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Gene Gene information from NCBI Gene database.
Entrez ID 55004
Gene name Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Gene symbol LAMTOR1
Synonyms (NCBI Gene)
C11orf59PDRORagulator1p18p27RF-Rho
Chromosome 11
Chromosome location 11q13.4
miRNA miRNA information provided by mirtarbase database.
565 Show/Hide all (565)
miRTarBase ID miRNA Experiments Reference
MIRT031493 hsa-miR-16-5p Proteomics 18668040
MIRT051830 hsa-let-7c-5p CLASH 23622248
MIRT050533 hsa-miR-20a-5p CLASH 23622248
MIRT712747 hsa-miR-548ac HITS-CLIP 19536157
MIRT712746 hsa-miR-548bb-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
76 Show/Hide all (76)
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IDA 28890335
GO:0001558 Process Regulation of cell growth IMP 20381137
GO:0001919 Process Regulation of receptor recycling IBA
GO:0001919 Process Regulation of receptor recycling IEA
GO:0001919 Process Regulation of receptor recycling ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613510 26068 ENSG00000149357
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6IAA8
Protein name Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)
Protein function Key component of the Ragulator complex, a multiprotein complex involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:20381137, Pub
PDB 5X6U , 5X6V , 5Y39 , 5Y3A , 5YK3 , 6B9X , 6EHP , 6EHR , 6NZD , 6U62 , 6ULG , 6WJ2 , 6WJ3 , 7T3A , 7T3B , 7T3C , 7UX2 , 7UXC , 7UXH , 8DHB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15454 LAMTOR 16 → 85 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Family
Sequence
MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAK
TASNIIDVSAADSQGMEQHEYMDRA
RQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLA
SEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
Sequence length 161
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
mTOR signaling pathway Macroautophagy
  mTOR signalling
  mTORC1-mediated signalling
  Energy dependent regulation of mTOR by LKB1-AMPK
  TP53 Regulates Metabolic Genes
  Neutrophil degranulation
  Regulation of PTEN gene transcription
  Amino acids regulate mTORC1