GGCT (gamma-glutamylcyclotransferase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79017
• Gene name: Gamma-glutamylcyclotransferase
• Gene symbol: GGCT
• Synonyms (NCBI Gene): C7orf24, CRF21, GCTG, GGC
• Chromosome: 7
• Chromosome location: 7p14.3
• Summary: The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in c

miRNA Show/Hide all (215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005232	hsa-let-7b-5p	pSILAC	18668040
MIRT028630	hsa-miR-30a-5p	Proteomics	18668040
MIRT005232	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT045750	hsa-miR-125a-5p	CLASH	23622248
MIRT043851	hsa-miR-340-3p	CLASH	23622248
MIRT1017947	hsa-miR-1184	CLIP-seq
MIRT1017948	hsa-miR-1205	CLIP-seq
MIRT1017949	hsa-miR-1226	CLIP-seq
MIRT1017950	hsa-miR-1231	CLIP-seq
MIRT1017951	hsa-miR-1283	CLIP-seq
MIRT1017952	hsa-miR-1324	CLIP-seq
MIRT1017953	hsa-miR-181a	CLIP-seq
MIRT1017954	hsa-miR-181b	CLIP-seq
MIRT1017955	hsa-miR-181c	CLIP-seq
MIRT1017956	hsa-miR-181d	CLIP-seq
MIRT1017957	hsa-miR-197	CLIP-seq
MIRT1017958	hsa-miR-1972	CLIP-seq
MIRT1017959	hsa-miR-216a	CLIP-seq
MIRT1017960	hsa-miR-2278	CLIP-seq
MIRT1017961	hsa-miR-23a	CLIP-seq
MIRT1017962	hsa-miR-23b	CLIP-seq
MIRT1017963	hsa-miR-23c	CLIP-seq
MIRT1017964	hsa-miR-27a	CLIP-seq
MIRT1017965	hsa-miR-27b	CLIP-seq
MIRT1017966	hsa-miR-29a	CLIP-seq
MIRT1017967	hsa-miR-29b	CLIP-seq
MIRT1017968	hsa-miR-29c	CLIP-seq
MIRT1017969	hsa-miR-3065-3p	CLIP-seq
MIRT1017970	hsa-miR-3154	CLIP-seq
MIRT1017971	hsa-miR-3158-5p	CLIP-seq
MIRT1017972	hsa-miR-3179	CLIP-seq
MIRT1017973	hsa-miR-346	CLIP-seq
MIRT1017974	hsa-miR-3680	CLIP-seq
MIRT1017975	hsa-miR-3936	CLIP-seq
MIRT1017976	hsa-miR-4255	CLIP-seq
MIRT1017977	hsa-miR-4262	CLIP-seq
MIRT1017978	hsa-miR-4276	CLIP-seq
MIRT1017979	hsa-miR-4288	CLIP-seq
MIRT1017980	hsa-miR-4302	CLIP-seq
MIRT1017981	hsa-miR-4330	CLIP-seq
MIRT1017982	hsa-miR-4468	CLIP-seq
MIRT1017983	hsa-miR-4650-5p	CLIP-seq
MIRT1017984	hsa-miR-4733-3p	CLIP-seq
MIRT1017985	hsa-miR-4733-5p	CLIP-seq
MIRT1017986	hsa-miR-4762-5p	CLIP-seq
MIRT1017987	hsa-miR-4764-3p	CLIP-seq
MIRT1017988	hsa-miR-4798-3p	CLIP-seq
MIRT1017989	hsa-miR-485-3p	CLIP-seq
MIRT1017990	hsa-miR-513a-5p	CLIP-seq
MIRT1017991	hsa-miR-579	CLIP-seq
MIRT1017992	hsa-miR-610	CLIP-seq
MIRT1017993	hsa-miR-632	CLIP-seq
MIRT1017994	hsa-miR-634	CLIP-seq
MIRT1017995	hsa-miR-664	CLIP-seq
MIRT1017996	hsa-miR-767-5p	CLIP-seq
MIRT1017958	hsa-miR-1972	CLIP-seq
MIRT1017983	hsa-miR-4650-5p	CLIP-seq
MIRT1017989	hsa-miR-485-3p	CLIP-seq
MIRT1017991	hsa-miR-579	CLIP-seq
MIRT1017995	hsa-miR-664	CLIP-seq
MIRT1017947	hsa-miR-1184	CLIP-seq
MIRT1017948	hsa-miR-1205	CLIP-seq
MIRT1017949	hsa-miR-1226	CLIP-seq
MIRT1017950	hsa-miR-1231	CLIP-seq
MIRT1017951	hsa-miR-1283	CLIP-seq
MIRT2001534	hsa-miR-1305	CLIP-seq
MIRT1017952	hsa-miR-1324	CLIP-seq
MIRT2001535	hsa-miR-144	CLIP-seq
MIRT1017953	hsa-miR-181a	CLIP-seq
