CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 782
• Gene name: Calcium voltage-gated channel auxiliary subunit beta 1
• Gene symbol: CACNB1
• Synonyms (NCBI Gene): CAB1, CACNLB1, CCHLB1
• Chromosome: 17
• Chromosome location: 17q12
• Summary: The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting

miRNA Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021151	hsa-miR-186-5p	Sequencing	20371350
MIRT716946	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT716945	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT716944	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT716943	hsa-miR-1470	HITS-CLIP	19536157
MIRT716942	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT716941	hsa-miR-6803-3p	HITS-CLIP	19536157
MIRT716940	hsa-miR-4469	HITS-CLIP	19536157
MIRT716939	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT716938	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT716937	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT716936	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT716935	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT487424	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT487423	hsa-miR-1324	PAR-CLIP	23592263
MIRT487421	hsa-miR-4270	PAR-CLIP	23592263
MIRT487422	hsa-miR-4441	PAR-CLIP	23592263
MIRT487420	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT487419	hsa-miR-7515	PAR-CLIP	23592263
MIRT487418	hsa-miR-3202	PAR-CLIP	23592263
MIRT487417	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT487416	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT487415	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487414	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487413	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487412	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487410	hsa-miR-4271	PAR-CLIP	23592263
MIRT487411	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487409	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487408	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT487407	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487406	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487405	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT716946	hsa-miR-6769a-3p	HITS-CLIP	19536157
MIRT716945	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT716944	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT716943	hsa-miR-1470	HITS-CLIP	19536157
MIRT716942	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT716941	hsa-miR-6803-3p	HITS-CLIP	19536157
MIRT716940	hsa-miR-4469	HITS-CLIP	19536157
MIRT716939	hsa-miR-1225-3p	HITS-CLIP	19536157
MIRT716938	hsa-miR-1233-3p	HITS-CLIP	19536157
MIRT716937	hsa-miR-4749-3p	HITS-CLIP	19536157
MIRT716936	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT716935	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT487424	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT487423	hsa-miR-1324	PAR-CLIP	23592263
MIRT487421	hsa-miR-4270	PAR-CLIP	23592263
MIRT487422	hsa-miR-4441	PAR-CLIP	23592263
MIRT487420	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT487419	hsa-miR-7515	PAR-CLIP	23592263
MIRT487418	hsa-miR-3202	PAR-CLIP	23592263
MIRT487417	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT487416	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT487415	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487414	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487413	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487412	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487410	hsa-miR-4271	PAR-CLIP	23592263
MIRT487411	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT487409	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT487408	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT487407	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487406	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487405	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT857843	hsa-miR-15a	CLIP-seq
MIRT857844	hsa-miR-15b	CLIP-seq
MIRT857845	hsa-miR-16	CLIP-seq
MIRT857846	hsa-miR-1827	CLIP-seq
MIRT857847	hsa-miR-195	CLIP-seq
MIRT857848	hsa-miR-2277-3p	CLIP-seq
MIRT857849	hsa-miR-3173-3p	CLIP-seq
MIRT857850	hsa-miR-331-3p	CLIP-seq
