LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 8649 |
| Gene name | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 |
| Gene symbol | LAMTOR3 |
| Synonyms (NCBI Gene) |
MAP2K1IP1MAPBPMAPKSP1MP1PRO0633Ragulator3
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| Chromosome | 4 |
| Chromosome location | 4q23 |
| Summary | This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UHA4 | ||||||||||
| Protein name | Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1) | ||||||||||
| Protein function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, PubMed:22980980, PubMed:289 | ||||||||||
| PDB | 1SKO , 2ZL1 , 3CPT , 5X6U , 5X6V , 5Y39 , 5Y3A , 5YK3 , 6B9X , 6EHP , 6EHR , 6NZD , 6U62 , 6ULG , 6WJ2 , 6WJ3 , 7T3A , 7T3B , 7T3C , 7UX2 , 7UXC , 7UXH , 8DHB | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 124 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with LAMTOR3 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to LAMTOR3 (see Related Genes above), that are NOT already directly curated for LAMTOR3 itself -- a lead worth checking, not a confirmed association.
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