Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	2963
Gene name	General transcription factor IIF subunit 2
Gene symbol	GTF2F2
Synonyms (NCBI Gene)	BTF4RAP30TF2F2TFIIF
Chromosome	13
Chromosome location	13q14.12-q14.13

136 Show/Hide all (136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT723130	hsa-miR-548ac	HITS-CLIP	19536157
MIRT723129	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT723128	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT723127	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT723126	hsa-miR-548z	HITS-CLIP	19536157
MIRT723125	hsa-miR-548as-3p	HITS-CLIP	19536157
MIRT723124	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT723123	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT723122	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT723130	hsa-miR-548ac	HITS-CLIP	19536157
MIRT723129	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT723128	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT723127	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT723126	hsa-miR-548z	HITS-CLIP	19536157
MIRT723125	hsa-miR-548as-3p	HITS-CLIP	19536157
MIRT723124	hsa-miR-500a-5p	HITS-CLIP	19536157
MIRT723123	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT723122	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT1036859	hsa-miR-1278	CLIP-seq
MIRT1036860	hsa-miR-3622a-3p	CLIP-seq
MIRT1036861	hsa-miR-3622b-3p	CLIP-seq
MIRT1036862	hsa-miR-3973	CLIP-seq
MIRT1036863	hsa-miR-520g	CLIP-seq
MIRT1036864	hsa-miR-520h	CLIP-seq
MIRT1036865	hsa-miR-539	CLIP-seq
MIRT1036866	hsa-miR-548k	CLIP-seq
MIRT1036867	hsa-miR-668	CLIP-seq
MIRT2007410	hsa-miR-145	CLIP-seq
MIRT2007411	hsa-miR-153	CLIP-seq
MIRT2007412	hsa-miR-3136-5p	CLIP-seq
MIRT2007413	hsa-miR-3137	CLIP-seq
MIRT2007414	hsa-miR-3143	CLIP-seq
MIRT2007415	hsa-miR-3614-3p	CLIP-seq
MIRT2007416	hsa-miR-3686	CLIP-seq
MIRT2007417	hsa-miR-4297	CLIP-seq
MIRT2007418	hsa-miR-4439	CLIP-seq
MIRT2007419	hsa-miR-448	CLIP-seq
MIRT2007420	hsa-miR-450b-5p	CLIP-seq
MIRT2007421	hsa-miR-452	CLIP-seq
MIRT2007422	hsa-miR-4652-3p	CLIP-seq
MIRT2007423	hsa-miR-4676-3p	CLIP-seq
MIRT2007424	hsa-miR-4703-3p	CLIP-seq
MIRT2007425	hsa-miR-4712-5p	CLIP-seq
MIRT2007426	hsa-miR-4794	CLIP-seq
MIRT2007427	hsa-miR-4803	CLIP-seq
MIRT2007428	hsa-miR-507	CLIP-seq
MIRT2007429	hsa-miR-557	CLIP-seq
MIRT1036867	hsa-miR-668	CLIP-seq
MIRT2007430	hsa-miR-770-5p	CLIP-seq
MIRT2007431	hsa-miR-943	CLIP-seq
MIRT2007414	hsa-miR-3143	CLIP-seq
MIRT2240086	hsa-miR-4282	CLIP-seq
MIRT2007427	hsa-miR-4803	CLIP-seq
MIRT2240087	hsa-miR-498	CLIP-seq
MIRT2240088	hsa-miR-513a-3p	CLIP-seq
MIRT1036867	hsa-miR-668	CLIP-seq
MIRT2007410	hsa-miR-145	CLIP-seq
MIRT2007414	hsa-miR-3143	CLIP-seq
