PGM2 (phosphoglucomutase 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55276
• Gene name: Phosphoglucomutase 2
• Gene symbol: PGM2
• Synonyms (NCBI Gene): MSTP006
• Chromosome: 4
• Chromosome location: 4p14

miRNA Show/Hide all (86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002766	hsa-miR-1-3p	Luciferase reporter assay, Microarray	15685193
MIRT019888	hsa-miR-375	Microarray	20215506
MIRT022985	hsa-miR-124-3p	Microarray	18668037
MIRT002766	hsa-miR-1-3p	Microarray;Other	15685193
MIRT644856	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT644855	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT644854	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT644853	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT644852	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT644851	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT644850	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT644849	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT644848	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT644847	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT644846	hsa-miR-9-3p	HITS-CLIP	23824327
MIRT644856	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT644855	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT644854	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT644853	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT644852	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT644851	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT644850	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT644849	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT644848	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT644847	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT644846	hsa-miR-9-3p	HITS-CLIP	23824327
MIRT1227565	hsa-miR-124	CLIP-seq
MIRT1227566	hsa-miR-1297	CLIP-seq
MIRT1227567	hsa-miR-1299	CLIP-seq
MIRT1227568	hsa-miR-1305	CLIP-seq
MIRT1227569	hsa-miR-142-5p	CLIP-seq
MIRT1227570	hsa-miR-26a	CLIP-seq
MIRT1227571	hsa-miR-26b	CLIP-seq
MIRT1227572	hsa-miR-30a	CLIP-seq
MIRT1227573	hsa-miR-30b	CLIP-seq
MIRT1227574	hsa-miR-30c	CLIP-seq
MIRT1227575	hsa-miR-30d	CLIP-seq
MIRT1227576	hsa-miR-30e	CLIP-seq
MIRT1227577	hsa-miR-3145-3p	CLIP-seq
MIRT1227578	hsa-miR-3147	CLIP-seq
MIRT1227579	hsa-miR-3187-3p	CLIP-seq
MIRT1227580	hsa-miR-3201	CLIP-seq
MIRT1227581	hsa-miR-3714	CLIP-seq
MIRT1227582	hsa-miR-3910	CLIP-seq
MIRT1227583	hsa-miR-3940-5p	CLIP-seq
MIRT1227584	hsa-miR-4275	CLIP-seq
MIRT1227585	hsa-miR-4425	CLIP-seq
MIRT1227586	hsa-miR-4435	CLIP-seq
MIRT1227587	hsa-miR-4465	CLIP-seq
MIRT1227588	hsa-miR-4496	CLIP-seq
MIRT1227589	hsa-miR-4507	CLIP-seq
MIRT1227590	hsa-miR-4529-5p	CLIP-seq
MIRT1227591	hsa-miR-4701-5p	CLIP-seq
MIRT1227592	hsa-miR-4729	CLIP-seq
MIRT1227593	hsa-miR-4782-5p	CLIP-seq
MIRT1227594	hsa-miR-4791	CLIP-seq
MIRT1227595	hsa-miR-487a	CLIP-seq
MIRT1227596	hsa-miR-491-3p	CLIP-seq
MIRT1227597	hsa-miR-498	CLIP-seq
MIRT1227598	hsa-miR-506	CLIP-seq
MIRT1227599	hsa-miR-5096	CLIP-seq
MIRT1227600	hsa-miR-516b	CLIP-seq
MIRT1227601	hsa-miR-548s	CLIP-seq
MIRT1227602	hsa-miR-588	CLIP-seq
MIRT1227603	hsa-miR-629	CLIP-seq
MIRT1227567	hsa-miR-1299	CLIP-seq
MIRT2066645	hsa-miR-223	CLIP-seq
MIRT1227577	hsa-miR-3145-3p	CLIP-seq
MIRT1227580	hsa-miR-3201	CLIP-seq
MIRT2066646	hsa-miR-4328	CLIP-seq
MIRT2066647	hsa-miR-4464	CLIP-seq
MIRT2066648	hsa-miR-4748	CLIP-seq
MIRT1227593	hsa-miR-4782-5p	CLIP-seq
MIRT1227594	hsa-miR-4791	CLIP-seq
MIRT1227596	hsa-miR-491-3p	CLIP-seq
MIRT1227597	hsa-miR-498	CLIP-seq
MIRT1227600	hsa-miR-516b	CLIP-seq
MIRT1227569	hsa-miR-142-5p	CLIP-seq
MIRT2294191	hsa-miR-3942-3p	CLIP-seq
MIRT2294192	hsa-miR-4731-3p	CLIP-seq
MIRT2294193	hsa-miR-4760-5p	CLIP-seq
MIRT2294194	hsa-miR-4801	CLIP-seq
MIRT1227597	hsa-miR-498	CLIP-seq
MIRT2592167	hsa-miR-3974	CLIP-seq
MIRT1227599	hsa-miR-5096	CLIP-seq
MIRT2592168	hsa-miR-548m	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004614	Function	Phosphoglucomutase activity	IDA	17804405
GO:0004614	Function	Phosphoglucomutase activity	IEA
GO:0005515	Function	Protein binding	IPI	21044950, 25277244
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	17804405
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005978	Process	Glycogen biosynthetic process	IEA
GO:0005980	Process	Glycogen catabolic process	IEA
GO:0006006	Process	Glucose metabolic process	IEA
GO:0006006	Process	Glucose metabolic process	IEA
GO:0006166	Process	Purine ribonucleoside salvage	IBA
GO:0008973	Function	Phosphopentomutase activity	IBA
GO:0008973	Function	Phosphopentomutase activity	IDA	17804405
GO:0008973	Function	Phosphopentomutase activity	IEA
GO:0016853	Function	Isomerase activity	IEA
GO:0016868	Function	Intramolecular phosphotransferase activity	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 172000
• HGNC: 8906
• e!Ensembl: ENSG00000169299

