Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	10331
Gene name	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Gene symbol	B3GNT3
Synonyms (NCBI Gene)	B3GAL-T8B3GN-T3B3GNT-3HP10328TMEM3beta3Gn-T3
Chromosome	19
Chromosome location	19p13.11
Summary	This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and

111 Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018502	hsa-miR-335-5p	Microarray	18185580
MIRT813329	hsa-miR-1184	CLIP-seq
MIRT813330	hsa-miR-1251	CLIP-seq
MIRT813331	hsa-miR-1343	CLIP-seq
MIRT813332	hsa-miR-184	CLIP-seq
MIRT813333	hsa-miR-324-5p	CLIP-seq
MIRT813334	hsa-miR-371-5p	CLIP-seq
MIRT813335	hsa-miR-378g	CLIP-seq
MIRT813336	hsa-miR-4418	CLIP-seq
MIRT813337	hsa-miR-4420	CLIP-seq
MIRT813338	hsa-miR-4437	CLIP-seq
MIRT813339	hsa-miR-4674	CLIP-seq
MIRT813340	hsa-miR-4680-5p	CLIP-seq
MIRT813341	hsa-miR-509-3-5p	CLIP-seq
MIRT813342	hsa-miR-509-5p	CLIP-seq
MIRT813343	hsa-miR-618	CLIP-seq
MIRT813344	hsa-miR-888	CLIP-seq
MIRT1545655	hsa-miR-3180	CLIP-seq
MIRT1545656	hsa-miR-3180-3p	CLIP-seq
MIRT1545657	hsa-miR-3196	CLIP-seq
MIRT1545658	hsa-miR-4488	CLIP-seq
MIRT1545659	hsa-miR-4697-5p	CLIP-seq
MIRT813329	hsa-miR-1184	CLIP-seq
MIRT1940406	hsa-miR-1245	CLIP-seq
MIRT1940407	hsa-miR-1252	CLIP-seq
MIRT1940408	hsa-miR-1254	CLIP-seq
MIRT1940409	hsa-miR-1265	CLIP-seq
MIRT813331	hsa-miR-1343	CLIP-seq
MIRT1940410	hsa-miR-149	CLIP-seq
MIRT1940411	hsa-miR-2052	CLIP-seq
MIRT1940412	hsa-miR-21	CLIP-seq
MIRT1940413	hsa-miR-3064-5p	CLIP-seq
MIRT1940414	hsa-miR-3116	CLIP-seq
MIRT1940415	hsa-miR-3144-5p	CLIP-seq
MIRT1940416	hsa-miR-3145-3p	CLIP-seq
MIRT1940417	hsa-miR-3158-5p	CLIP-seq
MIRT1940418	hsa-miR-3166	CLIP-seq
MIRT1940419	hsa-miR-3176	CLIP-seq
MIRT1940420	hsa-miR-3191	CLIP-seq
MIRT1940421	hsa-miR-3652	CLIP-seq
MIRT813335	hsa-miR-378g	CLIP-seq
MIRT1940422	hsa-miR-3922-3p	CLIP-seq
MIRT813336	hsa-miR-4418	CLIP-seq
MIRT813337	hsa-miR-4420	CLIP-seq
MIRT1940423	hsa-miR-4430	CLIP-seq
MIRT1940424	hsa-miR-4433	CLIP-seq
MIRT813338	hsa-miR-4437	CLIP-seq
MIRT1940425	hsa-miR-4505	CLIP-seq
MIRT1940426	hsa-miR-4652-5p	CLIP-seq
MIRT1940427	hsa-miR-4667-5p	CLIP-seq
MIRT813339	hsa-miR-4674	CLIP-seq
MIRT1940428	hsa-miR-4686	CLIP-seq
MIRT1940429	hsa-miR-4700-5p	CLIP-seq
MIRT1940430	hsa-miR-4725-5p	CLIP-seq
MIRT1940431	hsa-miR-4727-5p	CLIP-seq
MIRT1940432	hsa-miR-4728-3p	CLIP-seq
MIRT1940433	hsa-miR-4731-5p	CLIP-seq
MIRT1940434	hsa-miR-4764-5p	CLIP-seq
MIRT1940435	hsa-miR-4769-3p	CLIP-seq
MIRT1940436	hsa-miR-4771	CLIP-seq
MIRT1940437	hsa-miR-4794	CLIP-seq
MIRT1940438	hsa-miR-485-5p	CLIP-seq
MIRT1940439	hsa-miR-504	CLIP-seq
MIRT813341	hsa-miR-509-3-5p	CLIP-seq
MIRT813342	hsa-miR-509-5p	CLIP-seq
MIRT1940440	hsa-miR-590-3p	CLIP-seq
MIRT1940441	hsa-miR-590-5p	CLIP-seq
MIRT1940442	hsa-miR-628-5p	CLIP-seq
MIRT1940443	hsa-miR-629	CLIP-seq
MIRT813329	hsa-miR-1184	CLIP-seq
MIRT1940408	hsa-miR-1254	CLIP-seq
MIRT2179343	hsa-miR-1264	CLIP-seq
MIRT813331	hsa-miR-1343	CLIP-seq
MIRT1940414	hsa-miR-3116	CLIP-seq
MIRT2179344	hsa-miR-3156-5p	CLIP-seq
MIRT1940417	hsa-miR-3158-5p	CLIP-seq
MIRT1940418	hsa-miR-3166	CLIP-seq
MIRT2179345	hsa-miR-3691-3p	CLIP-seq
MIRT813335	hsa-miR-378g	CLIP-seq
MIRT2179346	hsa-miR-412	CLIP-seq
MIRT813336	hsa-miR-4418	CLIP-seq
MIRT813337	hsa-miR-4420	CLIP-seq
MIRT813338	hsa-miR-4437	CLIP-seq
MIRT813339	hsa-miR-4674	CLIP-seq
MIRT1940436	hsa-miR-4771	CLIP-seq
MIRT813341	hsa-miR-509-3-5p	CLIP-seq
MIRT813342	hsa-miR-509-5p	CLIP-seq
MIRT2179347	hsa-miR-515-5p	CLIP-seq
MIRT813329	hsa-miR-1184	CLIP-seq
MIRT813331	hsa-miR-1343	CLIP-seq
MIRT2384704	hsa-miR-2681	CLIP-seq
MIRT813335	hsa-miR-378g	CLIP-seq
MIRT813336	hsa-miR-4418	CLIP-seq
MIRT813338	hsa-miR-4437	CLIP-seq
MIRT813339	hsa-miR-4674	CLIP-seq
MIRT813341	hsa-miR-509-3-5p	CLIP-seq
MIRT813342	hsa-miR-509-5p	CLIP-seq
MIRT813329	hsa-miR-1184	CLIP-seq
MIRT813336	hsa-miR-4418	CLIP-seq
MIRT813337	hsa-miR-4420	CLIP-seq
MIRT813341	hsa-miR-509-3-5p	CLIP-seq
MIRT813342	hsa-miR-509-5p	CLIP-seq
MIRT813329	hsa-miR-1184	CLIP-seq
MIRT813336	hsa-miR-4418	CLIP-seq
MIRT813337	hsa-miR-4420	CLIP-seq
MIRT813341	hsa-miR-509-3-5p	CLIP-seq
MIRT813342	hsa-miR-509-5p	CLIP-seq
MIRT2675817	hsa-miR-3120-3p	CLIP-seq
MIRT2675818	hsa-miR-4310	CLIP-seq
MIRT2675819	hsa-miR-640	CLIP-seq
MIRT2675820	hsa-miR-885-5p	CLIP-seq

