Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5535
Gene name	Protein phosphatase 3 regulatory subunit B, beta
Gene symbol	PPP3R2
Synonyms (NCBI Gene)	PPP3RL
Chromosome	9
Chromosome location	9q31.1

65 Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016810	hsa-miR-335-5p	Microarray	18185580
MIRT037913	hsa-miR-532-3p	CLASH	23622248
MIRT1258446	hsa-miR-1	CLIP-seq
MIRT1258447	hsa-miR-1178	CLIP-seq
MIRT1258448	hsa-miR-1267	CLIP-seq
MIRT1258449	hsa-miR-1321	CLIP-seq
MIRT1258450	hsa-miR-1343	CLIP-seq
MIRT1258451	hsa-miR-182	CLIP-seq
MIRT1258452	hsa-miR-199a-5p	CLIP-seq
MIRT1258453	hsa-miR-199b-5p	CLIP-seq
MIRT1258454	hsa-miR-205	CLIP-seq
MIRT1258455	hsa-miR-206	CLIP-seq
MIRT1258456	hsa-miR-219-1-3p	CLIP-seq
MIRT1258457	hsa-miR-2276	CLIP-seq
MIRT1258458	hsa-miR-3127-3p	CLIP-seq
MIRT1258459	hsa-miR-3128	CLIP-seq
MIRT1258460	hsa-miR-3135b	CLIP-seq
MIRT1258461	hsa-miR-3140-3p	CLIP-seq
MIRT1258462	hsa-miR-3162-5p	CLIP-seq
MIRT1258463	hsa-miR-342-3p	CLIP-seq
MIRT1258464	hsa-miR-3545-3p	CLIP-seq
MIRT1258465	hsa-miR-3646	CLIP-seq
MIRT1258466	hsa-miR-3650	CLIP-seq
MIRT1258467	hsa-miR-3673	CLIP-seq
MIRT1258468	hsa-miR-3689d	CLIP-seq
MIRT1258469	hsa-miR-3690	CLIP-seq
MIRT1258470	hsa-miR-375	CLIP-seq
MIRT1258471	hsa-miR-377	CLIP-seq
MIRT1258472	hsa-miR-3934	CLIP-seq
MIRT1258473	hsa-miR-3975	CLIP-seq
MIRT1258474	hsa-miR-4254	CLIP-seq
MIRT1258475	hsa-miR-4280	CLIP-seq
MIRT1258476	hsa-miR-4646-3p	CLIP-seq
MIRT1258477	hsa-miR-4682	CLIP-seq
MIRT1258478	hsa-miR-4684-3p	CLIP-seq
MIRT1258479	hsa-miR-4712-3p	CLIP-seq
MIRT1258480	hsa-miR-4739	CLIP-seq
MIRT1258481	hsa-miR-4756-5p	CLIP-seq
MIRT1258482	hsa-miR-4772-3p	CLIP-seq
MIRT1258483	hsa-miR-516a-3p	CLIP-seq
MIRT1258484	hsa-miR-532-5p	CLIP-seq
MIRT1258485	hsa-miR-567	CLIP-seq
MIRT1258486	hsa-miR-571	CLIP-seq
MIRT1258487	hsa-miR-613	CLIP-seq
MIRT1258488	hsa-miR-633	CLIP-seq
MIRT1258489	hsa-miR-637	CLIP-seq
MIRT1258490	hsa-miR-664	CLIP-seq
MIRT1258491	hsa-miR-944	CLIP-seq
MIRT2076153	hsa-miR-3978	CLIP-seq
MIRT2076154	hsa-miR-4691-5p	CLIP-seq
MIRT2076155	hsa-miR-586	CLIP-seq
MIRT2302766	hsa-miR-28-5p	CLIP-seq
MIRT1258460	hsa-miR-3135b	CLIP-seq
MIRT2302767	hsa-miR-3139	CLIP-seq
MIRT2302768	hsa-miR-4433	CLIP-seq
MIRT2302769	hsa-miR-4459	CLIP-seq
MIRT2302770	hsa-miR-4487	CLIP-seq
MIRT2302771	hsa-miR-4747-5p	CLIP-seq
MIRT2302772	hsa-miR-4768-3p	CLIP-seq
MIRT2302773	hsa-miR-708	CLIP-seq
MIRT1258476	hsa-miR-4646-3p	CLIP-seq
MIRT2457073	hsa-miR-2053	CLIP-seq
MIRT2457074	hsa-miR-3183	CLIP-seq
MIRT2457075	hsa-miR-4723-3p	CLIP-seq
MIRT2457076	hsa-miR-4753-3p	CLIP-seq

