Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["TP53 Regulates Metabolic Genes","Pre-NOTCH Transcription and Translation","Oxidative Stress Induced Senescence","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","Oncogene Induced Senescence","MAPK6\/MAPK4 signaling","Regulation of RUNX1 Expression and Activity","Estrogen-dependent gene expression","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Transcriptional Regulation by VENTX","Ca2+ pathway","Regulation of PTEN mRNA translation"]
["TP53 Regulates Metabolic Genes","Pre-NOTCH Transcription and Translation","Oxidative Stress Induced Senescence","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","Oncogene Induced Senescence","MAPK6\/MAPK4 signaling","Regulation of RUNX1 Expression and Activity","Estrogen-dependent gene expression","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Transcriptional Regulation by VENTX","Ca2+ pathway","Regulation of PTEN mRNA translation"]
["TP53 Regulates Metabolic Genes","Pre-NOTCH Transcription and Translation","Oxidative Stress Induced Senescence","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","Oncogene Induced Senescence","MAPK6\/MAPK4 signaling","Regulation of RUNX1 Expression and Activity","Estrogen-dependent gene expression","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Transcriptional Regulation by VENTX","Ca2+ pathway","Regulation of PTEN mRNA translation"]
["TP53 Regulates Metabolic Genes","Pre-NOTCH Transcription and Translation","Oxidative Stress Induced Senescence","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","Oncogene Induced Senescence","MAPK6\/MAPK4 signaling","Regulation of RUNX1 Expression and Activity","Estrogen-dependent gene expression","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Transcriptional Regulation by VENTX","Ca2+ pathway","Regulation of PTEN mRNA translation"]
["TP53 Regulates Metabolic Genes","Pre-NOTCH Transcription and Translation","Oxidative Stress Induced Senescence","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","Oncogene Induced Senescence","MAPK6\/MAPK4 signaling","Regulation of RUNX1 Expression and Activity","Estrogen-dependent gene expression","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Transcriptional Regulation by VENTX","Ca2+ pathway","Regulation of PTEN mRNA translation"]
0
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Diseases Linked via Similar GenesDiseases curated for genes most similar to MOV10 (see Related Genes above), that are NOT already directly curated for MOV10 itself -- a lead worth checking, not a confirmed association.