Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	4832
Gene name	NME/NM23 nucleoside diphosphate kinase 3
Gene symbol	NME3
Synonyms (NCBI Gene)	DR-nm23NDPK-CNDPKCNM23-H3NM23H3c371H6.2
Chromosome	16
Chromosome location	16p13.3

74 Show/Hide all (74)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043040	hsa-miR-324-5p	CLASH	23622248
MIRT2054306	hsa-miR-1247	CLIP-seq
MIRT2054307	hsa-miR-4436a	CLIP-seq
MIRT2054308	hsa-miR-4733-3p	CLIP-seq
MIRT2054309	hsa-miR-564	CLIP-seq
MIRT2283426	hsa-miR-10a	CLIP-seq
MIRT2283427	hsa-miR-10b	CLIP-seq
MIRT2283428	hsa-miR-4496	CLIP-seq
MIRT2283429	hsa-miR-486-5p	CLIP-seq
MIRT2283426	hsa-miR-10a	CLIP-seq
MIRT2283427	hsa-miR-10b	CLIP-seq
MIRT2581627	hsa-miR-1270	CLIP-seq
MIRT2581628	hsa-miR-1324	CLIP-seq
MIRT2581629	hsa-miR-1539	CLIP-seq
MIRT2581630	hsa-miR-185	CLIP-seq
MIRT2581631	hsa-miR-198	CLIP-seq
MIRT2581632	hsa-miR-3155	CLIP-seq
MIRT2581633	hsa-miR-3155b	CLIP-seq
MIRT2581634	hsa-miR-3165	CLIP-seq
MIRT2581635	hsa-miR-3180-5p	CLIP-seq
MIRT2581636	hsa-miR-3690	CLIP-seq
MIRT2581637	hsa-miR-3691-5p	CLIP-seq
MIRT2581638	hsa-miR-4254	CLIP-seq
MIRT2581639	hsa-miR-4268	CLIP-seq
MIRT2581640	hsa-miR-4306	CLIP-seq
MIRT2283428	hsa-miR-4496	CLIP-seq
MIRT2581641	hsa-miR-4531	CLIP-seq
MIRT2581642	hsa-miR-4644	CLIP-seq
MIRT2581643	hsa-miR-4645-5p	CLIP-seq
MIRT2581644	hsa-miR-4660	CLIP-seq
MIRT2581645	hsa-miR-4673	CLIP-seq
MIRT2581646	hsa-miR-4764-5p	CLIP-seq
MIRT2581647	hsa-miR-484	CLIP-seq
MIRT2283429	hsa-miR-486-5p	CLIP-seq
MIRT2581648	hsa-miR-552	CLIP-seq
MIRT2054309	hsa-miR-564	CLIP-seq
MIRT2581649	hsa-miR-620	CLIP-seq
MIRT2581650	hsa-miR-646	CLIP-seq
MIRT2581651	hsa-miR-891a	CLIP-seq
MIRT2283426	hsa-miR-10a	CLIP-seq
MIRT2283427	hsa-miR-10b	CLIP-seq
MIRT2581627	hsa-miR-1270	CLIP-seq
MIRT2581628	hsa-miR-1324	CLIP-seq
MIRT2581629	hsa-miR-1539	CLIP-seq
MIRT2581630	hsa-miR-185	CLIP-seq
MIRT2581631	hsa-miR-198	CLIP-seq
MIRT2686403	hsa-miR-214	CLIP-seq
MIRT2581632	hsa-miR-3155	CLIP-seq
MIRT2581633	hsa-miR-3155b	CLIP-seq
MIRT2581634	hsa-miR-3165	CLIP-seq
MIRT2581635	hsa-miR-3180-5p	CLIP-seq
MIRT2686404	hsa-miR-3619-5p	CLIP-seq
MIRT2581636	hsa-miR-3690	CLIP-seq
MIRT2581637	hsa-miR-3691-5p	CLIP-seq
MIRT2581638	hsa-miR-4254	CLIP-seq
MIRT2581639	hsa-miR-4268	CLIP-seq
MIRT2686405	hsa-miR-4291	CLIP-seq
MIRT2581640	hsa-miR-4306	CLIP-seq
MIRT2283428	hsa-miR-4496	CLIP-seq
MIRT2581641	hsa-miR-4531	CLIP-seq
MIRT2581642	hsa-miR-4644	CLIP-seq
MIRT2581643	hsa-miR-4645-5p	CLIP-seq
MIRT2581644	hsa-miR-4660	CLIP-seq
MIRT2581645	hsa-miR-4673	CLIP-seq
MIRT2581646	hsa-miR-4764-5p	CLIP-seq
MIRT2581647	hsa-miR-484	CLIP-seq
MIRT2283429	hsa-miR-486-5p	CLIP-seq
MIRT2581648	hsa-miR-552	CLIP-seq
MIRT2054309	hsa-miR-564	CLIP-seq
MIRT2581649	hsa-miR-620	CLIP-seq
MIRT2581650	hsa-miR-646	CLIP-seq
MIRT2686406	hsa-miR-761	CLIP-seq
MIRT2581651	hsa-miR-891a	CLIP-seq
MIRT2686407	hsa-miR-922	CLIP-seq

Transcription factor	Regulation	Reference
TFAP2A	Activation	9067290

39 Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004550	Function	Nucleoside diphosphate kinase activity	IBA
GO:0004550	Function	Nucleoside diphosphate kinase activity	IDA	11277919, 30587587, 39337255
GO:0004550	Function	Nucleoside diphosphate kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 25416956, 26945015, 31515488, 32296183, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	26945015
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IDA	37584589
GO:0005741	Component	Mitochondrial outer membrane	IDA	30587587
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006183	Process	GTP biosynthetic process	IEA
GO:0006228	Process	UTP biosynthetic process	IEA
GO:0006235	Process	DTTP biosynthetic process	IDA	11277919
GO:0006241	Process	CTP biosynthetic process	IEA
GO:0006281	Process	DNA repair	IMP	26945015
GO:0006915	Process	Apoptotic process	TAS	7638209
GO:0008053	Process	Mitochondrial fusion	IDA	37584589
GO:0008053	Process	Mitochondrial fusion	IMP	30587587
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0009142	Process	Nucleoside triphosphate biosynthetic process	IDA	30587587, 39337255
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019003	Function	GDP binding	IDA	39337255
GO:0030552	Function	CAMP binding	IDA	39337255
GO:0034214	Process	Protein hexamerization	IDA	11277919, 37584589
GO:0036064	Component	Ciliary basal body	IEA
GO:0036064	Component	Ciliary basal body	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043531	Function	ADP binding	IDA	39337255
GO:0046872	Function	Metal ion binding	IEA
GO:0070300	Function	Phosphatidic acid binding	IDA	37584589
GO:0160204	Function	Mitochondrion-mitochondrion outer membrane tether activity	IDA	37584589
GO:1990626	Process	Mitochondrial outer membrane fusion	IDA	37584589

MIM	HGNC	e!Ensembl
601817	7851	ENSG00000103024

Q13232

Protein name

Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3)

Protein function

Catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor (PubMed:11277919, PubMed:30587587). The ATP gamma phosphate is tran

PDB

1ZS6 , 8QVY , 8QVZ , 8QW0 , 8QW1 , 8QW2 , 8QW3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00334	NDK	22 → 156	Nucleoside diphosphate kinase	Domain

Sequence

MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQA
SEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGT
IRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE

Sequence length

169

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Purine metabolism	Interconversion of nucleotide di- and triphosphates
Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
Biosynthesis of cofactors

NME3 (NME/NM23 nucleoside diphosphate kinase 3)

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