Protein

• UniProt ID: Q96G03
• Protein name: Phosphopentomutase (EC 5.4.2.7) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphoglucomutase-2) (EC 5.4.2.2)
• Protein function: Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses (PubMed:17804405). Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00408	PGM_PMM_IV	516 → 592	Phosphoglucomutase/phosphomannomutase, C-terminal domain	Family
  PF02878	PGM_PMM_I	54 → 203	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I	Domain
  PF02879	PGM_PMM_II	227 → 336	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	Domain
  PF02880	PGM_PMM_III	343 → 472	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	Domain

• Sequence:

  MAAPEGSGLGEDARLDQETAQWLRWDKNSLTLEAVKRLIAEGNKEELRKCFGARMEFGTA
  GLRAAMGPGISRMNDLTIIQTTQGFCRYLEKQFSDLKQKGIVISFDARAHPSSGGSSRRF
  ARLAATTFISQGIPVYLFSDITPTPFVPFTVSHLKLCAGIMITASHNPKQDNGYKVYWDN
  GAQIISPHDKGISQAIEENLEPWPQAWDDSLIDSSPLLHNPSASINNDYFEDLKKYCFHR
  SVNRETKVKFVHTSVHGVGHSFVQSAFKAFDLVPPEAVPEQKDPDPEFPTVKYPNPEEGK
  GVLTLSFALADKTKARIVLANDPDADRLAVAEKQDSGEWRVFSGNELGALLGWWLFTSWK
  EKNQDRSALKDTYMLSSTVSSKILRAIALKEGFHFEETLTGFKWMGNRAKQLIDQGKTVL
  FAFEEAIGYMCCPFVLDKDGVSAAVISAELASFLATKNLSLSQQLKAIYVEYGYHITKAS
  YFICHDQETIKKLFENLRNYDGKNNYPKACGKFEISAIRDLTTGYDDSQPDKKAVLPTSK
  SSQMITFTFANGGVATMRTSGTEPKIKYYAELCAPPGNSDPEQLKKELNELVSAIEEHFF
  QPQKYNLQPKAD