21 Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 34446558
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	NAS	22343722, 28126489
GO:0005955	Component	Calcineurin complex	IBA
GO:0005955	Component	Calcineurin complex	IEA
GO:0005955	Component	Calcineurin complex	NAS	11123943
GO:0007341	Process	Penetration of zona pellucida	IEA
GO:0008287	Component	Protein serine/threonine phosphatase complex	NAS	22343722
GO:0008597	Function	Calcium-dependent protein serine/threonine phosphatase regulator activity	IBA
GO:0008597	Function	Calcium-dependent protein serine/threonine phosphatase regulator activity	IDA	26429887
GO:0008597	Function	Calcium-dependent protein serine/threonine phosphatase regulator activity	IEA
GO:0019902	Function	Phosphatase binding	IBA
GO:0036126	Component	Sperm flagellum	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	NAS	8631904, 22343722
GO:0097225	Component	Sperm midpiece	IEA
GO:0097226	Component	Sperm mitochondrial sheath	IEA
GO:0097720	Process	Calcineurin-mediated signaling	IBA
GO:1905665	Process	Positive regulation of calcium ion import across plasma membrane	NAS	17640527
GO:1905949	Process	Negative regulation of calcium ion import across plasma membrane	NAS	17640527

MIM	HGNC	e!Ensembl
613821	9318	ENSG00000188386

Q96LZ3

Protein name

Calcineurin subunit B type 2 (Calcineurin B-like protein) (CBLP) (Calcineurin BII) (CNBII) (PPP3R1-like) (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform)

Protein function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00036	EF-hand_1	91 → 119	EF hand	Domain
PF13202	EF-hand_5	23 → 47	EF hand	Domain
PF13499	EF-hand_7	89 → 158	EF-hand domain pair	Domain
PF13499	EF-hand_7	20 → 79	EF-hand domain pair	Domain

Tissue specificity

TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:15865209}.

Sequence

MGNEASYPAEMCSHFDNDEIKRLGRRFKKLDLDKSGSLSVEEFMSLPELRHNPLVRRVID
VFDTDGDGEVDFKEFILGTSQFSVKGDEEQKLRFAFSIYDMDKDGYISNGELFQVLKMMV
GNNLTDWQLQQLVDKTIIILDKDGDGKISFEEFSAVVRDLEIHKKLVLIV

Sequence length

170

Interactions

View interactions

KEGG Pathway
MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Cellular senescence
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
C-type lectin receptor signaling pathway
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Alzheimer disease
Amyotrophic lateral sclerosis
Prion disease
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Tuberculosis
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
PPP3CC	[]	29	["MAPK signaling pathway","Calcium signaling pathway","cGMP-PKG signaling pathway","Oocyte meiosis","Cellular senescence","Wnt signaling pathway","Axon guidance","VEGF signaling pathway","Osteoclast differentiation","C-type lectin receptor signaling pathway","Natural killer cell mediated cytotoxicity","Th1 and Th2 cell differentiation"]	[]
PPP3CA	[]	29	["MAPK signaling pathway","Calcium signaling pathway","cGMP-PKG signaling pathway","Oocyte meiosis","Cellular senescence","Wnt signaling pathway","Axon guidance","VEGF signaling pathway","Osteoclast differentiation","C-type lectin receptor signaling pathway","Natural killer cell mediated cytotoxicity","Th1 and Th2 cell differentiation"]	[]
PPP3CB	[]	29	["MAPK signaling pathway","Calcium signaling pathway","cGMP-PKG signaling pathway","Oocyte meiosis","Cellular senescence","Wnt signaling pathway","Axon guidance","VEGF signaling pathway","Osteoclast differentiation","C-type lectin receptor signaling pathway","Natural killer cell mediated cytotoxicity","Th1 and Th2 cell differentiation"]	[]
PPP3R1	[]	29	["MAPK signaling pathway","Calcium signaling pathway","cGMP-PKG signaling pathway","Oocyte meiosis","Cellular senescence","Wnt signaling pathway","Axon guidance","VEGF signaling pathway","Osteoclast differentiation","C-type lectin receptor signaling pathway","Natural killer cell mediated cytotoxicity","Th1 and Th2 cell differentiation"]	[]
NFATC2	[]	20	["Calcium signaling pathway","cGMP-PKG signaling pathway","Cellular senescence","Wnt signaling pathway","Axon guidance","VEGF signaling pathway","Osteoclast differentiation","C-type lectin receptor signaling pathway","Natural killer cell mediated cytotoxicity","Th1 and Th2 cell differentiation","Th17 cell differentiation","T cell receptor signaling pathway"]	[]

PPP3R2 (protein phosphatase 3 regulatory subunit B, beta)

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