Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	5432
Gene name	RNA polymerase II subunit C
Gene symbol	POLR2C
Synonyms (NCBI Gene)	RPB3RPB31hRPB33hsRPB3
Chromosome	16
Chromosome location	16q21
Summary	This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit

145 Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001607	hsa-let-7b-5p	pSILAC	18668040
MIRT021037	hsa-miR-155-5p	Proteomics	18668040
MIRT028639	hsa-miR-30a-5p	Proteomics	18668040
MIRT001607	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT042934	hsa-miR-324-3p	CLASH	23622248
MIRT041266	hsa-miR-193b-3p	CLASH	23622248
MIRT021037	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT021037	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1248422	hsa-miR-1182	CLIP-seq
MIRT1248423	hsa-miR-1253	CLIP-seq
MIRT1248424	hsa-miR-127-5p	CLIP-seq
MIRT1248425	hsa-miR-1276	CLIP-seq
MIRT1248426	hsa-miR-129-5p	CLIP-seq
MIRT1248427	hsa-miR-1303	CLIP-seq
MIRT1248428	hsa-miR-137	CLIP-seq
MIRT1248429	hsa-miR-155	CLIP-seq
MIRT1248430	hsa-miR-185	CLIP-seq
MIRT1248431	hsa-miR-205	CLIP-seq
MIRT1248432	hsa-miR-218	CLIP-seq
MIRT1248433	hsa-miR-2681	CLIP-seq
MIRT1248434	hsa-miR-28-3p	CLIP-seq
MIRT1248435	hsa-miR-3123	CLIP-seq
MIRT1248436	hsa-miR-3150a-3p	CLIP-seq
MIRT1248437	hsa-miR-3162-3p	CLIP-seq
MIRT1248438	hsa-miR-3162-5p	CLIP-seq
MIRT1248439	hsa-miR-3173-3p	CLIP-seq
MIRT1248440	hsa-miR-3175	CLIP-seq
MIRT1248441	hsa-miR-3192	CLIP-seq
MIRT1248442	hsa-miR-3646	CLIP-seq
MIRT1248443	hsa-miR-3647-3p	CLIP-seq
MIRT1248444	hsa-miR-378	CLIP-seq
MIRT1248445	hsa-miR-378b	CLIP-seq
MIRT1248446	hsa-miR-378c	CLIP-seq
MIRT1248447	hsa-miR-378d	CLIP-seq
MIRT1248448	hsa-miR-378e	CLIP-seq
MIRT1248449	hsa-miR-378f	CLIP-seq
MIRT1248450	hsa-miR-378h	CLIP-seq
MIRT1248451	hsa-miR-378i	CLIP-seq
MIRT1248452	hsa-miR-3919	CLIP-seq
MIRT1248453	hsa-miR-411	CLIP-seq
MIRT1248454	hsa-miR-422a	CLIP-seq
MIRT1248455	hsa-miR-4259	CLIP-seq
MIRT1248456	hsa-miR-4306	CLIP-seq
MIRT1248457	hsa-miR-4311	CLIP-seq
MIRT1248458	hsa-miR-4314	CLIP-seq
MIRT1248459	hsa-miR-4330	CLIP-seq
MIRT1248460	hsa-miR-4428	CLIP-seq
MIRT1248461	hsa-miR-4477b	CLIP-seq
MIRT1248462	hsa-miR-4487	CLIP-seq
MIRT1248463	hsa-miR-450b-3p	CLIP-seq
MIRT1248464	hsa-miR-4521	CLIP-seq
MIRT1248465	hsa-miR-4644	CLIP-seq
MIRT1248466	hsa-miR-4646-5p	CLIP-seq
MIRT1248467	hsa-miR-4667-5p	CLIP-seq
MIRT1248468	hsa-miR-4690-5p	CLIP-seq
MIRT1248469	hsa-miR-4700-5p	CLIP-seq
MIRT1248470	hsa-miR-4709-3p	CLIP-seq
MIRT1248471	hsa-miR-4709-5p	CLIP-seq
MIRT1248472	hsa-miR-4713-3p	CLIP-seq
MIRT1248473	hsa-miR-4715-5p	CLIP-seq
MIRT1248474	hsa-miR-4728-5p	CLIP-seq
MIRT1248475	hsa-miR-4742-5p	CLIP-seq
MIRT1248476	hsa-miR-4768-3p	CLIP-seq
MIRT1248477	hsa-miR-4781-3p	CLIP-seq
MIRT1248478	hsa-miR-491-5p	CLIP-seq
MIRT1248479	hsa-miR-539	CLIP-seq
