Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	79643
Gene name	Charged multivesicular body protein 6
Gene symbol	CHMP6
Synonyms (NCBI Gene)	VPS20
Chromosome	17
Chromosome location	17q25.3
Summary	This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in bio

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028818	hsa-miR-26b-5p	Microarray	19088304
MIRT890858	hsa-miR-1538	CLIP-seq
MIRT890859	hsa-miR-1827	CLIP-seq
MIRT890860	hsa-miR-2467-3p	CLIP-seq
MIRT890861	hsa-miR-3612	CLIP-seq
MIRT890862	hsa-miR-3689d	CLIP-seq
MIRT890863	hsa-miR-4258	CLIP-seq
MIRT890864	hsa-miR-4455	CLIP-seq
MIRT890865	hsa-miR-4466	CLIP-seq
MIRT890866	hsa-miR-4707-3p	CLIP-seq
MIRT890867	hsa-miR-4745-3p	CLIP-seq
MIRT890868	hsa-miR-609	CLIP-seq
MIRT890869	hsa-miR-650	CLIP-seq
MIRT890870	hsa-miR-658	CLIP-seq
MIRT890871	hsa-miR-675	CLIP-seq
MIRT890859	hsa-miR-1827	CLIP-seq
MIRT1964044	hsa-miR-214	CLIP-seq
MIRT890860	hsa-miR-2467-3p	CLIP-seq
MIRT1964045	hsa-miR-3065-3p	CLIP-seq
MIRT890861	hsa-miR-3612	CLIP-seq
MIRT1964046	hsa-miR-3619-5p	CLIP-seq
MIRT890862	hsa-miR-3689d	CLIP-seq
MIRT1964047	hsa-miR-378g	CLIP-seq
MIRT1964048	hsa-miR-4291	CLIP-seq
MIRT1964049	hsa-miR-4437	CLIP-seq
MIRT890864	hsa-miR-4455	CLIP-seq
MIRT890865	hsa-miR-4466	CLIP-seq
MIRT1964050	hsa-miR-4674	CLIP-seq
MIRT1964051	hsa-miR-4685-5p	CLIP-seq
MIRT890868	hsa-miR-609	CLIP-seq
MIRT890869	hsa-miR-650	CLIP-seq
MIRT890870	hsa-miR-658	CLIP-seq
MIRT890871	hsa-miR-675	CLIP-seq
MIRT1964052	hsa-miR-761	CLIP-seq
MIRT1964053	hsa-miR-922	CLIP-seq
MIRT2200245	hsa-miR-1226	CLIP-seq
MIRT890858	hsa-miR-1538	CLIP-seq
MIRT2200246	hsa-miR-1909	CLIP-seq
MIRT2200247	hsa-miR-331-3p	CLIP-seq
MIRT890862	hsa-miR-3689d	CLIP-seq
MIRT1964047	hsa-miR-378g	CLIP-seq
MIRT890863	hsa-miR-4258	CLIP-seq
MIRT1964048	hsa-miR-4291	CLIP-seq
MIRT1964049	hsa-miR-4437	CLIP-seq
MIRT2200248	hsa-miR-451b	CLIP-seq
MIRT1964050	hsa-miR-4674	CLIP-seq
MIRT1964051	hsa-miR-4685-5p	CLIP-seq
MIRT890866	hsa-miR-4707-3p	CLIP-seq
MIRT890867	hsa-miR-4745-3p	CLIP-seq
MIRT2200249	hsa-miR-545	CLIP-seq
MIRT2503079	hsa-miR-1289	CLIP-seq
MIRT2503080	hsa-miR-139-3p	CLIP-seq
MIRT2503081	hsa-miR-1972	CLIP-seq
MIRT2503082	hsa-miR-1976	CLIP-seq
MIRT2503083	hsa-miR-2278	CLIP-seq
MIRT2503084	hsa-miR-3155	CLIP-seq
MIRT2503085	hsa-miR-3155b	CLIP-seq
MIRT2503086	hsa-miR-3193	CLIP-seq
MIRT2503087	hsa-miR-3198	CLIP-seq
MIRT2503088	hsa-miR-3925-3p	CLIP-seq
MIRT2503089	hsa-miR-4294	CLIP-seq
MIRT2503090	hsa-miR-4309	CLIP-seq
MIRT2503091	hsa-miR-4520a-5p	CLIP-seq
MIRT2503092	hsa-miR-4520b-5p	CLIP-seq
MIRT2503093	hsa-miR-4690-5p	CLIP-seq
MIRT2503094	hsa-miR-4761-5p	CLIP-seq
MIRT2503095	hsa-miR-4768-3p	CLIP-seq
MIRT2503096	hsa-miR-4787-3p	CLIP-seq
MIRT2503097	hsa-miR-484	CLIP-seq
MIRT2503098	hsa-miR-516b	CLIP-seq
MIRT2503099	hsa-miR-566	CLIP-seq
MIRT2503100	hsa-miR-665	CLIP-seq
MIRT2503101	hsa-miR-766	CLIP-seq
MIRT2503079	hsa-miR-1289	CLIP-seq
MIRT2503080	hsa-miR-139-3p	CLIP-seq
MIRT2503081	hsa-miR-1972	CLIP-seq
MIRT2503083	hsa-miR-2278	CLIP-seq
MIRT2503084	hsa-miR-3155	CLIP-seq
MIRT2503085	hsa-miR-3155b	CLIP-seq
MIRT2503087	hsa-miR-3198	CLIP-seq
MIRT2503088	hsa-miR-3925-3p	CLIP-seq
MIRT2503089	hsa-miR-4294	CLIP-seq
MIRT2503090	hsa-miR-4309	CLIP-seq
MIRT2503093	hsa-miR-4690-5p	CLIP-seq
MIRT2503094	hsa-miR-4761-5p	CLIP-seq
MIRT2503095	hsa-miR-4768-3p	CLIP-seq
MIRT2503097	hsa-miR-484	CLIP-seq
MIRT2503098	hsa-miR-516b	CLIP-seq
MIRT2503099	hsa-miR-566	CLIP-seq
MIRT2503100	hsa-miR-665	CLIP-seq
