977	HITS-CLIP	23824327
MIRT662494	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662493	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662492	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662491	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT662490	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT662489	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT662488	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT662487	hsa-miR-3689c	HITS-CLIP	23824327
MIRT662486	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT662485	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT662484	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662483	hsa-miR-3122	HITS-CLIP	23824327
MIRT662482	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662481	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662480	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT662479	hsa-miR-665	HITS-CLIP	23824327
MIRT607762	hsa-miR-4797-5p	HITS-CLIP	24906430
MIRT607761	hsa-miR-508-5p	HITS-CLIP	24906430
MIRT607760	hsa-miR-3664-5p	HITS-CLIP	24906430
MIRT607759	hsa-miR-5586-3p	HITS-CLIP	24906430
MIRT607758	hsa-miR-759	HITS-CLIP	24906430
MIRT607757	hsa-miR-1273g-3p	HITS-CLIP	24906430
MIRT607756	hsa-miR-6849-3p	HITS-CLIP	24906430
MIRT607755	hsa-miR-6742-3p	HITS-CLIP	24906430
MIRT607754	hsa-miR-371b-5p	HITS-CLIP	24906430
MIRT607753	hsa-miR-373-5p	HITS-CLIP	24906430
MIRT607752	hsa-miR-616-5p	HITS-CLIP	24906430
MIRT607751	hsa-miR-371a-5p	HITS-CLIP	24906430
MIRT607750	hsa-miR-372-5p	HITS-CLIP	24906430
MIRT607749	hsa-miR-766-3p	HITS-CLIP	24906430
MIRT607748	hsa-miR-4793-3p	HITS-CLIP	24906430
MIRT607747	hsa-miR-6776-5p	HITS-CLIP	24906430
MIRT607746	hsa-miR-3120-5p	HITS-CLIP	24906430
MIRT607745	hsa-miR-4522	HITS-CLIP	24906430
MIRT607744	hsa-miR-873-3p	HITS-CLIP	24906430
MIRT607743	hsa-miR-4252	HITS-CLIP	24906430
MIRT607742	hsa-miR-661	HITS-CLIP	24906430
MIRT607741	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT607740	hsa-miR-6512-3p	HITS-CLIP	24906430
MIRT607739	hsa-miR-6720-5p	HITS-CLIP	24906430
MIRT607738	hsa-miR-6888-3p	HITS-CLIP	24906430
MIRT607737	hsa-miR-3672	HITS-CLIP	24906430
MIRT607736	hsa-miR-6864-3p	HITS-CLIP	24906430
MIRT607735	hsa-miR-7703	HITS-CLIP	24906430
MIRT607734	hsa-miR-1262	HITS-CLIP	24906430
MIRT607733	hsa-miR-4701-3p	HITS-CLIP	24906430
MIRT607732	hsa-miR-6736-5p	HITS-CLIP	24906430
MIRT607731	hsa-miR-6510-3p	HITS-CLIP	24906430
MIRT607734	hsa-miR-1262	PAR-CLIP	27292025
MIRT607757	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT607746	hsa-miR-3120-5p	PAR-CLIP	27292025
MIRT607760	hsa-miR-3664-5p	PAR-CLIP	27292025
MIRT607737	hsa-miR-3672	PAR-CLIP	27292025
MIRT607743	hsa-miR-4252	PAR-CLIP	27292025
MIRT607745	hsa-miR-4522	PAR-CLIP	27292025
MIRT607733	hsa-miR-4701-3p	PAR-CLIP	27292025
MIRT607748	hsa-miR-4793-3p	PAR-CLIP	27292025
MIRT607762	hsa-miR-4797-5p	PAR-CLIP	27292025
MIRT607761	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT607741	hsa-miR-542-3p	PAR-CLIP	27292025
MIRT607759	hsa-miR-5586-3p	PAR-CLIP	27292025
MIRT607731	hsa-miR-6510-3p	PAR-CLIP	27292025
MIRT607740	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT607742	hsa-miR-661	PAR-CLIP	27292025
MIRT607739	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT607732	hsa-miR-6736-5p	PAR-CLIP	27292025
MIRT607755	hsa-miR-6742-3p	PAR-CLIP	27292025
MIRT607747	hsa-miR-6776-5p	PAR-CLIP	27292025
MIRT607756	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT607736	hsa-miR-6864-3p	PAR-CLIP	27292025
MIRT607738	hsa-miR-6888-3p	PAR-CLIP	27292025
MIRT607758	hsa-miR-759	PAR-CLIP	27292025
MIRT607749	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT607735	hsa-miR-7703	PAR-CLIP	27292025
MIRT607744	hsa-miR-873-3p	PAR-CLIP	27292025
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT709498	hsa-miR-6716-5p	HITS-CLIP	19536157
MIRT709497	hsa-miR-5587-5p	HITS-CLIP	19536157
MIRT709496	hsa-miR-133a-3p	HITS-CLIP	19536157
MIRT709495	hsa-miR-133b	HITS-CLIP	19536157
MIRT662519	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662518	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662517	hsa-miR-940	HITS-CLIP	23824327
MIRT662516	hsa-miR-3929	HITS-CLIP	23824327
MIRT662515	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662514	hsa-miR-4478	HITS-CLIP	23824327
MIRT662513	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT662512	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT662511	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662510	hsa-miR-1827	HITS-CLIP	23824327
MIRT662509	hsa-miR-5008-5p	HITS-CLIP	23824327
MIRT662508	hsa-miR-6089	HITS-CLIP	23824327
MIRT662507	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT662506	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT662505	hsa-miR-3665	HITS-CLIP	23824327
MIRT662504	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT662503	hsa-miR-4736	HITS-CLIP	23824327
MIRT662502	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT662501	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT662500	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT662499	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT662498	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT662497	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT662496	hsa-miR-3165	HITS-CLIP	23824327
MIRT662495	hsa-miR-7977	HITS-CLIP	23824327
MIRT662494	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662493	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662492	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662491	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT662490	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT662489	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT662488	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT662487	hsa-miR-3689c	HITS-CLIP	23824327
MIRT662486	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT662485	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT662484	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662483	hsa-miR-3122	HITS-CLIP	23824327
MIRT662482	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662481	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662480	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT662479	hsa-miR-665	HITS-CLIP	23824327
MIRT1930656	hsa-miR-149	CLIP-seq
MIRT1930657	hsa-miR-1915	CLIP-seq
MIRT1930658	hsa-miR-24	CLIP-seq
MIRT1930659	hsa-miR-3664-3p	CLIP-seq
MIRT1930660	hsa-miR-4284	CLIP-seq
MIRT1930661	hsa-miR-4716-5p	CLIP-seq
MIRT1930662	hsa-miR-671-5p	CLIP-seq
MIRT1930663	hsa-miR-873	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001935	Process	Endothelial cell proliferation	IDA	10025962
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	10025962
GO:0007165	Process	Signal transduction	IBA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007596	Process	Blood coagulation	IEA
GO:0010595	Process	Positive regulation of endothelial cell migration	IDA	12958144
GO:0016525	Process	Negative regulation of angiogenesis	IDA	16790085
GO:0030297	Function	Transmembrane receptor protein tyrosine kinase activator activity	IDA	10051567, 15851516
GO:0030971	Function	Receptor tyrosine kinase binding	IBA
GO:0030971	Function	Receptor tyrosine kinase binding	IDA	10051567
GO:0031012	Component	Extracellular matrix	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	12958144, 15284220
GO:0043536	Process	Positive regulation of blood vessel endothelial cell migration	IDA	15284220
GO:0043537	Process	Negative regulation of blood vessel endothelial cell migration	IDA	16790085
GO:0045766	Process	Positive regulation of angiogenesis	IDA	15284220
GO:0050731	Process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	15851516
GO:0071456	Process	Cellular response to hypoxia	IEP	12958144