MIRT857851	hsa-miR-3612	CLIP-seq
MIRT857852	hsa-miR-3689a-3p	CLIP-seq
MIRT857853	hsa-miR-3689c	CLIP-seq
MIRT857854	hsa-miR-3943	CLIP-seq
MIRT857855	hsa-miR-424	CLIP-seq
MIRT857856	hsa-miR-4254	CLIP-seq
MIRT857857	hsa-miR-4308	CLIP-seq
MIRT857858	hsa-miR-4313	CLIP-seq
MIRT857859	hsa-miR-4419a	CLIP-seq
MIRT857860	hsa-miR-4510	CLIP-seq
MIRT857861	hsa-miR-4690-5p	CLIP-seq
MIRT857862	hsa-miR-4779	CLIP-seq
MIRT857863	hsa-miR-497	CLIP-seq
MIRT857864	hsa-miR-650	CLIP-seq
MIRT1954748	hsa-miR-129-3p	CLIP-seq
MIRT857846	hsa-miR-1827	CLIP-seq
MIRT1954749	hsa-miR-214	CLIP-seq
MIRT1954750	hsa-miR-2355-5p	CLIP-seq
MIRT1954751	hsa-miR-3619-5p	CLIP-seq
MIRT1954752	hsa-miR-3622b-5p	CLIP-seq
MIRT1954753	hsa-miR-3929	CLIP-seq
MIRT1954754	hsa-miR-4419b	CLIP-seq
MIRT1954755	hsa-miR-4478	CLIP-seq
MIRT1954756	hsa-miR-4649-3p	CLIP-seq
MIRT1954757	hsa-miR-4651	CLIP-seq
MIRT1954758	hsa-miR-4660	CLIP-seq
MIRT1954759	hsa-miR-4802-5p	CLIP-seq
MIRT1954760	hsa-miR-518a-3p	CLIP-seq
MIRT1954761	hsa-miR-518b	CLIP-seq
MIRT1954762	hsa-miR-518c	CLIP-seq
MIRT1954763	hsa-miR-518d-3p	CLIP-seq
MIRT1954764	hsa-miR-518f	CLIP-seq
MIRT1954765	hsa-miR-608	CLIP-seq
MIRT1954766	hsa-miR-646	CLIP-seq
MIRT1954767	hsa-miR-761	CLIP-seq
MIRT2192329	hsa-miR-1233	CLIP-seq
MIRT2192330	hsa-miR-1252	CLIP-seq
MIRT2192331	hsa-miR-1266	CLIP-seq
MIRT2192332	hsa-miR-1271	CLIP-seq
MIRT1954748	hsa-miR-129-3p	CLIP-seq
MIRT857843	hsa-miR-15a	CLIP-seq
MIRT857844	hsa-miR-15b	CLIP-seq
MIRT857845	hsa-miR-16	CLIP-seq
MIRT857847	hsa-miR-195	CLIP-seq
MIRT2192333	hsa-miR-2278	CLIP-seq
MIRT2192334	hsa-miR-3150b-3p	CLIP-seq
MIRT2192335	hsa-miR-361-3p	CLIP-seq
MIRT2192336	hsa-miR-3667-3p	CLIP-seq
MIRT2192337	hsa-miR-3689d	CLIP-seq
MIRT857854	hsa-miR-3943	CLIP-seq
MIRT857855	hsa-miR-424	CLIP-seq
MIRT2192338	hsa-miR-4258	CLIP-seq
MIRT2192339	hsa-miR-4454	CLIP-seq
MIRT2192340	hsa-miR-4459	CLIP-seq
MIRT2192341	hsa-miR-4518	CLIP-seq
MIRT1954758	hsa-miR-4660	CLIP-seq
MIRT2192342	hsa-miR-4683	CLIP-seq
MIRT2192343	hsa-miR-4691-5p	CLIP-seq
MIRT2192344	hsa-miR-4710	CLIP-seq
MIRT2192345	hsa-miR-4784	CLIP-seq
MIRT2192346	hsa-miR-4797-5p	CLIP-seq
MIRT2192347	hsa-miR-483-3p	CLIP-seq
MIRT857863	hsa-miR-497	CLIP-seq
MIRT2192348	hsa-miR-635	CLIP-seq
MIRT2192349	hsa-miR-644	CLIP-seq
MIRT1954766	hsa-miR-646	CLIP-seq
MIRT2192350	hsa-miR-663b	CLIP-seq
MIRT2192351	hsa-miR-96	CLIP-seq
MIRT2192329	hsa-miR-1233	CLIP-seq
MIRT1954748	hsa-miR-129-3p	CLIP-seq
MIRT2192336	hsa-miR-3667-3p	CLIP-seq
MIRT2385462	hsa-miR-378g	CLIP-seq
MIRT2192338	hsa-miR-4258	CLIP-seq
MIRT2192343	hsa-miR-4691-5p	CLIP-seq
MIRT2192349	hsa-miR-644	CLIP-seq
MIRT2192350	hsa-miR-663b	CLIP-seq
MIRT857843	hsa-miR-15a	CLIP-seq
MIRT857844	hsa-miR-15b	CLIP-seq
MIRT857845	hsa-miR-16	CLIP-seq
MIRT857847	hsa-miR-195	CLIP-seq
MIRT2192333	hsa-miR-2278	CLIP-seq
MIRT857855	hsa-miR-424	CLIP-seq
MIRT857863	hsa-miR-497	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IEA
GO:0005245	Function	Voltage-gated calcium channel activity	TAS	1385409
GO:0005246	Function	Calcium channel regulator activity	IGI	21883149
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	17052716, 18535142, 32296183, 35122502
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005891	Component	Voltage-gated calcium channel complex	IBA
GO:0005891	Component	Voltage-gated calcium channel complex	IEA
GO:0005891	Component	Voltage-gated calcium channel complex	IGI	21883149
GO:0005891	Component	Voltage-gated calcium channel complex	TAS	1385409
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IBA
GO:0006816	Process	Calcium ion transport	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA
GO:0008331	Function	High voltage-gated calcium channel activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0030315	Component	T-tubule	NAS	27273705
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0045202	Component	Synapse	IEA
GO:0045933	Process	Positive regulation of muscle contraction	NAS	22982493
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	NAS	22982493
GO:1902514	Process	Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IGI	21883149
GO:1904646	Process	Cellular response to amyloid-beta	IGI	21883149
GO:1990454	Component	L-type voltage-gated calcium channel complex	ISO

