Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	83444
Gene name	INO80 complex subunit B
Gene symbol	INO80B
Synonyms (NCBI Gene)	HMGA1L4HMGIYL4IES2PAP-1BPPAPA-1PAPA1ZNHIT4hIes2
Chromosome	2
Chromosome location	2p13.1
Summary	This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downs

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018307	hsa-miR-335-5p	Microarray	18185580
MIRT047255	hsa-miR-181b-5p	CLASH	23622248
MIRT042253	hsa-miR-484	CLASH	23622248
MIRT497025	hsa-miR-888-3p	PAR-CLIP	22291592
MIRT497024	hsa-miR-323b-3p	PAR-CLIP	22291592
MIRT497023	hsa-miR-3660	PAR-CLIP	22291592
MIRT497022	hsa-miR-4526	PAR-CLIP	22291592
MIRT497021	hsa-miR-2277-3p	PAR-CLIP	22291592
MIRT497020	hsa-miR-4513	PAR-CLIP	22291592
MIRT497019	hsa-miR-6855-3p	PAR-CLIP	22291592
MIRT497018	hsa-miR-6857-3p	PAR-CLIP	22291592
MIRT497017	hsa-miR-4662a-5p	PAR-CLIP	22291592
MIRT497016	hsa-miR-3136-5p	PAR-CLIP	22291592
MIRT497015	hsa-miR-4439	PAR-CLIP	22291592
MIRT497025	hsa-miR-888-3p	PAR-CLIP	22291592
MIRT497024	hsa-miR-323b-3p	PAR-CLIP	22291592
MIRT497023	hsa-miR-3660	PAR-CLIP	22291592
MIRT497022	hsa-miR-4526	PAR-CLIP	22291592
MIRT497021	hsa-miR-2277-3p	PAR-CLIP	22291592
MIRT497020	hsa-miR-4513	PAR-CLIP	22291592
MIRT497019	hsa-miR-6855-3p	PAR-CLIP	22291592
MIRT497018	hsa-miR-6857-3p	PAR-CLIP	22291592
MIRT497017	hsa-miR-4662a-5p	PAR-CLIP	22291592
MIRT497016	hsa-miR-3136-5p	PAR-CLIP	22291592
MIRT497015	hsa-miR-4439	PAR-CLIP	22291592
MIRT1066808	hsa-miR-335	CLIP-seq
MIRT1066809	hsa-miR-3622b-5p	CLIP-seq
MIRT1066810	hsa-miR-4253	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000723	Process	Telomere maintenance	ISO
GO:0005515	Function	Protein binding	IPI	19095771, 25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006275	Process	Regulation of DNA replication	IMP	25016522
GO:0006281	Process	DNA repair	IEA
GO:0006282	Process	Regulation of DNA repair	ISO
GO:0006310	Process	DNA recombination	IEA
GO:0006338	Process	Chromatin remodeling	IDA	21303910
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0031011	Component	Ino80 complex	IBA
GO:0031011	Component	Ino80 complex	IDA	21303910
GO:0031011	Component	Ino80 complex	IEA
GO:0033044	Process	Regulation of chromosome organization	IMP	26340092
GO:0045739	Process	Positive regulation of DNA repair	ISO
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	27641337
GO:0045995	Process	Regulation of embryonic development	ISO
GO:0046872	Function	Metal ion binding	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	26340092
GO:0060382	Process	Regulation of DNA strand elongation	IMP	25016522
GO:1904507	Process	Positive regulation of telomere maintenance in response to DNA damage	ISO

MIM	HGNC	e!Ensembl
616456	13324	ENSG00000115274

Q9C086

Protein name

INO80 complex subunit B (High mobility group AT-hook 1-like 4) (IES2 homolog) (hIes2) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4)

Protein function

Induces growth and cell cycle arrests at the G1 phase of the cell cycle. ; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication

PDB

6HTS , 7ZI4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04438	zf-HIT	305 → 336	HIT zinc finger	Domain
PF04795	PAPA-1	211 → 290	PAPA-1-like conserved region	Family

Sequence

MSKLWRRGSTSGAMEAPEPGEALELSLAGAHGHGVHKKKHKKHKKKHKKKHHQEEDAGPT
QPSPAKPQLKLKIKLGGQVLGTKSVPTFTVIPEGPRSPSPLMVVDNEEEPMEGVPLEQYR
AWLDEDSNLSPSPLRDLSGGLGGQEEEEEQRWLDALEKGELDDNGDLKKEINERLLTARQ
RALLQKARSQPSPMLPLPVAEGCPPPALTEEMLLKREERARKRRLQAARRAEEHKNQTIE
RLTKTAATSGRGGRGGARGERRGGRAAAPAPMVRYCSGAQGSTLSFPPGVPAPTAVSQRP
SPSGPPPRCSVPGCPHPRRYACSRTGQALCSLQCYRINLQMRLGGPEGPGSPLLAT

Sequence length

356

Interactions

View interactions

KEGG Pathway	Reactome Pathway
ATP-dependent chromatin remodeling	UCH proteinases
	DNA Damage Recognition in GG-NER

INO80B (INO80 complex subunit B)

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