Other IDs

• MIM: 603705
• HGNC: 487
• e!Ensembl: ENSG00000101280

Protein

• UniProt ID: Q9Y264
• Protein name: Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3)
• Protein function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00147	Fibrinogen_C	287 → 501	Fibrinogen beta and gamma chains, C-terminal globular domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the lung with much lower levels found in other tissues.
• Sequence:

  MLSQLAMLQGSLLLVVATMSVAQQTRQEADRGCETLVVQHGHCSYTFLLPKSEPCPPGPE
  VSRDSNTLQRESLANPLHLGKLPTQQVKQLEQALQNNTQWLKKLERAIKTILRSKLEQVQ
  QQMAQNQTAPMLELGTSLLNQTTAQIRKLTDMEAQLLNQTSRMDAQMPETFLSTNKLENQ
  LLLQRQKLQQLQGQNSALEKRLQALETKQQEELASILSKKAKLLNTLSRQSAALTNIERG
  LRGVRHNSSLLQDQQHSLRQLLVLLRHLVQERANASAPAFIMAGEQVFQDCAEIQRSGAS
  ASGVYTIQVSNATKPRKVFCDLQSSGGRWTLIQRRENGTVNFQRNWKDYKQGFGDPAGEH
  WLGNEVVHQLTRRAAYSLRVELQDWEGHEAYAQYEHFHLGSENQLYRLSVVGYSGSAGRQ
  SSLVLQNTSFSTLDSDNDHCLCKCAQVMSGGWWFDACGLSNLNGVYYHAPDNKYKMDGIR
  WHYFKGPSYSLRASRMMIRPLDI

