CCL3L1 (C-C motif chemokine ligand 3 like 1)

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Gene miRNA Gene ontology Other IDs Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6349
• Gene name: C-C motif chemokine ligand 3 like 1
• Gene symbol: CCL3L1
• Synonyms (NCBI Gene): 464.2, D17S1718, G0S19-2, LD78, LD78-beta(1-70), LD78BETA, MIP1AP, SCYA3L, SCYA3L1
• Chromosome: 17
• Chromosome location: 17q21.1
• Summary: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemok

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026329	hsa-miR-192-5p	Microarray	19074876
MIRT871053	hsa-miR-3126-5p	CLIP-seq
MIRT871054	hsa-miR-4419a	CLIP-seq
MIRT871055	hsa-miR-4510	CLIP-seq
MIRT871056	hsa-miR-4747-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005125	Function	Cytokine activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0006954	Process	Inflammatory response	IBA
GO:0006954	Process	Inflammatory response	TAS	1694014
GO:0006955	Process	Immune response	IEA
GO:0008009	Function	Chemokine activity	IBA
GO:0008009	Function	Chemokine activity	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	2271120
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0048020	Function	CCR chemokine receptor binding	IBA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA
GO:0070098	Process	Chemokine-mediated signaling pathway	IBA

Other IDs

• MIM: 601395
• HGNC: 10628
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG Pathway	Reactome Pathway
Cytokine-cytokine receptor interaction	Chemokine receptors bind chemokines
Viral protein interaction with cytokine and cytokine receptor	Interleukin-10 signaling
Chemokine signaling pathway
Toll-like receptor signaling pathway
Chagas disease
Human cytomegalovirus infection
Rheumatoid arthritis
Lipid and atherosclerosis

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CCL3L3 10 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, Chagas disease, Human cytomegalovirus infection, Rheumatoid arthritis, Lipid and atherosclerosis, Chemokine receptors bind chemokines, Interleukin-10 signaling Related via 10 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor. CCL3 10 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, Chagas disease, Human cytomegalovirus infection, Rheumatoid arthritis, Lipid and atherosclerosis, Chemokine receptors bind chemokines, Interleukin-10 signaling Related via 10 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor. CCL4L1 7 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, Human cytomegalovirus infection, Chemokine receptors bind chemokines, Interleukin-10 signaling Related via 7 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor. CCL4 7 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, Human cytomegalovirus infection, Chemokine receptors bind chemokines, Interleukin-10 signaling Related via 7 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor. CCL5 10 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, Chagas disease, Human cytomegalovirus infection, Rheumatoid arthritis, Lipid and atherosclerosis, Chemokine receptors bind chemokines, Interleukin-10 signaling Related via 10 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CCL3L3	0	[]	10	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Toll-like receptor signaling pathway","Chagas disease","Human cytomegalovirus infection","Rheumatoid arthritis","Lipid and atherosclerosis","Chemokine receptors bind chemokines","Interleukin-10 signaling"]	0	[]
CCL3	0	[]	10	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Toll-like receptor signaling pathway","Chagas disease","Human cytomegalovirus infection","Rheumatoid arthritis","Lipid and atherosclerosis","Chemokine receptors bind chemokines","Interleukin-10 signaling"]	0	[]
CCL4L1	0	[]	7	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Toll-like receptor signaling pathway","Human cytomegalovirus infection","Chemokine receptors bind chemokines","Interleukin-10 signaling"]	0	[]
CCL4	0	[]	7	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Toll-like receptor signaling pathway","Human cytomegalovirus infection","Chemokine receptors bind chemokines","Interleukin-10 signaling"]	0	[]
CCL5	0	[]	10	["Cytokine-cytokine receptor interaction","Viral protein interaction with cytokine and cytokine receptor","Chemokine signaling pathway","Toll-like receptor signaling pathway","Chagas disease","Human cytomegalovirus infection","Rheumatoid arthritis","Lipid and atherosclerosis","Chemokine receptors bind chemokines","Interleukin-10 signaling"]	0	[]

Diseases Linked via Similar Genes

Glomerulonephritis Linked via 3 of 5 related genesCCL3, CCL4, CCL5 Pulmonary fibrosis Linked via 3 of 5 related genesCCL3, CCL4, CCL5 Skin disease Linked via 2 of 5 related genesCCL3L3, CCL4 Atherosclerosis Linked via 2 of 5 related genesCCL3, CCL4 Brain ischemia Linked via 2 of 5 related genesCCL3, CCL4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Glomerulonephritis	3	["CCL3","CCL4","CCL5"]
Pulmonary fibrosis	3	["CCL3","CCL4","CCL5"]
Skin disease	2	["CCL3L3","CCL4"]
Atherosclerosis	2	["CCL3","CCL4"]
Brain ischemia	2	["CCL3","CCL4"]