MIRT2007415	hsa-miR-3614-3p	CLIP-seq
MIRT2007417	hsa-miR-4297	CLIP-seq
MIRT2007420	hsa-miR-450b-5p	CLIP-seq
MIRT2007425	hsa-miR-4712-5p	CLIP-seq
MIRT2007427	hsa-miR-4803	CLIP-seq
MIRT2240087	hsa-miR-498	CLIP-seq
MIRT2007428	hsa-miR-507	CLIP-seq
MIRT2007429	hsa-miR-557	CLIP-seq
MIRT1036867	hsa-miR-668	CLIP-seq
MIRT2007430	hsa-miR-770-5p	CLIP-seq
MIRT2543747	hsa-miR-1284	CLIP-seq
MIRT2007410	hsa-miR-145	CLIP-seq
MIRT2007411	hsa-miR-153	CLIP-seq
MIRT2543748	hsa-miR-300	CLIP-seq
MIRT2543749	hsa-miR-3132	CLIP-seq
MIRT2007412	hsa-miR-3136-5p	CLIP-seq
MIRT2007413	hsa-miR-3137	CLIP-seq
MIRT2007414	hsa-miR-3143	CLIP-seq
MIRT2543750	hsa-miR-3189-3p	CLIP-seq
MIRT2007415	hsa-miR-3614-3p	CLIP-seq
MIRT2543751	hsa-miR-3658	CLIP-seq
MIRT2007416	hsa-miR-3686	CLIP-seq
MIRT2543752	hsa-miR-381	CLIP-seq
MIRT2543753	hsa-miR-3940-5p	CLIP-seq
MIRT2543754	hsa-miR-4279	CLIP-seq
MIRT2543755	hsa-miR-4294	CLIP-seq
MIRT2007417	hsa-miR-4297	CLIP-seq
MIRT2007418	hsa-miR-4439	CLIP-seq
MIRT2543756	hsa-miR-4448	CLIP-seq
MIRT2543757	hsa-miR-4451	CLIP-seq
MIRT2007419	hsa-miR-448	CLIP-seq
MIRT2543758	hsa-miR-4507	CLIP-seq
MIRT2007420	hsa-miR-450b-5p	CLIP-seq
MIRT2007421	hsa-miR-452	CLIP-seq
MIRT2007422	hsa-miR-4652-3p	CLIP-seq
MIRT2543759	hsa-miR-4666-3p	CLIP-seq
MIRT2007423	hsa-miR-4676-3p	CLIP-seq
MIRT2543760	hsa-miR-4698	CLIP-seq
MIRT2007424	hsa-miR-4703-3p	CLIP-seq
MIRT2007425	hsa-miR-4712-5p	CLIP-seq
MIRT2543761	hsa-miR-4742-3p	CLIP-seq
MIRT2543762	hsa-miR-4777-3p	CLIP-seq
MIRT2007426	hsa-miR-4794	CLIP-seq
MIRT2007427	hsa-miR-4803	CLIP-seq
MIRT2240087	hsa-miR-498	CLIP-seq
MIRT2007428	hsa-miR-507	CLIP-seq
MIRT2543763	hsa-miR-548al	CLIP-seq
MIRT2543764	hsa-miR-556-3p	CLIP-seq
MIRT2007429	hsa-miR-557	CLIP-seq
MIRT2543765	hsa-miR-578	CLIP-seq
MIRT2543766	hsa-miR-607	CLIP-seq
MIRT2543767	hsa-miR-629	CLIP-seq
MIRT2543768	hsa-miR-639	CLIP-seq
MIRT1036867	hsa-miR-668	CLIP-seq
MIRT2007430	hsa-miR-770-5p	CLIP-seq
MIRT2543769	hsa-miR-924	CLIP-seq
MIRT2007431	hsa-miR-943	CLIP-seq
MIRT2007410	hsa-miR-145	CLIP-seq
MIRT2007411	hsa-miR-153	CLIP-seq
MIRT2007414	hsa-miR-3143	CLIP-seq
MIRT2007415	hsa-miR-3614-3p	CLIP-seq
MIRT2543753	hsa-miR-3940-5p	CLIP-seq
MIRT2007417	hsa-miR-4297	CLIP-seq
MIRT2007419	hsa-miR-448	CLIP-seq
MIRT2543758	hsa-miR-4507	CLIP-seq
MIRT2007420	hsa-miR-450b-5p	CLIP-seq
MIRT2543760	hsa-miR-4698	CLIP-seq
MIRT2007425	hsa-miR-4712-5p	CLIP-seq
MIRT2007426	hsa-miR-4794	CLIP-seq
MIRT2007427	hsa-miR-4803	CLIP-seq
MIRT2240087	hsa-miR-498	CLIP-seq
MIRT2007428	hsa-miR-507	CLIP-seq
MIRT2007429	hsa-miR-557	CLIP-seq
MIRT2543766	hsa-miR-607	CLIP-seq
MIRT2543767	hsa-miR-629	CLIP-seq
MIRT2543768	hsa-miR-639	CLIP-seq
MIRT1036867	hsa-miR-668	CLIP-seq
MIRT2007430	hsa-miR-770-5p	CLIP-seq

