ECSIT (ECSIT signaling integrator)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51295
• Gene name: ECSIT signaling integrator
• Gene symbol: ECSIT
• Synonyms (NCBI Gene): SITPEC
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA Show/Hide all (51)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038614	hsa-miR-186-3p	CLASH	23622248
MIRT485941	hsa-miR-941	PAR-CLIP	20371350
MIRT485940	hsa-miR-1247-3p	PAR-CLIP	20371350
MIRT485939	hsa-miR-4532	PAR-CLIP	20371350
MIRT485937	hsa-miR-4285	PAR-CLIP	20371350
MIRT485938	hsa-miR-6087	PAR-CLIP	20371350
MIRT485936	hsa-miR-711	PAR-CLIP	20371350
MIRT485935	hsa-miR-363-5p	PAR-CLIP	20371350
MIRT485934	hsa-miR-6745	PAR-CLIP	20371350
MIRT485933	hsa-miR-8071	PAR-CLIP	20371350
MIRT485932	hsa-miR-4800-5p	PAR-CLIP	20371350
MIRT485941	hsa-miR-941	PAR-CLIP	23592263
MIRT485940	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT485939	hsa-miR-4532	PAR-CLIP	23592263
MIRT485937	hsa-miR-4285	PAR-CLIP	23592263
MIRT485938	hsa-miR-6087	PAR-CLIP	23592263
MIRT485936	hsa-miR-711	PAR-CLIP	23592263
MIRT485935	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT485934	hsa-miR-6745	PAR-CLIP	23592263
MIRT485933	hsa-miR-8071	PAR-CLIP	23592263
MIRT485932	hsa-miR-4800-5p	PAR-CLIP	23592263
MIRT485941	hsa-miR-941	PAR-CLIP	20371350
MIRT485940	hsa-miR-1247-3p	PAR-CLIP	20371350
MIRT485939	hsa-miR-4532	PAR-CLIP	20371350
MIRT485937	hsa-miR-4285	PAR-CLIP	20371350
MIRT485938	hsa-miR-6087	PAR-CLIP	20371350
MIRT485936	hsa-miR-711	PAR-CLIP	20371350
MIRT485935	hsa-miR-363-5p	PAR-CLIP	20371350
MIRT485934	hsa-miR-6745	PAR-CLIP	20371350
MIRT485933	hsa-miR-8071	PAR-CLIP	20371350
MIRT485932	hsa-miR-4800-5p	PAR-CLIP	20371350
MIRT485941	hsa-miR-941	PAR-CLIP	23592263
MIRT485940	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT485939	hsa-miR-4532	PAR-CLIP	23592263
MIRT485937	hsa-miR-4285	PAR-CLIP	23592263
MIRT485938	hsa-miR-6087	PAR-CLIP	23592263
MIRT485936	hsa-miR-711	PAR-CLIP	23592263
MIRT485935	hsa-miR-363-5p	PAR-CLIP	23592263
MIRT485934	hsa-miR-6745	PAR-CLIP	23592263
MIRT485933	hsa-miR-8071	PAR-CLIP	23592263
MIRT485932	hsa-miR-4800-5p	PAR-CLIP	23592263
MIRT951807	hsa-miR-1299	CLIP-seq
MIRT951808	hsa-miR-3158-5p	CLIP-seq
MIRT951809	hsa-miR-3197	CLIP-seq
MIRT951810	hsa-miR-4452	CLIP-seq
MIRT951811	hsa-miR-4782-5p	CLIP-seq
MIRT951812	hsa-miR-516b	CLIP-seq
MIRT951813	hsa-miR-566	CLIP-seq
MIRT951814	hsa-miR-589	CLIP-seq
MIRT951810	hsa-miR-4452	CLIP-seq
MIRT951814	hsa-miR-589	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	17344420, 20816094, 21163940, 32296183, 32320651, 33753518
GO:0005634	Component	Nucleus	IDA	17344420
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IC	25371197
GO:0005737	Component	Cytoplasm	IDA	17344420
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	17344420
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	32320651
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005829	Component	Cytosol	IDA
GO:0007178	Process	Cell surface receptor protein serine/threonine kinase signaling pathway	IBA
GO:0032981	Process	Mitochondrial respiratory chain complex I assembly	NAS	32320651
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	7479976, 25355951, 25371197, 26189595
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	25371197
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	IDA	12048232, 26189595
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0051341	Process	Regulation of oxidoreductase activity	IDA	17344420
GO:0060090	Function	Molecular adaptor activity	IDA	25371197
GO:0061635	Process	Regulation of protein complex stability	IDA	17344420