• Sequence length: 612

Pathways

KEGG Pathway	Reactome Pathway
Glycolysis / Gluconeogenesis	Glycogen synthesis
Pentose phosphate pathway	Neutrophil degranulation
Galactose metabolism	Glycogen breakdown (glycogenolysis)
Purine metabolism	Galactose catabolism
Starch and sucrose metabolism	Pentose phosphate pathway
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Biosynthesis of nucleotide sugars

Related Genes

Sort by: Blended Diseases Pathways Evidence source

PGM1 8 shared pathwaysGlycolysis / Gluconeogenesis, Pentose phosphate pathway, Galactose metabolism, Purine metabolism, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism, Biosynthesis of nucleotide sugars, Glycogen synthesis Related via 8 shared pathways including Glycolysis / Gluconeogenesis, Pentose phosphate pathway. GALE 4 shared pathwaysGalactose metabolism, Amino sugar and nucleotide sugar metabolism, Biosynthesis of nucleotide sugars, Galactose catabolism Related via 4 shared pathways including Galactose metabolism, Amino sugar and nucleotide sugar metabolism. GALK1 4 shared pathwaysGalactose metabolism, Amino sugar and nucleotide sugar metabolism, Biosynthesis of nucleotide sugars, Galactose catabolism Related via 4 shared pathways including Galactose metabolism, Amino sugar and nucleotide sugar metabolism. PGM2L1 4 shared pathwaysStarch and sucrose metabolism, Glycogen breakdown (glycogenolysis), Galactose catabolism, Glycogen synthesis Related via 4 shared pathways including Starch and sucrose metabolism, Glycogen breakdown (glycogenolysis). GPI 5 shared pathwaysGlycolysis / Gluconeogenesis, Pentose phosphate pathway, Starch and sucrose metabolism, Amino sugar and nucleotide sugar metabolism, Biosynthesis of nucleotide sugars Related via 5 shared pathways including Glycolysis / Gluconeogenesis, Pentose phosphate pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
PGM1	0	[]	8	["Glycolysis \/ Gluconeogenesis","Pentose phosphate pathway","Galactose metabolism","Purine metabolism","Starch and sucrose metabolism","Amino sugar and nucleotide sugar metabolism","Biosynthesis of nucleotide sugars","Glycogen synthesis"]	0	[]
GALE	0	[]	4	["Galactose metabolism","Amino sugar and nucleotide sugar metabolism","Biosynthesis of nucleotide sugars","Galactose catabolism"]	0	[]
GALK1	0	[]	4	["Galactose metabolism","Amino sugar and nucleotide sugar metabolism","Biosynthesis of nucleotide sugars","Galactose catabolism"]	0	[]
PGM2L1	0	[]	4	["Starch and sucrose metabolism","Glycogen breakdown (glycogenolysis)","Galactose catabolism","Glycogen synthesis"]	0	[]
GPI	0	[]	5	["Glycolysis \/ Gluconeogenesis","Pentose phosphate pathway","Starch and sucrose metabolism","Amino sugar and nucleotide sugar metabolism","Biosynthesis of nucleotide sugars"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesPGM1, GALK1 Galactosemia Linked via 2 of 5 related genesGALE, GALK1 Neurodevelopmental disorder Linked via 2 of 5 related genesPGM2L1, GPI Colorectal neoplasms Linked via 1 of 5 related genesPGM1 Congenital disorder of glycosylation Linked via 1 of 5 related genesPGM1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["PGM1","GALK1"]
Galactosemia	2	["GALE","GALK1"]
Neurodevelopmental disorder	2	["PGM2L1","GPI"]
Colorectal neoplasms	1	["PGM1"]
Congenital disorder of glycosylation	1	["PGM1"]