PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 90809
• Gene name: Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
• Gene symbol: PIP4P1
• Synonyms (NCBI Gene): C14orf9, TMEM55B
• Chromosome: 14
• Chromosome location: 14q11.2
• Summary: TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

miRNA Show/Hide all (63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT520593	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT114357	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT114352	hsa-miR-4643	PAR-CLIP	20371350
MIRT520592	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT520591	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT114348	hsa-miR-466	PAR-CLIP	20371350
MIRT520590	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT520589	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT520588	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT520593	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT114357	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT114352	hsa-miR-4643	PAR-CLIP	20371350
MIRT520592	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT520591	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT114348	hsa-miR-466	PAR-CLIP	20371350
MIRT520590	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT520589	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT520588	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT520593	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT114357	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT114352	hsa-miR-4643	PAR-CLIP	20371350
MIRT520592	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT520591	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT114348	hsa-miR-466	PAR-CLIP	20371350
MIRT520590	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT520589	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT520588	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT520593	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT114357	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT114352	hsa-miR-4643	PAR-CLIP	20371350
MIRT520592	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT520591	hsa-miR-4733-5p	PAR-CLIP	20371350
MIRT114348	hsa-miR-466	PAR-CLIP	20371350
MIRT520590	hsa-miR-4789-5p	PAR-CLIP	20371350
MIRT520589	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT520588	hsa-miR-188-3p	PAR-CLIP	20371350
MIRT520593	hsa-miR-3121-3p	PAR-CLIP	21572407
MIRT114357	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT114352	hsa-miR-4643	PAR-CLIP	21572407
MIRT553498	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT520592	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT520591	hsa-miR-4733-5p	PAR-CLIP	21572407
MIRT553497	hsa-miR-584-3p	PAR-CLIP	21572407
MIRT553496	hsa-miR-4277	PAR-CLIP	21572407
MIRT114348	hsa-miR-466	PAR-CLIP	21572407
MIRT520590	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT520589	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT520588	hsa-miR-188-3p	PAR-CLIP	21572407
MIRT520593	hsa-miR-3121-3p	PAR-CLIP	23446348
MIRT114357	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT114352	hsa-miR-4643	PAR-CLIP	23446348
MIRT520592	hsa-miR-101-5p	PAR-CLIP	23446348
MIRT520591	hsa-miR-4733-5p	PAR-CLIP	23446348
MIRT114348	hsa-miR-466	PAR-CLIP	23446348
MIRT520590	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT520589	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT520588	hsa-miR-188-3p	PAR-CLIP	23446348
MIRT439430	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT726287	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726286	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT031583	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726285	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT439430	hsa-miR-205-5p	HITS-CLIP	22473208

Gene ontology (GO) Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	29644770, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	TAS
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	16365287, 29146937
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	TAS
GO:0006991	Process	Response to sterol depletion	IDA	25035345, 29146937
GO:0008203	Process	Cholesterol metabolic process	IMP	25035345
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030670	Component	Phagocytic vesicle membrane	IBA
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	16365287
GO:0031902	Component	Late endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	TAS
GO:0032418	Process	Lysosome localization	IMP	29146937
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IBA
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IDA	16365287
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IEA
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	TAS
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IBA
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IDA	16365287
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IEA
GO:0070070	Process	Proton-transporting V-type ATPase complex assembly	IEA
GO:0070070	Process	Proton-transporting V-type ATPase complex assembly	ISS
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:1904263	Process	Positive regulation of TORC1 signaling	IEA
GO:1904263	Process	Positive regulation of TORC1 signaling	IMP	29644770

Other IDs

• MIM: 609865
• HGNC: 19299
• e!Ensembl: ENSG00000165782

Protein

• UniProt ID: Q86T03
• Protein name: Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)
• Protein function: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosph
• PDB: 8OQH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09788	Tmemb_55A	4 → 270	Transmembrane protein 55A	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16365287}.
• Sequence:

  MAADGERSPLLSEPIDGGAGGNGLVGPGGSGAGPGGGLTPSAPPYGAAFPPFPEGHPAVL
  PGEDPPPYSPLTSPDSGSAPMITCRVCQSLINVEGKMHQHVVKCGVCNEATPIKNAPPGK
  KYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNT
  FLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKHARRY
  GGIYAAWAFVILLAVLCLGRALYWACMKVSHPVQNFS

• Sequence length: 277

Pathways

KEGG Pathway	Reactome Pathway
Phosphatidylinositol signaling system	PI5P Regulates TP53 Acetylation
	Synthesis of PIPs in the nucleus

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PIP4K2A 3 shared pathwaysPhosphatidylinositol signaling system, PI5P Regulates TP53 Acetylation, Synthesis of PIPs in the nucleus Related via 3 shared pathways including Phosphatidylinositol signaling system, PI5P Regulates TP53 Acetylation. PIP4K2C 3 shared pathwaysPhosphatidylinositol signaling system, PI5P Regulates TP53 Acetylation, Synthesis of PIPs in the nucleus Related via 3 shared pathways including Phosphatidylinositol signaling system, PI5P Regulates TP53 Acetylation. PIP4K2B 3 shared pathwaysPhosphatidylinositol signaling system, PI5P Regulates TP53 Acetylation, Synthesis of PIPs in the nucleus Related via 3 shared pathways including Phosphatidylinositol signaling system, PI5P Regulates TP53 Acetylation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PIP4K2A	0	[]	3	["Phosphatidylinositol signaling system","PI5P Regulates TP53 Acetylation","Synthesis of PIPs in the nucleus"]	0	[]
PIP4K2C	0	[]	3	["Phosphatidylinositol signaling system","PI5P Regulates TP53 Acetylation","Synthesis of PIPs in the nucleus"]	0	[]
PIP4K2B	0	[]	3	["Phosphatidylinositol signaling system","PI5P Regulates TP53 Acetylation","Synthesis of PIPs in the nucleus"]	0	[]

Diseases Linked via Similar Genes

Bipolar disorder Linked via 2 of 3 related genesPIP4K2A, PIP4K2C Breast cancer Linked via 2 of 3 related genesPIP4K2A, PIP4K2B Schizophrenia Linked via 2 of 3 related genesPIP4K2A, PIP4K2C Alzheimer disease Linked via 1 of 3 related genesPIP4K2A B-cell acute lymphoblastic leukemia Linked via 1 of 3 related genesPIP4K2A

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Bipolar disorder	2	["PIP4K2A","PIP4K2C"]
Breast cancer	2	["PIP4K2A","PIP4K2B"]
Schizophrenia	2	["PIP4K2A","PIP4K2C"]
Alzheimer disease	1	["PIP4K2A"]
B-cell acute lymphoblastic leukemia	1	["PIP4K2A"]