NKIRAS2 (NFKB inhibitor interacting Ras like 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 28511 |
| Gene name | NFKB inhibitor interacting Ras like 2 |
| Gene symbol | NKIRAS2 |
| Synonyms (NCBI Gene) |
KBRAS2kappaB-Ras2
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| Chromosome | 17 |
| Chromosome location | 17q21.2 |
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miRNA
miRNA information provided by mirtarbase database.
600
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9NYR9 | ||||||||||
| Protein name | NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2) | ||||||||||
| Protein function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking pho | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10657303}. | ||||||||||
| Sequence | |||||||||||
| Sequence length | 191 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with NKIRAS2 across shared curated disease and pathway associations.
5
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to NKIRAS2 (see Related Genes above), that are NOT already directly curated for NKIRAS2 itself -- a lead worth checking, not a confirmed association.
5
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