Other IDs

• MIM: 608388
• HGNC: 29548
• e!Ensembl: ENSG00000130159

Protein

• UniProt ID: Q9BQ95
• Protein name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
• Protein function: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to ac
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06239	ECSIT	45 → 266	Evolutionarily conserved signalling intermediate in Toll pathway	Family
  PF14784	ECSIT_C	269 → 393	C-terminal domain of the ECSIT protein	Domain

• Sequence:

  MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE
  PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY
  GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE
  FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA
  RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV
  YYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMC
  MAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEED
  DNLQRQQQGQS

• Sequence length: 431

Pathways

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
	Complex I biogenesis
	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
	MyD88 cascade initiated on plasma membrane

Related Genes

Sort by: Blended Diseases Pathways Evidence source

MAP3K1 4 shared pathwaysMAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, MyD88 cascade initiated on plasma membrane Related via 4 shared pathways including MAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane. IRAK2 3 shared pathwaysMyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, MyD88 cascade initiated on plasma membrane Related via 3 shared pathways including MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation. IRAK4 4 shared pathwaysMAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, MyD88 cascade initiated on plasma membrane Related via 4 shared pathways including MAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane. IRAK1 4 shared pathwaysMAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, MyD88 cascade initiated on plasma membrane Related via 4 shared pathways including MAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane. MYD88 4 shared pathwaysMAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, MyD88 cascade initiated on plasma membrane Related via 4 shared pathways including MAPK signaling pathway, MyD88:MAL(TIRAP) cascade initiated on plasma membrane.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MAP3K1	0	[]	4	["MAPK signaling pathway","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7\/8 or 9 activation","MyD88 cascade initiated on plasma membrane"]	0	[]
IRAK2	0	[]	3	["MyD88:MAL(TIRAP) cascade initiated on plasma membrane","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7\/8 or 9 activation","MyD88 cascade initiated on plasma membrane"]	0	[]
IRAK4	0	[]	4	["MAPK signaling pathway","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7\/8 or 9 activation","MyD88 cascade initiated on plasma membrane"]	0	[]
IRAK1	0	[]	4	["MAPK signaling pathway","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7\/8 or 9 activation","MyD88 cascade initiated on plasma membrane"]	0	[]
MYD88	0	[]	4	["MAPK signaling pathway","MyD88:MAL(TIRAP) cascade initiated on plasma membrane","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7\/8 or 9 activation","MyD88 cascade initiated on plasma membrane"]	0	[]

Diseases Linked via Similar Genes

Coronary artery disease Linked via 2 of 5 related genesMAP3K1, IRAK1 Hypertension Linked via 2 of 5 related genesMAP3K1, MYD88 Prostatic neoplasms Linked via 2 of 5 related genesMAP3K1, IRAK4 Immunodeficiency Linked via 2 of 5 related genesIRAK4, MYD88 Systemic lupus erythematosus Linked via 2 of 5 related genesIRAK4, IRAK1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Coronary artery disease	2	["MAP3K1","IRAK1"]
Hypertension	2	["MAP3K1","MYD88"]
Prostatic neoplasms	2	["MAP3K1","IRAK4"]
Immunodeficiency	2	["IRAK4","MYD88"]
Systemic lupus erythematosus	2	["IRAK4","IRAK1"]