NME1-NME2 (NME1-NME2 readthrough)

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Gene miRNA Other IDs Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 654364
• Gene name: NME1-NME2 readthrough
• Gene symbol: NME1-NME2
• Synonyms (NCBI Gene): NM23-LV, NMELV
• Chromosome: 17
• Chromosome location: 17q21.33
• Summary: This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternati

miRNA Show/Hide all (76)

miRTarBase ID	miRNA	Experiments	Reference
MIRT472130	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT472129	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT472128	hsa-miR-4257	PAR-CLIP	23592263
MIRT472127	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT472126	hsa-miR-1292-3p	PAR-CLIP	23592263
MIRT472125	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT472124	hsa-miR-558	PAR-CLIP	23592263
MIRT472123	hsa-miR-4487	PAR-CLIP	23592263
MIRT472122	hsa-miR-1827	PAR-CLIP	23592263
MIRT472121	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT472120	hsa-miR-6086	PAR-CLIP	23592263
MIRT472119	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT472118	hsa-miR-3612	PAR-CLIP	23592263
MIRT472117	hsa-miR-650	PAR-CLIP	23592263
MIRT472116	hsa-miR-4792	PAR-CLIP	23592263
MIRT472115	hsa-miR-4710	PAR-CLIP	23592263
MIRT472114	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT472130	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT472129	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT472128	hsa-miR-4257	PAR-CLIP	23592263
MIRT472127	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT472126	hsa-miR-1292-3p	PAR-CLIP	23592263
MIRT472125	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT472124	hsa-miR-558	PAR-CLIP	23592263
MIRT472123	hsa-miR-4487	PAR-CLIP	23592263
MIRT472122	hsa-miR-1827	PAR-CLIP	23592263
MIRT472121	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT472120	hsa-miR-6086	PAR-CLIP	23592263
MIRT472119	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT472118	hsa-miR-3612	PAR-CLIP	23592263
MIRT472117	hsa-miR-650	PAR-CLIP	23592263
MIRT472116	hsa-miR-4792	PAR-CLIP	23592263
MIRT472115	hsa-miR-4710	PAR-CLIP	23592263
MIRT472114	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT1187541	hsa-miR-182	CLIP-seq
MIRT1187542	hsa-miR-186	CLIP-seq
MIRT1187543	hsa-miR-2115	CLIP-seq
MIRT1187544	hsa-miR-3163	CLIP-seq
MIRT1187545	hsa-miR-4470	CLIP-seq
MIRT2054284	hsa-miR-1	CLIP-seq
MIRT2054285	hsa-miR-1252	CLIP-seq
MIRT1187541	hsa-miR-182	CLIP-seq
MIRT2054286	hsa-miR-198	CLIP-seq
MIRT2054287	hsa-miR-206	CLIP-seq
MIRT1187543	hsa-miR-2115	CLIP-seq
MIRT2054288	hsa-miR-224	CLIP-seq
MIRT2054289	hsa-miR-3152-5p	CLIP-seq
MIRT2054290	hsa-miR-329	CLIP-seq
MIRT2054291	hsa-miR-362-3p	CLIP-seq
MIRT2054292	hsa-miR-3657	CLIP-seq
MIRT2054293	hsa-miR-3673	CLIP-seq
MIRT2054294	hsa-miR-4423-5p	CLIP-seq
MIRT1187545	hsa-miR-4470	CLIP-seq
MIRT2054295	hsa-miR-4669	CLIP-seq
MIRT2054296	hsa-miR-4685-5p	CLIP-seq
MIRT2054297	hsa-miR-4709-3p	CLIP-seq
MIRT2054298	hsa-miR-613	CLIP-seq
MIRT2054284	hsa-miR-1	CLIP-seq
MIRT1187541	hsa-miR-182	CLIP-seq
MIRT1187542	hsa-miR-186	CLIP-seq
MIRT2054286	hsa-miR-198	CLIP-seq
MIRT2054287	hsa-miR-206	CLIP-seq
MIRT1187543	hsa-miR-2115	CLIP-seq
MIRT2054288	hsa-miR-224	CLIP-seq
MIRT2054289	hsa-miR-3152-5p	CLIP-seq
MIRT1187544	hsa-miR-3163	CLIP-seq
MIRT2054290	hsa-miR-329	CLIP-seq
MIRT2054291	hsa-miR-362-3p	CLIP-seq
MIRT2054292	hsa-miR-3657	CLIP-seq
MIRT2054293	hsa-miR-3673	CLIP-seq
MIRT2054294	hsa-miR-4423-5p	CLIP-seq
MIRT1187545	hsa-miR-4470	CLIP-seq
MIRT2054295	hsa-miR-4669	CLIP-seq
MIRT2054296	hsa-miR-4685-5p	CLIP-seq
MIRT2054297	hsa-miR-4709-3p	CLIP-seq
MIRT2054298	hsa-miR-613	CLIP-seq