MIRT2503101	hsa-miR-766	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000421	Component	Autophagosome membrane	IDA	17984323
GO:0000776	Component	Kinetochore	IDA	26040712
GO:0000776	Component	Kinetochore	IEA
GO:0000815	Component	ESCRT III complex	IBA
GO:0000815	Component	ESCRT III complex	IDA	24878737
GO:0000815	Component	ESCRT III complex	NAS	36107470
GO:0000815	Component	ESCRT III complex	TAS	20588296
GO:0001778	Process	Plasma membrane repair	IDA	24482116
GO:0001778	Process	Plasma membrane repair	IEA
GO:0005515	Function	Protein binding	IPI	14505570, 14519844, 16730941, 16856878, 16973552, 18606141, 21543490, 32296183, 32814053, 33961781
GO:0005643	Component	Nuclear pore	IDA	26040713
GO:0005643	Component	Nuclear pore	IEA
GO:0005765	Component	Lysosomal membrane	IDA	17984323
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005771	Component	Multivesicular body	IBA
GO:0005828	Component	Kinetochore microtubule	IDA	26040712
GO:0005828	Component	Kinetochore microtubule	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	24878737
GO:0006900	Process	Vesicle budding from membrane	IBA
GO:0006914	Process	Autophagy	IMP	17984323
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0007034	Process	Vacuolar transport	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	20616062
GO:0007175	Process	Negative regulation of epidermal growth factor-activated receptor activity	IMP	16973552
GO:0010008	Component	Endosome membrane	IDA	16973552
GO:0010008	Component	Endosome membrane	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0030496	Component	Midbody	IDA	26040712
GO:0030496	Component	Midbody	IEA
GO:0031468	Process	Nuclear membrane reassembly	IEA
GO:0031468	Process	Nuclear membrane reassembly	IMP	26040713
GO:0031902	Component	Late endosome membrane	IEA
GO:0032511	Process	Late endosome to vacuole transport via multivesicular body sorting pathway	IBA
GO:0032585	Component	Multivesicular body membrane	IDA	16554368
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	16505166
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IDA	24878737
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0042176	Process	Regulation of protein catabolic process	IMP	18606141
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA	17984323
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IEA
GO:0044877	Function	Protein-containing complex binding	IDA	16973552
GO:0046761	Process	Viral budding from plasma membrane	IDA	24878737
GO:0046761	Process	Viral budding from plasma membrane	IEA
GO:0051469	Process	Vesicle fusion with vacuole	NAS	16505166
GO:0061763	Process	Multivesicular body-lysosome fusion	NAS	16505166
GO:0061952	Process	Midbody abscission	IEA
GO:0061952	Process	Midbody abscission	IMP	20616062
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0071985	Process	Multivesicular body sorting pathway	IDA	16554368
GO:0071985	Process	Multivesicular body sorting pathway	IEA
GO:0090148	Process	Membrane fission	NAS	19234443
GO:0097352	Process	Autophagosome maturation	IEA
GO:0097352	Process	Autophagosome maturation	IMP	17984323
GO:1901673	Process	Regulation of mitotic spindle assembly	IEA
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	20616062
GO:1902774	Process	Late endosome to lysosome transport	IEA
GO:1902774	Process	Late endosome to lysosome transport	IMP	17984323
GO:1903541	Process	Regulation of exosomal secretion	IMP	22660413
GO:1904902	Process	ESCRT III complex assembly	NAS	20588296
GO:1904930	Component	Amphisome membrane	IDA	17984323
GO:1904930	Component	Amphisome membrane	IEA

