Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	494143
Gene name	ChaC glutathione specific gamma-glutamylcyclotransferase 2
Gene symbol	CHAC2
Synonyms (NCBI Gene)	GCG1
Chromosome	2
Chromosome location	2p16.2
Summary	The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the g

24 Show/Hide all (24)

miRTarBase ID	miRNA	Experiments
MIRT888483	hsa-miR-1208	CLIP-seq
MIRT888484	hsa-miR-1279	CLIP-seq
MIRT888485	hsa-miR-186	CLIP-seq
MIRT888486	hsa-miR-205	CLIP-seq
MIRT888487	hsa-miR-3133	CLIP-seq
MIRT888488	hsa-miR-3156-5p	CLIP-seq
MIRT888489	hsa-miR-3174	CLIP-seq
MIRT888490	hsa-miR-3662	CLIP-seq
MIRT888491	hsa-miR-3680	CLIP-seq
MIRT888492	hsa-miR-374a	CLIP-seq
MIRT888493	hsa-miR-374b	CLIP-seq
MIRT888494	hsa-miR-4255	CLIP-seq
MIRT888495	hsa-miR-4263	CLIP-seq
MIRT888496	hsa-miR-4420	CLIP-seq
MIRT888497	hsa-miR-4509	CLIP-seq
MIRT888498	hsa-miR-4511	CLIP-seq
MIRT888499	hsa-miR-4742-3p	CLIP-seq
MIRT888500	hsa-miR-4744	CLIP-seq
MIRT888501	hsa-miR-4799-5p	CLIP-seq
MIRT888502	hsa-miR-532-5p	CLIP-seq
MIRT888503	hsa-miR-576-5p	CLIP-seq
MIRT888504	hsa-miR-587	CLIP-seq
MIRT888505	hsa-miR-595	CLIP-seq
MIRT888506	hsa-miR-921	CLIP-seq

12 Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003839	Function	Gamma-glutamylcyclotransferase activity	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006750	Process	Glutathione biosynthetic process	TAS
GO:0006751	Process	Glutathione catabolic process	IBA
GO:0006751	Process	Glutathione catabolic process	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0061928	Function	Glutathione specific gamma-glutamylcyclotransferase activity	IBA
GO:0061928	Function	Glutathione specific gamma-glutamylcyclotransferase activity	IDA	27913623
GO:0061928	Function	Glutathione specific gamma-glutamylcyclotransferase activity	IEA

MIM	HGNC	e!Ensembl
617446	32363	ENSG00000143942

Q8WUX2

Protein name

Glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 4.3.2.7) (Cation transport regulator-like protein 2)

Protein function

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

PDB

6K95 , 6KY0 , 6KY1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04752	ChaC	1 → 174	ChaC-like protein	Family

Sequence

MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPAGCV
WGVAYRLPVGKEEEVKAYLDFREKGGYRTTTVIFYPKDPTTKPFSVLLYIGTCDNPDYLG
PAPLEDIAEQIFNAAGPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKERLEGKQN
LNCI

Sequence length

184

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glutathione metabolism	Glutathione synthesis and recycling
Metabolic pathways

CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)

Bookmark This Gene