24 Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	TAS	10072769
GO:0006486	Process	Protein glycosylation	IEA
GO:0006493	Process	Protein O-linked glycosylation	IBA
GO:0008499	Function	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IEA
GO:0008499	Function	N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	TAS
GO:0008532	Function	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IBA
GO:0008532	Function	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IDA	11042166
GO:0008532	Function	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	IEA
GO:0008532	Function	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016758	Function	Hexosyltransferase activity	IEA
GO:0018146	Process	Keratan sulfate proteoglycan biosynthetic process	TAS
GO:0030311	Process	Poly-N-acetyllactosamine biosynthetic process	IBA
GO:0030311	Process	Poly-N-acetyllactosamine biosynthetic process	IDA	11042166
GO:0047223	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IEA

MIM	HGNC	e!Ensembl
605863	13528	ENSG00000179913

Q9Y2A9

Protein name

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 (EC 2.4.1.149) (Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase) (EC 2.4.1.146) (Beta-1,3-galactosyltransferase 8) (Beta-1,3-GalTase 8) (Beta3Gal-T8) (Be

Protein function

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01762	Galactosyl_T	121 → 315	Galactosyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in colon, jejunum, stomach, esophagus, placenta and trachea. {ECO:0000269|PubMed:11042166}.

Sequence

MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIPEALAWPTPPTRPAPAP
CHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSKCAQPVFLLLVIKSSPSNY
VRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVNRLLELEAQTHGDILQWDFHD
SFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTDNMVFYLQDHDPGRHLFVGQLIQ
NVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLSRFTAAALRRAAHVLDIFPIDDVFL
GMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDPCFYRDLLLVHRFLPYEMLLMWDALNQ
PNLTCGNQTQIY

Sequence length

372

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Mucin type O-glycan biosynthesis	Keratan sulfate biosynthesis
Glycosphingolipid biosynthesis - lacto and neolacto series	O-linked glycosylation of mucins
Metabolic pathways

B3GNT3 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3)

Bookmark This Gene