MIM	HGNC	e!Ensembl
610901	25675	ENSG00000176108

Q96FZ7

Protein name

Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20)

Protein function

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (IL

PDB

2K3W , 3HTU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03357	Snf7	18 → 178	Snf7	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:15511219}.

Sequence

MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERERALARQLLRDGRKERA
KLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQFGNECLNKMHQVMSI
EEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEELSAITQEQIELPEVPSEPLPE
KIPENVPVKARPRQAELVAAS

Sequence length

201

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Viral life cycle - HIV-1	Budding and maturation of HIV virion
Endocytosis	Macroautophagy
Necroptosis	Endosomal Sorting Complex Required For Transport (ESCRT)
	HCMV Late Events
	Sealing of the nuclear envelope (NE) by ESCRT-III

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
CHMP4B	[]	8	["Viral life cycle - HIV-1","Endocytosis","Necroptosis","Budding and maturation of HIV virion","Macroautophagy","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Sealing of the nuclear envelope (NE) by ESCRT-III"]	[]
CHMP4A	[]	8	["Viral life cycle - HIV-1","Endocytosis","Necroptosis","Budding and maturation of HIV virion","Macroautophagy","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Sealing of the nuclear envelope (NE) by ESCRT-III"]	[]
RNF103-CHMP3	[]	7	["Endocytosis","Necroptosis","Budding and maturation of HIV virion","Macroautophagy","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Sealing of the nuclear envelope (NE) by ESCRT-III"]	[]
CHMP2B	[]	7	["Endocytosis","Necroptosis","Budding and maturation of HIV virion","Macroautophagy","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Sealing of the nuclear envelope (NE) by ESCRT-III"]	[]
CHMP3	[]	7	["Endocytosis","Necroptosis","Budding and maturation of HIV virion","Macroautophagy","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Sealing of the nuclear envelope (NE) by ESCRT-III"]	[]

CHMP6 (charged multivesicular body protein 6)

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