MIRT1017954	hsa-miR-181b	CLIP-seq
MIRT1017955	hsa-miR-181c	CLIP-seq
MIRT1017956	hsa-miR-181d	CLIP-seq
MIRT1017957	hsa-miR-197	CLIP-seq
MIRT1017958	hsa-miR-1972	CLIP-seq
MIRT1017959	hsa-miR-216a	CLIP-seq
MIRT1017960	hsa-miR-2278	CLIP-seq
MIRT1017961	hsa-miR-23a	CLIP-seq
MIRT1017962	hsa-miR-23b	CLIP-seq
MIRT1017963	hsa-miR-23c	CLIP-seq
MIRT1017964	hsa-miR-27a	CLIP-seq
MIRT1017965	hsa-miR-27b	CLIP-seq
MIRT1017966	hsa-miR-29a	CLIP-seq
MIRT1017967	hsa-miR-29b	CLIP-seq
MIRT1017968	hsa-miR-29c	CLIP-seq
MIRT1017969	hsa-miR-3065-3p	CLIP-seq
MIRT2001536	hsa-miR-3124-3p	CLIP-seq
MIRT1017970	hsa-miR-3154	CLIP-seq
MIRT1017971	hsa-miR-3158-5p	CLIP-seq
MIRT1017972	hsa-miR-3179	CLIP-seq
MIRT1017973	hsa-miR-346	CLIP-seq
MIRT1017974	hsa-miR-3680	CLIP-seq
MIRT1017975	hsa-miR-3936	CLIP-seq
MIRT1017976	hsa-miR-4255	CLIP-seq
MIRT1017977	hsa-miR-4262	CLIP-seq
MIRT1017978	hsa-miR-4276	CLIP-seq
MIRT1017979	hsa-miR-4288	CLIP-seq
MIRT1017980	hsa-miR-4302	CLIP-seq
MIRT1017981	hsa-miR-4330	CLIP-seq
MIRT2001537	hsa-miR-4428	CLIP-seq
MIRT1017982	hsa-miR-4468	CLIP-seq
MIRT1017983	hsa-miR-4650-5p	CLIP-seq
MIRT2001538	hsa-miR-4698	CLIP-seq
MIRT1017984	hsa-miR-4733-3p	CLIP-seq
MIRT1017986	hsa-miR-4762-5p	CLIP-seq
MIRT2001539	hsa-miR-4795-3p	CLIP-seq
MIRT1017988	hsa-miR-4798-3p	CLIP-seq
MIRT1017989	hsa-miR-485-3p	CLIP-seq
MIRT1017990	hsa-miR-513a-5p	CLIP-seq
MIRT2001540	hsa-miR-548c-3p	CLIP-seq
MIRT1017991	hsa-miR-579	CLIP-seq
MIRT2001541	hsa-miR-607	CLIP-seq
MIRT1017992	hsa-miR-610	CLIP-seq
MIRT1017993	hsa-miR-632	CLIP-seq
MIRT1017994	hsa-miR-634	CLIP-seq
MIRT1017995	hsa-miR-664	CLIP-seq
MIRT1017996	hsa-miR-767-5p	CLIP-seq
MIRT1017947	hsa-miR-1184	CLIP-seq
MIRT1017948	hsa-miR-1205	CLIP-seq
MIRT1017949	hsa-miR-1226	CLIP-seq
MIRT1017950	hsa-miR-1231	CLIP-seq
MIRT2234554	hsa-miR-1270	CLIP-seq
MIRT1017951	hsa-miR-1283	CLIP-seq
MIRT2001534	hsa-miR-1305	CLIP-seq
MIRT1017952	hsa-miR-1324	CLIP-seq
MIRT1017953	hsa-miR-181a	CLIP-seq
MIRT1017954	hsa-miR-181b	CLIP-seq
MIRT1017955	hsa-miR-181c	CLIP-seq
MIRT1017956	hsa-miR-181d	CLIP-seq
MIRT1017957	hsa-miR-197	CLIP-seq
MIRT1017958	hsa-miR-1972	CLIP-seq
MIRT2234555	hsa-miR-205	CLIP-seq
MIRT1017959	hsa-miR-216a	CLIP-seq
MIRT1017960	hsa-miR-2278	CLIP-seq
MIRT1017961	hsa-miR-23a	CLIP-seq
MIRT1017962	hsa-miR-23b	CLIP-seq
MIRT1017963	hsa-miR-23c	CLIP-seq
MIRT1017964	hsa-miR-27a	CLIP-seq
MIRT1017965	hsa-miR-27b	CLIP-seq
MIRT1017966	hsa-miR-29a	CLIP-seq
MIRT1017967	hsa-miR-29b	CLIP-seq
MIRT1017968	hsa-miR-29c	CLIP-seq
MIRT1017969	hsa-miR-3065-3p	CLIP-seq
MIRT2234556	hsa-miR-3123	CLIP-seq
MIRT2001536	hsa-miR-3124-3p	CLIP-seq
MIRT1017970	hsa-miR-3154	CLIP-seq
MIRT2234557	hsa-miR-3156-5p	CLIP-seq
MIRT1017971	hsa-miR-3158-5p	CLIP-seq
MIRT1017972	hsa-miR-3179	CLIP-seq
MIRT2234558	hsa-miR-335	CLIP-seq
MIRT1017973	hsa-miR-346	CLIP-seq
MIRT2234559	hsa-miR-361-3p	CLIP-seq
