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Gene Gene information from NCBI Gene database.
Entrez ID 3312
Gene name Heat shock protein family A (Hsp70) member 8
Gene symbol HSPA8
Synonyms (NCBI Gene)
HEL-33HEL-S-72pHSC54HSC70HSC71HSP71HSP73HSPA10LAP-1LAP1NIP71
Chromosome 11
Chromosome location 11q24.1
Summary This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a
miRNA miRNA information provided by mirtarbase database.
1331 Show/Hide all (1331)
miRTarBase ID miRNA Experiments Reference
MIRT052021 hsa-let-7b-5p CLASH 23622248
MIRT052021 hsa-let-7b-5p CLASH 23622248
MIRT051117 hsa-miR-16-5p CLASH 23622248
MIRT051117 hsa-miR-16-5p CLASH 23622248
MIRT050343 hsa-miR-25-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
KLF4 Activation 18379898
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
117 Show/Hide all (117)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000398 Process MRNA splicing, via spliceosome NAS 23742842
GO:0000974 Component Prp19 complex IDA 20176811
GO:0000974 Component Prp19 complex IPI 20176811
GO:0001664 Function G protein-coupled receptor binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600816 5241 ENSG00000109971
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11142
Protein name Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Heat shock protein family A member 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
Protein function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfold
PDB 3AGY , 3AGZ , 3ESK , 3FZF , 3FZH , 3FZK , 3FZL , 3FZM , 3LDQ , 3M3Z , 4H5N , 4H5R , 4H5T , 4H5V , 4H5W , 4HWI , 4KBQ , 5AQF , 5AQG , 5AQH , 5AQI , 5AQJ , 5AQK , 5AQL , 5AQM , 5AQN , 5AQO , 5AQP , 5AQQ , 5AQR , 5AQS , 5AQT , 5AQU , 5AQV , 6B1I , 6B1M , 6B1N , 6ZYJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 6 → 612 Hsp70 protein Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11276205}.
Sequence
Sequence length 646
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Spliceosome Regulation of HSF1-mediated heat shock response
MAPK signaling pathway HSP90 chaperone cycle for steroid hormone receptors (SHR)
Protein processing in endoplasmic reticulum Attenuation phase
Endocytosis HSF1-dependent transactivation
Longevity regulating pathway - multiple species Lysosome Vesicle Biogenesis
Antigen processing and presentation Golgi Associated Vesicle Biogenesis
Estrogen signaling pathway AUF1 (hnRNP D0) binds and destabilizes mRNA
Prion disease Interleukin-4 and Interleukin-13 signaling
Legionellosis Neutrophil degranulation
Toxoplasmosis mRNA Splicing - Major Pathway
Measles Clathrin-mediated endocytosis
Lipid and atherosclerosis Protein methylation
  GABA synthesis, release, reuptake and degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (8)
Phenotype Name Clinical Significance Source Reference Evidence Score
CARCINOMA, SQUAMOUS CELL — CTD 15274141
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MOUTH NEOPLASMS — CTD 15274141
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
POST-OPERATIVE ACUTE KIDNEY INJURY — GWAS catalog 30678657
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (129)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome CTD_human_DG 21751358
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma CTD_human_DG 15378696
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22743058
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Basal Cell Adenocarcinoma CTD_human_DG 15378696
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Oxyphilic Adenocarcinoma CTD_human_DG 15378696
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Tubular Adenocarcinoma CTD_human_DG 15378696
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 36246562 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 28978466
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 32687490 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 10225814, 14730603 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only