• Sequence length: 503

Pathways

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	Tie2 Signaling
Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (7)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	26993346	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM	—	GWAS catalog	29531279	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	24554482	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POSTERIOR CORTICAL ATROPHY	—	GWAS catalog	26993346	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	33398198	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	33398198	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	38162683	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (34)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Brain Neoplasms	Brain neoplasms	Pubtator	26277786	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	15342395		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31642813, 34685578	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	31738968		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	30949864		★☆☆☆☆ Found in Text Mining only
Chronic Disease	Chronic disease	Pubtator	27773939	Associate	★☆☆☆☆ Found in Text Mining only
Corneal Neovascularization	Corneal Neovascularization	LHGDN	15284220		★☆☆☆☆ Found in Text Mining only
Corneal Neovascularization	Corneal Neovascularization	BEFREE	15284220		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	30957437		★☆☆☆☆ Found in Text Mining only
Dementia, Vascular	Dementia	BEFREE	20596041		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	35932065	Inhibit	★☆☆☆☆ Found in Text Mining only
Fibroid Tumor	Leiomyoma	LHGDN	17724803		★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	22531314, 25977256		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	LHGDN	17724803		★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	Pubtator	17724803	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20823154	Stimulate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	20823154		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20823154		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	20020177		★☆☆☆☆ Found in Text Mining only
Hemangiosarcoma	Hemangiosarcoma	Pubtator	10854238	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	31786978		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	15198927	Stimulate	★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	17724803	Associate	★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	26277786	Inhibit	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11309342, 25977256		★☆☆☆☆ Found in Text Mining only
Neurilemmoma	Neurilemmoma	LHGDN	17724803		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	27773939	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	37884970	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30361641	Associate	★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	12434420		★☆☆☆☆ Found in Text Mining only
Sarcoma Kaposi	Sarcoma	Pubtator	10854238	Associate	★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	26277786	Inhibit	★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	20596041		★☆☆☆☆ Found in Text Mining only
Vascular Remodeling	Vascular remodeling	Pubtator	32582222	Inhibit	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ANGPT2 5 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Tie2 Signaling Related via 5 shared pathways including MAPK signaling pathway, Ras signaling pathway. ANGPT1 5 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Tie2 Signaling Related via 5 shared pathways including MAPK signaling pathway, Ras signaling pathway. TEK 5 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, Tie2 Signaling Related via 5 shared pathways including MAPK signaling pathway, Ras signaling pathway. RAPGEF5 2 shared pathwaysRas signaling pathway, Rap1 signaling pathway Related via 2 shared pathways including Ras signaling pathway, Rap1 signaling pathway. RASGRP3 3 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway Related via 3 shared pathways including MAPK signaling pathway, Ras signaling pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ANGPT2	0	[]	5	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","HIF-1 signaling pathway","Tie2 Signaling"]	0	[]
ANGPT1	0	[]	5	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","HIF-1 signaling pathway","Tie2 Signaling"]	0	[]
TEK	0	[]	5	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","HIF-1 signaling pathway","Tie2 Signaling"]	0	[]
RAPGEF5	0	[]	2	["Ras signaling pathway","Rap1 signaling pathway"]	0	[]
RASGRP3	0	[]	3	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway"]	0	[]

Diseases Linked via Similar Genes

Glaucoma Linked via 3 of 5 related genesANGPT1, TEK, RAPGEF5 Hemangiosarcoma Linked via 2 of 5 related genesANGPT2, TEK Open angle glaucoma Linked via 2 of 5 related genesANGPT2, ANGPT1 Primary congenital glaucoma Linked via 2 of 5 related genesANGPT1, TEK Major depressive disorder Linked via 2 of 5 related genesRAPGEF5, RASGRP3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Glaucoma	3	["ANGPT1","TEK","RAPGEF5"]
Hemangiosarcoma	2	["ANGPT2","TEK"]
Open angle glaucoma	2	["ANGPT2","ANGPT1"]
Primary congenital glaucoma	2	["ANGPT1","TEK"]
Major depressive disorder	2	["RAPGEF5","RASGRP3"]