MIRT2234560	hsa-miR-3647-3p	CLIP-seq
MIRT1017974	hsa-miR-3680	CLIP-seq
MIRT2234561	hsa-miR-376c	CLIP-seq
MIRT1017975	hsa-miR-3936	CLIP-seq
MIRT1017976	hsa-miR-4255	CLIP-seq
MIRT1017977	hsa-miR-4262	CLIP-seq
MIRT1017978	hsa-miR-4276	CLIP-seq
MIRT1017979	hsa-miR-4288	CLIP-seq
MIRT1017980	hsa-miR-4302	CLIP-seq
MIRT1017981	hsa-miR-4330	CLIP-seq
MIRT2001537	hsa-miR-4428	CLIP-seq
MIRT1017982	hsa-miR-4468	CLIP-seq
MIRT1017983	hsa-miR-4650-5p	CLIP-seq
MIRT2234562	hsa-miR-4662a-3p	CLIP-seq
MIRT2234563	hsa-miR-4683	CLIP-seq
MIRT2234564	hsa-miR-4694-3p	CLIP-seq
MIRT2001538	hsa-miR-4698	CLIP-seq
MIRT1017984	hsa-miR-4733-3p	CLIP-seq
MIRT1017986	hsa-miR-4762-5p	CLIP-seq
MIRT1017987	hsa-miR-4764-3p	CLIP-seq
MIRT2001539	hsa-miR-4795-3p	CLIP-seq
MIRT1017988	hsa-miR-4798-3p	CLIP-seq
MIRT1017989	hsa-miR-485-3p	CLIP-seq
MIRT1017990	hsa-miR-513a-5p	CLIP-seq
MIRT2234565	hsa-miR-548ac	CLIP-seq
MIRT2234566	hsa-miR-548ae	CLIP-seq
MIRT2234567	hsa-miR-548aj	CLIP-seq
MIRT2234568	hsa-miR-548am	CLIP-seq
MIRT2001540	hsa-miR-548c-3p	CLIP-seq
MIRT2234569	hsa-miR-548d-3p	CLIP-seq
MIRT2234570	hsa-miR-548x	CLIP-seq
MIRT2234571	hsa-miR-548z	CLIP-seq
MIRT1017991	hsa-miR-579	CLIP-seq
MIRT2001541	hsa-miR-607	CLIP-seq
MIRT1017992	hsa-miR-610	CLIP-seq
MIRT2234572	hsa-miR-620	CLIP-seq
MIRT1017993	hsa-miR-632	CLIP-seq
MIRT1017994	hsa-miR-634	CLIP-seq
MIRT2234573	hsa-miR-656	CLIP-seq
MIRT1017995	hsa-miR-664	CLIP-seq
MIRT1017996	hsa-miR-767-5p	CLIP-seq
MIRT1017949	hsa-miR-1226	CLIP-seq
MIRT1017957	hsa-miR-197	CLIP-seq
MIRT1017960	hsa-miR-2278	CLIP-seq
MIRT1017964	hsa-miR-27a	CLIP-seq
MIRT1017965	hsa-miR-27b	CLIP-seq
MIRT1017966	hsa-miR-29a	CLIP-seq
MIRT1017967	hsa-miR-29b	CLIP-seq
MIRT1017968	hsa-miR-29c	CLIP-seq
MIRT1017969	hsa-miR-3065-3p	CLIP-seq
MIRT1017970	hsa-miR-3154	CLIP-seq
MIRT1017972	hsa-miR-3179	CLIP-seq
MIRT1017974	hsa-miR-3680	CLIP-seq
MIRT1017975	hsa-miR-3936	CLIP-seq
MIRT1017976	hsa-miR-4255	CLIP-seq
MIRT1017978	hsa-miR-4276	CLIP-seq
MIRT1017980	hsa-miR-4302	CLIP-seq
MIRT1017982	hsa-miR-4468	CLIP-seq
MIRT1017984	hsa-miR-4733-3p	CLIP-seq
MIRT1017986	hsa-miR-4762-5p	CLIP-seq
MIRT1017988	hsa-miR-4798-3p	CLIP-seq
MIRT1017990	hsa-miR-513a-5p	CLIP-seq
MIRT1017994	hsa-miR-634	CLIP-seq
MIRT1017996	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001836	Process	Release of cytochrome c from mitochondria	IMP	16765912
GO:0003839	Function	Gamma-glutamylcyclotransferase activity	IBA
GO:0003839	Function	Gamma-glutamylcyclotransferase activity	IDA	18515354
GO:0003839	Function	Gamma-glutamylcyclotransferase activity	IEA
GO:0005829	Component	Cytosol	IDA	16765912
GO:0005829	Component	Cytosol	TAS
GO:0016829	Function	Lyase activity	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	17932939, 18515354
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 137170
• HGNC: 21705
• e!Ensembl: ENSG00000006625

