GADD45GIP1 (GADD45G interacting protein 1)

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Gene Gene information from NCBI Gene database.
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Entrez ID 90480
Gene name GADD45G interacting protein 1
Gene symbol GADD45GIP1
Synonyms (NCBI Gene)
CKBBP2CKbetaBP2CRIF1MRP-L59PLINPPLINP-1PRG6Plinp1mL64
Chromosome 19
Chromosome location 19p13.13
Summary This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT029523 hsa-miR-26b-5p Microarray 19088304
MIRT052572 hsa-let-7a-5p CLASH 23622248
MIRT040436 hsa-miR-615-3p CLASH 23622248
MIRT723628 hsa-miR-2392 HITS-CLIP 19536157
MIRT723627 hsa-miR-1265 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 12716909, 18200042, 25278503, 25416956, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
605162 29996 ENSG00000179271
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TAE8
Protein name Large ribosomal subunit protein mL64 (39S ribosomal protein L59, mitochondrial) (MRP-L59) (CKII beta-associating protein) (CR6-interacting factor 1) (CRIF1) (Growth arrest and DNA damage-inducible proteins-interacting protein 1) (Papillomavirus L2-interac
Protein function Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan
PDB 3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10147 CR6_interact 1 → 211 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal aden
Sequence
Sequence length 222
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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Reactome Pathway
Mitochondrial translation elongation
Mitochondrial translation termination
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MRPS31 2 shared pathwaysMitochondrial translation elongation, Mitochondrial translation termination Related via 2 shared pathways including Mitochondrial translation elongation, Mitochondrial translation termination. MRPS30 2 shared pathwaysMitochondrial translation elongation, Mitochondrial translation termination Related via 2 shared pathways including Mitochondrial translation elongation, Mitochondrial translation termination. MRPL53 2 shared pathwaysMitochondrial translation elongation, Mitochondrial translation termination Related via 2 shared pathways including Mitochondrial translation elongation, Mitochondrial translation termination. MRPL54 2 shared pathwaysMitochondrial translation elongation, Mitochondrial translation termination Related via 2 shared pathways including Mitochondrial translation elongation, Mitochondrial translation termination. CHCHD1 2 shared pathwaysMitochondrial translation elongation, Mitochondrial translation termination Related via 2 shared pathways including Mitochondrial translation elongation, Mitochondrial translation termination.
Myeloproliferative disorder Linked via 1 of 5 related genesMRPS31 Alzheimer disease Linked via 1 of 5 related genesMRPS30 Anorexia nervosa Linked via 1 of 5 related genesMRPS30 Attention deficit hyperactivity disorder Linked via 1 of 5 related genesMRPS30 Breast cancer Linked via 1 of 5 related genesMRPS30