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Gene Gene information from NCBI Gene database.
Entrez ID 124975
Gene name Gamma-glutamyltransferase 6
Gene symbol GGT6
Synonyms (NCBI Gene)
-
Chromosome 17
Chromosome location 17p13.2
Summary GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT
miRNA miRNA information provided by mirtarbase database.
365 Show/Hide all (365)
miRTarBase ID miRNA Experiments Reference
MIRT611552 hsa-miR-605-5p HITS-CLIP 23824327
MIRT611551 hsa-miR-500a-5p HITS-CLIP 23824327
MIRT611550 hsa-miR-501-5p HITS-CLIP 23824327
MIRT611549 hsa-miR-7702 HITS-CLIP 23824327
MIRT611552 hsa-miR-605-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11 Show/Hide all (11)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0006749 Process Glutathione metabolic process IEA
GO:0006750 Process Glutathione biosynthetic process IEA
GO:0016020 Component Membrane IEA
GO:0016740 Function Transferase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612341 26891 ENSG00000167741
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6P531
Protein name Glutathione hydrolase 6 (EC 3.4.19.13) (Gamma-glutamyltransferase 6) (GGT 6) (EC 2.3.2.2) (Gamma-glutamyltranspeptidase 6) [Cleaved into: Glutathione hydrolase 6 heavy chain; Glutathione hydrolase 6 light chain]
Protein function Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01019 G_glu_transpept 166 → 269 Domain
PF01019 G_glu_transpept 116 → 176 Domain
PF01019 G_glu_transpept 326 → 401 Domain
Sequence
MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQDSSRNKAGGLPGTWARV
VAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGPGVYHHGAIISPAGRELLV
AGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLFHDSSSGNSTAL
TSGPAQTLAPGLGLP
AALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGTEGLCPLLCHADG
TPLGAGARATNPQLAAVLRSAALAPTSDL
AGDALLSLLAGDLGVEVPSAVPRPTLEPAEQ
LPVPQGILFTTPSPSAGPELLALLEAALRSGAPIPDPCPPFLQTAVSPESSALAAVDSSG
SVLLLTSSLNCSFGSAHLSPSTGVLLSNLVAKSTTSAWACP
LILRGSLDDTEADVLGLVA
SGTPDVARAMTHTLLRHLAARPPTQAQHQHQGQQEPTEHPSTCGQGTLLQVAAHTEHAHV
SSVPHACCPFQGF
Sequence length 493
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Taurine and hypotaurine metabolism Glutathione synthesis and recycling
Glutathione metabolism Aflatoxin activation and detoxification
Metabolic pathways