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Gene Gene information from NCBI Gene database.
Entrez ID 51727
Gene name Cytidine/uridine monophosphate kinase 1
Gene symbol CMPK1
Synonyms (NCBI Gene)
CKCMKCMPKUMKUMP-CMPKUMPK
Chromosome 1
Chromosome location 1p33
Summary This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in bo
miRNA miRNA information provided by mirtarbase database.
751 Show/Hide all (751)
miRTarBase ID miRNA Experiments Reference
MIRT016049 hsa-miR-374b-5p Sequencing 20371350
MIRT016177 hsa-miR-590-3p Sequencing 20371350
MIRT024406 hsa-miR-215-5p Microarray 19074876
MIRT025229 hsa-miR-34a-5p Proteomics 21566225
MIRT025229 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39 Show/Hide all (39)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004550 Function Nucleoside diphosphate kinase activity IDA 23416111
GO:0004550 Function Nucleoside diphosphate kinase activity IEA
GO:0004849 Function Uridine kinase activity TAS 10462544
GO:0005515 Function Protein binding IPI 28514442, 32296183, 32814053, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
191710 18170 ENSG00000162368
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30085
Protein name UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK)
Protein function Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleo
PDB 1TEV , 7E9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00406 ADK 8 → 171 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:11681623}.
Sequence
Sequence length 196
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Pyrimidine metabolism Interconversion of nucleotide di- and triphosphates
Drug metabolism - other enzymes  
Metabolic pathways  
Nucleotide metabolism  
Biosynthesis of cofactors