Other IDs

• MIM: 114207
• HGNC: 1401
• e!Ensembl: ENSG00000067191

Protein

• UniProt ID: Q02641
• Protein name: Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)
• Protein function: Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964). Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity). Regulates the activity of L-type cal
• PDB: 7VFS , 7VFU , 7VFV , 7VFW , 7XLQ , 7YG5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00625	Guanylate_kin	228 → 408	Guanylate kinase	Domain
  PF12052	VGCC_beta4Aa_N	58 → 99	Voltage gated calcium channel subunit beta domain 4Aa N terminal	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in heart ventricle (at protein level) (PubMed:15615847). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. {ECO:0000269|Pu
• Sequence:

  MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA
  ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP
  VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR
  LGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK
  GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA
  EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG
  KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP
  NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYP
  SSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGT
  PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR

• Sequence length: 598

Pathways

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	Presynaptic depolarization and calcium channel opening
Cardiac muscle contraction	Phase 0 - rapid depolarisation
Adrenergic signaling in cardiomyocytes	Phase 2 - plateau phase
Oxytocin signaling pathway
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CACNA2D3 10 shared pathwaysMAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Phase 2 - plateau phase, Phase 0 - rapid depolarisation, Presynaptic depolarization and calcium channel opening Related via 10 shared pathways including MAPK signaling pathway, Cardiac muscle contraction. CACNA2D1 10 shared pathwaysMAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Phase 2 - plateau phase, Phase 0 - rapid depolarisation, Presynaptic depolarization and calcium channel opening Related via 10 shared pathways including MAPK signaling pathway, Cardiac muscle contraction. CACNB4 10 shared pathwaysMAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Phase 2 - plateau phase, Phase 0 - rapid depolarisation, Presynaptic depolarization and calcium channel opening Related via 10 shared pathways including MAPK signaling pathway, Cardiac muscle contraction. CACNB2 10 shared pathwaysMAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Phase 2 - plateau phase, Phase 0 - rapid depolarisation, Presynaptic depolarization and calcium channel opening Related via 10 shared pathways including MAPK signaling pathway, Cardiac muscle contraction. CACNB3 10 shared pathwaysMAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy, Phase 2 - plateau phase, Phase 0 - rapid depolarisation, Presynaptic depolarization and calcium channel opening Related via 10 shared pathways including MAPK signaling pathway, Cardiac muscle contraction.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CACNA2D3	0	[]	10	["MAPK signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Oxytocin signaling pathway","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Phase 2 - plateau phase","Phase 0 - rapid depolarisation","Presynaptic depolarization and calcium channel opening"]	0	[]
CACNA2D1	0	[]	10	["MAPK signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Oxytocin signaling pathway","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Phase 2 - plateau phase","Phase 0 - rapid depolarisation","Presynaptic depolarization and calcium channel opening"]	0	[]
CACNB4	0	[]	10	["MAPK signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Oxytocin signaling pathway","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Phase 2 - plateau phase","Phase 0 - rapid depolarisation","Presynaptic depolarization and calcium channel opening"]	0	[]
CACNB2	0	[]	10	["MAPK signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Oxytocin signaling pathway","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Phase 2 - plateau phase","Phase 0 - rapid depolarisation","Presynaptic depolarization and calcium channel opening"]	0	[]
CACNB3	0	[]	10	["MAPK signaling pathway","Cardiac muscle contraction","Adrenergic signaling in cardiomyocytes","Oxytocin signaling pathway","Hypertrophic cardiomyopathy","Arrhythmogenic right ventricular cardiomyopathy","Dilated cardiomyopathy","Phase 2 - plateau phase","Phase 0 - rapid depolarisation","Presynaptic depolarization and calcium channel opening"]	0	[]

Diseases Linked via Similar Genes

Bipolar disorder Linked via 4 of 5 related genesCACNA2D3, CACNA2D1, CACNB2, CACNB3 Major depressive disorder Linked via 3 of 5 related genesCACNA2D3, CACNA2D1, CACNB2 Schizophrenia Linked via 3 of 5 related genesCACNA2D3, CACNA2D1, CACNB2 Alzheimer disease Linked via 2 of 5 related genesCACNA2D3, CACNB2 Attention deficit hyperactivity disorder Linked via 2 of 5 related genesCACNA2D3, CACNB2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Bipolar disorder	4	["CACNA2D3","CACNA2D1","CACNB2","CACNB3"]
Major depressive disorder	3	["CACNA2D3","CACNA2D1","CACNB2"]
Schizophrenia	3	["CACNA2D3","CACNA2D1","CACNB2"]
Alzheimer disease	2	["CACNA2D3","CACNB2"]
Attention deficit hyperactivity disorder	2	["CACNA2D3","CACNB2"]