MIRT1248480	hsa-miR-541	CLIP-seq
MIRT1248481	hsa-miR-548ag	CLIP-seq
MIRT1248482	hsa-miR-548ai	CLIP-seq
MIRT1248483	hsa-miR-583	CLIP-seq
MIRT1248484	hsa-miR-628-5p	CLIP-seq
MIRT1248485	hsa-miR-629	CLIP-seq
MIRT1248486	hsa-miR-637	CLIP-seq
MIRT1248487	hsa-miR-638	CLIP-seq
MIRT1248488	hsa-miR-654-5p	CLIP-seq
MIRT1248489	hsa-miR-659	CLIP-seq
MIRT1248490	hsa-miR-665	CLIP-seq
MIRT1248491	hsa-miR-769-3p	CLIP-seq
MIRT1248492	hsa-miR-936	CLIP-seq
MIRT1248493	hsa-miR-939	CLIP-seq
MIRT2073338	hsa-miR-1206	CLIP-seq
MIRT2073339	hsa-miR-1237	CLIP-seq
MIRT2073340	hsa-miR-1287	CLIP-seq
MIRT2073341	hsa-miR-1539	CLIP-seq
MIRT1248429	hsa-miR-155	CLIP-seq
MIRT2073342	hsa-miR-1976	CLIP-seq
MIRT2073343	hsa-miR-2115	CLIP-seq
MIRT2073344	hsa-miR-214	CLIP-seq
MIRT2073345	hsa-miR-3135b	CLIP-seq
MIRT1248436	hsa-miR-3150a-3p	CLIP-seq
MIRT1248440	hsa-miR-3175	CLIP-seq
MIRT1248441	hsa-miR-3192	CLIP-seq
MIRT2073346	hsa-miR-3193	CLIP-seq
MIRT2073347	hsa-miR-338-3p	CLIP-seq
MIRT2073348	hsa-miR-3591-3p	CLIP-seq
MIRT2073349	hsa-miR-3619-5p	CLIP-seq
MIRT2073350	hsa-miR-3649	CLIP-seq
MIRT2073351	hsa-miR-4268	CLIP-seq
MIRT1248458	hsa-miR-4314	CLIP-seq
MIRT2073352	hsa-miR-433	CLIP-seq
MIRT2073353	hsa-miR-4448	CLIP-seq
MIRT1248463	hsa-miR-450b-3p	CLIP-seq
MIRT2073354	hsa-miR-4520a-3p	CLIP-seq
MIRT2073355	hsa-miR-4530	CLIP-seq
MIRT2073356	hsa-miR-4638-3p	CLIP-seq
MIRT1248466	hsa-miR-4646-5p	CLIP-seq
MIRT2073357	hsa-miR-4652-3p	CLIP-seq
MIRT1248467	hsa-miR-4667-5p	CLIP-seq
MIRT1248469	hsa-miR-4700-5p	CLIP-seq
MIRT1248472	hsa-miR-4713-3p	CLIP-seq
MIRT2073358	hsa-miR-508-5p	CLIP-seq
MIRT2073359	hsa-miR-516a-3p	CLIP-seq
MIRT1248486	hsa-miR-637	CLIP-seq
MIRT1248487	hsa-miR-638	CLIP-seq
MIRT2073360	hsa-miR-640	CLIP-seq
MIRT2073361	hsa-miR-761	CLIP-seq
MIRT2073362	hsa-miR-766	CLIP-seq
MIRT1248491	hsa-miR-769-3p	CLIP-seq
MIRT1248493	hsa-miR-939	CLIP-seq
MIRT2073338	hsa-miR-1206	CLIP-seq
MIRT1248434	hsa-miR-28-3p	CLIP-seq
MIRT1248436	hsa-miR-3150a-3p	CLIP-seq
MIRT1248440	hsa-miR-3175	CLIP-seq
MIRT2300432	hsa-miR-3179	CLIP-seq
MIRT1248443	hsa-miR-3647-3p	CLIP-seq
MIRT2300433	hsa-miR-3662	CLIP-seq
MIRT2300434	hsa-miR-3689d	CLIP-seq
MIRT2300435	hsa-miR-3936	CLIP-seq
MIRT1248453	hsa-miR-411	CLIP-seq
MIRT2073352	hsa-miR-433	CLIP-seq
MIRT1248459	hsa-miR-4330	CLIP-seq
MIRT1248471	hsa-miR-4709-5p	CLIP-seq
MIRT1248492	hsa-miR-936	CLIP-seq
MIRT1248493	hsa-miR-939	CLIP-seq
MIRT2597177	hsa-miR-1263	CLIP-seq
MIRT2597178	hsa-miR-2964a-5p	CLIP-seq
MIRT1248455	hsa-miR-4259	CLIP-seq
MIRT2597179	hsa-miR-4480	CLIP-seq
MIRT1248471	hsa-miR-4709-5p	CLIP-seq
MIRT1248473	hsa-miR-4715-5p	CLIP-seq
MIRT2597180	hsa-miR-4722-3p	CLIP-seq
MIRT2597177	hsa-miR-1263	CLIP-seq
MIRT2597178	hsa-miR-2964a-5p	CLIP-seq
MIRT1248455	hsa-miR-4259	CLIP-seq
MIRT1248473	hsa-miR-4715-5p	CLIP-seq

