NME4 (NME/NM23 nucleoside diphosphate kinase 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 4833
• Gene name: NME/NM23 nucleoside diphosphate kinase 4
• Gene symbol: NME4
• Synonyms (NCBI Gene): NDK, NDPK-D, NDPKD, NM23H4, nm23-H4
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm2

miRNA Show/Hide all (320)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002663	hsa-miR-124-3p	Microarray	15685193
MIRT052558	hsa-let-7a-5p	CLASH	23622248
MIRT052182	hsa-let-7b-5p	CLASH	23622248
MIRT051761	hsa-let-7c-5p	CLASH	23622248
MIRT051476	hsa-let-7e-5p	CLASH	23622248
MIRT043937	hsa-miR-378a-3p	CLASH	23622248
MIRT042220	hsa-miR-484	CLASH	23622248
MIRT041585	hsa-miR-193b-3p	CLASH	23622248
MIRT039059	hsa-miR-769-3p	CLASH	23622248
MIRT1187559	hsa-let-7a	CLIP-seq
MIRT1187560	hsa-let-7b	CLIP-seq
MIRT1187561	hsa-let-7c	CLIP-seq
MIRT1187562	hsa-let-7d	CLIP-seq
MIRT1187563	hsa-let-7e	CLIP-seq
MIRT1187564	hsa-let-7f	CLIP-seq
MIRT1187565	hsa-let-7g	CLIP-seq
MIRT1187566	hsa-let-7i	CLIP-seq
MIRT1187567	hsa-miR-124	CLIP-seq
MIRT1187568	hsa-miR-128	CLIP-seq
MIRT1187569	hsa-miR-1285	CLIP-seq
MIRT1187570	hsa-miR-1302	CLIP-seq
MIRT1187571	hsa-miR-1303	CLIP-seq
MIRT1187572	hsa-miR-133a	CLIP-seq
MIRT1187573	hsa-miR-133b	CLIP-seq
MIRT1187574	hsa-miR-140-5p	CLIP-seq
MIRT1187575	hsa-miR-154	CLIP-seq
MIRT1187576	hsa-miR-155	CLIP-seq
MIRT1187577	hsa-miR-1587	CLIP-seq
MIRT1187578	hsa-miR-196a	CLIP-seq
MIRT1187579	hsa-miR-196b	CLIP-seq
MIRT1187580	hsa-miR-218	CLIP-seq
MIRT1187581	hsa-miR-24	CLIP-seq
MIRT1187582	hsa-miR-2467-3p	CLIP-seq
MIRT1187583	hsa-miR-299-3p	CLIP-seq
MIRT1187584	hsa-miR-3122	CLIP-seq
MIRT1187585	hsa-miR-3125	CLIP-seq
MIRT1187586	hsa-miR-3127-3p	CLIP-seq
MIRT1187587	hsa-miR-3150b-3p	CLIP-seq
MIRT1187588	hsa-miR-3151	CLIP-seq
MIRT1187589	hsa-miR-3170	CLIP-seq
MIRT1187590	hsa-miR-3187-5p	CLIP-seq
MIRT1187591	hsa-miR-326	CLIP-seq
MIRT1187592	hsa-miR-330-5p	CLIP-seq
MIRT1187593	hsa-miR-342-5p	CLIP-seq
MIRT1187594	hsa-miR-3611	CLIP-seq
MIRT1187595	hsa-miR-365	CLIP-seq
MIRT1187596	hsa-miR-3667-5p	CLIP-seq
MIRT1187597	hsa-miR-371-5p	CLIP-seq
MIRT1187598	hsa-miR-378g	CLIP-seq
MIRT1187599	hsa-miR-3913-5p	CLIP-seq
MIRT1187600	hsa-miR-3916	CLIP-seq
MIRT1187601	hsa-miR-3940-5p	CLIP-seq
MIRT1187602	hsa-miR-4257	CLIP-seq
MIRT1187603	hsa-miR-4259	CLIP-seq
MIRT1187604	hsa-miR-4265	CLIP-seq
MIRT1187605	hsa-miR-4284	CLIP-seq
MIRT1187606	hsa-miR-4296	CLIP-seq
MIRT1187607	hsa-miR-4298	CLIP-seq
MIRT1187608	hsa-miR-4322	CLIP-seq
MIRT1187609	hsa-miR-4417	CLIP-seq
MIRT1187610	hsa-miR-4458	CLIP-seq
MIRT1187611	hsa-miR-4464	CLIP-seq
MIRT1187612	hsa-miR-4486	CLIP-seq
MIRT1187613	hsa-miR-4492	CLIP-seq
MIRT1187614	hsa-miR-4498	CLIP-seq