25 Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	7854423, 8504927, 8662660, 11183778, 12737519, 20195357, 24981860, 31467278, 32296183, 37398436
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005634	Component	Nucleus	IDA	9841876
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005674	Component	Transcription factor TFIIF complex	IBA
GO:0005674	Component	Transcription factor TFIIF complex	IEA
GO:0005674	Component	Transcription factor TFIIF complex	IPI	11183778
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006366	Process	Transcription by RNA polymerase II	IMP	8662660
GO:0006366	Process	Transcription by RNA polymerase II	TAS	7929273
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IBA
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IDA	15351637
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IEA
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	ISS
GO:0006368	Process	Transcription elongation by RNA polymerase II	IDA	15351637
GO:0006368	Process	Transcription elongation by RNA polymerase II	IEA
GO:0006368	Process	Transcription elongation by RNA polymerase II	TAS	7929273
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	ISS
GO:0016591	Component	RNA polymerase II, holoenzyme	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	15351637
GO:0090575	Component	RNA polymerase II transcription regulator complex	IEA

MIM	HGNC	e!Ensembl
189969	4653	ENSG00000188342

P13984

Protein name

General transcription factor IIF subunit 2 (General transcription factor IIF 30 kDa subunit) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) (Transcription initiation factor RAP30)

Protein function

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.

PDB

1BBY , 1F3U , 2BBY , 5IY6 , 5IY7 , 5IY8 , 5IY9 , 5IYA , 5IYB , 5IYC , 5IYD , 6O9L , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7ENA , 7ENC , 7LBM , 7NVR , 7NVS , 7NVT , 7NVU , 7NVY , 7NVZ , 7NW0 , 7ZWD , 7ZX7 , 7ZX8 , 8BVW , 8BYQ , 8BZ1 , 8GXQ , 8GXS , 8S51 , 8S52 , 8S54 , 8S55 , 8S5N , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR , 8WAS , 8WAT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02270	TFIIF_beta	176 → 240	TFIIF, beta subunit HTH domain	Domain
PF17683	TFIIF_beta_N	15 → 198	TFIIF, beta subunit N-terminus	Family

Sequence

MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNE
DLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAA
SENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADK
QHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYR
HYQGEEKSD

Sequence length

249

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Basal transcription factors	Formation of RNA Pol II elongation complex
	Formation of the Early Elongation Complex
	Formation of HIV-1 elongation complex containing HIV-1 Tat
	Viral Messenger RNA Synthesis
	RNA Polymerase II Pre-transcription Events
	TP53 Regulates Transcription of DNA Repair Genes
	FGFR2 alternative splicing
	RNA polymerase II transcribes snRNA genes
	mRNA Capping
	mRNA Splicing - Major Pathway
	mRNA Splicing - Minor Pathway
	Processing of Capped Intron-Containing Pre-mRNA
	RNA Polymerase II Promoter Escape
	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
	RNA Polymerase II Transcription Initiation
	RNA Polymerase II Transcription Elongation
	RNA Polymerase II Transcription Initiation And Promoter Clearance
	RNA Pol II CTD phosphorylation and interaction with CE
	Estrogen-dependent gene expression

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	25760438	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	18398031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	18398031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucopolysaccharidosis I	Mucopolysaccharidosis	Pubtator	32880920	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	36857354	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
GTF2F1	[]	20	["Basal transcription factors","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway","Formation of the Early Elongation Complex","RNA polymerase II transcribes snRNA genes","mRNA Capping","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"]	[]
POLR2A	[]	19	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway","Formation of the Early Elongation Complex","RNA polymerase II transcribes snRNA genes","mRNA Capping","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation"]	[]
POLR2B	[]	19	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway","Formation of the Early Elongation Complex","RNA polymerase II transcribes snRNA genes","mRNA Capping","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation"]	[]
POLR2C	[]	19	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway","Formation of the Early Elongation Complex","RNA polymerase II transcribes snRNA genes","mRNA Capping","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation"]	[]
POLR2D	[]	19	["Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway","Formation of the Early Elongation Complex","RNA polymerase II transcribes snRNA genes","mRNA Capping","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation"]	[]

GTF2F2 (general transcription factor IIF subunit 2)

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