BEX3 (brain expressed X-linked 3)

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Gene Gene information from NCBI Gene database.
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Entrez ID 27018
Gene name Brain expressed X-linked 3
Gene symbol BEX3
Synonyms (NCBI Gene)
BexDXS6984EHGR74Hero20NADENGFRAP1
Chromosome X
Chromosome location Xq22.2
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT472209 hsa-miR-216a-5p PAR-CLIP 24398324
MIRT472208 hsa-miR-144-3p PAR-CLIP 24398324
MIRT501803 hsa-miR-27b-3p PAR-CLIP 24398324
MIRT501802 hsa-miR-27a-3p PAR-CLIP 24398324
MIRT472207 hsa-miR-216a-3p PAR-CLIP 24398324
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding IBA
GO:0005123 Function Death receptor binding IEA
GO:0005163 Function Nerve growth factor receptor binding IEA
GO:0005515 Function Protein binding IPI 17355907, 21516116, 25416956, 32296183, 32814053
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
300361 13388 ENSG00000166681
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q00994
Protein name Protein BEX3 (Brain-expressed X-linked protein 3) (Nerve growth factor receptor-associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) (p75NTR-associated cell death executor)
Protein function May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04538 BEX 1 → 107 Brain expressed X-linked like family Family
Tissue specificity TISSUE SPECIFICITY: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. {ECO:0000269|PubMed:15958283}.
Sequence
Sequence length 111
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Neurotrophin signaling pathway NADE modulates death signalling
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NGFR 2 shared pathwaysNeurotrophin signaling pathway, NADE modulates death signalling Related via 2 shared pathways including Neurotrophin signaling pathway, NADE modulates death signalling. NGF 2 shared pathwaysNeurotrophin signaling pathway, NADE modulates death signalling Related via 2 shared pathways including Neurotrophin signaling pathway, NADE modulates death signalling. YWHAE 2 shared pathwaysNeurotrophin signaling pathway, NADE modulates death signalling Related via 2 shared pathways including Neurotrophin signaling pathway, NADE modulates death signalling.
Bipolar disorder Linked via 3 of 3 related genesNGFR, NGF, YWHAE Schizophrenia Linked via 3 of 3 related genesNGFR, NGF, YWHAE Degenerative disorder Linked via 2 of 3 related genesNGFR, NGF Major depressive disorder Linked via 2 of 3 related genesNGFR, NGF Neurodegenerative disorder Linked via 2 of 3 related genesNGFR, NGF