MIRT1187615	hsa-miR-4500	CLIP-seq
MIRT1187616	hsa-miR-4505	CLIP-seq
MIRT1187617	hsa-miR-4507	CLIP-seq
MIRT1187618	hsa-miR-4514	CLIP-seq
MIRT1187619	hsa-miR-4651	CLIP-seq
MIRT1187620	hsa-miR-4656	CLIP-seq
MIRT1187621	hsa-miR-4664-5p	CLIP-seq
MIRT1187622	hsa-miR-4670-3p	CLIP-seq
MIRT1187623	hsa-miR-4675	CLIP-seq
MIRT1187624	hsa-miR-4692	CLIP-seq
MIRT1187625	hsa-miR-4703-3p	CLIP-seq
MIRT1187626	hsa-miR-4715-5p	CLIP-seq
MIRT1187627	hsa-miR-4731-5p	CLIP-seq
MIRT1187628	hsa-miR-4736	CLIP-seq
MIRT1187629	hsa-miR-4741	CLIP-seq
MIRT1187630	hsa-miR-4748	CLIP-seq
MIRT1187631	hsa-miR-4764-5p	CLIP-seq
MIRT1187632	hsa-miR-4784	CLIP-seq
MIRT1187633	hsa-miR-486-3p	CLIP-seq
MIRT1187634	hsa-miR-506	CLIP-seq
MIRT1187635	hsa-miR-548an	CLIP-seq
MIRT1187636	hsa-miR-581	CLIP-seq
MIRT1187637	hsa-miR-590-3p	CLIP-seq
MIRT1187638	hsa-miR-608	CLIP-seq
MIRT1187639	hsa-miR-612	CLIP-seq
MIRT1187640	hsa-miR-628-5p	CLIP-seq
MIRT1187641	hsa-miR-657	CLIP-seq
MIRT1187642	hsa-miR-762	CLIP-seq
MIRT1187643	hsa-miR-877	CLIP-seq
MIRT1187644	hsa-miR-940	CLIP-seq
MIRT1187645	hsa-miR-98	CLIP-seq
MIRT1187559	hsa-let-7a	CLIP-seq
MIRT1187560	hsa-let-7b	CLIP-seq
MIRT1187561	hsa-let-7c	CLIP-seq
MIRT1187562	hsa-let-7d	CLIP-seq
MIRT1187563	hsa-let-7e	CLIP-seq
MIRT1187564	hsa-let-7f	CLIP-seq
MIRT1187565	hsa-let-7g	CLIP-seq
MIRT1187566	hsa-let-7i	CLIP-seq
MIRT1187567	hsa-miR-124	CLIP-seq
MIRT2054310	hsa-miR-1275	CLIP-seq
MIRT1187569	hsa-miR-1285	CLIP-seq
MIRT1187570	hsa-miR-1302	CLIP-seq
MIRT1187572	hsa-miR-133a	CLIP-seq
MIRT1187573	hsa-miR-133b	CLIP-seq
MIRT1187574	hsa-miR-140-5p	CLIP-seq
MIRT2054311	hsa-miR-1539	CLIP-seq
MIRT1187575	hsa-miR-154	CLIP-seq
MIRT1187577	hsa-miR-1587	CLIP-seq
MIRT1187578	hsa-miR-196a	CLIP-seq
MIRT1187579	hsa-miR-196b	CLIP-seq
MIRT2054312	hsa-miR-19a	CLIP-seq
MIRT2054313	hsa-miR-19b	CLIP-seq
MIRT1187580	hsa-miR-218	CLIP-seq
MIRT1187581	hsa-miR-24	CLIP-seq
MIRT1187582	hsa-miR-2467-3p	CLIP-seq
MIRT1187583	hsa-miR-299-3p	CLIP-seq
MIRT1187584	hsa-miR-3122	CLIP-seq
MIRT1187588	hsa-miR-3151	CLIP-seq
MIRT1187589	hsa-miR-3170	CLIP-seq
MIRT1187590	hsa-miR-3187-5p	CLIP-seq
MIRT2054314	hsa-miR-3193	CLIP-seq
MIRT2054315	hsa-miR-323b-5p	CLIP-seq
MIRT1187591	hsa-miR-326	CLIP-seq
MIRT1187592	hsa-miR-330-5p	CLIP-seq
MIRT1187593	hsa-miR-342-5p	CLIP-seq
MIRT1187594	hsa-miR-3611	CLIP-seq
MIRT1187596	hsa-miR-3667-5p	CLIP-seq
MIRT1187597	hsa-miR-371-5p	CLIP-seq
MIRT1187598	hsa-miR-378g	CLIP-seq
MIRT1187599	hsa-miR-3913-5p	CLIP-seq
MIRT1187601	hsa-miR-3940-5p	CLIP-seq
MIRT1187602	hsa-miR-4257	CLIP-seq
MIRT1187603	hsa-miR-4259	CLIP-seq
MIRT1187604	hsa-miR-4265	CLIP-seq
MIRT2054316	hsa-miR-4271	CLIP-seq
MIRT1187605	hsa-miR-4284	CLIP-seq
