EFNA2 (ephrin A2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1943
• Gene name: Ephrin A2
• Gene symbol: EFNA2
• Synonyms (NCBI Gene): ELF-1, EPLG6, HEK7-L, LERK-6, LERK6
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyros

miRNA Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018404	hsa-miR-335-5p	Microarray	18185580
MIRT029892	hsa-miR-26b-5p	Microarray	19088304
MIRT491631	hsa-miR-548n	PAR-CLIP	23592263
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	23592263
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	26701625
MIRT491631	hsa-miR-548n	PAR-CLIP	23592263
MIRT491630	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT491629	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT491627	hsa-miR-6507-3p	PAR-CLIP	23592263
MIRT953996	hsa-miR-125a-5p	CLIP-seq
MIRT953997	hsa-miR-125b	CLIP-seq
MIRT953998	hsa-miR-2278	CLIP-seq
MIRT953999	hsa-miR-2467-3p	CLIP-seq
MIRT954000	hsa-miR-3064-5p	CLIP-seq
MIRT954001	hsa-miR-3199	CLIP-seq
MIRT954002	hsa-miR-330-3p	CLIP-seq
MIRT954003	hsa-miR-342-5p	CLIP-seq
MIRT954004	hsa-miR-361-3p	CLIP-seq
MIRT954005	hsa-miR-3616-3p	CLIP-seq
MIRT954006	hsa-miR-3617	CLIP-seq
MIRT954007	hsa-miR-3678-3p	CLIP-seq
MIRT954008	hsa-miR-3679-3p	CLIP-seq
MIRT954009	hsa-miR-3926	CLIP-seq
MIRT954010	hsa-miR-4263	CLIP-seq
MIRT954011	hsa-miR-4319	CLIP-seq
MIRT954012	hsa-miR-4325	CLIP-seq
MIRT954013	hsa-miR-4446-3p	CLIP-seq
MIRT954014	hsa-miR-4462	CLIP-seq
MIRT954015	hsa-miR-4468	CLIP-seq
MIRT954016	hsa-miR-4481	CLIP-seq
MIRT954017	hsa-miR-4492	CLIP-seq
MIRT954018	hsa-miR-4498	CLIP-seq
MIRT954019	hsa-miR-4651	CLIP-seq
MIRT954020	hsa-miR-4664-5p	CLIP-seq
MIRT954021	hsa-miR-4665-3p	CLIP-seq
MIRT954022	hsa-miR-4671-5p	CLIP-seq
MIRT954023	hsa-miR-4679	CLIP-seq
MIRT954024	hsa-miR-4687-3p	CLIP-seq
MIRT954025	hsa-miR-4721	CLIP-seq
MIRT954026	hsa-miR-4732-3p	CLIP-seq
MIRT954027	hsa-miR-4742-3p	CLIP-seq
MIRT954028	hsa-miR-4745-5p	CLIP-seq
MIRT954029	hsa-miR-507	CLIP-seq
MIRT954030	hsa-miR-544b	CLIP-seq
MIRT954031	hsa-miR-557	CLIP-seq
MIRT954032	hsa-miR-576-5p	CLIP-seq
MIRT954033	hsa-miR-608	CLIP-seq
MIRT954034	hsa-miR-641	CLIP-seq
MIRT954035	hsa-miR-670	CLIP-seq
MIRT954036	hsa-miR-762	CLIP-seq
MIRT954037	hsa-miR-939	CLIP-seq
MIRT1982492	hsa-miR-3180	CLIP-seq
MIRT1982493	hsa-miR-3180-3p	CLIP-seq
MIRT1982494	hsa-miR-3196	CLIP-seq
MIRT953996	hsa-miR-125a-5p	CLIP-seq
MIRT953997	hsa-miR-125b	CLIP-seq
MIRT2217362	hsa-miR-129-5p	CLIP-seq
MIRT2217363	hsa-miR-140-5p	CLIP-seq
MIRT2217364	hsa-miR-3545-5p	CLIP-seq
MIRT954005	hsa-miR-3616-3p	CLIP-seq
MIRT954006	hsa-miR-3617	CLIP-seq
MIRT954008	hsa-miR-3679-3p	CLIP-seq
MIRT954011	hsa-miR-4319	CLIP-seq
MIRT954013	hsa-miR-4446-3p	CLIP-seq
MIRT2217365	hsa-miR-4460	CLIP-seq
MIRT954014	hsa-miR-4462	CLIP-seq
MIRT954021	hsa-miR-4665-3p	CLIP-seq
MIRT954025	hsa-miR-4721	CLIP-seq
MIRT954026	hsa-miR-4732-3p	CLIP-seq
MIRT954030	hsa-miR-544b	CLIP-seq
MIRT954034	hsa-miR-641	CLIP-seq
MIRT954035	hsa-miR-670	CLIP-seq
MIRT2521270	hsa-miR-1184	CLIP-seq
MIRT2521271	hsa-miR-1301	CLIP-seq
MIRT2521272	hsa-miR-1587	CLIP-seq
MIRT2521273	hsa-miR-29a	CLIP-seq
MIRT2521274	hsa-miR-29b	CLIP-seq
MIRT2521275	hsa-miR-29c	CLIP-seq
MIRT954004	hsa-miR-361-3p	CLIP-seq
MIRT2521276	hsa-miR-3663-3p	CLIP-seq
MIRT954008	hsa-miR-3679-3p	CLIP-seq
MIRT2521277	hsa-miR-4254	CLIP-seq
MIRT2521278	hsa-miR-4417	CLIP-seq
MIRT954017	hsa-miR-4492	CLIP-seq
MIRT954018	hsa-miR-4498	CLIP-seq
MIRT2521279	hsa-miR-4656	CLIP-seq
MIRT2521280	hsa-miR-4660	CLIP-seq
MIRT2521281	hsa-miR-4675	CLIP-seq
MIRT2521282	hsa-miR-4733-3p	CLIP-seq
MIRT2521283	hsa-miR-4741	CLIP-seq
MIRT2521284	hsa-miR-490-3p	CLIP-seq
MIRT2521285	hsa-miR-5047	CLIP-seq
MIRT2521286	hsa-miR-541	CLIP-seq
MIRT2521287	hsa-miR-615-5p	CLIP-seq
MIRT2521288	hsa-miR-619	CLIP-seq
MIRT2521289	hsa-miR-654-5p	CLIP-seq
MIRT954036	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19836338
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007267	Process	Cell-cell signaling	TAS	9826538
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0016020	Component	Membrane	IEA
GO:0021772	Process	Olfactory bulb development	IEA
GO:0030316	Process	Osteoclast differentiation	IBA
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0031594	Component	Neuromuscular junction	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0046849	Process	Bone remodeling	IBA
GO:0046849	Process	Bone remodeling	IEA
GO:0046849	Process	Bone remodeling	ISS
GO:0046875	Function	Ephrin receptor binding	IBA
GO:0046875	Function	Ephrin receptor binding	IEA
GO:0046875	Function	Ephrin receptor binding	TAS	9826538
GO:0048013	Process	Ephrin receptor signaling pathway	IBA
GO:0048013	Process	Ephrin receptor signaling pathway	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:0098552	Component	Side of membrane	IEA