Protein

• UniProt ID: O75223
• Protein name: Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21)
• Protein function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:
• PDB: 2I5T , 2PN7 , 2Q53 , 2RBH , 3CRY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13772	AIG2_2	78 → 160		Family

• Sequence:

  MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKT
  SQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEI
  TCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDII
  KKGETQTL

• Sequence length: 188

Pathways

KEGG Pathway	Reactome Pathway
Glutathione metabolism	Glutathione synthesis and recycling
Metabolic pathways

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CHAC2 2 shared pathwaysGlutathione metabolism, Glutathione synthesis and recycling Related via 2 shared pathways including Glutathione metabolism, Glutathione synthesis and recycling. CHAC1 2 shared pathwaysGlutathione metabolism, Glutathione synthesis and recycling Related via 2 shared pathways including Glutathione metabolism, Glutathione synthesis and recycling. OPLAH 2 shared pathwaysGlutathione metabolism, Glutathione synthesis and recycling Related via 2 shared pathways including Glutathione metabolism, Glutathione synthesis and recycling. GGT6 2 shared pathwaysGlutathione metabolism, Glutathione synthesis and recycling Related via 2 shared pathways including Glutathione metabolism, Glutathione synthesis and recycling. GGT7 2 shared pathwaysGlutathione metabolism, Glutathione synthesis and recycling Related via 2 shared pathways including Glutathione metabolism, Glutathione synthesis and recycling.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CHAC2	0	[]	2	["Glutathione metabolism","Glutathione synthesis and recycling"]	0	[]
CHAC1	0	[]	2	["Glutathione metabolism","Glutathione synthesis and recycling"]	0	[]
OPLAH	0	[]	2	["Glutathione metabolism","Glutathione synthesis and recycling"]	0	[]
GGT6	0	[]	2	["Glutathione metabolism","Glutathione synthesis and recycling"]	0	[]
GGT7	0	[]	2	["Glutathione metabolism","Glutathione synthesis and recycling"]	0	[]

Diseases Linked via Similar Genes

Hypertension Linked via 1 of 5 related genesCHAC1 5-oxoprolinase deficiency Linked via 1 of 5 related genesOPLAH Alzheimer disease Linked via 1 of 5 related genesOPLAH Atrial fibrillation Linked via 1 of 5 related genesOPLAH Atrial flutter Linked via 1 of 5 related genesOPLAH

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hypertension	1	["CHAC1"]
5-oxoprolinase deficiency	1	["OPLAH"]
Alzheimer disease	1	["OPLAH"]
Atrial fibrillation	1	["OPLAH"]
Atrial flutter	1	["OPLAH"]