MIRT1187606	hsa-miR-4296	CLIP-seq
MIRT1187607	hsa-miR-4298	CLIP-seq
MIRT1187608	hsa-miR-4322	CLIP-seq
MIRT1187609	hsa-miR-4417	CLIP-seq
MIRT1187610	hsa-miR-4458	CLIP-seq
MIRT1187611	hsa-miR-4464	CLIP-seq
MIRT1187612	hsa-miR-4486	CLIP-seq
MIRT2054317	hsa-miR-4487	CLIP-seq
MIRT1187613	hsa-miR-4492	CLIP-seq
MIRT1187614	hsa-miR-4498	CLIP-seq
MIRT1187615	hsa-miR-4500	CLIP-seq
MIRT1187616	hsa-miR-4505	CLIP-seq
MIRT1187617	hsa-miR-4507	CLIP-seq
MIRT1187618	hsa-miR-4514	CLIP-seq
MIRT2054318	hsa-miR-4520a-5p	CLIP-seq
MIRT2054319	hsa-miR-4520b-5p	CLIP-seq
MIRT2054320	hsa-miR-4525	CLIP-seq
MIRT1187619	hsa-miR-4651	CLIP-seq
MIRT1187620	hsa-miR-4656	CLIP-seq
MIRT1187621	hsa-miR-4664-5p	CLIP-seq
MIRT2054321	hsa-miR-4665-5p	CLIP-seq
MIRT1187622	hsa-miR-4670-3p	CLIP-seq
MIRT1187623	hsa-miR-4675	CLIP-seq
MIRT1187624	hsa-miR-4692	CLIP-seq
MIRT1187625	hsa-miR-4703-3p	CLIP-seq
MIRT1187626	hsa-miR-4715-5p	CLIP-seq
MIRT2054322	hsa-miR-4723-5p	CLIP-seq
MIRT2054323	hsa-miR-4725-3p	CLIP-seq
MIRT1187627	hsa-miR-4731-5p	CLIP-seq
MIRT1187628	hsa-miR-4736	CLIP-seq
MIRT1187629	hsa-miR-4741	CLIP-seq
MIRT1187630	hsa-miR-4748	CLIP-seq
MIRT1187631	hsa-miR-4764-5p	CLIP-seq
MIRT2054324	hsa-miR-4777-3p	CLIP-seq
MIRT1187633	hsa-miR-486-3p	CLIP-seq
MIRT1187634	hsa-miR-506	CLIP-seq
MIRT2054325	hsa-miR-509-3p	CLIP-seq
MIRT1187635	hsa-miR-548an	CLIP-seq
MIRT1187636	hsa-miR-581	CLIP-seq
MIRT1187638	hsa-miR-608	CLIP-seq
MIRT1187639	hsa-miR-612	CLIP-seq
MIRT2054326	hsa-miR-625	CLIP-seq
MIRT1187640	hsa-miR-628-5p	CLIP-seq
MIRT2054327	hsa-miR-637	CLIP-seq
MIRT1187641	hsa-miR-657	CLIP-seq
MIRT1187642	hsa-miR-762	CLIP-seq
MIRT2054328	hsa-miR-9	CLIP-seq
MIRT1187644	hsa-miR-940	CLIP-seq
MIRT1187645	hsa-miR-98	CLIP-seq
MIRT1187559	hsa-let-7a	CLIP-seq
MIRT1187560	hsa-let-7b	CLIP-seq
MIRT1187561	hsa-let-7c	CLIP-seq
MIRT1187562	hsa-let-7d	CLIP-seq
MIRT1187563	hsa-let-7e	CLIP-seq
MIRT1187564	hsa-let-7f	CLIP-seq
MIRT1187565	hsa-let-7g	CLIP-seq
MIRT1187566	hsa-let-7i	CLIP-seq
MIRT1187567	hsa-miR-124	CLIP-seq
MIRT2054310	hsa-miR-1275	CLIP-seq
MIRT1187569	hsa-miR-1285	CLIP-seq
MIRT1187570	hsa-miR-1302	CLIP-seq
MIRT1187572	hsa-miR-133a	CLIP-seq
MIRT1187573	hsa-miR-133b	CLIP-seq
MIRT1187574	hsa-miR-140-5p	CLIP-seq
MIRT2283430	hsa-miR-153	CLIP-seq
MIRT2054311	hsa-miR-1539	CLIP-seq
MIRT1187577	hsa-miR-1587	CLIP-seq
MIRT1187578	hsa-miR-196a	CLIP-seq
MIRT1187579	hsa-miR-196b	CLIP-seq
MIRT1187580	hsa-miR-218	CLIP-seq
MIRT1187581	hsa-miR-24	CLIP-seq
MIRT1187582	hsa-miR-2467-3p	CLIP-seq
MIRT1187583	hsa-miR-299-3p	CLIP-seq
MIRT1187584	hsa-miR-3122	CLIP-seq
MIRT1187588	hsa-miR-3151	CLIP-seq
MIRT1187589	hsa-miR-3170	CLIP-seq
MIRT2283431	hsa-miR-3186-5p	CLIP-seq