Other IDs

• MIM: 602756
• HGNC: 3222
• e!Ensembl: ENSG00000099617

Protein

• UniProt ID: O43921
• Protein name: Ephrin-A2 (EPH-related receptor tyrosine kinase ligand 6) (LERK-6) (HEK7 ligand) (HEK7-L)
• Protein function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on ad
• PDB: 2WO3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00812	Ephrin	34 → 170	Ephrin	Domain

• Sequence:

  MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYT
  VEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAP
  GGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEA
  PEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS

• Sequence length: 213

Pathways

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	EPH-Ephrin signaling
Ras signaling pathway	EPHA-mediated growth cone collapse
Rap1 signaling pathway	EPH-ephrin mediated repulsion of cells
PI3K-Akt signaling pathway
Axon guidance
MicroRNAs in cancer

Related Genes

Sort by: Blended Diseases Pathways Evidence source

EFNA1 7 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Axon guidance, EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, EPHA-mediated growth cone collapse Related via 7 shared pathways including MAPK signaling pathway, Ras signaling pathway. EFNA3 7 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Axon guidance, EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, EPHA-mediated growth cone collapse Related via 7 shared pathways including MAPK signaling pathway, Ras signaling pathway. EFNA4 7 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Axon guidance, EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, EPHA-mediated growth cone collapse Related via 7 shared pathways including MAPK signaling pathway, Ras signaling pathway. EFNA5 7 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Axon guidance, EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, EPHA-mediated growth cone collapse Related via 7 shared pathways including MAPK signaling pathway, Ras signaling pathway. EPHA2 7 shared pathwaysMAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Axon guidance, EPH-ephrin mediated repulsion of cells, EPH-Ephrin signaling, EPHA-mediated growth cone collapse Related via 7 shared pathways including MAPK signaling pathway, Ras signaling pathway.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
EFNA1	0	[]	7	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Axon guidance","EPH-ephrin mediated repulsion of cells","EPH-Ephrin signaling","EPHA-mediated growth cone collapse"]	0	[]
EFNA3	0	[]	7	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Axon guidance","EPH-ephrin mediated repulsion of cells","EPH-Ephrin signaling","EPHA-mediated growth cone collapse"]	0	[]
EFNA4	0	[]	7	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Axon guidance","EPH-ephrin mediated repulsion of cells","EPH-Ephrin signaling","EPHA-mediated growth cone collapse"]	0	[]
EFNA5	0	[]	7	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Axon guidance","EPH-ephrin mediated repulsion of cells","EPH-Ephrin signaling","EPHA-mediated growth cone collapse"]	0	[]
EPHA2	0	[]	7	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Axon guidance","EPH-ephrin mediated repulsion of cells","EPH-Ephrin signaling","EPHA-mediated growth cone collapse"]	0	[]

Diseases Linked via Similar Genes

Cataract Linked via 3 of 5 related genesEFNA3, EFNA5, EPHA2 Nonalcoholic fatty liver disease Linked via 2 of 5 related genesEFNA3, EPHA2 Schizophrenia Linked via 2 of 5 related genesEFNA3, EFNA5 Bladder exstrophy Linked via 1 of 5 related genesEFNA1 Breast neoplasms Linked via 1 of 5 related genesEFNA1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Cataract	3	["EFNA3","EFNA5","EPHA2"]
Nonalcoholic fatty liver disease	2	["EFNA3","EPHA2"]
Schizophrenia	2	["EFNA3","EFNA5"]
Bladder exstrophy	1	["EFNA1"]
Breast neoplasms	1	["EFNA1"]