17 Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000428	Component	DNA-directed RNA polymerase complex	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003899	Function	DNA-directed RNA polymerase activity	IBA
GO:0003899	Function	DNA-directed RNA polymerase activity	IEA
GO:0005515	Function	Protein binding	IPI	12860379
GO:0005634	Component	Nucleus	IDA	9852112
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005665	Component	RNA polymerase II, core complex	IBA
GO:0005665	Component	RNA polymerase II, core complex	IDA	9852112
GO:0005829	Component	Cytosol	IDA
GO:0006351	Process	DNA-templated transcription	IEA
GO:0006366	Process	Transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IDA	9852112
GO:0046983	Function	Protein dimerization activity	IEA

MIM	HGNC	e!Ensembl
180663	9189	ENSG00000102978

P19387

Protein name

DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)

Protein function

Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. {ECO:0000269|PubMed:27193682, ECO:00002

PDB

5IY6 , 5IY7 , 5IY8 , 5IY9 , 5IYA , 5IYB , 5IYC , 5IYD , 6DRD , 6O9L , 6XRE , 7LBM , 9EHZ , 9EI1 , 9EI3 , 9EI4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01000	RNA_pol_A_bac	50 → 177	RNA polymerase Rpb3/RpoA insert domain	Domain
PF01193	RNA_pol_L	20 → 256	RNA polymerase Rpb3/Rpb11 dimerisation domain	Domain

Sequence

MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLISDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence length

275

Interactions

View interactions

KEGG Pathway	Reactome Pathway
RNA polymerase	Formation of RNA Pol II elongation complex
Nucleotide excision repair	Formation of the Early Elongation Complex
Huntington disease	Formation of HIV-1 elongation complex containing HIV-1 Tat
	Viral Messenger RNA Synthesis
	MicroRNA (miRNA) biogenesis
	Transcriptional regulation by small RNAs
	RNA Polymerase II Pre-transcription Events
	Formation of TC-NER Pre-Incision Complex
	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	TP53 Regulates Transcription of DNA Repair Genes
	FGFR2 alternative splicing
	RNA polymerase II transcribes snRNA genes
	mRNA Capping
	mRNA Splicing - Major Pathway
	mRNA Splicing - Minor Pathway
	Processing of Capped Intron-Containing Pre-mRNA
	RNA Polymerase II Promoter Escape
	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
	RNA Polymerase II Transcription Initiation
	RNA Polymerase II Transcription Elongation
	RNA Polymerase II Transcription Initiation And Promoter Clearance
	RNA Pol II CTD phosphorylation and interaction with CE
	Estrogen-dependent gene expression

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Genetic non-acquired premature ovarian failure	Likely pathogenic	rs901733146, rs770336099	RCV001661767 RCV001663372	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Deafness	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Infertility disorder	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (7)
Breast Neoplasms	Breast neoplasm	Pubtator	40551112	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33845647	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33845647	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25211001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25211001		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30851225		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis vulgaris	Psoriasis vulgaris	BEFREE	16141233		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
POLR2A	[]	27	["RNA polymerase","Nucleotide excision repair","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway"]	[]
POLR2B	[]	27	["RNA polymerase","Nucleotide excision repair","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway"]	[]
POLR2D	[]	27	["RNA polymerase","Nucleotide excision repair","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway"]	[]
POLR2G	[]	27	["RNA polymerase","Nucleotide excision repair","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway"]	[]
POLR2I	[]	27	["RNA polymerase","Nucleotide excision repair","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of TC-NER Pre-Incision Complex","Transcription-Coupled Nucleotide Excision Repair (TC-NER)","Dual incision in TC-NER","Gap-filling DNA repair synthesis and ligation in TC-NER","mRNA Splicing - Major Pathway","mRNA Splicing - Minor Pathway"]	[]

POLR2C (RNA polymerase II subunit C)

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