MIRT1187590	hsa-miR-3187-5p	CLIP-seq
MIRT2054314	hsa-miR-3193	CLIP-seq
MIRT1187591	hsa-miR-326	CLIP-seq
MIRT1187592	hsa-miR-330-5p	CLIP-seq
MIRT1187593	hsa-miR-342-5p	CLIP-seq
MIRT1187597	hsa-miR-371-5p	CLIP-seq
MIRT1187598	hsa-miR-378g	CLIP-seq
MIRT1187599	hsa-miR-3913-5p	CLIP-seq
MIRT1187601	hsa-miR-3940-5p	CLIP-seq
MIRT1187602	hsa-miR-4257	CLIP-seq
MIRT1187603	hsa-miR-4259	CLIP-seq
MIRT1187604	hsa-miR-4265	CLIP-seq
MIRT2054316	hsa-miR-4271	CLIP-seq
MIRT1187605	hsa-miR-4284	CLIP-seq
MIRT1187606	hsa-miR-4296	CLIP-seq
MIRT1187607	hsa-miR-4298	CLIP-seq
MIRT1187608	hsa-miR-4322	CLIP-seq
MIRT1187609	hsa-miR-4417	CLIP-seq
MIRT1187610	hsa-miR-4458	CLIP-seq
MIRT1187611	hsa-miR-4464	CLIP-seq
MIRT2283432	hsa-miR-448	CLIP-seq
MIRT2283433	hsa-miR-4484	CLIP-seq
MIRT1187612	hsa-miR-4486	CLIP-seq
MIRT2054317	hsa-miR-4487	CLIP-seq
MIRT1187613	hsa-miR-4492	CLIP-seq
MIRT1187614	hsa-miR-4498	CLIP-seq
MIRT1187615	hsa-miR-4500	CLIP-seq
MIRT1187616	hsa-miR-4505	CLIP-seq
MIRT1187617	hsa-miR-4507	CLIP-seq
MIRT1187618	hsa-miR-4514	CLIP-seq
MIRT2054318	hsa-miR-4520a-5p	CLIP-seq
MIRT2054319	hsa-miR-4520b-5p	CLIP-seq
MIRT2054320	hsa-miR-4525	CLIP-seq
MIRT1187619	hsa-miR-4651	CLIP-seq
MIRT1187620	hsa-miR-4656	CLIP-seq
MIRT1187621	hsa-miR-4664-5p	CLIP-seq
MIRT2054321	hsa-miR-4665-5p	CLIP-seq
MIRT1187622	hsa-miR-4670-3p	CLIP-seq
MIRT1187623	hsa-miR-4675	CLIP-seq
MIRT1187624	hsa-miR-4692	CLIP-seq
MIRT1187625	hsa-miR-4703-3p	CLIP-seq
MIRT1187626	hsa-miR-4715-5p	CLIP-seq
MIRT2054322	hsa-miR-4723-5p	CLIP-seq
MIRT2054323	hsa-miR-4725-3p	CLIP-seq
MIRT1187627	hsa-miR-4731-5p	CLIP-seq
MIRT1187628	hsa-miR-4736	CLIP-seq
MIRT1187629	hsa-miR-4741	CLIP-seq
MIRT1187630	hsa-miR-4748	CLIP-seq
MIRT1187631	hsa-miR-4764-5p	CLIP-seq
MIRT2054324	hsa-miR-4777-3p	CLIP-seq
MIRT1187633	hsa-miR-486-3p	CLIP-seq
MIRT1187634	hsa-miR-506	CLIP-seq
MIRT2054325	hsa-miR-509-3p	CLIP-seq
MIRT1187635	hsa-miR-548an	CLIP-seq
MIRT1187636	hsa-miR-581	CLIP-seq
MIRT1187638	hsa-miR-608	CLIP-seq
MIRT1187639	hsa-miR-612	CLIP-seq
MIRT2054326	hsa-miR-625	CLIP-seq
MIRT1187640	hsa-miR-628-5p	CLIP-seq
MIRT2054327	hsa-miR-637	CLIP-seq
MIRT1187641	hsa-miR-657	CLIP-seq
MIRT1187642	hsa-miR-762	CLIP-seq
MIRT1187644	hsa-miR-940	CLIP-seq
MIRT1187645	hsa-miR-98	CLIP-seq
MIRT1187569	hsa-miR-1285	CLIP-seq
MIRT1187577	hsa-miR-1587	CLIP-seq
MIRT1187582	hsa-miR-2467-3p	CLIP-seq
MIRT1187588	hsa-miR-3151	CLIP-seq
MIRT1187590	hsa-miR-3187-5p	CLIP-seq
MIRT1187591	hsa-miR-326	CLIP-seq
MIRT1187592	hsa-miR-330-5p	CLIP-seq
MIRT1187593	hsa-miR-342-5p	CLIP-seq
MIRT1187597	hsa-miR-371-5p	CLIP-seq
MIRT1187598	hsa-miR-378g	CLIP-seq
MIRT1187602	hsa-miR-4257	CLIP-seq
MIRT1187612	hsa-miR-4486	CLIP-seq