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG Pathway	Reactome Pathway
Purine metabolism	Interconversion of nucleotide di- and triphosphates
Pyrimidine metabolism	Neutrophil degranulation
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
Biosynthesis of cofactors

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	40645996	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NME1-NME2-related disorder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (39)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	7515452		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	17272673		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	17272673		★☆☆☆☆ Found in Text Mining only
Benign Neoplasm	Benign Neoplasm	BEFREE	7907945		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	7614395		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18586674, 8102131		★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	8418304		★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	7614395		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	25277864		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	8418304		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	8418304		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	8549951		★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	16862176		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	25900369, 30002415		★☆☆☆☆ Found in Text Mining only
Diverticular Diseases	Diverticular Diseases	BEFREE	31250368		★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	7542225		★☆☆☆☆ Found in Text Mining only
Germ cell tumor	Tumor	BEFREE	9334657		★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	9490665		★☆☆☆☆ Found in Text Mining only
Kidney Neoplasm	Kidney Neoplasm	BEFREE	9615786		★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	8896423		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22192927, 7530600, 8168032		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18586674, 8102131		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	7907945		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	7614395		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15079086, 28128954, 31250368, 31260268, 7669582, 8102131, 8375920		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	31287738, 8418304		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	1988104		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	11058869, 22699362		★☆☆☆☆ Found in Text Mining only
Metastatic Prostate Carcinoma	Metastatic Prostate Carcinoma	BEFREE	7515452		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	18496563, 22251158, 8896423, 9490665		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15674352, 16442775, 18496563, 22192927, 23021215, 31441682, 7497458, 7515452, 7614395, 7669582, 7745027, 8375920, 8384356, 8637723, 9036878		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	11960382, 16442775, 8637723		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	8375920		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	29630434		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	8636741		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	16862176		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	10632374, 18665757		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	BEFREE	8375920		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	18665757		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NME1 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME2 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME3 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME4 6 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors, Interconversion of nucleotide di- and triphosphates Related via 6 shared pathways including Purine metabolism, Pyrimidine metabolism. NME6 5 shared pathwaysPurine metabolism, Pyrimidine metabolism, Drug metabolism - other enzymes, Nucleotide metabolism, Biosynthesis of cofactors Related via 5 shared pathways including Purine metabolism, Pyrimidine metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NME1	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME2	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME3	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME4	0	[]	6	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates"]	0	[]
NME6	0	[]	5	["Purine metabolism","Pyrimidine metabolism","Drug metabolism - other enzymes","Nucleotide metabolism","Biosynthesis of cofactors"]	0	[]

Diseases Linked via Similar Genes

Colorectal neoplasms Linked via 2 of 5 related genesNME1, NME2 Myocardial infarction Linked via 2 of 5 related genesNME1, NME6 Hepatocellular carcinoma Linked via 1 of 5 related genesNME1 Cardiomyopathy Linked via 1 of 5 related genesNME1 Hypertrophic cardiomyopathy Linked via 1 of 5 related genesNME1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Colorectal neoplasms	2	["NME1","NME2"]
Myocardial infarction	2	["NME1","NME6"]
Hepatocellular carcinoma	1	["NME1"]
Cardiomyopathy	1	["NME1"]
Hypertrophic cardiomyopathy	1	["NME1"]