MIRT1187613	hsa-miR-4492	CLIP-seq
MIRT1187614	hsa-miR-4498	CLIP-seq
MIRT1187616	hsa-miR-4505	CLIP-seq
MIRT1187619	hsa-miR-4651	CLIP-seq
MIRT1187620	hsa-miR-4656	CLIP-seq
MIRT1187621	hsa-miR-4664-5p	CLIP-seq
MIRT1187623	hsa-miR-4675	CLIP-seq
MIRT1187627	hsa-miR-4731-5p	CLIP-seq
MIRT1187629	hsa-miR-4741	CLIP-seq
MIRT1187633	hsa-miR-486-3p	CLIP-seq
MIRT1187638	hsa-miR-608	CLIP-seq
MIRT1187639	hsa-miR-612	CLIP-seq
MIRT1187642	hsa-miR-762	CLIP-seq
MIRT1187570	hsa-miR-1302	CLIP-seq
MIRT1187584	hsa-miR-3122	CLIP-seq
MIRT1187599	hsa-miR-3913-5p	CLIP-seq
MIRT1187607	hsa-miR-4298	CLIP-seq
MIRT1187611	hsa-miR-4464	CLIP-seq
MIRT1187618	hsa-miR-4514	CLIP-seq
MIRT1187624	hsa-miR-4692	CLIP-seq
MIRT1187628	hsa-miR-4736	CLIP-seq
MIRT1187630	hsa-miR-4748	CLIP-seq
MIRT1187631	hsa-miR-4764-5p	CLIP-seq
MIRT1187641	hsa-miR-657	CLIP-seq
MIRT1187644	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004550	Function	Nucleoside diphosphate kinase activity	IBA
GO:0004550	Function	Nucleoside diphosphate kinase activity	IDA	10799505, 16313181, 18635542, 23150663
GO:0004550	Function	Nucleoside diphosphate kinase activity	IEA
GO:0004550	Function	Nucleoside diphosphate kinase activity	TAS	9099850
GO:0005515	Function	Protein binding	IPI	16189514, 21988832, 23275563, 25416956, 27499296, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005543	Function	Phospholipid binding	IDA	18635542
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	9099850
GO:0005741	Component	Mitochondrial outer membrane	IDA	10799505
GO:0005743	Component	Mitochondrial inner membrane	IDA	10799505
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005758	Component	Mitochondrial intermembrane space	IDA	18635542, 23150663
GO:0005758	Component	Mitochondrial intermembrane space	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	18635542
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0006183	Process	GTP biosynthetic process	IEA
GO:0006228	Process	UTP biosynthetic process	IEA
GO:0006241	Process	CTP biosynthetic process	IEA
GO:0006869	Process	Lipid transport	IDA	23150663
GO:0008289	Function	Lipid binding	IEA
GO:0009116	Process	Nucleoside metabolic process	TAS	9099850
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0034214	Process	Protein hexamerization	IDA	10799505
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051020	Function	GTPase binding	IEA
GO:0120010	Process	Intermembrane phospholipid transfer	IDA	17028143, 23150663
GO:0140339	Function	Phosphatidylglycerol transfer activity	IDA	17028143, 23150663
GO:0160204	Function	Mitochondrion-mitochondrion outer membrane tether activity	IDA	17028143, 23150663
GO:1901612	Function	Cardiolipin binding	IDA	23150663

Other IDs

• MIM: 601818
• HGNC: 7852
• e!Ensembl: ENSG00000103202

Protein

• UniProt ID: O00746
• Protein name: Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)
• Protein function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange o
• PDB: 1EHW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00334	NDK	38 → 172	Nucleoside diphosphate kinase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.
• Sequence:

  MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR
  FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS
  RAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQ
  HSSIHPA

• Sequence length: 187

Pathways

KEGG Pathway	Reactome Pathway
Purine metabolism	Interconversion of nucleotide di- and triphosphates
Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
Biosynthesis of cofactors

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NME1 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME2 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME3 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME1-NME2 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME6 5 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors Related via 5 shared pathways including Purine metabolism, Pyrimidine metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NME1	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME2	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME3	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME1-NME2	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME6	0	[]	5	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors"]	0	[]

Diseases Linked via Similar Genes

Colorectal neoplasms Linked via 2 of 5 related genesNME1, NME2 Myocardial infarction Linked via 2 of 5 related genesNME1, NME6 Atrial fibrillation Linked via 2 of 5 related genesNME2, NME1-NME2 Hepatocellular carcinoma Linked via 1 of 5 related genesNME1 Cardiomyopathy Linked via 1 of 5 related genesNME1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Colorectal neoplasms	2	["NME1","NME2"]
Myocardial infarction	2	["NME1","NME6"]
Atrial fibrillation	2	["NME2","NME1-NME2"]
Hepatocellular carcinoma	1	["NME1"]
Cardiomyopathy	1	["NME1"]